Glucosamine Hydrochloride

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  • Identifiers

    CAS number
    66-84-2

    Molecular formula
    C6H14ClNO5

    SMILES
    C([C@H]([C@H]([C@@H]([C@H](C=O)N)O)O)O)O.Cl

    Safety labels

  • Odor profile

    Fragrance
    Odorless 75.79%
    Sweet 34.51%
    Savory 22.42%
    Fishy 20.44%
    Bitter 17.02%
    Cooling 15.87%
    Alcoholic 14.99%
    Caramellic 14.16%
    Buttery 14.03%
    Malty 13.57%

     

    Flavor
    Odorless 65.83%
    Sweet-like 29.64%
    Bitter 27.33%
    Sweet 27.21%
    Very mild 23.83%
    Bland 23.75%
    Mild 22.97%
    Very slight 20.68%
    Yeast 20.03%
    Nitrile 18.84%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.0 (weak acid)

    Molecular weight
    215.63 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    707°C

    Flash point

    • 221.53 ˚C est.

  • Synonyms

    • D-Glucosamine hydrochloride
    • (2R,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
    • Cosamin
    • D-Glucose, 2-amino-2-deoxy-, hydrochloride
    • Chitosamine hydrochloride
    • D-Glucosamine chloride
    • 2-Amino-2-deoxy-D-glucose hydrochloride
    • Artrox (TN)
    • D-Glucosamine monohydrochloride
    • NSC 758
    • EINECS 200-638-1
    • 2-Amino-D-glucose
    • 750W5330FY
    • NSC 234443
    • 2-Deoxy-2-amino-D-glucose hydrochloride
    • Glucosamine (as hydrochloride)
    • AI3-26077
    • Glucosamine hydrochloride [NF]
    • UNII-750W5330FY
    • D-Glucose, 2-amino-2-deoxy-, hydrochloride (1:1)
    • Glucopyranose, 2-amino-2-deoxy-, hydrochloride, D-
    • GLUCOSAMINE HYDROCHLORIDE [MART.]
    • GLUCOSAMINE HYDROCHLORIDE [USP-RS]
    • GLUCOSAMINE HYDROCHLORIDE [WHO-DD]
    • EC 200-638-1
    • GLUCOSAMINE HYDROCHLORIDE [EP MONOGRAPH]
    • NSC-758
    • NSC-234443
    • GLUCOSAMINE HYDROCHLORIDE (MART.)
    • 200-638-1
    • GLUCOSAMINE HYDROCHLORIDE (USP-RS)
    • GLUCOSAMINE HYDROCHLORIDE (EP MONOGRAPH)
    • Alateris
    • Fosachew
    • Fosaveg
    • Gosachew
    • Gosaveg
    • Ardern
    • Artrox
    • d(+)Glucosamine hydrochloride
    • Cozachew fizz
    • Bio-health
    • Flexi-melt
    • Pro coxam
    • Br pharm
    • Joint-flex daily
    • Cozachew fizz combi
    • DGlucosamine chloride
    • Cozachew meltdown combi
    • Glucosamine hcl meltdown
    • Cozachew meltdown 1500
    • DGlucosamine hydrochloride
    • RefChem:143623
    • CHITOSAMINA CLORIDRATO
    • DGlucosamine monohydrochloride
    • GLUCOSAMINE HCL [INCI]
    • 2Amino2deoxyDglucose hydrochloride
    • 2Deoxy2aminoDglucose hydrochloride
    • DGlucose, 2amino2deoxy, hydrochloride
    • 2Amino2deoxybetaDglucopyranose hydrochloride
    • Glucopyranose, 2amino2deoxy, hydrochloride, D
    • (3R,4R,5S,6R)-3-AMINO-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,4,5-TRIOL HYDROCHLORIDE
    • 66-84-2
    • D-(+)-Glucosamine hydrochloride
    • DTXCID3017236
    • DTXSID5037236
    • GLUCOSAMINE HCL
    • Glucosamine Hydrochloride
    • D-Glucosamine HCl
    • Glucosamine (hydrochloride)
    • C6H14ClNO5
    • glucosaminehydrochloride
    • SCHEMBL19711
    • 2-Amino-2-deoxy-beta-D-glucopyranose hydrochloride
    • HY-N0733R
    • CBOJBBMQJBVCMW-BTVCFUMJSA-N
    • HMS6018E10
    • HY-N0733
    • MFCD00067674
    • AKOS015951259
    • D-Glucosamine HCl - sea shell origin
    • AT10935
    • CS-4919
    • EBC-152241
    • Glucosamine (hydrochloride) (Standard)
    • MG10695
    • AS-14149
    • BP-13611
    • ST50825652
    • D08022
    • EN300-157752
    • 2-Amino-2-deoxy-D-glucose hydrochloride (1:1)
    • Q27266322
    • Z1954805520
    • 7070F368-3591-43D6-830F-335576FD1BAE
    • 66-84-2

  • Applications

    Glucosamine Hydrochloride (CAS 66-84-2) is used across sectors including nutraceuticals as a dietary supplement ingredient, cosmetics/personal care as a skin-conditioning additive, pharmaceuticals as an intermediate or formulation excipient in drug development, and veterinary/animal health products as a feed supplement. It also serves as a chemical intermediate and precursor in glycosaminoglycan-related bioprocessing and related biopolymer synthesis in industrial settings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.19
    methanol 1.3
    isopropanol 0.08
    water 575.18
    ethyl acetate 0.11
    n-propanol 0.14
    acetone 0.15
    n-butanol 0.09
    acetonitrile 0.18
    DMF 15.96
    toluene 0.05
    isobutanol 0.09
    1,4-dioxane 0.54
    methyl acetate 0.08
    THF 0.27
    2-butanone 0.12
    n-pentanol 0.05
    sec-butanol 0.12
    n-hexane 0.02
    ethylene glycol 19.28
    NMP 30.92
    cyclohexane 0.14
    DMSO 72.47
    n-butyl acetate 0.08
    n-octanol 0.08
    chloroform 0.03
    n-propyl acetate 0.05
    acetic acid 2.8
    dichloromethane 0.05
    cyclohexanone 0.58
    propylene glycol 4.42
    isopropyl acetate 0.07
    DMAc 11.95
    2-ethoxyethanol 1.14
    isopentanol 0.08
    n-heptane 0.1
    ethyl formate 0.14
    1,2-dichloroethane 0.07
    n-hexanol 0.15
    2-methoxyethanol 4.33
    isobutyl acetate 0.02
    tetrachloromethane 0.04
    n-pentyl acetate 0.05
    transcutol 1.36
    n-heptanol 0.15
    ethylbenzene 0.03
    MIBK 0.08
    2-propoxyethanol 1.03
    tert-butanol 0.14
    MTBE 0.05
    2-butoxyethanol 0.59
    propionic acid 0.71
    o-xylene 0.12
    formic acid 111.51
    diethyl ether 0.05
    m-xylene 0.07
    p-xylene 0.04
    chlorobenzene 0.02
    dimethyl carbonate 0.53
    n-octane 0.04
    formamide 42.68
    cyclopentanone 0.65
    2-pentanone 0.12
    anisole 0.06
    cyclopentyl methyl ether 0.3
    gamma-butyrolactone 1.02
    1-methoxy-2-propanol 1.92
    pyridine 0.23
    3-pentanone 0.18
    furfural 1.97
    n-dodecane 0.01
    diethylene glycol 6.12
    diisopropyl ether 0.04
    tert-amyl alcohol 0.19
    acetylacetone 0.36
    n-hexadecane 0.02
    acetophenone 0.17
    methyl propionate 0.32
    isopentyl acetate 0.06
    trichloroethylene 0.08
    n-nonanol 0.08
    cyclohexanol 0.43
    benzyl alcohol 0.18
    2-ethylhexanol 0.12
    isooctanol 0.11
    dipropyl ether 0.14
    1,2-dichlorobenzene 0.04
    ethyl lactate 0.41
    propylene carbonate 0.39
    n-methylformamide 5.2
    2-pentanol 0.08
    n-pentane 0.02
    1-propoxy-2-propanol 0.71
    1-methoxy-2-propyl acetate 0.35
    2-(2-methoxypropoxy) propanol 0.66
    mesitylene 0.09
    ε-caprolactone 0.58
    p-cymene 0.09
    epichlorohydrin 0.25
    1,1,1-trichloroethane 0.02
    2-aminoethanol 5.6
    morpholine-4-carbaldehyde 13.37
    sulfolane 12.88
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.19
    n-hexyl acetate 0.06
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 0.79
    sec-butyl acetate 0.03
    tert-butyl acetate 0.1
    decalin 0.03
    glycerin 40.33
    diglyme 1.59
    acrylic acid 1.99
    isopropyl myristate 0.03
    n-butyric acid 0.4
    acetyl acetate 0.13
    di(2-ethylhexyl) phthalate 0.09
    ethyl propionate 0.08
    nitromethane 2.78
    1,2-diethoxyethane 0.1
    benzonitrile 0.08
    trioctyl phosphate 0.08
    1-bromopropane 0.02
    gamma-valerolactone 2.32
    n-decanol 0.07
    triethyl phosphate 0.18
    4-methyl-2-pentanol 0.06
    propionitrile 0.08
    vinylene carbonate 0.4
    1,1,2-trichlorotrifluoroethane 4.19
    DMS 0.16
    cumene 0.04
    2-octanol 0.08
    2-hexanone 0.05
    octyl acetate 0.05
    limonene 0.16
    1,2-dimethoxyethane 0.6
    ethyl orthosilicate 0.16
    tributyl phosphate 0.07
    diacetone alcohol 0.66
    N,N-dimethylaniline 0.16
    acrylonitrile 0.21
    aniline 0.14
    1,3-propanediol 2.45
    bromobenzene 0.02
    dibromomethane 0.03
    1,1,2,2-tetrachloroethane 0.11
    2-methyl-cyclohexyl acetate 0.11
    tetrabutyl urea 0.2
    diisobutyl methanol 0.11
    2-phenylethanol 0.19
    styrene 0.02
    dioctyl adipate 0.07
    dimethyl sulfate 3.16
    ethyl butyrate 0.11
    methyl lactate 2.3
    butyl lactate 0.23
    diethyl carbonate 0.07
    propanediol butyl ether 0.82
    triethyl orthoformate 0.15
    p-tert-butyltoluene 0.1
    methyl 4-tert-butylbenzoate 0.36
    morpholine 0.89
    tert-butylamine 0.06
    n-dodecanol 0.06
    dimethoxymethane 1.17
    ethylene carbonate 0.27
    cyrene 3.12
    2-ethoxyethyl acetate 0.1
    2-ethylhexyl acetate 0.06
    1,2,4-trichlorobenzene 0.05
    4-methylpyridine 0.14
    dibutyl ether 0.04
    2,6-dimethyl-4-heptanol 0.11
    DEF 1.26
    dimethyl isosorbide 1.39
    tetrachloroethylene 0.17
    eugenol 0.46
    triacetin 0.21
    span 80 0.7
    1,4-butanediol 0.97
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.05
    methyl formate 1.75
    2-methyl-1-butanol 0.1
    n-decane 0.03
    butyronitrile 0.05
    3,7-dimethyl-1-octanol 0.06
    1-chlorooctane 0.03
    1-chlorotetradecane 0.02
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.09
    cyclopentanol 0.47
    tetrahydropyran 0.17
    tert-amyl methyl ether 0.1
    2,5,8-trioxanonane 1.56
    1-hexene 0.02
    2-isopropoxyethanol 0.41
    2,2,2-trifluoroethanol 6.2
    methyl butyrate 0.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction