Gluconic Acid

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  • Identifiers

    CAS number
    526-95-4

    Molecular formula
    C6H12O7

    SMILES
    C([C@H]([C@H]([C@@H]([C@H](C(=O)O)O)O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 71.89%
    Sweet 41.17%
    Caramellic 29.94%
    Buttery 23.17%
    Milky 18.4%
    Savory 18.29%
    Clean 18.25%
    Sharp 17.01%
    Bitter 15.87%
    Alcoholic 15.62%

     

    Flavor
    Odorless 73.57%
    Sweet 34.15%
    Very mild 31.46%
    Sweet-like 30.79%
    Bland 23.89%
    Mild 22.03%
    Very slight 20.57%
    Yeast 20.39%
    Caramellic 20.0%
    Acetoin 18.8%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.4

    pKa est.
    3.01 (weak acid)

    Molecular weight
    196.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    777°C

    Melting point expt.

    • 131 °C
    • 113 - 118 °C

    Flash point

    • 250.59 ˚C est.

    Solubility expt.

    • FREELY SOL IN WATER; SLIGHTLY SOL IN ALC, INSOLUBLE IN ETHER AND MOST OTHER ORGANIC SOLVENTS
    • 316 mg/mL at 25 °C
    • Solubility in water, g/100ml at 25 °C: 100 (good)

  • Synonyms

    • gluconic acid
    • D-gluconic acid
    • 526-95-4
    • dextronic acid
    • maltonic acid
    • Glycogenic acid
    • (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
    • Glosanto
    • Pentahydroxycaproic acid
    • D-Gluco-hexonic acid
    • R4R8J0Q44B
    • DTXSID8027169
    • DTXCID307169
    • INS NO.574
    • DTXSID8042000
    • CHEBI:33198
    • INS-574
    • NSC-77381
    • E-574
    • NSC77381
    • RefChem:5859
    • GlyTouCan:G12678RQ
    • CHEBI:24266
    • DTXCID201012074
    • G12678RQ
    • 208-401-4
    • Gluconic acid, D-
    • Gluconic acid (VAN)
    • 133-42-6
    • D-Gluconsaeure
    • D-Glukonsaeure
    • BRN 1726055
    • MFCD00004240
    • Glyconic acid
    • Hexonic acid
    • C6H12O7
    • D-Gluconic Acid (50% in Water)
    • Dextronate
    • Glycogenate
    • Glyconate
    • Maltonate
    • NSC 77381
    • GCO
    • 124423-64-9
    • HSDB 487
    • EINECS 208-401-4
    • UNII-R4R8J0Q44B
    • sodium-gluconate
    • ketogluconic acid
    • 2,3,4,5,6-Pentahydroxycaproic acid
    • D-?Gluconic acid
    • Pentahydroxycaproate
    • L-glycero-Hexonic acid
    • GLUCONAL GA-50
    • SCHEMBL971
    • bmse000084
    • EC 208-401-4
    • GLUCONIC ACID [MI]
    • GLUCONIC ACID [HSDB]
    • 4-03-00-01255 (Beilstein Handbook Reference)
    • GLUCONIC ACID [VANDF]
    • GLUCONIC ACID [MART.]
    • CHEMBL464345
    • orb1909580
    • D-Gluconic acid 50% in water
    • GLUCONIC ACID [WHO-DD]
    • SCHEMBL28144132
    • MSK3252
    • GluconicAcid(containsGluconolactone)
    • HY-Y0569
    • 2,3,4,5,6-pentahydroxy-hexanoate
    • Tox21_202745
    • EBC-26178
    • s3595
    • SBB066208
    • AKOS015895892
    • D-Gluconic acid - 45-50% in water
    • DB13180
    • MG15339
    • 2,3,4,5,6-pentahydroxy-hexanoic acid
    • GLUCONIC ACID (50% IN WATER)
    • Gluconic Acid (contains Gluconolactone)
    • NCGC00260293-01
    • CAS-526-95-4
    • E574
    • CS-0015343
    • G0036
    • NS00008847
    • 2,3,4,5,6-Pentahydroxycaproic acid solution
    • C00257
    • D70789
    • SBI-0635367.0002
    • EN300-7392806
    • Q407569
    • BRD-K93201765-001-01-0
    • (3S,2R,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
    • Gluconic Acid (contains Gluconolactone) (45-50% in Water)
    • 6E52B5FC-5676-4139-977A-4D643EDDB159
    • (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanoic acid (50% in H2O, w/w)
    • 526-95-4

  • Applications

    Gluconic Acid (CAS 526-95-4) is used as a metal-chelating agent and stabilizer in household and industrial cleaners; as an acidulant and sequestrant in food processing and beverages; as a chelating agent and stabilizer in cosmetics and personal care formulations; in agriculture and fertilizers, gluconate salts are used to chelate metals and deliver micronutrients to crops; and it serves as an intermediate for producing gluconate salts (for example calcium gluconate) used in pharmaceutical and nutritional applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.37
    methanol 14.01
    isopropanol 1.17
    water 989.11
    ethyl acetate 0.45
    n-propanol 1.42
    acetone 1.38
    n-butanol 0.81
    acetonitrile 0.54
    DMF 113.94
    toluene 0.19
    isobutanol 0.68
    1,4-dioxane 2.98
    methyl acetate 0.43
    THF 1.75
    2-butanone 0.69
    n-pentanol 0.4
    sec-butanol 1.12
    n-hexane 0.07
    ethylene glycol 142.84
    NMP 100.46
    cyclohexane 0.55
    DMSO 371.85
    n-butyl acetate 0.25
    n-octanol 0.43
    chloroform 0.05
    n-propyl acetate 0.17
    acetic acid 7.44
    dichloromethane 0.1
    cyclohexanone 1.72
    propylene glycol 37.21
    isopropyl acetate 0.34
    DMAc 56.51
    2-ethoxyethanol 8.93
    isopentanol 0.65
    n-heptane 0.48
    ethyl formate 0.48
    1,2-dichloroethane 0.23
    n-hexanol 0.88
    2-methoxyethanol 34.79
    isobutyl acetate 0.05
    tetrachloromethane 0.1
    n-pentyl acetate 0.2
    transcutol 6.34
    n-heptanol 0.75
    ethylbenzene 0.12
    MIBK 0.49
    2-propoxyethanol 6.33
    tert-butanol 2.09
    MTBE 0.42
    2-butoxyethanol 2.72
    propionic acid 3.21
    o-xylene 0.5
    formic acid 212.32
    diethyl ether 0.42
    m-xylene 0.32
    p-xylene 0.13
    chlorobenzene 0.04
    dimethyl carbonate 2.61
    n-octane 0.14
    formamide 141.01
    cyclopentanone 2.2
    2-pentanone 0.78
    anisole 0.26
    cyclopentyl methyl ether 1.59
    gamma-butyrolactone 3.02
    1-methoxy-2-propanol 17.41
    pyridine 0.76
    3-pentanone 0.93
    furfural 3.81
    n-dodecane 0.06
    diethylene glycol 31.39
    diisopropyl ether 0.26
    tert-amyl alcohol 1.91
    acetylacetone 1.88
    n-hexadecane 0.07
    acetophenone 0.5
    methyl propionate 1.61
    isopentyl acetate 0.19
    trichloroethylene 0.19
    n-nonanol 0.41
    cyclohexanol 2.16
    benzyl alcohol 0.7
    2-ethylhexanol 0.51
    isooctanol 0.48
    dipropyl ether 0.78
    1,2-dichlorobenzene 0.08
    ethyl lactate 1.49
    propylene carbonate 0.83
    n-methylformamide 28.89
    2-pentanol 0.82
    n-pentane 0.14
    1-propoxy-2-propanol 3.75
    1-methoxy-2-propyl acetate 1.43
    2-(2-methoxypropoxy) propanol 2.57
    mesitylene 0.37
    ε-caprolactone 1.65
    p-cymene 0.3
    epichlorohydrin 1.0
    1,1,1-trichloroethane 0.06
    2-aminoethanol 49.36
    morpholine-4-carbaldehyde 48.88
    sulfolane 34.68
    2,2,4-trimethylpentane 0.1
    2-methyltetrahydrofuran 1.0
    n-hexyl acetate 0.25
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 3.36
    sec-butyl acetate 0.11
    tert-butyl acetate 0.57
    decalin 0.11
    glycerin 201.41
    diglyme 7.05
    acrylic acid 7.04
    isopropyl myristate 0.13
    n-butyric acid 1.39
    acetyl acetate 0.39
    di(2-ethylhexyl) phthalate 0.21
    ethyl propionate 0.33
    nitromethane 9.03
    1,2-diethoxyethane 0.51
    benzonitrile 0.15
    trioctyl phosphate 0.26
    1-bromopropane 0.08
    gamma-valerolactone 7.31
    n-decanol 0.32
    triethyl phosphate 0.5
    4-methyl-2-pentanol 0.46
    propionitrile 0.28
    vinylene carbonate 0.73
    1,1,2-trichlorotrifluoroethane 10.43
    DMS 0.55
    cumene 0.12
    2-octanol 0.39
    2-hexanone 0.2
    octyl acetate 0.19
    limonene 0.56
    1,2-dimethoxyethane 3.86
    ethyl orthosilicate 0.46
    tributyl phosphate 0.19
    diacetone alcohol 4.23
    N,N-dimethylaniline 0.72
    acrylonitrile 0.7
    aniline 0.64
    1,3-propanediol 20.74
    bromobenzene 0.03
    dibromomethane 0.07
    1,1,2,2-tetrachloroethane 0.33
    2-methyl-cyclohexyl acetate 0.28
    tetrabutyl urea 0.62
    diisobutyl methanol 0.48
    2-phenylethanol 0.7
    styrene 0.09
    dioctyl adipate 0.21
    dimethyl sulfate 12.75
    ethyl butyrate 0.35
    methyl lactate 10.93
    butyl lactate 0.71
    diethyl carbonate 0.21
    propanediol butyl ether 3.58
    triethyl orthoformate 0.49
    p-tert-butyltoluene 0.36
    methyl 4-tert-butylbenzoate 1.21
    morpholine 5.26
    tert-butylamine 0.78
    n-dodecanol 0.26
    dimethoxymethane 11.35
    ethylene carbonate 0.6
    cyrene 8.16
    2-ethoxyethyl acetate 0.39
    2-ethylhexyl acetate 0.16
    1,2,4-trichlorobenzene 0.11
    4-methylpyridine 0.49
    dibutyl ether 0.19
    2,6-dimethyl-4-heptanol 0.48
    DEF 6.64
    dimethyl isosorbide 3.99
    tetrachloroethylene 0.46
    eugenol 1.39
    triacetin 0.61
    span 80 2.5
    1,4-butanediol 7.11
    1,1-dichloroethane 0.05
    2-methyl-1-pentanol 0.31
    methyl formate 9.19
    2-methyl-1-butanol 0.75
    n-decane 0.11
    butyronitrile 0.17
    3,7-dimethyl-1-octanol 0.26
    1-chlorooctane 0.12
    1-chlorotetradecane 0.07
    n-nonane 0.12
    undecane 0.08
    tert-butylcyclohexane 0.06
    cyclooctane 0.41
    cyclopentanol 2.39
    tetrahydropyran 0.79
    tert-amyl methyl ether 0.77
    2,5,8-trioxanonane 6.19
    1-hexene 0.07
    2-isopropoxyethanol 2.77
    2,2,2-trifluoroethanol 13.96
    methyl butyrate 0.38

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction