Glutathione palmitamide

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  • Identifiers

    CAS number
    110995-58-9

    Molecular formula
    C26H47N3O7S

    SMILES
    CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 49.99%
    Savory 45.07%
    Meaty 37.1%
    Cooling 29.15%
    Milky 20.86%
    Fatty 20.86%
    Oily 20.11%
    Fishy 20.0%
    Cooked 19.29%
    Animal 16.34%

     

    Flavor
    Odorless 53.54%
    Bland 40.21%
    Bitter 37.6%
    Mild 31.07%
    Faint 22.29%
    Sweet-like 21.69%
    Slightly waxy 19.51%
    Bay oil 19.49%
    Cedarleaf 19.32%
    Nitrile 19.16%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.4

    pKa est.
    6.24 (neutral)

    Molecular weight
    545.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    616°C

    Flash point

    • 306.72 ˚C est.

  • Synonyms

    • Glutathione palmitamide
    • P-GSH
    • UNII-K3KKO8VYM2
    • K3KKO8VYM2
    • Glutathione palmitamide [INCI]
    • 110995-58-9
    • DTXSID70149435
    • Glycine, N-(N-(N-(1-oxohexadecyl)-l-gamma-glutamyl)-l-cysteinyl)-
    • GLYCINE, N-(N-(N-(1-OXOHEXADECYL)-L-.GAMMA.-GLUTAMYL)-L-CYSTEINYL)-
    • RefChem:143723
    • DTXCID4071926
    • palmitoyl glutathione
    • SCHEMBL574321
    • orb1738039
    • N-Hexadecanoyl-L-gamma-glutamyl-L-cysteinylglycine
    • Q27281904
    • 110995-58-9

  • Applications

    Chemical name: Glutathione palmitamide (CAS 110995-58-9) is a lipid-conjugated derivative of glutathione commonly considered for cosmetic and personal-care applications as an antioxidant and skin-conditioning ingredient, with the palmitoyl moiety enhancing oil compatibility and formulation stability. In practice, it is often viewed as an intermediate for the synthesis of lipidated glutathione or lipid-conjugated peptides; it may function as an antioxidant additive or stabilizer in specialty polymers and coatings. In industrial manufacturing and coating technologies, it can serve as a lipid carrier or stabilizer in specific formulations, subject to regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.1
    methanol 11.51
    isopropanol 2.15
    water 0.77
    ethyl acetate 2.03
    n-propanol 3.37
    acetone 7.1
    n-butanol 2.04
    acetonitrile 1.44
    DMF 60.99
    toluene 0.58
    isobutanol 1.67
    1,4-dioxane 5.85
    methyl acetate 3.6
    THF 12.62
    2-butanone 5.92
    n-pentanol 2.29
    sec-butanol 2.64
    n-hexane 0.13
    ethylene glycol 2.73
    NMP 86.22
    cyclohexane 0.14
    DMSO 58.58
    n-butyl acetate 1.41
    n-octanol 1.44
    chloroform 2.42
    n-propyl acetate 2.13
    acetic acid 16.0
    dichloromethane 2.72
    cyclohexanone 9.57
    propylene glycol 4.92
    isopropyl acetate 1.57
    DMAc 119.03
    2-ethoxyethanol 11.45
    isopentanol 1.36
    n-heptane 0.08
    ethyl formate 3.01
    1,2-dichloroethane 2.07
    n-hexanol 0.9
    2-methoxyethanol 16.39
    isobutyl acetate 1.04
    tetrachloromethane 0.63
    n-pentyl acetate 2.58
    transcutol 28.09
    n-heptanol 1.34
    ethylbenzene 0.52
    MIBK 1.58
    2-propoxyethanol 6.42
    tert-butanol 1.9
    MTBE 1.55
    2-butoxyethanol 7.26
    propionic acid 6.31
    o-xylene 0.72
    formic acid 18.25
    diethyl ether 1.12
    m-xylene 0.43
    p-xylene 0.76
    chlorobenzene 0.6
    dimethyl carbonate 3.75
    n-octane 0.08
    formamide 24.76
    cyclopentanone 14.88
    2-pentanone 3.3
    anisole 1.69
    cyclopentyl methyl ether 2.83
    gamma-butyrolactone 16.05
    1-methoxy-2-propanol 11.36
    pyridine 4.62
    3-pentanone 3.27
    furfural 14.27
    n-dodecane 0.05
    diethylene glycol 6.49
    diisopropyl ether 0.28
    tert-amyl alcohol 2.81
    acetylacetone 5.74
    n-hexadecane 0.06
    acetophenone 3.52
    methyl propionate 3.58
    isopentyl acetate 1.22
    trichloroethylene 4.54
    n-nonanol 1.46
    cyclohexanol 2.17
    benzyl alcohol 2.86
    2-ethylhexanol 0.55
    isooctanol 0.94
    dipropyl ether 0.94
    1,2-dichlorobenzene 0.83
    ethyl lactate 3.61
    propylene carbonate 6.5
    n-methylformamide 16.52
    2-pentanol 1.13
    n-pentane 0.08
    1-propoxy-2-propanol 4.37
    1-methoxy-2-propyl acetate 3.22
    2-(2-methoxypropoxy) propanol 7.81
    mesitylene 0.26
    ε-caprolactone 9.9
    p-cymene 0.29
    epichlorohydrin 9.98
    1,1,1-trichloroethane 1.4
    2-aminoethanol 5.87
    morpholine-4-carbaldehyde 40.37
    sulfolane 47.98
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 5.14
    n-hexyl acetate 2.87
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 10.37
    sec-butyl acetate 1.49
    tert-butyl acetate 1.95
    decalin 0.1
    glycerin 11.21
    diglyme 18.96
    acrylic acid 7.75
    isopropyl myristate 0.77
    n-butyric acid 5.2
    acetyl acetate 1.94
    di(2-ethylhexyl) phthalate 1.59
    ethyl propionate 2.0
    nitromethane 20.08
    1,2-diethoxyethane 3.75
    benzonitrile 1.53
    trioctyl phosphate 1.12
    1-bromopropane 0.76
    gamma-valerolactone 29.98
    n-decanol 0.89
    triethyl phosphate 1.56
    4-methyl-2-pentanol 0.54
    propionitrile 1.26
    vinylene carbonate 5.63
    1,1,2-trichlorotrifluoroethane 18.88
    DMS 3.31
    cumene 0.42
    2-octanol 0.95
    2-hexanone 3.23
    octyl acetate 1.43
    limonene 0.42
    1,2-dimethoxyethane 13.77
    ethyl orthosilicate 1.43
    tributyl phosphate 1.37
    diacetone alcohol 5.54
    N,N-dimethylaniline 2.18
    acrylonitrile 2.22
    aniline 1.7
    1,3-propanediol 6.18
    bromobenzene 0.46
    dibromomethane 1.26
    1,1,2,2-tetrachloroethane 5.16
    2-methyl-cyclohexyl acetate 1.6
    tetrabutyl urea 3.18
    diisobutyl methanol 0.3
    2-phenylethanol 1.54
    styrene 0.54
    dioctyl adipate 1.94
    dimethyl sulfate 14.26
    ethyl butyrate 1.47
    methyl lactate 6.97
    butyl lactate 4.52
    diethyl carbonate 1.0
    propanediol butyl ether 8.89
    triethyl orthoformate 1.86
    p-tert-butyltoluene 0.28
    methyl 4-tert-butylbenzoate 5.12
    morpholine 10.62
    tert-butylamine 0.72
    n-dodecanol 0.56
    dimethoxymethane 10.26
    ethylene carbonate 4.02
    cyrene 12.21
    2-ethoxyethyl acetate 5.23
    2-ethylhexyl acetate 0.98
    1,2,4-trichlorobenzene 1.47
    4-methylpyridine 3.65
    dibutyl ether 1.17
    2,6-dimethyl-4-heptanol 0.3
    DEF 9.83
    dimethyl isosorbide 9.43
    tetrachloroethylene 3.43
    eugenol 5.36
    triacetin 6.35
    span 80 5.46
    1,4-butanediol 3.71
    1,1-dichloroethane 1.31
    2-methyl-1-pentanol 1.76
    methyl formate 9.68
    2-methyl-1-butanol 1.83
    n-decane 0.11
    butyronitrile 1.1
    3,7-dimethyl-1-octanol 0.76
    1-chlorooctane 0.49
    1-chlorotetradecane 0.17
    n-nonane 0.1
    undecane 0.07
    tert-butylcyclohexane 0.08
    cyclooctane 0.06
    cyclopentanol 3.86
    tetrahydropyran 3.13
    tert-amyl methyl ether 1.86
    2,5,8-trioxanonane 12.79
    1-hexene 0.46
    2-isopropoxyethanol 6.11
    2,2,2-trifluoroethanol 9.74
    methyl butyrate 3.35

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction