Glabridin

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  • Identifiers

    CAS number
    59870-68-7

    Molecular formula
    C20H20O4

    SMILES
    CC1(C=CC2=C(O1)C=CC3=C2OC[C@H](C3)C4=C(C=C(C=C4)O)O)C

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 53.39%
    Sweet 47.77%
    Spicy 41.73%
    Vanilla 31.81%
    Smoky 29.05%
    Animal 24.78%
    Medicinal 24.77%
    Balsamic 24.1%
    Powdery 23.85%
    Creamy 23.3%

     

    Flavor
    Bitter 89.69%
    Cedarleaf 20.59%
    Parsley 20.23%
    Lovage 19.94%
    Ripe apricot 19.52%
    Indole 19.32%
    Very strong 19.31%
    Sweet-like 19.19%
    Red fruit 19.14%
    Eugenol 18.97%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.9

    pKa est.
    9.83 (weak base)

    Molecular weight
    324.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    838°C

    Flash point

    • 244.01 ˚C est.

  • Synonyms

    • Glabridin
    • 59870-68-7
    • 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol
    • DTXSID00208589
    • HOC5567T41
    • 4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-1,3-benzenediol
    • 1,3-Benzenediol, 4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-, (R)-
    • CHEBI:5369
    • 1,3-BENZENEDIOL, 4-((3R)-3,4-DIHYDRO-8,8-DIMETHYL-2H,8H-BENZO(1,2-B:3,4-B')DIPYRAN-3-YL)-
    • 4-((3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano(2,3-f)chromen-3-yl)benzene-1,3-diol
    • 4-[3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-1,3-benzenediol
    • 1,3-Benzenediol, 4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-
    • RefChem:37165
    • DTXCID00131080
    • (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-1,3-benzenediol
    • 611-908-7
    • MFCD03427694
    • UNII-HOC5567T41
    • (R)-4-(8,8-dimethyl-2,3,4,8-tetrahydropyrano[2,3-f]chromen-3-yl)benzene-1,3-diol
    • 1,3-Benzenediol,4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl)-,(R)-
    • 4-[(3R)-8,8-DIMETHYL-2H,3H,4H,8H-PYRANO[2,3-F]CHROMEN-3-YL]BENZENE-1,3-DIOL
    • (R)-4-(8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl)benzene-1,3-diol
    • (R)-Glabridin
    • 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-1,3-benzenediol
    • 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]benzene-1,3-diol
    • 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol
    • LBQIJVLKGVZRIW-ZDUSSCGKSA-N
    • 1,3-Benzenediol, 4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-; 1,3-Benzenediol, 4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl)-, (R)-; 2H,8H-Benzo[1,2-b:3,4-b']dipyran, 1,3-benzenediol deriv.; 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-1,3-benzenediol; Glabridin
    • Glabridin (Standard)
    • GLABRIDIN [WHO-DD]
    • 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol
    • MLS000697609
    • BIDD:ER0172
    • Glabridin, analytical standard
    • SCHEMBL114869
    • Glabridin - Bio-X trade mark
    • CHEMBL480477
    • orb1304234
    • SCHEMBL29362676
    • SCHEMBL29612227
    • SCHEMBL30631322
    • HY-N0393R
    • GLXC-03194
    • HMS2271G14
    • HMS3885M04
    • HMS6018N09
    • HY-N0393
    • MSK40257
    • BDBM50441626
    • LMPK12080012
    • s3786
    • STL566095
    • AKOS015903270
    • Glabridin, >=98% (HPLC), powder
    • CCG-223443
    • EBC-473044
    • FG41835
    • NCGC00247524-01
    • NCGC00247524-06
    • (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b inverted exclamation marka]dipyran-3-yl)-1,3-benzenediol
    • AC-31452
    • AS-74264
    • BG300083
    • SMR000470944
    • CS-0008929
    • NS00034259
    • 870G687
    • Q2386110
    • 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen- 3-yl]benzene-1,3-diol
    • 4-((R)-8,8-Dimethyl-3,4-dihydro-2H,8H-benzo[1,2-b:4,3-b']dipyran-3-yl)-benzene-1,3-diol
    • 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b?]dipyran-3-yl]-1,3-benzenediol
    • 59870-68-7

  • Applications

    Glabridin (CAS 59870-68-7), an isoflavonoid derived from licorice root (Glycyrrhiza glabra), is commonly used in cosmetics and personal care as a skin-brightening agent and antioxidant; it is also investigated in pharmaceutical research for various bioactivities; owing to its stabilizing and antioxidant properties, it may be evaluated as a functional additive in polymer or coating formulations; and it occurs in licorice extracts used in food processing as a natural constituent.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 27.33
    methanol 34.81
    isopropanol 35.22
    water 0.05
    ethyl acetate 60.64
    n-propanol 39.63
    acetone 100.51
    n-butanol 37.97
    acetonitrile 40.14
    DMF 89.76
    toluene 16.46
    isobutanol 28.43
    1,4-dioxane 129.55
    methyl acetate 58.79
    THF 380.37
    2-butanone 79.21
    n-pentanol 25.69
    sec-butanol 19.9
    n-hexane 0.62
    ethylene glycol 9.03
    NMP 42.57
    cyclohexane 1.42
    DMSO 196.09
    n-butyl acetate 41.93
    n-octanol 13.75
    chloroform 120.8
    n-propyl acetate 37.25
    acetic acid 47.41
    dichloromethane 72.37
    cyclohexanone 79.88
    propylene glycol 13.68
    isopropyl acetate 44.7
    DMAc 153.87
    2-ethoxyethanol 75.02
    isopentanol 34.5
    n-heptane 1.29
    ethyl formate 33.48
    1,2-dichloroethane 58.79
    n-hexanol 27.11
    2-methoxyethanol 123.05
    isobutyl acetate 34.43
    tetrachloromethane 6.57
    n-pentyl acetate 27.5
    transcutol 240.84
    n-heptanol 15.87
    ethylbenzene 6.73
    MIBK 43.7
    2-propoxyethanol 104.54
    tert-butanol 42.09
    MTBE 33.11
    2-butoxyethanol 49.59
    propionic acid 26.22
    o-xylene 8.76
    formic acid 16.98
    diethyl ether 46.85
    m-xylene 12.15
    p-xylene 9.61
    chlorobenzene 23.11
    dimethyl carbonate 42.74
    n-octane 0.85
    formamide 32.24
    cyclopentanone 109.6
    2-pentanone 64.88
    anisole 29.18
    cyclopentyl methyl ether 61.72
    gamma-butyrolactone 95.39
    1-methoxy-2-propanol 100.73
    pyridine 54.05
    3-pentanone 51.66
    furfural 64.8
    n-dodecane 1.32
    diethylene glycol 91.02
    diisopropyl ether 13.39
    tert-amyl alcohol 21.55
    acetylacetone 78.6
    n-hexadecane 1.56
    acetophenone 31.18
    methyl propionate 54.86
    isopentyl acetate 43.4
    trichloroethylene 108.84
    n-nonanol 15.48
    cyclohexanol 26.93
    benzyl alcohol 28.22
    2-ethylhexanol 17.98
    isooctanol 15.09
    dipropyl ether 27.33
    1,2-dichlorobenzene 21.12
    ethyl lactate 28.86
    propylene carbonate 42.45
    n-methylformamide 42.69
    2-pentanol 20.47
    n-pentane 0.75
    1-propoxy-2-propanol 62.13
    1-methoxy-2-propyl acetate 71.41
    2-(2-methoxypropoxy) propanol 57.9
    mesitylene 7.49
    ε-caprolactone 58.86
    p-cymene 9.05
    epichlorohydrin 150.45
    1,1,1-trichloroethane 39.46
    2-aminoethanol 21.0
    morpholine-4-carbaldehyde 95.01
    sulfolane 95.73
    2,2,4-trimethylpentane 0.96
    2-methyltetrahydrofuran 83.96
    n-hexyl acetate 34.72
    isooctane 1.02
    2-(2-butoxyethoxy)ethanol 80.58
    sec-butyl acetate 30.95
    tert-butyl acetate 46.99
    decalin 1.42
    glycerin 30.76
    diglyme 142.99
    acrylic acid 23.2
    isopropyl myristate 19.76
    n-butyric acid 50.02
    acetyl acetate 41.09
    di(2-ethylhexyl) phthalate 20.52
    ethyl propionate 36.86
    nitromethane 96.74
    1,2-diethoxyethane 78.75
    benzonitrile 30.28
    trioctyl phosphate 15.77
    1-bromopropane 25.14
    gamma-valerolactone 132.84
    n-decanol 12.71
    triethyl phosphate 24.48
    4-methyl-2-pentanol 17.48
    propionitrile 44.68
    vinylene carbonate 45.28
    1,1,2-trichlorotrifluoroethane 80.06
    DMS 43.87
    cumene 6.34
    2-octanol 10.12
    2-hexanone 39.09
    octyl acetate 22.5
    limonene 10.86
    1,2-dimethoxyethane 126.67
    ethyl orthosilicate 23.99
    tributyl phosphate 20.18
    diacetone alcohol 56.38
    N,N-dimethylaniline 18.06
    acrylonitrile 50.27
    aniline 28.55
    1,3-propanediol 50.61
    bromobenzene 21.12
    dibromomethane 40.81
    1,1,2,2-tetrachloroethane 89.98
    2-methyl-cyclohexyl acetate 30.9
    tetrabutyl urea 26.19
    diisobutyl methanol 13.43
    2-phenylethanol 32.67
    styrene 8.15
    dioctyl adipate 28.58
    dimethyl sulfate 54.63
    ethyl butyrate 32.8
    methyl lactate 38.01
    butyl lactate 28.01
    diethyl carbonate 27.68
    propanediol butyl ether 36.68
    triethyl orthoformate 33.99
    p-tert-butyltoluene 8.74
    methyl 4-tert-butylbenzoate 34.57
    morpholine 134.72
    tert-butylamine 16.26
    n-dodecanol 10.36
    dimethoxymethane 149.32
    ethylene carbonate 45.94
    cyrene 45.08
    2-ethoxyethyl acetate 53.73
    2-ethylhexyl acetate 32.72
    1,2,4-trichlorobenzene 27.43
    4-methylpyridine 47.4
    dibutyl ether 22.38
    2,6-dimethyl-4-heptanol 13.43
    DEF 49.23
    dimethyl isosorbide 86.96
    tetrachloroethylene 44.97
    eugenol 35.34
    triacetin 46.04
    span 80 34.64
    1,4-butanediol 17.99
    1,1-dichloroethane 52.28
    2-methyl-1-pentanol 23.11
    methyl formate 39.9
    2-methyl-1-butanol 25.75
    n-decane 1.98
    butyronitrile 38.07
    3,7-dimethyl-1-octanol 16.58
    1-chlorooctane 8.65
    1-chlorotetradecane 4.57
    n-nonane 1.52
    undecane 1.57
    tert-butylcyclohexane 1.3
    cyclooctane 0.75
    cyclopentanol 30.98
    tetrahydropyran 91.63
    tert-amyl methyl ether 22.01
    2,5,8-trioxanonane 106.81
    1-hexene 3.68
    2-isopropoxyethanol 54.32
    2,2,2-trifluoroethanol 17.44
    methyl butyrate 40.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction