Ginsenoside Rh1

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  • Identifiers

    CAS number
    63223-86-9

    Molecular formula
    C36H62O9

    SMILES
    CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)O)C)O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 61.68%
    Sweet 44.55%
    Balsamic 40.69%
    Mint 37.8%
    Spicy 37.75%
    Amber 35.61%
    Sandalwood 33.17%
    Cooling 32.54%
    Herbal 32.38%
    Odorless 32.0%

     

    Flavor
    Bitter 40.16%
    Herbal 38.68%
    Sweet 35.52%
    Woody 31.86%
    Minty 31.75%
    Pine 30.43%
    Balsam 29.02%
    Earthy 26.72%
    Fresh 25.35%
    Odorless 23.2%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.3

    pKa est.
    5.54 (weak acid)

    Molecular weight
    638.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    498°C

    Flash point

    • 254.85 ˚C est.

  • Synonyms

    • Ginsenoside Rh1
    • 63223-86-9
    • 20(S)-Ginsenoside Rh1
    • Sanchinoside Rh1
    • ginsenoside Rh(1)
    • ginsenoside G-Rh(1)
    • Prosapogenin A2
    • XBR6F7G8FU
    • DTXSID80979245
    • GINSENOSIDE RH1, (20S)-
    • beta-D-Glucopyranoside, (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl
    • (2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-((2S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-6-(hydroxymethyl)oxane-3,4,5-triol
    • (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
    • RefChem:639974
    • DTXCID601776153
    • MFCD09951797
    • Sanchinoside B2
    • (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,10R,12R,14R,17S)-3,12-dihydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
    • (2R,3R,4S,5S,6R)-2-{[(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)-7,11-dihydroxy-1-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-3a,3b,6,6,9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-5-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    • 20(S)?-?Ginsenoside Rh1
    • ginsenoside-Rh1
    • (20S)-ginsenoside Rh1
    • (S)-GINSENOSIDE RH1
    • Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1
    • UNII-XBR6F7G8FU
    • S-GINSENOSIDE RH1
    • 20(S)-Ginsenoside?Rh1
    • BIDD:ER0183
    • CHEMBL466844
    • orb1304831
    • SCHEMBL29376381
    • CHEBI:142487
    • HMS3886D18
    • HY-N0604
    • BDBM50023447
    • Ginsenoside Rh1, analytical standard
    • MSK168594
    • s9129
    • AKOS025311542
    • CCG-270315
    • CS-3834
    • EBC-615618
    • OG09292
    • AS-75346
    • DA-73730
    • SY068757
    • C22129
    • 3beta,12beta,20-Trihydroxydammar-24-en-6alpha-yl beta-D-glucopyranoside
    • (3beta,6alpha,12beta)-3,12,20-Trihydroxydammar-24-en-6-yl beta-D-glucopyranoside
    • (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-3,12,20-TRIHYDROXYDAMMAR-24-EN-6-YL
    • 63223-86-9

  • Applications

    Ginsenoside Rh1 (CAS 63223-86-9) is a ginseng-derived saponin with potential as a bioactive across several industries. In cosmetics and personal care, it is evaluated as an active ingredient for skin care formulations due to its antioxidant and anti-inflammatory activity. In pharmaceuticals and research, Rh1 is studied for biological effects such as antioxidant and anti-inflammatory activity in preclinical contexts. In nutraceuticals, it may be included in ginseng-derived dietary supplements as a functional component. In analytical laboratories, Rh1 is used as a reference standard for quantifying ginsenosides in ginseng extracts, supporting method development and quality control.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.31
    methanol 42.62
    isopropanol 2.32
    water 0.08
    ethyl acetate 3.14
    n-propanol 4.95
    acetone 10.44
    n-butanol 2.06
    acetonitrile 1.79
    DMF 48.18
    toluene 1.19
    isobutanol 1.9
    1,4-dioxane 19.35
    methyl acetate 3.45
    THF 53.92
    2-butanone 5.29
    n-pentanol 2.06
    sec-butanol 1.22
    n-hexane 0.08
    ethylene glycol 5.04
    NMP 44.9
    cyclohexane 0.12
    DMSO 70.13
    n-butyl acetate 2.03
    n-octanol 1.97
    chloroform 6.48
    n-propyl acetate 1.99
    acetic acid 31.03
    dichloromethane 5.32
    cyclohexanone 8.57
    propylene glycol 5.13
    isopropyl acetate 2.2
    DMAc 38.47
    2-ethoxyethanol 18.45
    isopentanol 1.23
    n-heptane 0.11
    ethyl formate 3.91
    1,2-dichloroethane 3.03
    n-hexanol 1.86
    2-methoxyethanol 38.44
    isobutyl acetate 1.37
    tetrachloromethane 0.99
    n-pentyl acetate 3.91
    transcutol 26.73
    n-heptanol 2.57
    ethylbenzene 0.6
    MIBK 2.46
    2-propoxyethanol 22.78
    tert-butanol 1.63
    MTBE 1.38
    2-butoxyethanol 15.02
    propionic acid 4.79
    o-xylene 0.74
    formic acid 25.32
    diethyl ether 2.41
    m-xylene 0.85
    p-xylene 0.68
    chlorobenzene 1.42
    dimethyl carbonate 5.67
    n-octane 0.06
    formamide 20.29
    cyclopentanone 20.31
    2-pentanone 3.9
    anisole 2.73
    cyclopentyl methyl ether 6.01
    gamma-butyrolactone 21.95
    1-methoxy-2-propanol 18.25
    pyridine 9.72
    3-pentanone 2.95
    furfural 19.25
    n-dodecane 0.04
    diethylene glycol 20.31
    diisopropyl ether 0.47
    tert-amyl alcohol 1.14
    acetylacetone 9.18
    n-hexadecane 0.04
    acetophenone 3.7
    methyl propionate 4.65
    isopentyl acetate 1.98
    trichloroethylene 8.14
    n-nonanol 2.03
    cyclohexanol 1.3
    benzyl alcohol 3.81
    2-ethylhexanol 0.86
    isooctanol 1.73
    dipropyl ether 1.78
    1,2-dichlorobenzene 1.35
    ethyl lactate 2.91
    propylene carbonate 6.32
    n-methylformamide 21.48
    2-pentanol 0.76
    n-pentane 0.09
    1-propoxy-2-propanol 8.95
    1-methoxy-2-propyl acetate 7.01
    2-(2-methoxypropoxy) propanol 8.17
    mesitylene 0.46
    ε-caprolactone 8.49
    p-cymene 0.5
    epichlorohydrin 23.28
    1,1,1-trichloroethane 1.56
    2-aminoethanol 10.85
    morpholine-4-carbaldehyde 49.97
    sulfolane 42.29
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 7.16
    n-hexyl acetate 3.97
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 13.47
    sec-butyl acetate 1.13
    tert-butyl acetate 2.63
    decalin 0.08
    glycerin 14.07
    diglyme 24.64
    acrylic acid 8.32
    isopropyl myristate 0.9
    n-butyric acid 5.11
    acetyl acetate 3.52
    di(2-ethylhexyl) phthalate 2.1
    ethyl propionate 1.72
    nitromethane 29.58
    1,2-diethoxyethane 4.94
    benzonitrile 1.87
    trioctyl phosphate 1.44
    1-bromopropane 0.98
    gamma-valerolactone 51.07
    n-decanol 1.06
    triethyl phosphate 1.24
    4-methyl-2-pentanol 0.62
    propionitrile 1.44
    vinylene carbonate 7.38
    1,1,2-trichlorotrifluoroethane 27.2
    DMS 3.67
    cumene 0.44
    2-octanol 1.11
    2-hexanone 2.45
    octyl acetate 1.73
    limonene 0.67
    1,2-dimethoxyethane 18.46
    ethyl orthosilicate 1.26
    tributyl phosphate 1.1
    diacetone alcohol 5.82
    N,N-dimethylaniline 2.21
    acrylonitrile 2.98
    aniline 2.26
    1,3-propanediol 10.47
    bromobenzene 1.22
    dibromomethane 2.77
    1,1,2,2-tetrachloroethane 5.7
    2-methyl-cyclohexyl acetate 2.11
    tetrabutyl urea 2.06
    diisobutyl methanol 0.49
    2-phenylethanol 4.03
    styrene 0.67
    dioctyl adipate 2.15
    dimethyl sulfate 12.62
    ethyl butyrate 1.63
    methyl lactate 7.84
    butyl lactate 4.99
    diethyl carbonate 1.01
    propanediol butyl ether 13.36
    triethyl orthoformate 1.89
    p-tert-butyltoluene 0.51
    methyl 4-tert-butylbenzoate 6.5
    morpholine 22.75
    tert-butylamine 0.49
    n-dodecanol 0.56
    dimethoxymethane 33.19
    ethylene carbonate 4.97
    cyrene 14.27
    2-ethoxyethyl acetate 9.23
    2-ethylhexyl acetate 1.46
    1,2,4-trichlorobenzene 2.18
    4-methylpyridine 4.73
    dibutyl ether 0.93
    2,6-dimethyl-4-heptanol 0.49
    DEF 6.45
    dimethyl isosorbide 14.63
    tetrachloroethylene 5.07
    eugenol 7.34
    triacetin 6.89
    span 80 7.93
    1,4-butanediol 4.11
    1,1-dichloroethane 1.56
    2-methyl-1-pentanol 1.2
    methyl formate 16.2
    2-methyl-1-butanol 1.23
    n-decane 0.1
    butyronitrile 1.14
    3,7-dimethyl-1-octanol 1.08
    1-chlorooctane 0.53
    1-chlorotetradecane 0.13
    n-nonane 0.08
    undecane 0.06
    tert-butylcyclohexane 0.06
    cyclooctane 0.06
    cyclopentanol 2.98
    tetrahydropyran 5.95
    tert-amyl methyl ether 1.15
    2,5,8-trioxanonane 14.3
    1-hexene 0.3
    2-isopropoxyethanol 7.9
    2,2,2-trifluoroethanol 9.05
    methyl butyrate 2.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction