Ginsenoside Rd

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  • Identifiers

    CAS number
    52705-93-8

    Molecular formula
    C48H82O18

    SMILES
    CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 48.86%
    Woody 42.97%
    Sweet 38.21%
    Spicy 29.82%
    Mint 28.51%
    Cooling 27.8%
    Amber 27.04%
    Balsamic 26.91%
    Dry 24.2%
    Sandalwood 23.63%

     

    Flavor
    Bitter 44.84%
    Sweet 38.45%
    Odorless 30.63%
    Fatty 27.88%
    Sweet-like 26.0%
    Herbal 22.22%
    Cedarleaf 21.64%
    Mentholic 21.44%
    Patchouli 21.03%
    Bland 20.98%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    4.17 (weak acid)

    Molecular weight
    947.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    2605°C

    Flash point

    • 238.89 ˚C est.

  • Synonyms

    • Ginsenoside Rd
    • 52705-93-8
    • Gypenoside VIII
    • Chikusetsusaponin fk7
    • WB232T95AV
    • DTXSID301031221
    • CHEBI:67988
    • 2-O-beta-D-Glucopyranosyl-(3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammara-24-en-3-yl-beta-D-glucopyranoside
    • RefChem:37442
    • UNII-WB232T95AV
    • DTXCID701516233
    • 258-118-5
    • (2S,3R,4S,5S,6R)-2-((2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-((2S)-6-methyl-2-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyhept-5-en-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-3-yl)oxy)oxan-3-yl)oxy-6-(hydroxymethyl)oxane-3,4,5-triol
    • ginsenoside-Rd
    • CHEMBL473659
    • GS-Rd
    • G-Rd
    • (20S)-ginsenoside Rd
    • 20(S)-ginsenoside Rd
    • (GS)-Rd
    • SCHEMBL669260
    • HMS3885A14
    • (3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • HY-N0043
    • MSK40199
    • EINECS 258-118-5
    • BDBM50317539
    • s3931
    • AKOS037514671
    • CCG-270588
    • CS-3839
    • EBC-618393
    • NCGC00522501-01
    • (2S,3R,4S,5S,6R)-2-{[(2S)-2-[(1S,3aR,3bR,5aR,7S,9aR,9bR,11R,11aR)-7-{[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-11-hydroxy-3a,3b,6,6,9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    • G0550
    • C20725
    • Q27136471
    • (3beta,12beta,20S)-20-[(beta-D-glucopyranosyl)oxy]-3-[(beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranosyl)oxy]dammar-24-en-12-ol
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-20-(.BETA.-D-GLUCOPYRANOSYLOXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-
    • 20(S)-protopanaxadiol-3-[O-beta-D-glucopyranosyl(1->2)-beta-D-glucopyranoside]-20-(O-beta-D-glucopyranoside)
    • 3-O-(beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranosyl)-20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol
    • beta-D-Glucopyranoside, (3-beta,12-beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-
    • GINSENOSIDE RD (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]
    • 52705-93-8

  • Applications

    Ginsenoside Rd is used in cosmetics and personal care as a botanical ingredient from ginseng extracts; it is studied for potential bioactivity in pharmaceutical research as a lead component for drug discovery; it may be present in nutraceuticals and dietary supplements as part of standardized ginseng extracts; it can function as a natural surfactant or foaming agent in cleaning and household formulations; and it serves as an analytical reference standard for quality control of ginseng products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.23
    methanol 21.43
    isopropanol 0.66
    water 0.14
    ethyl acetate 2.8
    n-propanol 1.26
    acetone 5.52
    n-butanol 0.51
    acetonitrile 1.97
    DMF 48.68
    toluene 0.68
    isobutanol 0.5
    1,4-dioxane 9.82
    methyl acetate 3.4
    THF 19.3
    2-butanone 3.04
    n-pentanol 0.52
    sec-butanol 0.43
    n-hexane 0.03
    ethylene glycol 4.52
    NMP 56.0
    cyclohexane 0.06
    DMSO 57.05
    n-butyl acetate 1.26
    n-octanol 0.81
    chloroform 5.29
    n-propyl acetate 1.37
    acetic acid 34.72
    dichloromethane 5.06
    cyclohexanone 4.42
    propylene glycol 3.39
    isopropyl acetate 1.66
    DMAc 43.32
    2-ethoxyethanol 8.87
    isopentanol 0.33
    n-heptane 0.05
    ethyl formate 3.0
    1,2-dichloroethane 2.24
    n-hexanol 0.51
    2-methoxyethanol 19.08
    isobutyl acetate 0.76
    tetrachloromethane 0.64
    n-pentyl acetate 2.26
    transcutol 15.84
    n-heptanol 0.97
    ethylbenzene 0.29
    MIBK 1.15
    2-propoxyethanol 9.35
    tert-butanol 0.55
    MTBE 0.6
    2-butoxyethanol 7.17
    propionic acid 4.03
    o-xylene 0.48
    formic acid 39.0
    diethyl ether 0.97
    m-xylene 0.5
    p-xylene 0.38
    chlorobenzene 0.96
    dimethyl carbonate 8.18
    n-octane 0.03
    formamide 27.3
    cyclopentanone 11.75
    2-pentanone 2.02
    anisole 1.64
    cyclopentyl methyl ether 2.99
    gamma-butyrolactone 19.72
    1-methoxy-2-propanol 9.12
    pyridine 6.33
    3-pentanone 1.99
    furfural 21.76
    n-dodecane 0.02
    diethylene glycol 12.52
    diisopropyl ether 0.22
    tert-amyl alcohol 0.46
    acetylacetone 8.58
    n-hexadecane 0.03
    acetophenone 2.77
    methyl propionate 4.45
    isopentyl acetate 1.06
    trichloroethylene 8.21
    n-nonanol 0.85
    cyclohexanol 0.5
    benzyl alcohol 1.91
    2-ethylhexanol 0.31
    isooctanol 0.64
    dipropyl ether 0.87
    1,2-dichlorobenzene 1.14
    ethyl lactate 2.57
    propylene carbonate 7.09
    n-methylformamide 19.93
    2-pentanol 0.26
    n-pentane 0.03
    1-propoxy-2-propanol 4.5
    1-methoxy-2-propyl acetate 5.39
    2-(2-methoxypropoxy) propanol 5.29
    mesitylene 0.27
    ε-caprolactone 5.4
    p-cymene 0.29
    epichlorohydrin 15.28
    1,1,1-trichloroethane 1.38
    2-aminoethanol 5.41
    morpholine-4-carbaldehyde 48.84
    sulfolane 46.69
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 2.98
    n-hexyl acetate 2.22
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 7.49
    sec-butyl acetate 0.77
    tert-butyl acetate 1.75
    decalin 0.03
    glycerin 12.58
    diglyme 16.58
    acrylic acid 9.53
    isopropyl myristate 0.53
    n-butyric acid 3.11
    acetyl acetate 4.63
    di(2-ethylhexyl) phthalate 1.25
    ethyl propionate 1.44
    nitromethane 49.02
    1,2-diethoxyethane 2.68
    benzonitrile 1.5
    trioctyl phosphate 0.79
    1-bromopropane 0.47
    gamma-valerolactone 38.32
    n-decanol 0.47
    triethyl phosphate 1.08
    4-methyl-2-pentanol 0.21
    propionitrile 1.02
    vinylene carbonate 9.17
    1,1,2-trichlorotrifluoroethane 31.71
    DMS 3.62
    cumene 0.21
    2-octanol 0.45
    2-hexanone 1.22
    octyl acetate 1.06
    limonene 0.35
    1,2-dimethoxyethane 10.11
    ethyl orthosilicate 0.92
    tributyl phosphate 0.67
    diacetone alcohol 3.91
    N,N-dimethylaniline 1.44
    acrylonitrile 2.94
    aniline 1.23
    1,3-propanediol 3.71
    bromobenzene 0.87
    dibromomethane 1.89
    1,1,2,2-tetrachloroethane 5.05
    2-methyl-cyclohexyl acetate 1.28
    tetrabutyl urea 1.32
    diisobutyl methanol 0.2
    2-phenylethanol 1.92
    styrene 0.36
    dioctyl adipate 1.41
    dimethyl sulfate 20.35
    ethyl butyrate 1.27
    methyl lactate 8.8
    butyl lactate 3.05
    diethyl carbonate 0.91
    propanediol butyl ether 6.97
    triethyl orthoformate 1.46
    p-tert-butyltoluene 0.31
    methyl 4-tert-butylbenzoate 4.88
    morpholine 9.77
    tert-butylamine 0.17
    n-dodecanol 0.27
    dimethoxymethane 22.47
    ethylene carbonate 5.12
    cyrene 12.06
    2-ethoxyethyl acetate 6.5
    2-ethylhexyl acetate 0.82
    1,2,4-trichlorobenzene 1.92
    4-methylpyridine 2.92
    dibutyl ether 0.46
    2,6-dimethyl-4-heptanol 0.2
    DEF 5.29
    dimethyl isosorbide 11.39
    tetrachloroethylene 4.19
    eugenol 4.93
    triacetin 6.61
    span 80 4.83
    1,4-butanediol 1.76
    1,1-dichloroethane 1.19
    2-methyl-1-pentanol 0.33
    methyl formate 19.2
    2-methyl-1-butanol 0.34
    n-decane 0.05
    butyronitrile 0.61
    3,7-dimethyl-1-octanol 0.43
    1-chlorooctane 0.27
    1-chlorotetradecane 0.08
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.03
    cyclopentanol 1.2
    tetrahydropyran 2.2
    tert-amyl methyl ether 0.58
    2,5,8-trioxanonane 10.16
    1-hexene 0.1
    2-isopropoxyethanol 3.63
    2,2,2-trifluoroethanol 14.07
    methyl butyrate 1.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction