Glutamyl-norvalyl-glycine

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  • Identifiers

    CAS number
    38837-71-7

    Molecular formula
    C12H21N3O6

    SMILES
    CCC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 65.8%
    Savory 44.05%
    Meaty 28.3%
    Cooling 25.62%
    Sweet 23.1%
    Fishy 20.88%
    Milky 20.01%
    Cooked 18.98%
    Alcoholic 16.56%
    Oily 16.09%

     

    Flavor
    Odorless 63.58%
    Bitter 42.01%
    Bland 32.93%
    Mild 30.72%
    Very mild 24.78%
    Sweet-like 23.12%
    Yeast 22.15%
    Faint 20.82%
    Nitrile 19.56%
    Taco 18.99%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.5

    pKa est.
    5.77 (weak acid)

    Molecular weight
    303.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    392°C

    Flash point

    • 275.38 ˚C est.

    Solubility expt.

    • Soluble

  • Synonyms

    • Glutamyl-norvalyl-glycine
    • Fema No. 4739
    • 3YS08W2SOF
    • L-Glutamyl-L-norvalyl-glycine
    • UNII-3YS08W2SOF
    • N-(N-L-gamma-Glutamyl-L-norvalyl)-glycine
    • 38837-71-7
    • Glutamyl-L-norvalylglycin
    • RefChem:143692
    • gamma-glutamyl-norvalyl-glycine
    • SCHEMBL14510079
    • (S)-2-Amino-5-(((S)-1-((carboxymethyl)amino)-1-oxopentan-2-yl)amino)-5-oxopentanoic acid
    • 38837-71-7

  • Applications

    Glutamyl-norvalyl-glycine (CAS 38837-71-7) is a short peptide primarily used as an intermediate and building block in the synthesis of more complex peptides for pharmaceutical research and development; it is also evaluated for use in cosmetic and personal care as a building block for bioactive peptides in skin-related formulations; in biochemical and analytical settings, it functions as a research reagent and reference standard for peptide studies; it may also serve as a precursor for peptide-based materials and conjugates in advanced materials research.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.9
    methanol 4.3
    isopropanol 0.61
    water 93.95
    ethyl acetate 0.59
    n-propanol 0.69
    acetone 0.88
    n-butanol 0.66
    acetonitrile 0.45
    DMF 57.41
    toluene 0.29
    isobutanol 0.51
    1,4-dioxane 2.61
    methyl acetate 0.53
    THF 2.4
    2-butanone 0.67
    n-pentanol 0.61
    sec-butanol 0.64
    n-hexane 0.22
    ethylene glycol 12.81
    NMP 70.54
    cyclohexane 0.24
    DMSO 106.35
    n-butyl acetate 0.38
    n-octanol 0.27
    chloroform 0.22
    n-propyl acetate 0.46
    acetic acid 12.55
    dichloromethane 0.37
    cyclohexanone 2.92
    propylene glycol 8.14
    isopropyl acetate 0.48
    DMAc 60.47
    2-ethoxyethanol 7.45
    isopentanol 0.59
    n-heptane 0.14
    ethyl formate 1.4
    1,2-dichloroethane 0.37
    n-hexanol 0.52
    2-methoxyethanol 17.35
    isobutyl acetate 0.22
    tetrachloromethane 0.11
    n-pentyl acetate 0.31
    transcutol 9.61
    n-heptanol 0.42
    ethylbenzene 0.27
    MIBK 0.5
    2-propoxyethanol 4.43
    tert-butanol 1.04
    MTBE 0.36
    2-butoxyethanol 2.66
    propionic acid 2.49
    o-xylene 0.49
    formic acid 83.99
    diethyl ether 0.39
    m-xylene 0.28
    p-xylene 0.42
    chlorobenzene 0.14
    dimethyl carbonate 2.03
    n-octane 0.09
    formamide 53.1
    cyclopentanone 3.37
    2-pentanone 0.72
    anisole 0.54
    cyclopentyl methyl ether 1.29
    gamma-butyrolactone 5.61
    1-methoxy-2-propanol 8.37
    pyridine 1.57
    3-pentanone 0.86
    furfural 11.09
    n-dodecane 0.04
    diethylene glycol 15.06
    diisopropyl ether 0.18
    tert-amyl alcohol 1.03
    acetylacetone 2.25
    n-hexadecane 0.04
    acetophenone 1.14
    methyl propionate 1.19
    isopentyl acetate 0.37
    trichloroethylene 0.53
    n-nonanol 0.3
    cyclohexanol 1.45
    benzyl alcohol 1.28
    2-ethylhexanol 0.3
    isooctanol 0.31
    dipropyl ether 0.54
    1,2-dichlorobenzene 0.22
    ethyl lactate 1.71
    propylene carbonate 2.71
    n-methylformamide 13.83
    2-pentanol 0.48
    n-pentane 0.11
    1-propoxy-2-propanol 2.37
    1-methoxy-2-propyl acetate 1.44
    2-(2-methoxypropoxy) propanol 3.67
    mesitylene 0.23
    ε-caprolactone 3.34
    p-cymene 0.17
    epichlorohydrin 2.23
    1,1,1-trichloroethane 0.12
    2-aminoethanol 9.5
    morpholine-4-carbaldehyde 41.54
    sulfolane 29.67
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 1.17
    n-hexyl acetate 0.35
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 4.82
    sec-butyl acetate 0.31
    tert-butyl acetate 0.6
    decalin 0.1
    glycerin 42.79
    diglyme 8.71
    acrylic acid 5.19
    isopropyl myristate 0.15
    n-butyric acid 2.3
    acetyl acetate 0.71
    di(2-ethylhexyl) phthalate 0.52
    ethyl propionate 0.61
    nitromethane 11.19
    1,2-diethoxyethane 1.03
    benzonitrile 0.55
    trioctyl phosphate 0.33
    1-bromopropane 0.17
    gamma-valerolactone 16.27
    n-decanol 0.25
    triethyl phosphate 0.73
    4-methyl-2-pentanol 0.31
    propionitrile 0.33
    vinylene carbonate 2.62
    1,1,2-trichlorotrifluoroethane 10.9
    DMS 0.98
    cumene 0.24
    2-octanol 0.27
    2-hexanone 0.56
    octyl acetate 0.24
    limonene 0.23
    1,2-dimethoxyethane 7.56
    ethyl orthosilicate 0.68
    tributyl phosphate 0.41
    diacetone alcohol 2.91
    N,N-dimethylaniline 1.04
    acrylonitrile 0.8
    aniline 0.88
    1,3-propanediol 7.22
    bromobenzene 0.11
    dibromomethane 0.21
    1,1,2,2-tetrachloroethane 0.7
    2-methyl-cyclohexyl acetate 0.52
    tetrabutyl urea 1.02
    diisobutyl methanol 0.24
    2-phenylethanol 0.76
    styrene 0.23
    dioctyl adipate 0.35
    dimethyl sulfate 8.41
    ethyl butyrate 0.52
    methyl lactate 5.91
    butyl lactate 1.15
    diethyl carbonate 0.42
    propanediol butyl ether 3.77
    triethyl orthoformate 0.75
    p-tert-butyltoluene 0.17
    methyl 4-tert-butylbenzoate 1.56
    morpholine 4.44
    tert-butylamine 0.41
    n-dodecanol 0.21
    dimethoxymethane 6.38
    ethylene carbonate 1.86
    cyrene 9.93
    2-ethoxyethyl acetate 0.72
    2-ethylhexyl acetate 0.29
    1,2,4-trichlorobenzene 0.33
    4-methylpyridine 1.33
    dibutyl ether 0.29
    2,6-dimethyl-4-heptanol 0.24
    DEF 4.96
    dimethyl isosorbide 5.82
    tetrachloroethylene 0.65
    eugenol 2.24
    triacetin 1.11
    span 80 2.68
    1,4-butanediol 3.92
    1,1-dichloroethane 0.13
    2-methyl-1-pentanol 0.59
    methyl formate 8.28
    2-methyl-1-butanol 0.64
    n-decane 0.07
    butyronitrile 0.36
    3,7-dimethyl-1-octanol 0.22
    1-chlorooctane 0.11
    1-chlorotetradecane 0.06
    n-nonane 0.08
    undecane 0.05
    tert-butylcyclohexane 0.06
    cyclooctane 0.12
    cyclopentanol 1.66
    tetrahydropyran 0.97
    tert-amyl methyl ether 0.56
    2,5,8-trioxanonane 8.06
    1-hexene 0.31
    2-isopropoxyethanol 2.97
    2,2,2-trifluoroethanol 9.54
    methyl butyrate 1.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction