Glycine, N,N-bis(2-hydroxyethyl)-, sodium salt (1:1)

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  • Identifiers

    CAS number
    139-41-3

    Molecular formula
    C6H12NNaO4

    SMILES
    C(CO)N(CCO)CC(=O)[O-].[Na+]

    Safety labels

  • Odor profile

    Fragrance
    Sweet 54.8%
    Odorless 53.88%
    Fishy 33.8%
    Alcoholic 24.23%
    Savory 21.68%
    Oily 18.88%
    Cooling 15.46%
    Milky 13.56%
    Bitter 13.51%
    Clean 13.48%

     

    Flavor
    Odorless 66.73%
    Mild 32.62%
    Bland 27.74%
    Sweet-like 26.33%
    Bitter 23.39%
    Very mild 21.56%
    Yeast 21.25%
    Sulfury 20.81%
    Very slight 20.63%
    Faint 20.45%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.33 (weak acid)

    Molecular weight
    185.15 g/mol

    Flash point

    • 187.05 ˚C est.

  • Synonyms

    • 139-41-3
    • Glycine, N,N-bis(2-hydroxyethyl)-, monosodium salt
    • IH8W456FUR
    • N,N-Bis(2-hydroxyethyl)glycine, monosodium salt
    • Glycine, N,N-bis(2-hydroxyethyl)-, sodium salt (1:1)
    • RefChem:568039
    • N,N-Bis(2-hydroxyethyl)glycine sodium salt
    • BICINE SODIUM
    • Sodium N,N-bis(2-hydroxyethyl)glycinate
    • sodium;2-[bis(2-hydroxyethyl)amino]acetate
    • sodium 2-[bis(2-hydroxyethyl)amino]acetate
    • N,N-Bis(2-hydroxyethyl)glycine, sodium salt
    • EINECS 205-360-4
    • UNII-IH8W456FUR
    • Sodium N,N-bis-2-hydroxyethyl glycinate
    • HAMPSHIRE DEG
    • MONAQUEST IA
    • SYNTRON D
    • sodium diethanolglycinate
    • CHELEST G 50
    • Glycine, N,N-bis(2-hydroxyethyl)-, sodium salt
    • SCHEMBL783494
    • CHEL 185
    • DTXSID3059686
    • CHEBI:182771
    • DIHYDROXYETHYLGLYCINE, SODIUM SALT
    • sodium [bis(2-hydroxyethyl)amino]acetate
    • 17123-43-2
    • BIS(HYDROXYETHYL)GLYCINE SODIUM SALT
    • DB-042472
    • NS00079368
    • sodium N,N-bis-(2-hydroxyethyl)aminoacetate
    • SODIUM N,N-DI-2-HYDROXYETHYLGLYCINATE
    • EN300-7827222
    • N,N-BIS(2-HYDROXYETHYL)GLYCINESODIUMSALT
    • SODIUM BIS(.BETA.-HYDROXYETHYL)GLYCINATE
    • SODIUM N,N-BIS(2-HYDROXYETHYL)AMINOACETATE
    • SODIUM N,N-BIS(.BETA.-HYDROXYETHYL)GLYCINATE
    • N,N-DI(2-HYDROXYETHYL)GLYCINE MONOSODIUM SALT
    • Q27280727
    • N,N-BIS(.BETA.-HYDROXYETHYL)GLYCINE SODIUM SALT
    • N,N-BIS-2-HYDROXYETHYLAMINOACETIC ACID SODIUM SALT
    • 139-41-3

  • Applications

    Glycine, N,N-bis(2-hydroxyethyl)-, sodium salt (1:1); CAS number: 139-41-3 is commonly employed as a buffering and stabilizing agent in biochemical and analytical workflows, notably in enzyme assays, protein preparation steps, and gel electrophoresis buffers. It is also used as an intermediate in pharmaceutical synthesis and may serve as a buffering or stabilizing additive in cosmetics and personal care formulations. In cleaning and detergent applications, it can function as a buffering/chelating component, helping to manage pH and sequester metal ions, subject to formulation requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.03
    methanol 48.29
    isopropanol 1.96
    water 377.15
    ethyl acetate 1.64
    n-propanol 4.7
    acetone 0.96
    n-butanol 2.35
    acetonitrile 1.6
    DMF 97.71
    toluene 0.26
    isobutanol 1.93
    1,4-dioxane 5.64
    methyl acetate 1.89
    THF 4.17
    2-butanone 0.96
    n-pentanol 1.14
    sec-butanol 1.64
    n-hexane 0.08
    ethylene glycol 119.88
    NMP 200.89
    cyclohexane 0.26
    DMSO 128.04
    n-butyl acetate 1.42
    n-octanol 1.29
    chloroform 0.83
    n-propyl acetate 0.86
    acetic acid 42.24
    dichloromethane 2.03
    cyclohexanone 5.89
    propylene glycol 43.38
    isopropyl acetate 0.78
    DMAc 73.82
    2-ethoxyethanol 12.94
    isopentanol 1.19
    n-heptane 0.27
    ethyl formate 4.16
    1,2-dichloroethane 1.72
    n-hexanol 1.91
    2-methoxyethanol 53.61
    isobutyl acetate 0.48
    tetrachloromethane 0.32
    n-pentyl acetate 1.04
    transcutol 22.9
    n-heptanol 1.5
    ethylbenzene 0.26
    MIBK 0.48
    2-propoxyethanol 13.9
    tert-butanol 1.54
    MTBE 0.35
    2-butoxyethanol 6.7
    propionic acid 20.66
    o-xylene 0.78
    formic acid 334.04
    diethyl ether 0.45
    m-xylene 0.47
    p-xylene 0.35
    chlorobenzene 0.5
    dimethyl carbonate 4.02
    n-octane 0.1
    formamide 188.73
    cyclopentanone 6.51
    2-pentanone 0.71
    anisole 0.73
    cyclopentyl methyl ether 1.72
    gamma-butyrolactone 26.74
    1-methoxy-2-propanol 17.46
    pyridine 2.72
    3-pentanone 1.02
    furfural 34.51
    n-dodecane 0.08
    diethylene glycol 43.53
    diisopropyl ether 0.19
    tert-amyl alcohol 1.54
    acetylacetone 1.95
    n-hexadecane 0.09
    acetophenone 2.05
    methyl propionate 3.61
    isopentyl acetate 1.05
    trichloroethylene 2.37
    n-nonanol 1.27
    cyclohexanol 3.54
    benzyl alcohol 2.58
    2-ethylhexanol 1.22
    isooctanol 1.07
    dipropyl ether 0.97
    1,2-dichlorobenzene 1.28
    ethyl lactate 5.27
    propylene carbonate 11.54
    n-methylformamide 59.56
    2-pentanol 0.79
    n-pentane 0.11
    1-propoxy-2-propanol 6.84
    1-methoxy-2-propyl acetate 4.29
    2-(2-methoxypropoxy) propanol 9.05
    mesitylene 0.48
    ε-caprolactone 11.85
    p-cymene 0.72
    epichlorohydrin 7.03
    1,1,1-trichloroethane 0.41
    2-aminoethanol 76.08
    morpholine-4-carbaldehyde 96.5
    sulfolane 90.85
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 2.0
    n-hexyl acetate 1.48
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 11.14
    sec-butyl acetate 0.49
    tert-butyl acetate 0.84
    decalin 0.15
    glycerin 146.93
    diglyme 15.14
    acrylic acid 42.04
    isopropyl myristate 0.65
    n-butyric acid 9.19
    acetyl acetate 1.59
    di(2-ethylhexyl) phthalate 2.59
    ethyl propionate 1.34
    nitromethane 28.1
    1,2-diethoxyethane 1.47
    benzonitrile 1.84
    trioctyl phosphate 1.78
    1-bromopropane 0.44
    gamma-valerolactone 31.9
    n-decanol 0.97
    triethyl phosphate 2.53
    4-methyl-2-pentanol 0.46
    propionitrile 1.48
    vinylene carbonate 14.59
    1,1,2-trichlorotrifluoroethane 37.17
    DMS 4.04
    cumene 0.35
    2-octanol 0.73
    2-hexanone 0.47
    octyl acetate 1.1
    limonene 0.99
    1,2-dimethoxyethane 6.57
    ethyl orthosilicate 1.91
    tributyl phosphate 1.97
    diacetone alcohol 3.35
    N,N-dimethylaniline 1.63
    acrylonitrile 4.53
    aniline 1.55
    1,3-propanediol 31.56
    bromobenzene 0.36
    dibromomethane 0.86
    1,1,2,2-tetrachloroethane 2.63
    2-methyl-cyclohexyl acetate 1.99
    tetrabutyl urea 3.91
    diisobutyl methanol 0.75
    2-phenylethanol 2.73
    styrene 0.24
    dioctyl adipate 1.93
    dimethyl sulfate 18.7
    ethyl butyrate 1.6
    methyl lactate 19.03
    butyl lactate 4.03
    diethyl carbonate 1.56
    propanediol butyl ether 10.31
    triethyl orthoformate 1.86
    p-tert-butyltoluene 0.67
    methyl 4-tert-butylbenzoate 5.01
    morpholine 10.71
    tert-butylamine 0.65
    n-dodecanol 0.76
    dimethoxymethane 8.85
    ethylene carbonate 9.14
    cyrene 23.04
    2-ethoxyethyl acetate 2.27
    2-ethylhexyl acetate 0.99
    1,2,4-trichlorobenzene 1.81
    4-methylpyridine 2.01
    dibutyl ether 0.57
    2,6-dimethyl-4-heptanol 0.75
    DEF 9.2
    dimethyl isosorbide 15.4
    tetrachloroethylene 2.44
    eugenol 7.13
    triacetin 4.46
    span 80 10.37
    1,4-butanediol 11.77
    1,1-dichloroethane 0.39
    2-methyl-1-pentanol 0.84
    methyl formate 24.46
    2-methyl-1-butanol 1.6
    n-decane 0.12
    butyronitrile 1.06
    3,7-dimethyl-1-octanol 1.03
    1-chlorooctane 0.36
    1-chlorotetradecane 0.2
    n-nonane 0.11
    undecane 0.1
    tert-butylcyclohexane 0.1
    cyclooctane 0.16
    cyclopentanol 4.71
    tetrahydropyran 1.46
    tert-amyl methyl ether 0.6
    2,5,8-trioxanonane 14.61
    1-hexene 0.16
    2-isopropoxyethanol 4.07
    2,2,2-trifluoroethanol 35.27
    methyl butyrate 1.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction