Glutamyl-norvaline

Overview IFRA Request a quote

  • Identifiers

    CAS number
    71133-09-0

    Molecular formula
    C10H18N2O5

    SMILES
    CCC[C@@H](C(=O)O)NC(=O)CC[C@@H](C(=O)O)N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 64.94%
    Savory 42.58%
    Meaty 26.91%
    Sweet 26.81%
    Cooling 26.62%
    Milky 21.76%
    Fishy 18.29%
    Cooked 18.07%
    Oily 16.92%
    Cocoa 16.24%

     

    Flavor
    Odorless 64.86%
    Bitter 33.91%
    Mild 32.72%
    Bland 32.07%
    Very mild 24.27%
    Sweet-like 23.17%
    Yeast 22.5%
    Faint 21.36%
    Nitrile 19.6%
    Taco 18.97%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.9

    pKa est.
    5.74 (weak acid)

    Molecular weight
    246.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    398°C

    Flash point

    • 235.59 ˚C est.

    Solubility expt.

    • Freely soluble

  • Synonyms

    • Glutamyl-norvaline
    • Fema No. 4740
    • AS79U4HS2R
    • L-gamma-Glutamyl-L-norvaline
    • gamma-Glu-Nva
    • UNII-AS79U4HS2R
    • N-(N-L-gamma-Glutamyl)-L-norvaline
    • 71133-09-0
    • RefChem:143691
    • gamma-glutamyl-norvaline
    • SCHEMBL2178818
    • (S)-2-Amino-5-(((S)-1-carboxybutyl)amino)-5-oxopentanoic acid
    • 71133-09-0

  • Applications

    Glutamyl-norvaline (CAS 71133-09-0) is used as an intermediate and building block in peptide synthesis and peptidomimetics for pharmaceutical development. It also serves as a biochemical research reagent in enzyme assays and protein analysis. Given its amino acid composition, it may be explored as a flavor-active dipeptide or flavor precursor in the flavor/fragrance domain, and could be evaluated for applications in food processing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.73
    methanol 9.34
    isopropanol 1.08
    water 100.98
    ethyl acetate 0.89
    n-propanol 1.13
    acetone 1.15
    n-butanol 0.98
    acetonitrile 0.5
    DMF 56.32
    toluene 0.38
    isobutanol 0.93
    1,4-dioxane 3.51
    methyl acetate 0.72
    THF 4.23
    2-butanone 0.89
    n-pentanol 1.03
    sec-butanol 1.1
    n-hexane 0.26
    ethylene glycol 27.41
    NMP 85.01
    cyclohexane 0.3
    DMSO 151.42
    n-butyl acetate 0.73
    n-octanol 0.46
    chloroform 0.29
    n-propyl acetate 0.63
    acetic acid 24.41
    dichloromethane 0.43
    cyclohexanone 4.78
    propylene glycol 17.65
    isopropyl acetate 0.83
    DMAc 73.75
    2-ethoxyethanol 13.63
    isopentanol 1.26
    n-heptane 0.18
    ethyl formate 2.21
    1,2-dichloroethane 0.52
    n-hexanol 1.21
    2-methoxyethanol 29.77
    isobutyl acetate 0.34
    tetrachloromethane 0.17
    n-pentyl acetate 0.62
    transcutol 15.81
    n-heptanol 0.87
    ethylbenzene 0.41
    MIBK 1.01
    2-propoxyethanol 8.59
    tert-butanol 2.72
    MTBE 0.76
    2-butoxyethanol 4.8
    propionic acid 4.5
    o-xylene 0.81
    formic acid 152.6
    diethyl ether 0.5
    m-xylene 0.5
    p-xylene 0.59
    chlorobenzene 0.23
    dimethyl carbonate 2.15
    n-octane 0.12
    formamide 87.2
    cyclopentanone 5.37
    2-pentanone 1.03
    anisole 0.85
    cyclopentyl methyl ether 2.06
    gamma-butyrolactone 9.37
    1-methoxy-2-propanol 13.34
    pyridine 1.9
    3-pentanone 1.12
    furfural 17.62
    n-dodecane 0.06
    diethylene glycol 28.18
    diisopropyl ether 0.3
    tert-amyl alcohol 2.72
    acetylacetone 3.84
    n-hexadecane 0.06
    acetophenone 1.94
    methyl propionate 1.58
    isopentyl acetate 0.94
    trichloroethylene 0.82
    n-nonanol 0.53
    cyclohexanol 2.48
    benzyl alcohol 2.33
    2-ethylhexanol 0.75
    isooctanol 0.76
    dipropyl ether 0.67
    1,2-dichlorobenzene 0.41
    ethyl lactate 2.63
    propylene carbonate 4.89
    n-methylformamide 16.18
    2-pentanol 0.77
    n-pentane 0.14
    1-propoxy-2-propanol 4.09
    1-methoxy-2-propyl acetate 2.85
    2-(2-methoxypropoxy) propanol 7.12
    mesitylene 0.46
    ε-caprolactone 6.01
    p-cymene 0.38
    epichlorohydrin 3.58
    1,1,1-trichloroethane 0.2
    2-aminoethanol 21.06
    morpholine-4-carbaldehyde 56.28
    sulfolane 47.95
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 2.04
    n-hexyl acetate 0.75
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 8.63
    sec-butyl acetate 0.48
    tert-butyl acetate 1.36
    decalin 0.16
    glycerin 70.19
    diglyme 13.92
    acrylic acid 9.06
    isopropyl myristate 0.34
    n-butyric acid 4.65
    acetyl acetate 1.16
    di(2-ethylhexyl) phthalate 1.28
    ethyl propionate 0.82
    nitromethane 15.8
    1,2-diethoxyethane 1.4
    benzonitrile 0.9
    trioctyl phosphate 0.81
    1-bromopropane 0.21
    gamma-valerolactone 25.47
    n-decanol 0.46
    triethyl phosphate 1.27
    4-methyl-2-pentanol 0.72
    propionitrile 0.39
    vinylene carbonate 4.19
    1,1,2-trichlorotrifluoroethane 18.75
    DMS 1.73
    cumene 0.41
    2-octanol 0.52
    2-hexanone 0.78
    octyl acetate 0.52
    limonene 0.5
    1,2-dimethoxyethane 11.03
    ethyl orthosilicate 1.16
    tributyl phosphate 0.87
    diacetone alcohol 7.27
    N,N-dimethylaniline 1.62
    acrylonitrile 0.99
    aniline 1.26
    1,3-propanediol 15.33
    bromobenzene 0.19
    dibromomethane 0.27
    1,1,2,2-tetrachloroethane 1.08
    2-methyl-cyclohexyl acetate 1.14
    tetrabutyl urea 1.83
    diisobutyl methanol 0.64
    2-phenylethanol 1.78
    styrene 0.33
    dioctyl adipate 0.79
    dimethyl sulfate 10.16
    ethyl butyrate 0.78
    methyl lactate 8.22
    butyl lactate 2.26
    diethyl carbonate 0.67
    propanediol butyl ether 6.75
    triethyl orthoformate 1.14
    p-tert-butyltoluene 0.39
    methyl 4-tert-butylbenzoate 3.39
    morpholine 5.72
    tert-butylamine 0.92
    n-dodecanol 0.39
    dimethoxymethane 7.22
    ethylene carbonate 3.08
    cyrene 16.22
    2-ethoxyethyl acetate 1.46
    2-ethylhexyl acetate 0.65
    1,2,4-trichlorobenzene 0.6
    4-methylpyridine 1.68
    dibutyl ether 0.37
    2,6-dimethyl-4-heptanol 0.64
    DEF 6.27
    dimethyl isosorbide 11.74
    tetrachloroethylene 1.07
    eugenol 4.6
    triacetin 2.17
    span 80 5.84
    1,4-butanediol 8.42
    1,1-dichloroethane 0.17
    2-methyl-1-pentanol 1.32
    methyl formate 11.25
    2-methyl-1-butanol 1.24
    n-decane 0.09
    butyronitrile 0.48
    3,7-dimethyl-1-octanol 0.53
    1-chlorooctane 0.16
    1-chlorotetradecane 0.1
    n-nonane 0.09
    undecane 0.07
    tert-butylcyclohexane 0.11
    cyclooctane 0.18
    cyclopentanol 2.92
    tetrahydropyran 1.17
    tert-amyl methyl ether 1.06
    2,5,8-trioxanonane 14.07
    1-hexene 0.39
    2-isopropoxyethanol 5.56
    2,2,2-trifluoroethanol 14.57
    methyl butyrate 1.43

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction