Glyceryl monothioglycolate

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  • Identifiers

    CAS number
    30618-84-9

    Molecular formula
    C5H10O4S

    SMILES
    C(C(COC(=O)CS)O)O

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sulfurous 50.9%
    Meaty 42.24%
    Savory 37.0%
    Odorless 35.76%
    Roasted 26.39%
    Cooked 22.25%
    Sweet 22.06%
    Tropical 21.43%
    Caramellic 19.01%
    Cheesy 18.86%

     

    Flavor
    Odorless 64.47%
    Sweet 33.2%
    Very mild 31.88%
    Sweet-like 28.85%
    Mild 24.29%
    Bland 23.8%
    Very slight 22.14%
    Yeast 21.79%
    Sour 21.53%
    Creamy 20.51%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    7.9 (neutral)

    Molecular weight
    166.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    345°C

    Flash point

    • 155.13 ˚C est.

  • Synonyms

    • Glyceryl monothioglycolate
    • 30618-84-9
    • Glycerol monomercaptoacetate
    • Acetic acid, 2-mercapto-, monoester with 1,2,3-propanetriol
    • 0FWE72AF2P
    • Mercaptoacetic acid, monoester with 1,2,3-propanetriol
    • CHEBI:156545
    • RefChem:663554
    • DTXSID2027965
    • 250-264-8
    • Glyceryl thioglycolate
    • 2,3-dihydroxypropyl 2-sulfanylacetate
    • Glyceryl 1-thioglycolate
    • Glyceryl 1-monothioglycolate
    • Glycerol 1-monothioglycolate
    • 68148-42-5
    • Acetic acid, mercapto-, monoester with 1,2,3-propanetriol
    • 2,3-dihydroxypropyl sulfanylacetate
    • Acetic acid, 2-mercapto-, 2,3-dihydroxypropyl ester
    • MFCD00153007
    • 0A100Y3J61
    • EINECS 250-264-8
    • UNII-0FWE72AF2P
    • UNII-0A100Y3J61
    • Mercaptoacetic acid, monoester with propane-1,2,3-triol
    • glycerol monothioglycolate
    • Glyceryl monothioglycolate, Technical grade
    • Glycerolmonomercaptoacetate
    • EC 250-264-8
    • Acetic acid, mercapto-, monoester with glycerol
    • SCHEMBL107724
    • DTXSID60873439
    • AKOS006274928
    • FG41621
    • Glyceryl monothioglycolate, Techincal grade
    • NS00008029
    • H10926
    • 618G849
    • Glycerol monomercaptoacetate, technical grade, 82%
    • Mercaptoacetic acid monoester with 1,2,3-propanetrio
    • Q27236512
    • 30618-84-9

  • Applications

    Glyceryl monothioglycolate (CAS 30618-84-9) is a glycerol-derived compound bearing a thiol group, used as an intermediate and thiol-functional additive across several industries: in cosmetics/personal care as a reducing agent or source of thiol groups to participate in keratin disulfide bond manipulation in hair-care formulations; in polymers/plastics as a thiol-functional monomer or crosslinking agent for polymer networks via thiol-ene or thiol-epoxy chemistry; in coatings and inks as a crosslinking agent to enhance film durability and adhesion; in adhesives as a thiol-compatible crosslinker for polymer matrices; and as a synthetic building block to prepare other thiol-containing derivatives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 335.7
    methanol 985.4
    isopropanol 174.79
    water 1311.96
    ethyl acetate 18.64
    n-propanol 156.72
    acetone 257.96
    n-butanol 102.17
    acetonitrile 78.66
    DMF 1847.0
    toluene 2.71
    isobutanol 68.63
    1,4-dioxane 127.71
    methyl acetate 39.72
    THF 147.12
    2-butanone 53.54
    n-pentanol 52.56
    sec-butanol 69.56
    n-hexane 1.52
    ethylene glycol 623.23
    NMP 529.56
    cyclohexane 6.02
    DMSO 2087.24
    n-butyl acetate 12.15
    n-octanol 19.26
    chloroform 6.64
    n-propyl acetate 19.41
    acetic acid 507.19
    dichloromethane 13.6
    cyclohexanone 74.79
    propylene glycol 269.95
    isopropyl acetate 11.75
    DMAc 792.48
    2-ethoxyethanol 270.48
    isopentanol 56.32
    n-heptane 3.29
    ethyl formate 69.75
    1,2-dichloroethane 18.45
    n-hexanol 23.41
    2-methoxyethanol 606.12
    isobutyl acetate 9.06
    tetrachloromethane 2.33
    n-pentyl acetate 10.7
    transcutol 245.28
    n-heptanol 16.79
    ethylbenzene 3.05
    MIBK 19.44
    2-propoxyethanol 92.13
    tert-butanol 145.94
    MTBE 25.34
    2-butoxyethanol 60.02
    propionic acid 119.06
    o-xylene 5.4
    formic acid 1175.44
    diethyl ether 21.82
    m-xylene 3.72
    p-xylene 4.65
    chlorobenzene 3.72
    dimethyl carbonate 34.59
    n-octane 1.44
    formamide 1096.08
    cyclopentanone 111.2
    2-pentanone 37.64
    anisole 17.35
    cyclopentyl methyl ether 28.41
    gamma-butyrolactone 122.28
    1-methoxy-2-propanol 232.23
    pyridine 38.18
    3-pentanone 22.66
    furfural 153.11
    n-dodecane 1.23
    diethylene glycol 225.77
    diisopropyl ether 5.24
    tert-amyl alcohol 70.06
    acetylacetone 58.42
    n-hexadecane 1.29
    acetophenone 28.57
    methyl propionate 33.61
    isopentyl acetate 10.27
    trichloroethylene 19.6
    n-nonanol 16.91
    cyclohexanol 53.13
    benzyl alcohol 37.41
    2-ethylhexanol 11.77
    isooctanol 12.81
    dipropyl ether 14.26
    1,2-dichlorobenzene 5.11
    ethyl lactate 37.66
    propylene carbonate 42.89
    n-methylformamide 652.94
    2-pentanol 32.58
    n-pentane 2.73
    1-propoxy-2-propanol 50.12
    1-methoxy-2-propyl acetate 22.62
    2-(2-methoxypropoxy) propanol 68.68
    mesitylene 4.33
    ε-caprolactone 58.96
    p-cymene 4.01
    epichlorohydrin 75.09
    1,1,1-trichloroethane 4.27
    2-aminoethanol 467.05
    morpholine-4-carbaldehyde 405.17
    sulfolane 254.22
    2,2,4-trimethylpentane 1.29
    2-methyltetrahydrofuran 44.39
    n-hexyl acetate 16.42
    isooctane 0.85
    2-(2-butoxyethoxy)ethanol 90.25
    sec-butyl acetate 8.48
    tert-butyl acetate 15.9
    decalin 1.6
    glycerin 503.12
    diglyme 175.32
    acrylic acid 172.51
    isopropyl myristate 7.83
    n-butyric acid 83.13
    acetyl acetate 15.85
    di(2-ethylhexyl) phthalate 16.06
    ethyl propionate 14.53
    nitromethane 490.95
    1,2-diethoxyethane 29.83
    benzonitrile 17.92
    trioctyl phosphate 11.92
    1-bromopropane 5.68
    gamma-valerolactone 194.92
    n-decanol 13.17
    triethyl phosphate 12.12
    4-methyl-2-pentanol 15.53
    propionitrile 31.78
    vinylene carbonate 48.88
    1,1,2-trichlorotrifluoroethane 143.71
    DMS 16.25
    cumene 3.35
    2-octanol 9.67
    2-hexanone 22.46
    octyl acetate 11.74
    limonene 6.83
    1,2-dimethoxyethane 263.75
    ethyl orthosilicate 10.72
    tributyl phosphate 12.04
    diacetone alcohol 57.38
    N,N-dimethylaniline 24.89
    acrylonitrile 65.42
    aniline 18.58
    1,3-propanediol 400.64
    bromobenzene 2.07
    dibromomethane 7.5
    1,1,2,2-tetrachloroethane 19.22
    2-methyl-cyclohexyl acetate 14.23
    tetrabutyl urea 28.54
    diisobutyl methanol 8.93
    2-phenylethanol 20.31
    styrene 3.75
    dioctyl adipate 19.94
    dimethyl sulfate 88.85
    ethyl butyrate 13.73
    methyl lactate 76.91
    butyl lactate 25.01
    diethyl carbonate 10.82
    propanediol butyl ether 85.73
    triethyl orthoformate 13.41
    p-tert-butyltoluene 4.24
    methyl 4-tert-butylbenzoate 32.22
    morpholine 191.95
    tert-butylamine 48.71
    n-dodecanol 10.54
    dimethoxymethane 253.75
    ethylene carbonate 36.95
    cyrene 93.51
    2-ethoxyethyl acetate 19.3
    2-ethylhexyl acetate 7.12
    1,2,4-trichlorobenzene 6.95
    4-methylpyridine 28.65
    dibutyl ether 10.11
    2,6-dimethyl-4-heptanol 8.93
    DEF 131.61
    dimethyl isosorbide 72.88
    tetrachloroethylene 16.79
    eugenol 44.32
    triacetin 30.68
    span 80 53.05
    1,4-butanediol 181.1
    1,1-dichloroethane 6.09
    2-methyl-1-pentanol 31.61
    methyl formate 337.62
    2-methyl-1-butanol 50.6
    n-decane 1.73
    butyronitrile 30.23
    3,7-dimethyl-1-octanol 14.29
    1-chlorooctane 4.25
    1-chlorotetradecane 2.37
    n-nonane 1.67
    undecane 1.41
    tert-butylcyclohexane 1.2
    cyclooctane 2.32
    cyclopentanol 76.39
    tetrahydropyran 44.83
    tert-amyl methyl ether 19.51
    2,5,8-trioxanonane 138.51
    1-hexene 3.73
    2-isopropoxyethanol 101.69
    2,2,2-trifluoroethanol 202.89
    methyl butyrate 30.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction