Glycinamide hydrochloride

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  • Identifiers

    CAS number
    1668-10-6

    Molecular formula
    C2H7ClN2O

    SMILES
    C(C(=O)N)N.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 64.64%
    Fishy 40.87%
    Sweet 25.81%
    Savory 22.84%
    Meaty 19.48%
    Pungent 18.18%
    Cheesy 16.7%
    Cocoa 16.5%
    Popcorn 16.26%
    Cooked 16.07%

     

    Flavor
    Odorless 49.52%
    Sulfury 26.56%
    Roasted 24.15%
    Mild 24.1%
    Cooked 22.54%
    Mousy 21.37%
    Bland 21.02%
    Sulfurous 20.66%
    Formyl 20.08%
    Yeast 19.92%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.13 (weak acid)

    Molecular weight
    110.54 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    268°C

    Flash point

    • 110.81 ˚C est.

  • Synonyms

    • Glycinamide hydrochloride
    • 1668-10-6
    • Glycine amide hydrochloride
    • 9SPG4KUG6A
    • RefChem:922338
    • 216-789-1
    • 2-Aminoacetamide hydrochloride
    • H-Gly-NH2.HCl
    • Glycinamide HCl
    • Glycinamide, HCl
    • MFCD00013008
    • Acetamide, 2-amino-, hydrochloride (1:1)
    • 2-aminoacetamide;hydrochloride
    • h-gly-nh2 hcl
    • GLYCINEAMIDE HCL
    • Glycineamide hydrochloride
    • Acetamide, 2-amino-, monohydrochloride
    • (2-amino-2-oxoethyl)azanium;chloride
    • Glycinamidehydrochloride
    • Glycinamide, monohydrochloride
    • glycinamide.HCl
    • glycinamide HCI
    • glycine amide HCl
    • GlyNH2.HCl
    • Gly- NH2.HCl
    • H-Gly-NH2?Cl
    • glycinamide, hydrochloride
    • aminoacetamide hydrochloride
    • glycinamide hydrochloride salt
    • 2-aminoacetamide.hydrochloride
    • SCHEMBL123980
    • 2-amino-acetamide hydrochloride
    • orb1304509
    • Glycinamide hydrochloride, 98%
    • CHEMBL1222057
    • DTXSID60937242
    • NSC9225
    • HY-Y1123
    • NSC-9225
    • AKOS015848110
    • AC-7069
    • CS-W019695
    • EBC-253268
    • FG38124
    • GS-6747
    • BP-11918
    • PD056429
    • SY003860
    • DB-002741
    • Glycinamide hydrochloride, >=99.0% (AT)
    • G0193
    • G0253
    • NS00081781
    • EN300-16216
    • Aminoethanimidic acid--hydrogen chloride (1/1)
    • G-4300
    • 2-Aminoethanimidic acid--hydrogen chloride (1/1)
    • 668G106
    • F078516
    • Q39047138
    • F2190-0517
    • Z1262254285
    • 1668-10-6

  • Applications

    Glycinamide hydrochloride is primarily used as an intermediate in pharmaceutical and fine chemical synthesis, serving as a source of the glycinamide moiety for building active compounds and as a building block in peptide and peptidomimetic chemistry. It functions as a versatile reagent in organic synthesis to install glycinamide functionality on target molecules, and its hydrochloride salt form improves aqueous solubility for reactions and formulation work. In addition, it is commonly evaluated as a starting material for process development and scale-up in the fine chemicals industry, enabling routes to glycine-derived compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.35
    methanol 13.26
    isopropanol 1.02
    water 954.43
    ethyl acetate 0.37
    n-propanol 1.68
    acetone 0.88
    n-butanol 1.29
    acetonitrile 1.29
    DMF 21.0
    toluene 0.14
    isobutanol 1.06
    1,4-dioxane 0.99
    methyl acetate 0.56
    THF 1.73
    2-butanone 0.64
    n-pentanol 0.65
    sec-butanol 0.93
    n-hexane 0.14
    ethylene glycol 19.45
    NMP 28.8
    cyclohexane 0.16
    DMSO 14.0
    n-butyl acetate 0.31
    n-octanol 0.26
    chloroform 0.34
    n-propyl acetate 0.24
    acetic acid 27.28
    dichloromethane 0.42
    cyclohexanone 1.47
    propylene glycol 10.76
    isopropyl acetate 0.22
    DMAc 13.99
    2-ethoxyethanol 3.18
    isopentanol 0.88
    n-heptane 0.15
    ethyl formate 2.54
    1,2-dichloroethane 0.27
    n-hexanol 0.57
    2-methoxyethanol 9.83
    isobutyl acetate 0.14
    tetrachloromethane 0.31
    n-pentyl acetate 0.33
    transcutol 2.93
    n-heptanol 0.52
    ethylbenzene 0.09
    MIBK 0.29
    2-propoxyethanol 2.55
    tert-butanol 0.95
    MTBE 0.28
    2-butoxyethanol 2.48
    propionic acid 5.1
    o-xylene 0.2
    formic acid 169.13
    diethyl ether 0.26
    m-xylene 0.13
    p-xylene 0.15
    chlorobenzene 0.15
    dimethyl carbonate 0.71
    n-octane 0.06
    formamide 68.11
    cyclopentanone 2.49
    2-pentanone 0.46
    anisole 0.19
    cyclopentyl methyl ether 0.71
    gamma-butyrolactone 4.18
    1-methoxy-2-propanol 3.49
    pyridine 1.06
    3-pentanone 0.41
    furfural 9.38
    n-dodecane 0.03
    diethylene glycol 7.21
    diisopropyl ether 0.09
    tert-amyl alcohol 1.07
    acetylacetone 0.61
    n-hexadecane 0.03
    acetophenone 0.37
    methyl propionate 0.62
    isopentyl acetate 0.26
    trichloroethylene 0.47
    n-nonanol 0.25
    cyclohexanol 1.04
    benzyl alcohol 0.61
    2-ethylhexanol 0.33
    isooctanol 0.41
    dipropyl ether 0.28
    1,2-dichlorobenzene 0.15
    ethyl lactate 0.84
    propylene carbonate 2.29
    n-methylformamide 16.86
    2-pentanol 0.51
    n-pentane 0.11
    1-propoxy-2-propanol 1.41
    1-methoxy-2-propyl acetate 0.5
    2-(2-methoxypropoxy) propanol 1.72
    mesitylene 0.11
    ε-caprolactone 1.77
    p-cymene 0.13
    epichlorohydrin 1.23
    1,1,1-trichloroethane 0.16
    2-aminoethanol 16.32
    morpholine-4-carbaldehyde 12.71
    sulfolane 11.8
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 0.91
    n-hexyl acetate 0.28
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 2.08
    sec-butyl acetate 0.13
    tert-butyl acetate 0.24
    decalin 0.06
    glycerin 37.32
    diglyme 3.29
    acrylic acid 9.83
    isopropyl myristate 0.11
    n-butyric acid 3.76
    acetyl acetate 0.39
    di(2-ethylhexyl) phthalate 0.45
    ethyl propionate 0.25
    nitromethane 13.27
    1,2-diethoxyethane 0.3
    benzonitrile 0.48
    trioctyl phosphate 0.31
    1-bromopropane 0.15
    gamma-valerolactone 6.73
    n-decanol 0.18
    triethyl phosphate 0.34
    4-methyl-2-pentanol 0.29
    propionitrile 0.68
    vinylene carbonate 2.34
    1,1,2-trichlorotrifluoroethane 6.87
    DMS 0.37
    cumene 0.1
    2-octanol 0.25
    2-hexanone 0.25
    octyl acetate 0.19
    limonene 0.19
    1,2-dimethoxyethane 2.22
    ethyl orthosilicate 0.35
    tributyl phosphate 0.34
    diacetone alcohol 1.12
    N,N-dimethylaniline 0.34
    acrylonitrile 1.41
    aniline 0.6
    1,3-propanediol 8.66
    bromobenzene 0.09
    dibromomethane 0.27
    1,1,2,2-tetrachloroethane 0.41
    2-methyl-cyclohexyl acetate 0.3
    tetrabutyl urea 0.63
    diisobutyl methanol 0.19
    2-phenylethanol 0.47
    styrene 0.09
    dioctyl adipate 0.24
    dimethyl sulfate 2.22
    ethyl butyrate 0.3
    methyl lactate 2.82
    butyl lactate 1.11
    diethyl carbonate 0.22
    propanediol butyl ether 3.07
    triethyl orthoformate 0.39
    p-tert-butyltoluene 0.13
    methyl 4-tert-butylbenzoate 0.91
    morpholine 1.95
    tert-butylamine 0.46
    n-dodecanol 0.13
    dimethoxymethane 1.93
    ethylene carbonate 1.49
    cyrene 3.33
    2-ethoxyethyl acetate 0.5
    2-ethylhexyl acetate 0.22
    1,2,4-trichlorobenzene 0.18
    4-methylpyridine 0.91
    dibutyl ether 0.15
    2,6-dimethyl-4-heptanol 0.19
    DEF 2.12
    dimethyl isosorbide 2.11
    tetrachloroethylene 0.61
    eugenol 1.6
    triacetin 0.6
    span 80 1.75
    1,4-butanediol 3.45
    1,1-dichloroethane 0.15
    2-methyl-1-pentanol 0.57
    methyl formate 9.65
    2-methyl-1-butanol 1.1
    n-decane 0.05
    butyronitrile 0.74
    3,7-dimethyl-1-octanol 0.21
    1-chlorooctane 0.07
    1-chlorotetradecane 0.03
    n-nonane 0.05
    undecane 0.03
    tert-butylcyclohexane 0.05
    cyclooctane 0.08
    cyclopentanol 1.81
    tetrahydropyran 0.53
    tert-amyl methyl ether 0.34
    2,5,8-trioxanonane 2.71
    1-hexene 0.19
    2-isopropoxyethanol 1.16
    2,2,2-trifluoroethanol 16.27
    methyl butyrate 0.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction