Glycidyltrimethylammonium chloride

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  • Identifiers

    CAS number
    3033-77-0

    Molecular formula
    C6H14ClNO

    SMILES
    C[N+](C)(C)CC1CO1.[Cl-]

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Green 50.35%
    Woody 36.1%
    Mint 34.25%
    Fermented 27.84%
    Fruity 25.67%
    Fresh 25.37%
    Ethereal 25.32%
    Earthy 25.17%
    Camphoreous 24.72%
    Musty 23.82%

     

    Flavor
    Green 37.68%
    Sulfurous 27.73%
    Earthy 23.58%
    Blackberry 21.21%
    Green pepper 20.85%
    Tomato leaf 20.76%
    Yeasty 20.45%
    Mild 20.38%
    Roasted 20.35%
    Catty 20.23%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.26 (weak acid)

    Molecular weight
    151.63 g/mol

    Flash point

    • -45.53 ˚C est.

    Solubility expt.

    • Solubility in water: miscible

  • Synonyms

    • 3033-77-0
    • 2,3-Epoxypropyltrimethylammonium chloride
    • GLYCIDYLTRIMETHYLAMMONIUM CHLORIDE
    • (2,3-Epoxypropyl)trimethylammonium chloride
    • Glycidyl trimethylammonium chloride
    • Glytac A 100
    • G-MAC
    • Oxiranemethanaminium, N,N,N-trimethyl-, chloride
    • Trimethylglycidylammonium chloride
    • 1-(Trimethylammonio)-2,3-epoxypropane chloride
    • N-Glycidyl-N,N,N-trimethylammonium chloride
    • Ammonium, (2,3-epoxypropyl)trimethyl-, chloride
    • DTXSID1044643
    • 283XH39M8X
    • N,N,N-Trimethyloxiranemethanaminium chloride
    • NSC-51213
    • DTXCID9024643
    • 2-Oxiranemethanaminium, N,N,N-trimethyl-, chloride (1:1)
    • glycidyl trimethyl ammonium chloride
    • EPTMAC
    • RefChem:663615
    • 2,3-epoxypropyl trimethylammonium chloride
    • 221-221-0
    • 2,3-epoxytrimethylammonium chloride
    • glycidyltrimethylammoniumchloride
    • trimethyl(oxiran-2-ylmethyl)azanium;chloride
    • Trimethyl[(oxiran-2-yl)methyl]azanium chloride
    • MFCD00011940
    • N,N,N-trimethyl(oxiran-2-yl)methanaminium chloride
    • Glycidyltrimethylammonium chloride (ca. 80% in water)
    • CCRIS 4128
    • Glycidyl-trimethyl-ammonium chloride
    • Glycidyltrimethylammonium Chloride (Technical Grade)
    • EINECS 221-221-0
    • NSC 51213
    • UNII-283XH39M8X
    • beta,gamma-Epoxypropyltrimethylammonium chloride
    • (2,3-Epoxypropyl)trimethylammonium chloride; N,N,N-trimethyloxiranemethanaminium chloride
    • Epoxypropyltrimethylammonium chloride
    • EC 221-221-0
    • SCHEMBL42703
    • CHEMBL3187272
    • DAA03377
    • NSC51213
    • Tox21_300176
    • AKOS024437790
    • 2,3-EPOXYPROPYLTRIMONIUM CHLORIDE
    • NCGC00254128-01
    • AS-15436
    • N-Glycidyl-N,N-trimethylammonium chloride
    • SY074803
    • CAS-3033-77-0
    • Ammonium,3-epoxypropyl)trimethyl-, chloride
    • DB-047761
    • G0476
    • NS00077213
    • trimethyl(oxiran-2-ylmethyl)ammonium;chloride
    • Oxiranemethanaminium,N,N-trimethyl-, chloride
    • E75838
    • EN300-244014
    • .beta.,.gamma.-Epoxypropyltrimethylammonium chloride
    • Q2939557
    • 1,2-EPOXY-3-(TRIMETHYLAMMONIO)PROPYL CHLORIDE
    • N,N,N-trimethyl-1-(oxiran-2-yl)methanaminium chloride
    • (.BETA.,.GAMMA.-EPOXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE
    • 3033-77-0

  • Applications

    Glycidyltrimethylammonium chloride (CAS 3033-77-0) is widely used as a reactive monomer to introduce quaternary ammonium functionality into polymers and resins, enabling the production of cationic polymers for coatings, adhesives, papermaking additives, and water-treatment formulations. The glycidyl (epoxy) group allows incorporation into epoxy systems as a functional crosslinker or reactive diluent, improving adhesion and film properties. It also serves as a building block for cationic surfactants and specialty polymers used in coatings, inks, and cleaner formulations. In papermaking and wastewater treatment, GTMAC-based polymers act as retention and flocculation aids to improve process efficiency. As an intermediate, GTMAC-derived materials are used to tailor positively charged functionalities in adhesives and other specialty resins, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 459.82
    methanol 816.1
    isopropanol 176.42
    water 76.69
    ethyl acetate 94.21
    n-propanol 249.69
    acetone 81.78
    n-butanol 167.87
    acetonitrile 121.68
    DMF 103.21
    toluene 22.08
    isobutanol 113.31
    1,4-dioxane 158.58
    methyl acetate 127.27
    THF 165.55
    2-butanone 77.88
    n-pentanol 65.1
    sec-butanol 130.29
    n-hexane 9.68
    ethylene glycol 380.9
    NMP 153.82
    cyclohexane 22.28
    DMSO 72.5
    n-butyl acetate 93.05
    n-octanol 49.93
    chloroform 410.29
    n-propyl acetate 54.3
    acetic acid 1237.59
    dichloromethane 251.66
    cyclohexanone 105.21
    propylene glycol 284.66
    isopropyl acetate 43.26
    DMAc 98.5
    2-ethoxyethanol 160.48
    isopentanol 71.62
    n-heptane 18.64
    ethyl formate 125.2
    1,2-dichloroethane 94.25
    n-hexanol 132.43
    2-methoxyethanol 372.69
    isobutyl acetate 36.45
    tetrachloromethane 98.22
    n-pentyl acetate 45.09
    transcutol 239.25
    n-heptanol 66.84
    ethylbenzene 11.47
    MIBK 24.39
    2-propoxyethanol 233.07
    tert-butanol 101.15
    MTBE 45.51
    2-butoxyethanol 125.17
    propionic acid 338.64
    o-xylene 17.88
    formic acid 891.76
    diethyl ether 71.69
    m-xylene 15.37
    p-xylene 17.07
    chlorobenzene 55.52
    dimethyl carbonate 40.97
    n-octane 5.56
    formamide 401.79
    cyclopentanone 106.49
    2-pentanone 48.22
    anisole 32.5
    cyclopentyl methyl ether 64.79
    gamma-butyrolactone 189.87
    1-methoxy-2-propanol 155.88
    pyridine 121.65
    3-pentanone 44.91
    furfural 199.37
    n-dodecane 4.44
    diethylene glycol 259.0
    diisopropyl ether 14.36
    tert-amyl alcohol 86.9
    acetylacetone 46.86
    n-hexadecane 4.56
    acetophenone 37.4
    methyl propionate 77.31
    isopentyl acetate 63.22
    trichloroethylene 235.34
    n-nonanol 44.67
    cyclohexanol 112.41
    benzyl alcohol 51.53
    2-ethylhexanol 65.2
    isooctanol 41.94
    dipropyl ether 54.43
    1,2-dichlorobenzene 54.35
    ethyl lactate 57.62
    propylene carbonate 130.12
    n-methylformamide 179.31
    2-pentanol 69.64
    n-pentane 15.21
    1-propoxy-2-propanol 145.26
    1-methoxy-2-propyl acetate 82.29
    2-(2-methoxypropoxy) propanol 80.19
    mesitylene 10.29
    ε-caprolactone 133.33
    p-cymene 24.14
    epichlorohydrin 141.55
    1,1,1-trichloroethane 114.59
    2-aminoethanol 404.17
    morpholine-4-carbaldehyde 161.53
    sulfolane 138.47
    2,2,4-trimethylpentane 8.09
    2-methyltetrahydrofuran 112.47
    n-hexyl acetate 61.9
    isooctane 4.88
    2-(2-butoxyethoxy)ethanol 112.39
    sec-butyl acetate 31.86
    tert-butyl acetate 37.98
    decalin 6.87
    glycerin 369.64
    diglyme 148.29
    acrylic acid 374.33
    isopropyl myristate 24.05
    n-butyric acid 269.21
    acetyl acetate 82.35
    di(2-ethylhexyl) phthalate 37.74
    ethyl propionate 44.63
    nitromethane 421.14
    1,2-diethoxyethane 57.61
    benzonitrile 56.47
    trioctyl phosphate 28.28
    1-bromopropane 62.36
    gamma-valerolactone 179.1
    n-decanol 32.38
    triethyl phosphate 39.82
    4-methyl-2-pentanol 30.11
    propionitrile 86.3
    vinylene carbonate 146.61
    1,1,2-trichlorotrifluoroethane 291.9
    DMS 57.95
    cumene 11.11
    2-octanol 31.68
    2-hexanone 32.83
    octyl acetate 37.63
    limonene 35.7
    1,2-dimethoxyethane 109.84
    ethyl orthosilicate 39.24
    tributyl phosphate 33.9
    diacetone alcohol 54.69
    N,N-dimethylaniline 22.91
    acrylonitrile 111.93
    aniline 64.85
    1,3-propanediol 337.62
    bromobenzene 41.14
    dibromomethane 167.1
    1,1,2,2-tetrachloroethane 172.21
    2-methyl-cyclohexyl acetate 60.8
    tetrabutyl urea 33.13
    diisobutyl methanol 29.86
    2-phenylethanol 74.0
    styrene 14.84
    dioctyl adipate 38.87
    dimethyl sulfate 49.19
    ethyl butyrate 60.38
    methyl lactate 84.24
    butyl lactate 62.47
    diethyl carbonate 50.05
    propanediol butyl ether 102.4
    triethyl orthoformate 55.97
    p-tert-butyltoluene 23.23
    methyl 4-tert-butylbenzoate 54.1
    morpholine 198.67
    tert-butylamine 64.88
    n-dodecanol 24.61
    dimethoxymethane 72.25
    ethylene carbonate 113.14
    cyrene 67.59
    2-ethoxyethyl acetate 65.72
    2-ethylhexyl acetate 53.54
    1,2,4-trichlorobenzene 78.99
    4-methylpyridine 66.64
    dibutyl ether 27.95
    2,6-dimethyl-4-heptanol 29.86
    DEF 61.76
    dimethyl isosorbide 103.44
    tetrachloroethylene 175.8
    eugenol 61.9
    triacetin 70.48
    span 80 86.3
    1,4-butanediol 117.59
    1,1-dichloroethane 113.78
    2-methyl-1-pentanol 39.8
    methyl formate 142.51
    2-methyl-1-butanol 86.97
    n-decane 7.27
    butyronitrile 75.53
    3,7-dimethyl-1-octanol 38.81
    1-chlorooctane 24.34
    1-chlorotetradecane 10.8
    n-nonane 6.9
    undecane 5.42
    tert-butylcyclohexane 7.15
    cyclooctane 6.61
    cyclopentanol 133.24
    tetrahydropyran 116.5
    tert-amyl methyl ether 40.14
    2,5,8-trioxanonane 107.0
    1-hexene 22.05
    2-isopropoxyethanol 82.79
    2,2,2-trifluoroethanol 429.43
    methyl butyrate 57.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction