Ginsenoside Rg3

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  • Identifiers

    CAS number
    14197-60-5

    Molecular formula
    C42H72O13

    SMILES
    CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 53.25%
    Sweet 42.93%
    Odorless 39.36%
    Balsamic 34.76%
    Spicy 33.99%
    Mint 33.69%
    Amber 33.14%
    Cooling 30.57%
    Sandalwood 29.85%
    Dry 28.2%

     

    Flavor
    Bitter 40.37%
    Sweet 39.06%
    Herbal 31.26%
    Odorless 26.87%
    Pine 25.98%
    Balsam 25.98%
    Woody 25.65%
    Fatty 24.62%
    Minty 23.99%
    Sweet-like 23.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.0

    pKa est.
    4.98 (weak acid)

    Molecular weight
    785.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    1057°C

    Flash point

    • 257.14 ˚C est.

  • Synonyms

    • Ginsenoside Rg3
    • 14197-60-5
    • (20S)-ginsenoside Rg3
    • (20S)-Propanaxadiol
    • 20S-propanaxadiol
    • 20s-ginsenoside rg3
    • S-Ginsenoside Rg3
    • ginsenoside 20-rg3
    • ginsenoside rg3, (s)-
    • ginsenoside rg3, (+)-
    • (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
    • 227D367Y57
    • CHEBI:67991
    • DTXSID101316982
    • (2S,3R,4S,5S,6R)-2-((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-Hydroxy-17-((2S)-2-Hydroxy-6-Methylhept-5-En-2-Yl)-4,4,8,10,14-Pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-Dodecahydro-1H-Cyclopenta(A)Phenanthren-3-Yl)Oxy)-6-(Hydroxymethyl)Oxan-3-Yl)Oxy-6-(Hydroxymethyl)Oxane-3,4,5-Triol
    • ginsenoside Rg(3)
    • RefChem:143224
    • 20(S)-ginsenoside Rg(3)
    • DTXCID901746804
    • beta-D-glucopyranoside, (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-
    • 3-O-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranosyldammar-24-ene-3beta,12beta,20s-triol
    • 20(S)-Ginsenoside Rg3
    • MFCD06410950
    • 20(S)-Propanaxidiol
    • CHEMBL398412
    • 11019-45-7
    • (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
    • 20(S)-Propanaxadiol;S-ginsenoside Rg3
    • UNII-227D367Y57
    • (R)Ginsenoside-Rg3
    • 20(S)-ginsenoisde Rg3
    • 20(S)-Ginsenoside-Rg3
    • GTPL7658
    • orb1304235
    • SCHEMBL29367045
    • GINSENOSIDE RG3 [WHO-DD]
    • GLXC-19139
    • HMS3886B14
    • (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • MSK40337
    • BDBM50317537
    • Ginsenoside Rg3, analytical standard
    • s9022
    • Ginsenoside Rg3, >=98% (HPLC)
    • AKOS037514674
    • CCG-270472
    • EBC-462065
    • OG09291
    • (2S,3R,4S,5S,6R)-2-{[(2R,3R,4S,5S,6R)-2-{[(1S,3aR,3bR,5aR,7S,9aR,9bR,11R,11aR)-11-hydroxy-1-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-3a,3b,6,6,9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    • AS-56617
    • Dammar-24-ene-12-beta,20-diol, 3-beta-((2-O-beta-D-glucopyranosyl-beta-D-glucopyransoyl)oxy)-
    • SY068871
    • C20778
    • 197G605
    • Q27077807
    • 12beta,20-Dihydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • 3?-[2-O-?-D-Glucopyranosyl-?-D-glucopyranosyl)oxy]-dammar-24-ene-12?-20 diol
    • (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-12,20-DIHYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-
    • 3-O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-.BETA.-D-GLUCOPYRANOSYLDAMMAR-24-ENE-3.BETA.,12.BETA.,20S-TRIOL
    • 3beta,12beta,20(R)-dihydroxydammar-24-ene 3-O-[beta-D-glucopyranosyl (1->2)-beta-D-glucopyranoside]
    • beta-D-Glucopyranoside, (3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-
    • dammar-24-ene-12beta,20-diol, 3-beta-((2-O-beta-D-glucopyranosyl-beta-D-glucopyransoyl)oxy)-
    • 14197-60-5

  • Applications

    Ginsenoside Rg3 (CAS 14197-60-5) is a ginsenoside saponin derived from ginseng with practical applications across several industries; in cosmetics/personal care it is evaluated as an active ingredient in skin and hair care formulations for its bioactive properties; in nutraceuticals/functional foods it is included in standardized ginseng extracts for dietary supplements; in pharmaceuticals it is studied as a bioactive lead compound in pharmacological research and the development of new therapeutics; and in cleaning/industrial contexts it is evaluated for natural surfactant-like behavior and potential use in cleaning formulations and related coatings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.68
    methanol 17.55
    isopropanol 0.42
    water 0.09
    ethyl acetate 1.42
    n-propanol 0.83
    acetone 3.94
    n-butanol 0.33
    acetonitrile 1.17
    DMF 32.87
    toluene 0.46
    isobutanol 0.33
    1,4-dioxane 7.32
    methyl acetate 1.84
    THF 13.95
    2-butanone 1.84
    n-pentanol 0.38
    sec-butanol 0.25
    n-hexane 0.02
    ethylene glycol 3.01
    NMP 32.74
    cyclohexane 0.03
    DMSO 38.67
    n-butyl acetate 0.74
    n-octanol 0.61
    chloroform 2.84
    n-propyl acetate 0.85
    acetic acid 19.63
    dichloromethane 2.77
    cyclohexanone 2.76
    propylene glycol 2.04
    isopropyl acetate 0.91
    DMAc 25.9
    2-ethoxyethanol 6.41
    isopentanol 0.22
    n-heptane 0.03
    ethyl formate 1.64
    1,2-dichloroethane 1.26
    n-hexanol 0.34
    2-methoxyethanol 12.71
    isobutyl acetate 0.54
    tetrachloromethane 0.37
    n-pentyl acetate 1.57
    transcutol 12.48
    n-heptanol 0.71
    ethylbenzene 0.22
    MIBK 0.79
    2-propoxyethanol 6.66
    tert-butanol 0.35
    MTBE 0.38
    2-butoxyethanol 5.49
    propionic acid 2.09
    o-xylene 0.32
    formic acid 24.89
    diethyl ether 0.62
    m-xylene 0.35
    p-xylene 0.29
    chlorobenzene 0.62
    dimethyl carbonate 4.34
    n-octane 0.02
    formamide 16.78
    cyclopentanone 7.46
    2-pentanone 1.24
    anisole 1.22
    cyclopentyl methyl ether 1.85
    gamma-butyrolactone 11.19
    1-methoxy-2-propanol 5.73
    pyridine 4.14
    3-pentanone 1.19
    furfural 13.65
    n-dodecane 0.02
    diethylene glycol 8.86
    diisopropyl ether 0.15
    tert-amyl alcohol 0.28
    acetylacetone 5.35
    n-hexadecane 0.02
    acetophenone 1.96
    methyl propionate 2.33
    isopentyl acetate 0.68
    trichloroethylene 4.66
    n-nonanol 0.64
    cyclohexanol 0.3
    benzyl alcohol 1.42
    2-ethylhexanol 0.21
    isooctanol 0.48
    dipropyl ether 0.61
    1,2-dichlorobenzene 0.71
    ethyl lactate 1.58
    propylene carbonate 3.58
    n-methylformamide 12.72
    2-pentanol 0.16
    n-pentane 0.02
    1-propoxy-2-propanol 3.03
    1-methoxy-2-propyl acetate 3.36
    2-(2-methoxypropoxy) propanol 4.1
    mesitylene 0.19
    ε-caprolactone 3.06
    p-cymene 0.21
    epichlorohydrin 9.73
    1,1,1-trichloroethane 0.71
    2-aminoethanol 3.7
    morpholine-4-carbaldehyde 31.52
    sulfolane 27.89
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.85
    n-hexyl acetate 1.55
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 6.03
    sec-butyl acetate 0.46
    tert-butyl acetate 1.08
    decalin 0.02
    glycerin 7.85
    diglyme 12.35
    acrylic acid 5.11
    isopropyl myristate 0.39
    n-butyric acid 1.54
    acetyl acetate 2.36
    di(2-ethylhexyl) phthalate 0.96
    ethyl propionate 0.8
    nitromethane 28.89
    1,2-diethoxyethane 1.98
    benzonitrile 1.0
    trioctyl phosphate 0.58
    1-bromopropane 0.27
    gamma-valerolactone 25.2
    n-decanol 0.35
    triethyl phosphate 0.66
    4-methyl-2-pentanol 0.14
    propionitrile 0.61
    vinylene carbonate 4.88
    1,1,2-trichlorotrifluoroethane 18.95
    DMS 2.16
    cumene 0.16
    2-octanol 0.33
    2-hexanone 0.87
    octyl acetate 0.75
    limonene 0.23
    1,2-dimethoxyethane 7.54
    ethyl orthosilicate 0.58
    tributyl phosphate 0.46
    diacetone alcohol 2.48
    N,N-dimethylaniline 1.09
    acrylonitrile 1.79
    aniline 0.77
    1,3-propanediol 2.33
    bromobenzene 0.57
    dibromomethane 1.06
    1,1,2,2-tetrachloroethane 2.8
    2-methyl-cyclohexyl acetate 0.88
    tetrabutyl urea 0.96
    diisobutyl methanol 0.14
    2-phenylethanol 1.4
    styrene 0.27
    dioctyl adipate 1.04
    dimethyl sulfate 11.0
    ethyl butyrate 0.76
    methyl lactate 4.71
    butyl lactate 2.11
    diethyl carbonate 0.51
    propanediol butyl ether 5.57
    triethyl orthoformate 0.91
    p-tert-butyltoluene 0.21
    methyl 4-tert-butylbenzoate 3.58
    morpholine 6.69
    tert-butylamine 0.11
    n-dodecanol 0.2
    dimethoxymethane 15.63
    ethylene carbonate 2.64
    cyrene 9.09
    2-ethoxyethyl acetate 4.49
    2-ethylhexyl acetate 0.53
    1,2,4-trichlorobenzene 1.16
    4-methylpyridine 1.91
    dibutyl ether 0.34
    2,6-dimethyl-4-heptanol 0.14
    DEF 2.91
    dimethyl isosorbide 8.5
    tetrachloroethylene 2.45
    eugenol 3.86
    triacetin 4.39
    span 80 3.69
    1,4-butanediol 1.28
    1,1-dichloroethane 0.63
    2-methyl-1-pentanol 0.24
    methyl formate 12.07
    2-methyl-1-butanol 0.22
    n-decane 0.04
    butyronitrile 0.36
    3,7-dimethyl-1-octanol 0.33
    1-chlorooctane 0.18
    1-chlorotetradecane 0.05
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.02
    cyclopentanol 0.69
    tetrahydropyran 1.42
    tert-amyl methyl ether 0.35
    2,5,8-trioxanonane 7.89
    1-hexene 0.07
    2-isopropoxyethanol 2.77
    2,2,2-trifluoroethanol 7.43
    methyl butyrate 1.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction