Glucaric Acid

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  • Identifiers

    CAS number
    25525-21-7

    Molecular formula
    C6H10O8

    SMILES
    [C@H]([C@@H]([C@@H](C(=O)O)O)O)([C@H](C(=O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 70.71%
    Caramellic 34.51%
    Sweet 29.66%
    Buttery 24.48%
    Sour 22.66%
    Savory 21.24%
    Sharp 20.09%
    Milky 19.49%
    Burnt 18.76%
    Clean 18.47%

     

    Flavor
    Odorless 71.97%
    Very mild 36.45%
    Sweet-like 26.29%
    Bland 25.62%
    Mild 23.91%
    Caramellic 23.12%
    Sour 21.71%
    Yeast 21.42%
    Very slight 18.78%
    Acetoin 18.5%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.5

    pKa est.
    2.14 (strong acid)

    Molecular weight
    210.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    603°C

    Melting point expt.

    • 125.5 °C

    Flash point

    • 255.87 ˚C est.

    Solubility expt.

    • 912 mg/mL

  • Synonyms

    • GLUCARIC ACID
    • Glucosaccharic acid
    • (2S,3S,4S,5R)-2,3,4,5-tetrahydroxyhexanedioic acid
    • 25525-21-7
    • QLZ991V4A2
    • DTXSID501340165
    • Acid, Saccharic
    • D Glucaric Acid
    • L Gularic Acid
    • D Saccharic Acid
    • Levo Gularic Acid
    • RefChem:663092
    • GlyTouCan:G37845XB
    • CHEBI:17301
    • DTXCID201769580
    • G37845XB
    • 201-768-1
    • D-glucaric acid
    • 87-73-0
    • Saccharic acid
    • D-saccharic acid
    • D-glucarate
    • D-glucosaccharic acid
    • (2R,3S,4S,5S)-2,3,4,5-tetrahydroxyhexanedioic acid
    • L-gularic acid
    • DL-Glucaric acid
    • saccharate
    • D-(+)-saccharic acid
    • D-saccharate
    • D-tetrahydroxyadipic acid
    • MFCD09752094
    • Glucaric acid, D-
    • 2S,3S,4S,5R-tetrahydroxy-hexanedioic acid
    • Calcium D-saccharate tetrahydrate
    • GKR
    • UNII-QLZ991V4A2
    • glucaric-acid
    • D-GLUCARIC ACID CALCIUM SALT TETRAHYDRATE
    • L-gularate
    • (2R,3S,4S,5S)-2,3,4,5-tetrahydroxyhexanedioate
    • D-glucosaccharate
    • D-aGlucaric acid
    • D-Saccharic acid calcium salt
    • D-glucosaccharicacid
    • EINECS 201-768-1
    • D-tetrahydroxyadipate
    • D-(+)-saccharate
    • bmse000239
    • SCHEMBL5496
    • D-GLUCARIC ACID [MI]
    • orb2802144
    • CHEMBL1794737
    • CHEBI:16002
    • DTXSID60859455
    • LMFA01170108
    • DB03603
    • MC04536
    • SY332289
    • CS-0456843
    • Glucosaccharic acid calcium salt tetrahydrate
    • NS00070008
    • C00818
    • D83869
    • F776779
    • Q424636
    • 52B6CA34-55ED-41A0-BE2A-45AABDC4DC81
    • BRD-K60150658-432-01-5
    • 87-73-0

  • Applications

    Glucaric Acid (CAS 25525-21-7) is a renewable platform chemical used as a building block in polymer and specialty-chemical synthesis. It serves as a precursor to biodegradable polymers and polyesters/polyamides via its difunctional carboxyl groups and is further converted into functional esters and crosslinkable derivatives for coatings, inks, and adhesives. In formulation chemistry, its salts can function as chelating agents to sequester metal ions in cleaners and water-treatment products, improving stability and performance. It is also explored as a precursor for environmentally friendly surfactants and other derivatized products in industrial formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.17
    methanol 29.34
    isopropanol 3.58
    water 457.32
    ethyl acetate 0.49
    n-propanol 4.05
    acetone 1.88
    n-butanol 1.88
    acetonitrile 0.34
    DMF 78.03
    toluene 0.23
    isobutanol 1.52
    1,4-dioxane 2.94
    methyl acetate 0.57
    THF 2.82
    2-butanone 1.06
    n-pentanol 0.69
    sec-butanol 2.41
    n-hexane 0.17
    ethylene glycol 108.88
    NMP 58.31
    cyclohexane 0.71
    DMSO 375.64
    n-butyl acetate 0.28
    n-octanol 0.64
    chloroform 0.07
    n-propyl acetate 0.14
    acetic acid 5.62
    dichloromethane 0.15
    cyclohexanone 1.41
    propylene glycol 37.12
    isopropyl acetate 0.3
    DMAc 44.59
    2-ethoxyethanol 9.74
    isopentanol 1.12
    n-heptane 0.69
    ethyl formate 0.71
    1,2-dichloroethane 0.32
    n-hexanol 1.32
    2-methoxyethanol 42.33
    isobutyl acetate 0.03
    tetrachloromethane 0.17
    n-pentyl acetate 0.23
    transcutol 5.69
    n-heptanol 1.02
    ethylbenzene 0.12
    MIBK 0.46
    2-propoxyethanol 6.84
    tert-butanol 4.71
    MTBE 0.76
    2-butoxyethanol 3.14
    propionic acid 3.21
    o-xylene 0.54
    formic acid 103.72
    diethyl ether 0.96
    m-xylene 0.28
    p-xylene 0.1
    chlorobenzene 0.03
    dimethyl carbonate 2.02
    n-octane 0.21
    formamide 96.66
    cyclopentanone 2.02
    2-pentanone 1.0
    anisole 0.2
    cyclopentyl methyl ether 1.85
    gamma-butyrolactone 2.55
    1-methoxy-2-propanol 18.61
    pyridine 0.83
    3-pentanone 1.13
    furfural 2.55
    n-dodecane 0.07
    diethylene glycol 22.64
    diisopropyl ether 0.36
    tert-amyl alcohol 3.26
    acetylacetone 1.16
    n-hexadecane 0.08
    acetophenone 0.32
    methyl propionate 1.61
    isopentyl acetate 0.16
    trichloroethylene 0.2
    n-nonanol 0.59
    cyclohexanol 2.41
    benzyl alcohol 0.48
    2-ethylhexanol 0.55
    isooctanol 0.51
    dipropyl ether 1.03
    1,2-dichlorobenzene 0.05
    ethyl lactate 0.97
    propylene carbonate 0.58
    n-methylformamide 27.77
    2-pentanol 1.57
    n-pentane 0.4
    1-propoxy-2-propanol 4.07
    1-methoxy-2-propyl acetate 1.04
    2-(2-methoxypropoxy) propanol 2.08
    mesitylene 0.3
    ε-caprolactone 1.26
    p-cymene 0.26
    epichlorohydrin 1.15
    1,1,1-trichloroethane 0.07
    2-aminoethanol 57.79
    morpholine-4-carbaldehyde 24.59
    sulfolane 21.97
    2,2,4-trimethylpentane 0.14
    2-methyltetrahydrofuran 1.37
    n-hexyl acetate 0.27
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 3.32
    sec-butyl acetate 0.08
    tert-butyl acetate 0.46
    decalin 0.11
    glycerin 108.25
    diglyme 5.7
    acrylic acid 4.97
    isopropyl myristate 0.12
    n-butyric acid 1.34
    acetyl acetate 0.24
    di(2-ethylhexyl) phthalate 0.16
    ethyl propionate 0.28
    nitromethane 5.5
    1,2-diethoxyethane 0.6
    benzonitrile 0.09
    trioctyl phosphate 0.23
    1-bromopropane 0.16
    gamma-valerolactone 4.78
    n-decanol 0.46
    triethyl phosphate 0.39
    4-methyl-2-pentanol 0.59
    propionitrile 0.31
    vinylene carbonate 0.44
    1,1,2-trichlorotrifluoroethane 6.21
    DMS 0.38
    cumene 0.1
    2-octanol 0.51
    2-hexanone 0.21
    octyl acetate 0.19
    limonene 0.51
    1,2-dimethoxyethane 4.47
    ethyl orthosilicate 0.38
    tributyl phosphate 0.16
    diacetone alcohol 3.33
    N,N-dimethylaniline 0.58
    acrylonitrile 0.55
    aniline 0.63
    1,3-propanediol 24.86
    bromobenzene 0.03
    dibromomethane 0.12
    1,1,2,2-tetrachloroethane 0.37
    2-methyl-cyclohexyl acetate 0.18
    tetrabutyl urea 0.55
    diisobutyl methanol 0.46
    2-phenylethanol 0.54
    styrene 0.08
    dioctyl adipate 0.16
    dimethyl sulfate 8.44
    ethyl butyrate 0.3
    methyl lactate 7.3
    butyl lactate 0.74
    diethyl carbonate 0.17
    propanediol butyl ether 3.46
    triethyl orthoformate 0.41
    p-tert-butyltoluene 0.31
    methyl 4-tert-butylbenzoate 0.9
    morpholine 6.43
    tert-butylamine 1.87
    n-dodecanol 0.35
    dimethoxymethane 14.13
    ethylene carbonate 0.38
    cyrene 3.61
    2-ethoxyethyl acetate 0.39
    2-ethylhexyl acetate 0.13
    1,2,4-trichlorobenzene 0.08
    4-methylpyridine 0.52
    dibutyl ether 0.24
    2,6-dimethyl-4-heptanol 0.46
    DEF 6.07
    dimethyl isosorbide 2.32
    tetrachloroethylene 0.57
    eugenol 0.93
    triacetin 0.4
    span 80 1.83
    1,4-butanediol 6.68
    1,1-dichloroethane 0.07
    2-methyl-1-pentanol 0.4
    methyl formate 9.41
    2-methyl-1-butanol 1.33
    n-decane 0.14
    butyronitrile 0.21
    3,7-dimethyl-1-octanol 0.3
    1-chlorooctane 0.16
    1-chlorotetradecane 0.07
    n-nonane 0.16
    undecane 0.1
    tert-butylcyclohexane 0.06
    cyclooctane 0.48
    cyclopentanol 2.93
    tetrahydropyran 1.16
    tert-amyl methyl ether 1.22
    2,5,8-trioxanonane 4.76
    1-hexene 0.15
    2-isopropoxyethanol 2.42
    2,2,2-trifluoroethanol 7.34
    methyl butyrate 0.33

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction