ginsenoside Rg4

Overview IFRA Request a quote

  • Identifiers

    CAS number
    126223-28-7

    Molecular formula
    C42H70O12

    SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@H]3C[C@@]4([C@H](C[C@H]([C@H]5[C@]4(CC[C@@H]5/C(=C\CC=C(C)C)/C)C)O)[C@@]6([C@@H]3C([C@H](CC6)O)(C)C)C)C)CO)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Woody 47.66%
    Odorless 40.59%
    Spicy 38.13%
    Sweet 35.3%
    Mint 29.62%
    Balsamic 27.18%
    Amber 26.17%
    Cooling 25.69%
    Sandalwood 24.72%
    Warm 24.39%

     

    Flavor
    Bitter 48.06%
    Herbal 29.85%
    Sweet 27.99%
    Minty 24.64%
    Fatty 24.11%
    Fresh 24.03%
    Balsam 23.29%
    Odorless 23.19%
    Pine 22.95%
    Sweet-like 22.87%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.5

    pKa est.
    4.15 (weak acid)

    Molecular weight
    767.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    1220°C

    Flash point

    • 223.81 ˚C est.

  • Synonyms

    • Ginsenoside RG4
    • 126223-28-7
    • (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2Z)-6-methylhepta-2,5-dien-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol
    • 3,6,12-Trihydroxydammar-10(22),24-diene-O-rhamnosyl-(1-2)-glucopyranoside
    • (2S,3R,4R,5R,6S)-2-((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((2Z)-6-methylhepta-2,5-dien-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl)oxy-6-methyloxane-3,4,5-triol
    • RefChem:143225
    • (20E)-Ginsenoside F4
    • 181225-33-2
    • (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-pentamethyl-17-((Z)-6-methylhepta-2,5-dien-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
    • 20(Z)-Ginsenoside F4
    • 20(22)Z-ginsenoside F4
    • orb1297360
    • SCHEMBL29376443
    • CHEBI:176310
    • DTXSID801354850
    • HY-N6580
    • MSK185091
    • AKOS037514667
    • EBC-616382
    • FS-7062
    • OG31932
    • (2S,3R,4R,5R,6S)-2-{[(2R,3R,4S,5S,6R)-2-{[(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)-7,11-dihydroxy-3a,3b,6,6,9a-pentamethyl-1-[(2Z)-6-methylhepta-2,5-dien-2-yl]-hexadecahydro-1H-cyclopenta[a]phenanthren-5-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-methyloxane-3,4,5-triol
    • DA-53558
    • DA-63766
    • CS-0034276
    • (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-[(1Z)-1,5-dimethylhexa-1,4-dienyl]-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-6-methyl-tetrahydropyran-3,4,5-triol
    • 126223-28-7

  • Applications

    Ginsenoside Rg4, CAS 126223-28-7, is a Panax ginseng saponin that finds practical use in several sectors: cosmetics/personal care as a potential bioactive ingredient for skin care; pharmaceutical and nutraceutical research, where it is evaluated for bioactivities in preclinical studies (without implying therapeutic claims); an analytical reference standard for quality control of ginseng extracts and ginsenoside mixtures; a natural surfactant/emulsifier that can play a role in specialized formulations such as cosmetics, cleaners, and coatings/inks; and cleaning-related applications or formulation systems where saponin properties may be leveraged, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.1
    methanol 20.1
    isopropanol 0.9
    water 0.05
    ethyl acetate 2.03
    n-propanol 2.01
    acetone 4.47
    n-butanol 0.94
    acetonitrile 1.24
    DMF 30.61
    toluene 0.65
    isobutanol 0.83
    1,4-dioxane 9.82
    methyl acetate 2.63
    THF 18.28
    2-butanone 3.02
    n-pentanol 0.86
    sec-butanol 0.61
    n-hexane 0.03
    ethylene glycol 3.22
    NMP 34.32
    cyclohexane 0.05
    DMSO 37.83
    n-butyl acetate 1.16
    n-octanol 0.95
    chloroform 5.65
    n-propyl acetate 1.19
    acetic acid 24.59
    dichloromethane 4.83
    cyclohexanone 4.62
    propylene glycol 3.53
    isopropyl acetate 1.28
    DMAc 27.45
    2-ethoxyethanol 9.97
    isopentanol 0.58
    n-heptane 0.05
    ethyl formate 2.76
    1,2-dichloroethane 2.08
    n-hexanol 0.81
    2-methoxyethanol 20.93
    isobutyl acetate 0.75
    tetrachloromethane 0.65
    n-pentyl acetate 2.39
    transcutol 15.77
    n-heptanol 1.29
    ethylbenzene 0.29
    MIBK 1.24
    2-propoxyethanol 11.77
    tert-butanol 0.69
    MTBE 0.66
    2-butoxyethanol 8.4
    propionic acid 3.88
    o-xylene 0.43
    formic acid 21.63
    diethyl ether 1.11
    m-xylene 0.45
    p-xylene 0.34
    chlorobenzene 0.88
    dimethyl carbonate 4.62
    n-octane 0.03
    formamide 15.74
    cyclopentanone 10.39
    2-pentanone 2.05
    anisole 1.58
    cyclopentyl methyl ether 2.62
    gamma-butyrolactone 14.53
    1-methoxy-2-propanol 9.86
    pyridine 5.6
    3-pentanone 1.7
    furfural 16.78
    n-dodecane 0.02
    diethylene glycol 12.01
    diisopropyl ether 0.22
    tert-amyl alcohol 0.62
    acetylacetone 5.86
    n-hexadecane 0.02
    acetophenone 2.38
    methyl propionate 3.22
    isopentyl acetate 1.13
    trichloroethylene 7.27
    n-nonanol 1.04
    cyclohexanol 0.66
    benzyl alcohol 2.19
    2-ethylhexanol 0.43
    isooctanol 0.87
    dipropyl ether 0.85
    1,2-dichlorobenzene 0.96
    ethyl lactate 2.1
    propylene carbonate 4.93
    n-methylformamide 14.97
    2-pentanol 0.38
    n-pentane 0.04
    1-propoxy-2-propanol 4.94
    1-methoxy-2-propyl acetate 4.48
    2-(2-methoxypropoxy) propanol 5.46
    mesitylene 0.24
    ε-caprolactone 5.4
    p-cymene 0.28
    epichlorohydrin 14.33
    1,1,1-trichloroethane 1.18
    2-aminoethanol 5.79
    morpholine-4-carbaldehyde 36.54
    sulfolane 30.62
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 3.06
    n-hexyl acetate 2.36
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 8.07
    sec-butyl acetate 0.67
    tert-butyl acetate 1.51
    decalin 0.03
    glycerin 10.9
    diglyme 16.17
    acrylic acid 7.68
    isopropyl myristate 0.52
    n-butyric acid 3.61
    acetyl acetate 2.76
    di(2-ethylhexyl) phthalate 1.39
    ethyl propionate 1.11
    nitromethane 26.16
    1,2-diethoxyethane 2.57
    benzonitrile 1.26
    trioctyl phosphate 0.86
    1-bromopropane 0.55
    gamma-valerolactone 34.0
    n-decanol 0.53
    triethyl phosphate 0.88
    4-methyl-2-pentanol 0.29
    propionitrile 0.91
    vinylene carbonate 6.44
    1,1,2-trichlorotrifluoroethane 26.61
    DMS 2.77
    cumene 0.21
    2-octanol 0.56
    2-hexanone 1.27
    octyl acetate 1.03
    limonene 0.34
    1,2-dimethoxyethane 10.51
    ethyl orthosilicate 0.82
    tributyl phosphate 0.68
    diacetone alcohol 3.68
    N,N-dimethylaniline 1.23
    acrylonitrile 2.22
    aniline 1.3
    1,3-propanediol 5.39
    bromobenzene 0.79
    dibromomethane 2.0
    1,1,2,2-tetrachloroethane 4.7
    2-methyl-cyclohexyl acetate 1.26
    tetrabutyl urea 1.2
    diisobutyl methanol 0.24
    2-phenylethanol 2.23
    styrene 0.35
    dioctyl adipate 1.38
    dimethyl sulfate 11.3
    ethyl butyrate 1.02
    methyl lactate 6.63
    butyl lactate 3.26
    diethyl carbonate 0.71
    propanediol butyl ether 7.8
    triethyl orthoformate 1.21
    p-tert-butyltoluene 0.28
    methyl 4-tert-butylbenzoate 4.4
    morpholine 10.81
    tert-butylamine 0.2
    n-dodecanol 0.28
    dimethoxymethane 16.82
    ethylene carbonate 3.94
    cyrene 10.82
    2-ethoxyethyl acetate 6.32
    2-ethylhexyl acetate 0.84
    1,2,4-trichlorobenzene 1.73
    4-methylpyridine 2.72
    dibutyl ether 0.45
    2,6-dimethyl-4-heptanol 0.24
    DEF 4.25
    dimethyl isosorbide 9.68
    tetrachloroethylene 3.82
    eugenol 4.81
    triacetin 5.61
    span 80 5.25
    1,4-butanediol 2.23
    1,1-dichloroethane 1.06
    2-methyl-1-pentanol 0.57
    methyl formate 12.1
    2-methyl-1-butanol 0.64
    n-decane 0.05
    butyronitrile 0.67
    3,7-dimethyl-1-octanol 0.54
    1-chlorooctane 0.27
    1-chlorotetradecane 0.07
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.03
    cyclooctane 0.03
    cyclopentanol 1.37
    tetrahydropyran 2.46
    tert-amyl methyl ether 0.62
    2,5,8-trioxanonane 9.67
    1-hexene 0.12
    2-isopropoxyethanol 4.2
    2,2,2-trifluoroethanol 8.67
    methyl butyrate 1.53

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction