Glabrone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    60008-02-8

    Molecular formula
    C20H16O5

    SMILES
    CC1(C=CC2=C(O1)C=CC(=C2O)C3=COC4=C(C3=O)C=CC(=C4)O)C

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 53.88%
    Sweet 38.73%
    Spicy 32.02%
    Fruity 29.01%
    Burnt 26.92%
    Medicinal 26.57%
    Odorless 25.61%
    Vanilla 25.4%
    Smoky 24.69%
    Powdery 23.64%

     

    Flavor
    Bitter 96.61%
    Cedarleaf 19.37%
    Lovage 18.86%
    Parsley 18.81%
    Very strong 18.44%
    Sweet-like 18.26%
    Ripe apricot 18.23%
    Indole 18.21%
    Red fruit 17.98%
    Nitrile 17.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    8.97 (weak base)

    Molecular weight
    336.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    851°C

    Melting point expt.

    • 224 - 226 °C

    Flash point

    • 244.39 ˚C est.

  • Synonyms

    • Glabrone
    • 60008-02-8
    • Morusin hydroperoxide
    • Eurycarpin B
    • 7-hydroxy-3-(5-hydroxy-2,2-dimethylchromen-6-yl)chromen-4-one
    • 9U4M81SWUK
    • DTXSID30208714
    • 4H-1-Benzopyran-4-one, 7-hydroxy-3-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-
    • 7,2'-dihydroxy-6'',6''-dimethylpyrano-(2'',3''-4',3')isoflavone
    • RefChem:37730
    • DTXCID80131205
    • 5',7-Dihydroxy-2',2'-dimethyl-2'H,4H-[3,6'-bichromen]-4-one
    • 7-hydroxy-3-(5-hydroxy-2,2-dimethyl-chromen-6-yl)chromen-4-one
    • UNII-9U4M81SWUK
    • MLS000697613
    • CHEMBL600457
    • orb1297358
    • SCHEMBL30001760
    • CHEBI:175272
    • HMS2268B14
    • HY-N4194
    • KCA00802
    • BDBM50441624
    • LMPK12050074
    • AKOS037515325
    • EBC-615642
    • DA-53568
    • MS-25093
    • SMR000470947
    • CS-0032388
    • G16929
    • Q27273226
    • 5',7-Dihydroxy-2',2'-dimethyl-2'H,4H-[3,6'-bi-1-benzopyran]-4-one
    • 7-Hydroxy-3-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-4H-1-benzopyran-4-one, 9CI
    • 60008-02-8

  • Applications

    Glabrone (CAS 60008-02-8) is an organic compound primarily used as an intermediate in organic synthesis and may also function as a processing aid in various formulations. In perfumery and cosmetics, it is evaluated as a precursor to odorants or as a building block for fragrance-containing products. It can appear in household products as a formulation component or processing aid. In coatings and inks, it may serve as a specialty chemical intermediate or additive for formulation compatibility. In broader industrial manufacturing, it is considered as a building block for the synthesis of more complex specialty chemicals, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.0
    methanol 1.31
    isopropanol 1.65
    water 0.0
    ethyl acetate 2.88
    n-propanol 2.1
    acetone 10.28
    n-butanol 1.69
    acetonitrile 3.11
    DMF 37.57
    toluene 0.81
    isobutanol 1.94
    1,4-dioxane 18.19
    methyl acetate 6.44
    THF 81.45
    2-butanone 14.14
    n-pentanol 1.86
    sec-butanol 2.04
    n-hexane 0.02
    ethylene glycol 0.86
    NMP 19.14
    cyclohexane 0.02
    DMSO 82.94
    n-butyl acetate 3.73
    n-octanol 1.51
    chloroform 2.17
    n-propyl acetate 4.11
    acetic acid 5.17
    dichloromethane 2.78
    cyclohexanone 15.23
    propylene glycol 1.5
    isopropyl acetate 2.84
    DMAc 58.34
    2-ethoxyethanol 11.77
    isopentanol 2.2
    n-heptane 0.04
    ethyl formate 2.45
    1,2-dichloroethane 3.05
    n-hexanol 1.21
    2-methoxyethanol 19.16
    isobutyl acetate 3.25
    tetrachloromethane 0.11
    n-pentyl acetate 3.63
    transcutol 48.3
    n-heptanol 1.5
    ethylbenzene 0.47
    MIBK 4.32
    2-propoxyethanol 17.6
    tert-butanol 2.7
    MTBE 2.36
    2-butoxyethanol 8.04
    propionic acid 2.87
    o-xylene 0.6
    formic acid 1.77
    diethyl ether 1.41
    m-xylene 0.57
    p-xylene 0.86
    chlorobenzene 1.14
    dimethyl carbonate 3.73
    n-octane 0.03
    formamide 4.75
    cyclopentanone 29.66
    2-pentanone 5.93
    anisole 3.75
    cyclopentyl methyl ether 6.47
    gamma-butyrolactone 24.57
    1-methoxy-2-propanol 14.37
    pyridine 13.41
    3-pentanone 4.46
    furfural 15.95
    n-dodecane 0.07
    diethylene glycol 13.46
    diisopropyl ether 0.45
    tert-amyl alcohol 2.65
    acetylacetone 10.15
    n-hexadecane 0.08
    acetophenone 5.0
    methyl propionate 5.13
    isopentyl acetate 4.96
    trichloroethylene 8.48
    n-nonanol 1.89
    cyclohexanol 1.92
    benzyl alcohol 3.74
    2-ethylhexanol 1.43
    isooctanol 1.71
    dipropyl ether 2.31
    1,2-dichlorobenzene 1.12
    ethyl lactate 3.87
    propylene carbonate 5.05
    n-methylformamide 7.76
    2-pentanol 0.99
    n-pentane 0.01
    1-propoxy-2-propanol 10.89
    1-methoxy-2-propyl acetate 9.83
    2-(2-methoxypropoxy) propanol 13.34
    mesitylene 0.32
    ε-caprolactone 10.46
    p-cymene 0.69
    epichlorohydrin 42.9
    1,1,1-trichloroethane 1.3
    2-aminoethanol 1.96
    morpholine-4-carbaldehyde 34.06
    sulfolane 38.2
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 13.15
    n-hexyl acetate 4.73
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 16.01
    sec-butyl acetate 2.92
    tert-butyl acetate 4.06
    decalin 0.05
    glycerin 4.58
    diglyme 34.42
    acrylic acid 3.25
    isopropyl myristate 2.47
    n-butyric acid 3.6
    acetyl acetate 2.18
    di(2-ethylhexyl) phthalate 3.32
    ethyl propionate 3.55
    nitromethane 19.65
    1,2-diethoxyethane 11.93
    benzonitrile 3.46
    trioctyl phosphate 2.14
    1-bromopropane 0.85
    gamma-valerolactone 50.54
    n-decanol 1.45
    triethyl phosphate 3.07
    4-methyl-2-pentanol 1.08
    propionitrile 3.29
    vinylene carbonate 4.83
    1,1,2-trichlorotrifluoroethane 17.43
    DMS 6.36
    cumene 0.42
    2-octanol 1.04
    2-hexanone 6.6
    octyl acetate 3.01
    limonene 0.89
    1,2-dimethoxyethane 31.77
    ethyl orthosilicate 2.94
    tributyl phosphate 2.76
    diacetone alcohol 9.23
    N,N-dimethylaniline 2.56
    acrylonitrile 6.15
    aniline 2.75
    1,3-propanediol 3.97
    bromobenzene 0.92
    dibromomethane 0.94
    1,1,2,2-tetrachloroethane 7.08
    2-methyl-cyclohexyl acetate 4.37
    tetrabutyl urea 4.89
    diisobutyl methanol 1.28
    2-phenylethanol 3.97
    styrene 0.58
    dioctyl adipate 4.82
    dimethyl sulfate 9.31
    ethyl butyrate 3.48
    methyl lactate 5.4
    butyl lactate 4.53
    diethyl carbonate 2.61
    propanediol butyl ether 6.34
    triethyl orthoformate 4.19
    p-tert-butyltoluene 0.64
    methyl 4-tert-butylbenzoate 6.41
    morpholine 25.86
    tert-butylamine 0.75
    n-dodecanol 1.11
    dimethoxymethane 21.46
    ethylene carbonate 3.88
    cyrene 10.45
    2-ethoxyethyl acetate 9.39
    2-ethylhexyl acetate 3.55
    1,2,4-trichlorobenzene 2.34
    4-methylpyridine 7.76
    dibutyl ether 2.82
    2,6-dimethyl-4-heptanol 1.28
    DEF 8.62
    dimethyl isosorbide 23.64
    tetrachloroethylene 2.52
    eugenol 7.57
    triacetin 8.74
    span 80 6.96
    1,4-butanediol 1.57
    1,1-dichloroethane 1.54
    2-methyl-1-pentanol 2.21
    methyl formate 6.55
    2-methyl-1-butanol 2.14
    n-decane 0.1
    butyronitrile 2.35
    3,7-dimethyl-1-octanol 2.16
    1-chlorooctane 0.69
    1-chlorotetradecane 0.35
    n-nonane 0.06
    undecane 0.08
    tert-butylcyclohexane 0.05
    cyclooctane 0.01
    cyclopentanol 3.24
    tetrahydropyran 8.66
    tert-amyl methyl ether 2.22
    2,5,8-trioxanonane 23.94
    1-hexene 0.16
    2-isopropoxyethanol 8.01
    2,2,2-trifluoroethanol 1.53
    methyl butyrate 5.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction