Glabrolide

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  • Identifiers

    CAS number
    10401-33-9

    Molecular formula
    C30H44O4

    SMILES
    C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2C(=O)C=C4[C@]3(CC[C@@]5([C@H]4C[C@@]6(C[C@H]5OC6=O)C)C)C)C)(C)C)O

    Safety labels

  • Odor profile

    Fragrance
    Woody 78.47%
    Cedar 50.12%
    Amber 48.16%
    Dry 42.96%
    Spicy 40.0%
    Camphoreous 36.62%
    Tobacco 35.29%
    Musk 32.94%
    Earthy 31.94%
    Balsamic 29.54%

     

    Flavor
    Bitter 66.12%
    Camphor 41.81%
    Woody 39.97%
    Pine 33.17%
    Herbal 27.34%
    Minty 26.81%
    Balsam 24.5%
    Spicy 24.3%
    Ripe apricot 24.14%
    Cedarleaf 23.93%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.9

    pKa est.
    6.0 (weak acid)

    Molecular weight
    468.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    112°C

    Flash point

    • 245.13 ˚C est.

  • Synonyms

    • Glabrolide
    • UNII-0WEA004YF1
    • 0WEA004YF1
    • RefChem:37729
    • 10401-33-9
    • 3beta,22beta-Dihydroxy-11-oxoolean-12-en-30-oic acid gamma-lactone
    • (1R,2R,5S,6R,9R,11S,14S,15R,19S,21R)-11-hydroxy-2,5,6,10,10,14,21-heptamethyl-23-oxahexacyclo[19.2.1.02,19.05,18.06,15.09,14]tetracos-17-ene-16,22-dione
    • Olean-12-en-29-oic acid, 3,22-dihydroxy-11-oxo-, gamma-lactone, (3beta,20beta,22beta)-
    • orb1684571
    • SCHEMBL29934548
    • CHEBI:183596
    • DTXSID101147723
    • HY-N4186
    • AKOS037515338
    • DA-70012
    • CS-0032379
    • Q27231192
    • 3beta-Hydroxy-22alpha-22,29-epoxyolean-12-ene-11,29-dione
    • OLEAN-12-EN-29-OIC ACID, 3,22-DIHYDROXY-11-OXO-, .GAMMA.-LACTONE, (3.BETA.,20.BETA.,22.BETA.)-
    • Olean-12-en-29-oic acid, 3,22-dihydroxy-11-oxo-, I(3)-lactone, (3I(2),20I(2),22I(2))-
    • 10401-33-9

  • Applications

    Glabrolide (CAS number 10401-33-9) is viewed as a specialty chemical used as an intermediate in organic synthesis and may be assessed for practical applications across several industries: fragrance/personal care (as a fragrance ingredient or additive), coatings and inks (as a processing aid or formulation component), adhesives (as a specialty additive or solvent), cleaning formulations, and polymers/plastics (as a processing aid or plastic formulation component).

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 33.13
    methanol 19.65
    isopropanol 35.23
    water 0.02
    ethyl acetate 24.73
    n-propanol 51.31
    acetone 36.24
    n-butanol 41.58
    acetonitrile 18.98
    DMF 189.4
    toluene 31.28
    isobutanol 31.03
    1,4-dioxane 87.62
    methyl acetate 21.26
    THF 163.99
    2-butanone 38.53
    n-pentanol 27.51
    sec-butanol 16.58
    n-hexane 0.8
    ethylene glycol 4.37
    NMP 100.5
    cyclohexane 1.26
    DMSO 50.97
    n-butyl acetate 19.27
    n-octanol 9.62
    chloroform 75.65
    n-propyl acetate 16.19
    acetic acid 27.79
    dichloromethane 38.94
    cyclohexanone 61.13
    propylene glycol 8.61
    isopropyl acetate 22.7
    DMAc 99.04
    2-ethoxyethanol 46.01
    isopentanol 25.26
    n-heptane 0.62
    ethyl formate 14.57
    1,2-dichloroethane 24.84
    n-hexanol 29.27
    2-methoxyethanol 76.18
    isobutyl acetate 15.84
    tetrachloromethane 10.45
    n-pentyl acetate 23.98
    transcutol 63.09
    n-heptanol 17.36
    ethylbenzene 10.99
    MIBK 24.48
    2-propoxyethanol 105.13
    tert-butanol 17.99
    MTBE 12.81
    2-butoxyethanol 51.1
    propionic acid 21.17
    o-xylene 13.01
    formic acid 10.73
    diethyl ether 27.1
    m-xylene 17.53
    p-xylene 12.49
    chlorobenzene 28.22
    dimethyl carbonate 26.0
    n-octane 0.26
    formamide 18.08
    cyclopentanone 90.09
    2-pentanone 36.63
    anisole 27.73
    cyclopentyl methyl ether 42.77
    gamma-butyrolactone 77.91
    1-methoxy-2-propanol 82.12
    pyridine 78.02
    3-pentanone 28.47
    furfural 61.27
    n-dodecane 0.18
    diethylene glycol 48.06
    diisopropyl ether 6.23
    tert-amyl alcohol 9.94
    acetylacetone 38.11
    n-hexadecane 0.23
    acetophenone 27.76
    methyl propionate 33.38
    isopentyl acetate 21.79
    trichloroethylene 61.78
    n-nonanol 11.25
    cyclohexanol 18.56
    benzyl alcohol 31.39
    2-ethylhexanol 11.48
    isooctanol 13.32
    dipropyl ether 13.39
    1,2-dichlorobenzene 23.41
    ethyl lactate 15.11
    propylene carbonate 30.47
    n-methylformamide 51.97
    2-pentanol 16.74
    n-pentane 1.0
    1-propoxy-2-propanol 54.73
    1-methoxy-2-propyl acetate 41.86
    2-(2-methoxypropoxy) propanol 29.26
    mesitylene 7.94
    ε-caprolactone 48.87
    p-cymene 6.2
    epichlorohydrin 88.41
    1,1,1-trichloroethane 24.32
    2-aminoethanol 18.57
    morpholine-4-carbaldehyde 140.26
    sulfolane 73.35
    2,2,4-trimethylpentane 0.53
    2-methyltetrahydrofuran 46.3
    n-hexyl acetate 24.76
    isooctane 0.55
    2-(2-butoxyethoxy)ethanol 42.29
    sec-butyl acetate 12.89
    tert-butyl acetate 21.72
    decalin 0.95
    glycerin 17.21
    diglyme 71.26
    acrylic acid 21.03
    isopropyl myristate 8.39
    n-butyric acid 36.77
    acetyl acetate 19.22
    di(2-ethylhexyl) phthalate 14.32
    ethyl propionate 16.99
    nitromethane 46.44
    1,2-diethoxyethane 21.99
    benzonitrile 28.23
    trioctyl phosphate 9.85
    1-bromopropane 16.01
    gamma-valerolactone 141.62
    n-decanol 6.34
    triethyl phosphate 10.09
    4-methyl-2-pentanol 11.32
    propionitrile 29.14
    vinylene carbonate 37.12
    1,1,2-trichlorotrifluoroethane 52.94
    DMS 22.33
    cumene 6.48
    2-octanol 7.93
    2-hexanone 22.4
    octyl acetate 11.77
    limonene 6.52
    1,2-dimethoxyethane 63.1
    ethyl orthosilicate 10.53
    tributyl phosphate 8.81
    diacetone alcohol 28.83
    N,N-dimethylaniline 19.45
    acrylonitrile 35.52
    aniline 36.88
    1,3-propanediol 37.11
    bromobenzene 26.45
    dibromomethane 26.99
    1,1,2,2-tetrachloroethane 47.99
    2-methyl-cyclohexyl acetate 18.29
    tetrabutyl urea 13.97
    diisobutyl methanol 6.11
    2-phenylethanol 37.67
    styrene 13.04
    dioctyl adipate 14.77
    dimethyl sulfate 34.56
    ethyl butyrate 14.91
    methyl lactate 26.88
    butyl lactate 24.41
    diethyl carbonate 9.87
    propanediol butyl ether 33.43
    triethyl orthoformate 15.53
    p-tert-butyltoluene 6.26
    methyl 4-tert-butylbenzoate 31.71
    morpholine 126.12
    tert-butylamine 8.51
    n-dodecanol 3.61
    dimethoxymethane 109.44
    ethylene carbonate 29.95
    cyrene 42.18
    2-ethoxyethyl acetate 37.22
    2-ethylhexyl acetate 17.05
    1,2,4-trichlorobenzene 32.43
    4-methylpyridine 65.31
    dibutyl ether 6.43
    2,6-dimethyl-4-heptanol 6.11
    DEF 41.9
    dimethyl isosorbide 51.93
    tetrachloroethylene 33.21
    eugenol 35.58
    triacetin 25.81
    span 80 27.23
    1,4-butanediol 14.04
    1,1-dichloroethane 25.37
    2-methyl-1-pentanol 16.04
    methyl formate 27.49
    2-methyl-1-butanol 21.32
    n-decane 0.47
    butyronitrile 26.95
    3,7-dimethyl-1-octanol 8.35
    1-chlorooctane 3.3
    1-chlorotetradecane 0.93
    n-nonane 0.36
    undecane 0.28
    tert-butylcyclohexane 0.82
    cyclooctane 0.55
    cyclopentanol 27.04
    tetrahydropyran 60.91
    tert-amyl methyl ether 9.47
    2,5,8-trioxanonane 42.12
    1-hexene 4.43
    2-isopropoxyethanol 30.53
    2,2,2-trifluoroethanol 12.52
    methyl butyrate 19.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction