Glycereth-3

Overview IFRA Request a quote

  • Identifiers

    CAS number
    21156-05-8

    Molecular formula
    C9H20O6

    SMILES
    C(COCC(COCCO)OCCO)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 61.85%
    Alcoholic 40.65%
    Fishy 22.28%
    Ethereal 20.18%
    Sweet 16.27%
    Solvent 15.51%
    Oily 15.04%
    Clean 13.72%
    Fresh 12.99%
    Buttery 10.88%

     

    Flavor
    Odorless 56.42%
    Sweet 47.61%
    Sweet-like 29.79%
    Bitter 29.27%
    Alcoholic 26.82%
    Fatty 25.38%
    Musty 24.78%
    Very slight 24.13%
    Creamy 23.49%
    Cauliflower 21.97%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.2

    pKa est.
    4.84 (weak acid)

    Molecular weight
    224.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    490°C

    Flash point

    • 204.57 ˚C est.

  • Synonyms

    • Glycereth-3
    • 21156-05-8
    • MHY4NJW64H
    • BLAUNON GL-3
    • EINECS 244-250-0
    • UNII-MHY4NJW64H
    • PEG-3 GLYCERYL ETHER
    • ETHANOL, 2,2',2''-(1,2,3-PROPANETRIYLTRIS(OXY))TRIS-
    • RefChem:143773
    • GLYCERETH-3 [INCI]
    • 244-250-0
    • 31694-55-0
    • 2,2',2''-Propane-1,2,3-triyltrioxytriethanol
    • 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol
    • SCHEMBL1357542
    • DTXSID60891355
    • UCYLROVJSUACAD-UHFFFAOYSA-N
    • NS00013684
    • Q27284035
    • 2,2',2''-[Propane-1,2,3-triyltris(oxy)]tri(ethan-1-ol)
    • 21156-05-8

  • Applications

    Glycereth-3 (CAS 21156-05-8) is used as a surfactant, secondary solvent, and humectant in cosmetics and personal care, helping to improve moisture retention and solubilize components; in household and cleaning products, it acts as a solvent and emulsifier to enhance cleaning performance; in coatings and inks, it serves as a wetting agent and processing aid to improve application and formulation uniformity; in adhesives and sealants, glycereth-3 functions as a surface-active additive and solvent to optimize surface bonding; in the plastics and polymer industry, it is used as a co-solvent or plasticizer to assist blending and material processing; and in electronics manufacturing, it may be used as a mild solvent for cleaning and surface preparation before processing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 75.29
    methanol 281.91
    isopropanol 24.31
    water 226.45
    ethyl acetate 11.06
    n-propanol 47.15
    acetone 17.96
    n-butanol 25.03
    acetonitrile 16.5
    DMF 368.22
    toluene 1.69
    isobutanol 22.12
    1,4-dioxane 35.59
    methyl acetate 17.28
    THF 39.17
    2-butanone 11.75
    n-pentanol 12.46
    sec-butanol 19.52
    n-hexane 0.76
    ethylene glycol 201.8
    NMP 341.9
    cyclohexane 3.61
    DMSO 745.36
    n-butyl acetate 8.57
    n-octanol 7.49
    chloroform 23.87
    n-propyl acetate 8.7
    acetic acid 327.22
    dichloromethane 31.77
    cyclohexanone 36.96
    propylene glycol 106.36
    isopropyl acetate 5.49
    DMAc 230.57
    2-ethoxyethanol 85.51
    isopentanol 12.58
    n-heptane 2.01
    ethyl formate 27.52
    1,2-dichloroethane 22.55
    n-hexanol 10.52
    2-methoxyethanol 192.34
    isobutyl acetate 4.72
    tetrachloromethane 5.64
    n-pentyl acetate 6.18
    transcutol 111.54
    n-heptanol 7.44
    ethylbenzene 1.39
    MIBK 4.08
    2-propoxyethanol 46.5
    tert-butanol 22.46
    MTBE 5.35
    2-butoxyethanol 26.28
    propionic acid 115.08
    o-xylene 3.56
    formic acid 699.94
    diethyl ether 5.16
    m-xylene 2.04
    p-xylene 2.17
    chlorobenzene 4.35
    dimethyl carbonate 17.43
    n-octane 0.8
    formamide 579.07
    cyclopentanone 50.3
    2-pentanone 6.81
    anisole 5.68
    cyclopentyl methyl ether 14.65
    gamma-butyrolactone 108.79
    1-methoxy-2-propanol 76.29
    pyridine 24.83
    3-pentanone 9.14
    furfural 123.31
    n-dodecane 0.64
    diethylene glycol 103.52
    diisopropyl ether 1.57
    tert-amyl alcohol 19.86
    acetylacetone 15.42
    n-hexadecane 0.69
    acetophenone 13.24
    methyl propionate 20.29
    isopentyl acetate 7.03
    trichloroethylene 36.95
    n-nonanol 7.12
    cyclohexanol 30.76
    benzyl alcohol 15.17
    2-ethylhexanol 6.4
    isooctanol 5.72
    dipropyl ether 6.98
    1,2-dichlorobenzene 7.98
    ethyl lactate 24.93
    propylene carbonate 48.79
    n-methylformamide 214.75
    2-pentanol 8.24
    n-pentane 1.12
    1-propoxy-2-propanol 27.92
    1-methoxy-2-propyl acetate 16.28
    2-(2-methoxypropoxy) propanol 33.93
    mesitylene 2.16
    ε-caprolactone 47.64
    p-cymene 3.41
    epichlorohydrin 51.27
    1,1,1-trichloroethane 7.85
    2-aminoethanol 191.05
    morpholine-4-carbaldehyde 199.49
    sulfolane 289.18
    2,2,4-trimethylpentane 0.99
    2-methyltetrahydrofuran 18.08
    n-hexyl acetate 8.7
    isooctane 0.39
    2-(2-butoxyethoxy)ethanol 38.9
    sec-butyl acetate 4.27
    tert-butyl acetate 6.67
    decalin 1.34
    glycerin 264.07
    diglyme 79.02
    acrylic acid 166.44
    isopropyl myristate 3.79
    n-butyric acid 61.04
    acetyl acetate 13.57
    di(2-ethylhexyl) phthalate 9.39
    ethyl propionate 8.86
    nitromethane 230.98
    1,2-diethoxyethane 11.34
    benzonitrile 11.19
    trioctyl phosphate 7.01
    1-bromopropane 6.01
    gamma-valerolactone 105.67
    n-decanol 5.26
    triethyl phosphate 14.33
    4-methyl-2-pentanol 4.0
    propionitrile 14.37
    vinylene carbonate 55.54
    1,1,2-trichlorotrifluoroethane 185.54
    DMS 14.9
    cumene 1.69
    2-octanol 3.9
    2-hexanone 5.44
    octyl acetate 5.92
    limonene 5.51
    1,2-dimethoxyethane 62.41
    ethyl orthosilicate 11.61
    tributyl phosphate 9.17
    diacetone alcohol 19.03
    N,N-dimethylaniline 8.95
    acrylonitrile 31.04
    aniline 12.1
    1,3-propanediol 130.3
    bromobenzene 3.17
    dibromomethane 16.29
    1,1,2,2-tetrachloroethane 40.93
    2-methyl-cyclohexyl acetate 11.09
    tetrabutyl urea 15.58
    diisobutyl methanol 4.36
    2-phenylethanol 10.95
    styrene 1.83
    dioctyl adipate 11.88
    dimethyl sulfate 72.63
    ethyl butyrate 9.97
    methyl lactate 52.84
    butyl lactate 17.12
    diethyl carbonate 9.69
    propanediol butyl ether 35.07
    triethyl orthoformate 12.26
    p-tert-butyltoluene 3.61
    methyl 4-tert-butylbenzoate 20.11
    morpholine 70.24
    tert-butylamine 10.34
    n-dodecanol 4.13
    dimethoxymethane 50.1
    ethylene carbonate 40.76
    cyrene 60.0
    2-ethoxyethyl acetate 10.75
    2-ethylhexyl acetate 5.84
    1,2,4-trichlorobenzene 12.06
    4-methylpyridine 12.61
    dibutyl ether 4.73
    2,6-dimethyl-4-heptanol 4.36
    DEF 45.48
    dimethyl isosorbide 53.5
    tetrachloroethylene 34.73
    eugenol 24.66
    triacetin 24.44
    span 80 31.6
    1,4-butanediol 55.7
    1,1-dichloroethane 7.08
    2-methyl-1-pentanol 7.92
    methyl formate 110.67
    2-methyl-1-butanol 16.45
    n-decane 1.03
    butyronitrile 9.66
    3,7-dimethyl-1-octanol 6.37
    1-chlorooctane 2.87
    1-chlorotetradecane 1.45
    n-nonane 0.96
    undecane 0.78
    tert-butylcyclohexane 0.87
    cyclooctane 1.44
    cyclopentanol 41.21
    tetrahydropyran 16.77
    tert-amyl methyl ether 6.7
    2,5,8-trioxanonane 62.81
    1-hexene 1.53
    2-isopropoxyethanol 28.33
    2,2,2-trifluoroethanol 203.4
    methyl butyrate 15.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction