Glycine Hydrochloride

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  • Identifiers

    CAS number
    6000-43-7

    Molecular formula
    C2H6ClNO2

    SMILES
    C(C(=O)O)N.Cl

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 81.62%
    Sour 23.0%
    Savory 20.23%
    Meaty 18.14%
    Sharp 17.6%
    Cheesy 17.05%
    Sulfurous 14.95%
    Fishy 14.81%
    Cooked 14.78%
    Caramellic 14.77%

     

    Flavor
    Odorless 70.93%
    Sour 41.61%
    Acidic 32.47%
    Pungent 26.5%
    Mild 26.35%
    Vinegar 25.07%
    Yeast 23.02%
    Bland 22.25%
    Soy 22.02%
    Rancid 21.94%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.08 (neutral)

    Molecular weight
    111.53 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    230°C

    Flash point

    • 119.72 ˚C est.

  • Synonyms

    • Glycine hydrochloride
    • 6000-43-7
    • GLYCINE, HYDROCHLORIDE
    • Aminoacetic acid hydrochloride
    • Glycocoll hydrochloride
    • 225ZLC74HX
    • DTXSID7064079
    • Hydrochloride, Glycine
    • RefChem:143839
    • DTXCID0042741
    • 227-841-8
    • 2-aminoacetic acid hydrochloride
    • GLYCINE HCl
    • MFCD00012872
    • glycine-hcl
    • Glycine, hydrochloride (1:1)
    • glycine, chloride
    • Glycinehydrochloride
    • ST093337
    • CCRIS 3355
    • EINECS 227-841-8
    • UNII-225ZLC74HX
    • Glycin HCl
    • H-Gly-OH.HCl
    • C2H6ClNO2
    • SCHEMBL37746
    • Amino acetic acid hydrochloride
    • SCHEMBL28220287
    • GLYCINE HYDROCHLORIDE [II]
    • GLYCINE HYDROCHLORIDE [MI]
    • Glycine--hydrogen chloride (1/1)
    • SBB071447
    • AKOS015847938
    • GLYCINE HYDROCHLORIDE [WHO-DD]
    • FG40444
    • Glycine hydrochloride, >=99% (HPLC)
    • AS-15481
    • CS-0158475
    • G0103
    • NS00082374
    • EN300-31218
    • F21278
    • F229198
    • Q27253616
    • F1905-7104
    • 6000-43-7

  • Applications

    Glycine Hydrochloride (CAS 6000-43-7) is widely used as a soluble source of glycine in biochemical research and pharmaceutical formulation development. In the laboratory, it serves as a reagent for enzyme assays and as a component of cell culture media; it provides a buffering salt to adjust pH in solution-based workflows; it is used as a building block or intermediate for peptide synthesis and related organic syntheses. In formulation contexts, it can function as an excipient or formulation aid, helping to stabilize solutions or tailor pH; its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.23
    methanol 3.67
    isopropanol 0.54
    water 275.99
    ethyl acetate 0.18
    n-propanol 0.75
    acetone 0.6
    n-butanol 0.73
    acetonitrile 0.55
    DMF 13.64
    toluene 0.11
    isobutanol 0.55
    1,4-dioxane 0.73
    methyl acetate 0.26
    THF 0.75
    2-butanone 0.35
    n-pentanol 0.44
    sec-butanol 0.56
    n-hexane 0.13
    ethylene glycol 7.61
    NMP 14.03
    cyclohexane 0.16
    DMSO 12.8
    n-butyl acetate 0.18
    n-octanol 0.21
    chloroform 0.15
    n-propyl acetate 0.14
    acetic acid 8.31
    dichloromethane 0.23
    cyclohexanone 0.81
    propylene glycol 3.86
    isopropyl acetate 0.14
    DMAc 7.96
    2-ethoxyethanol 1.67
    isopentanol 0.64
    n-heptane 0.15
    ethyl formate 1.05
    1,2-dichloroethane 0.2
    n-hexanol 0.35
    2-methoxyethanol 4.7
    isobutyl acetate 0.07
    tetrachloromethane 0.16
    n-pentyl acetate 0.22
    transcutol 2.46
    n-heptanol 0.37
    ethylbenzene 0.08
    MIBK 0.22
    2-propoxyethanol 1.17
    tert-butanol 0.76
    MTBE 0.25
    2-butoxyethanol 1.37
    propionic acid 1.66
    o-xylene 0.2
    formic acid 43.59
    diethyl ether 0.19
    m-xylene 0.12
    p-xylene 0.13
    chlorobenzene 0.08
    dimethyl carbonate 0.46
    n-octane 0.07
    formamide 24.73
    cyclopentanone 1.08
    2-pentanone 0.29
    anisole 0.16
    cyclopentyl methyl ether 0.39
    gamma-butyrolactone 1.55
    1-methoxy-2-propanol 1.99
    pyridine 0.53
    3-pentanone 0.26
    furfural 3.85
    n-dodecane 0.03
    diethylene glycol 3.72
    diisopropyl ether 0.09
    tert-amyl alcohol 0.89
    acetylacetone 0.46
    n-hexadecane 0.03
    acetophenone 0.29
    methyl propionate 0.29
    isopentyl acetate 0.17
    trichloroethylene 0.27
    n-nonanol 0.21
    cyclohexanol 0.67
    benzyl alcohol 0.43
    2-ethylhexanol 0.24
    isooctanol 0.3
    dipropyl ether 0.2
    1,2-dichlorobenzene 0.11
    ethyl lactate 0.48
    propylene carbonate 0.91
    n-methylformamide 6.42
    2-pentanol 0.37
    n-pentane 0.11
    1-propoxy-2-propanol 0.78
    1-methoxy-2-propyl acetate 0.32
    2-(2-methoxypropoxy) propanol 1.57
    mesitylene 0.13
    ε-caprolactone 0.87
    p-cymene 0.13
    epichlorohydrin 0.6
    1,1,1-trichloroethane 0.1
    2-aminoethanol 5.69
    morpholine-4-carbaldehyde 7.75
    sulfolane 6.17
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 0.45
    n-hexyl acetate 0.21
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 1.71
    sec-butyl acetate 0.09
    tert-butyl acetate 0.19
    decalin 0.07
    glycerin 14.88
    diglyme 2.62
    acrylic acid 3.23
    isopropyl myristate 0.1
    n-butyric acid 1.42
    acetyl acetate 0.23
    di(2-ethylhexyl) phthalate 0.34
    ethyl propionate 0.14
    nitromethane 4.98
    1,2-diethoxyethane 0.28
    benzonitrile 0.25
    trioctyl phosphate 0.26
    1-bromopropane 0.1
    gamma-valerolactone 2.99
    n-decanol 0.17
    triethyl phosphate 0.26
    4-methyl-2-pentanol 0.26
    propionitrile 0.29
    vinylene carbonate 1.0
    1,1,2-trichlorotrifluoroethane 2.85
    DMS 0.25
    cumene 0.1
    2-octanol 0.21
    2-hexanone 0.19
    octyl acetate 0.15
    limonene 0.16
    1,2-dimethoxyethane 1.66
    ethyl orthosilicate 0.26
    tributyl phosphate 0.27
    diacetone alcohol 0.89
    N,N-dimethylaniline 0.36
    acrylonitrile 0.56
    aniline 0.32
    1,3-propanediol 4.02
    bromobenzene 0.05
    dibromomethane 0.15
    1,1,2,2-tetrachloroethane 0.28
    2-methyl-cyclohexyl acetate 0.19
    tetrabutyl urea 0.56
    diisobutyl methanol 0.2
    2-phenylethanol 0.31
    styrene 0.08
    dioctyl adipate 0.21
    dimethyl sulfate 1.6
    ethyl butyrate 0.18
    methyl lactate 1.41
    butyl lactate 0.72
    diethyl carbonate 0.14
    propanediol butyl ether 1.97
    triethyl orthoformate 0.26
    p-tert-butyltoluene 0.13
    methyl 4-tert-butylbenzoate 0.79
    morpholine 1.08
    tert-butylamine 0.4
    n-dodecanol 0.14
    dimethoxymethane 1.34
    ethylene carbonate 0.67
    cyrene 2.25
    2-ethoxyethyl acetate 0.33
    2-ethylhexyl acetate 0.14
    1,2,4-trichlorobenzene 0.12
    4-methylpyridine 0.48
    dibutyl ether 0.13
    2,6-dimethyl-4-heptanol 0.2
    DEF 1.51
    dimethyl isosorbide 1.67
    tetrachloroethylene 0.42
    eugenol 1.18
    triacetin 0.42
    span 80 1.32
    1,4-butanediol 1.79
    1,1-dichloroethane 0.09
    2-methyl-1-pentanol 0.43
    methyl formate 4.04
    2-methyl-1-butanol 0.71
    n-decane 0.05
    butyronitrile 0.36
    3,7-dimethyl-1-octanol 0.18
    1-chlorooctane 0.06
    1-chlorotetradecane 0.04
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.05
    cyclooctane 0.1
    cyclopentanol 0.87
    tetrahydropyran 0.33
    tert-amyl methyl ether 0.32
    2,5,8-trioxanonane 2.66
    1-hexene 0.15
    2-isopropoxyethanol 0.75
    2,2,2-trifluoroethanol 5.4
    methyl butyrate 0.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction