Ginkgolic acid

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  • Identifiers

    CAS number
    22910-60-7

    Molecular formula
    C22H34O3

    SMILES
    CCCCCC/C=C\CCCCCCCC1=C(C(=CC=C1)O)C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Waxy 59.79%
    Fatty 51.99%
    Oily 40.3%
    Balsamic 36.97%
    Floral 31.87%
    Sweet 29.77%
    Odorless 26.84%
    Spicy 24.74%
    Woody 23.0%
    Animal 20.94%

     

    Flavor
    Fatty 29.64%
    Mild 28.98%
    Faint 28.29%
    Waxy 26.52%
    Woody 24.11%
    Odorless 23.62%
    Bland 23.47%
    Slightly waxy 22.33%
    Herbal 21.11%
    Delicate 20.71%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.5

    pKa est.
    6.94 (neutral)

    Molecular weight
    346.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    449°C

    Flash point

    • 224.43 ˚C est.

  • Synonyms

    • Ginkgolic acid
    • 22910-60-7
    • Ginkgoic acid
    • 2-hydroxy-6-[(Z)-pentadec-8-enyl]benzoic acid
    • (Z)-2-Hydroxy-6-(8-pentadecenyl)benzoic acid
    • 2-hydroxy-6-((Z)-pentadec-8-enyl)benzoic acid
    • RefChem:639959
    • 2-hydroxy-6-((8E)-pentadec-8-en-1-yl)benzoic acid
    • Ginkgolic acid C15:1
    • Ginkgolic acid I
    • Ginkgolic acid 15:1
    • Romanicardic acid
    • Benzoic acid, 2-hydroxy-6-(8Z)-8-pentadecenyl-
    • 6-[(8Z)-Pentadecenyl]-salicylic acid
    • 2-hydroxy-6-[(8Z)-pentadec-8-en-1-yl]benzoic acid
    • CHEMBL445177
    • (Z)-2-Hydroxy-6-(pentadec-8-en-1-yl)benzoic acid
    • Anacardic acid monoene
    • Gingkolic Acid
    • Ginkgolic acid (C15:1)
    • 2-hydroxy-6-(pentadec-8-en-1-yl)benzoic acid
    • DTXSID50872875
    • YXHVCZZLWZYHSA-FPLPWBNLSA-N
    • Spectrum5_000899
    • Ginkgolic Acid (Standard)
    • BSPBio_002625
    • Anacardic acid 8''Z-monoene
    • SCHEMBL163525
    • SPECTRUM1505247
    • CHEBI:5354
    • orb1300167
    • SCHEMBL29349859
    • HY-N0077R
    • 6-(8Z)-Pentadecenylsalicylic acid
    • HY-N0077
    • MSK15691
    • 6-(8'z-pentadecenyl)salicylic acid
    • BDBM50242188
    • CCG-38715
    • LMPK15040003
    • MFCD03093717
    • s9432
    • 6-(8''Z-pentadecenyl)-salicylicacid
    • 6-{8(Z)-pentadecenyl}salicylic acid
    • AKOS015920035
    • CS-3728
    • EBC-460093
    • FG42762
    • SDCCGMLS-0066799.P001
    • 6[8'(Z )-Pentadecenyl]Salicylic Acid
    • 6-[8''(Z)-pentadecenyl]salicylic acid
    • 6-[8(Z)-pentadecatrienyl]salicylic acid
    • 6[8''(Z )-pentadecenyl]salicylic acid
    • NCGC00095338-01
    • NCGC00095338-02
    • NCGC00095338-03
    • AC-12804
    • AS-79331
    • DA-63759
    • Ginkgolic acid C15:1, analytical standard
    • 6-((Z)-heptadec-8-en-1-yl)salicylic acid
    • NS00094737
    • 910G607
    • A878392
    • Ginkgolic Acid (15:1) - CAS 22910-60-7
    • Ginkgolic acid C15:1, primary reference standard
    • SR-05000002608
    • (Z)-2-(heptadec-8-en-1-yl)-6-hydroxybenzoic acid
    • Q1525050
    • SR-05000002608-1
    • Benzoic acid, 2-hydroxy-6-(8-pentadecenyl)-, (Z)-
    • BRD-K81965037-001-03-2
    • 22910-60-7

  • Applications

    Ginkgolic acid (CAS 22910-60-7) is a phenolic lipid derived from Ginkgo biloba extracts and is commonly used as an analytical standard and quality-control marker for ginkgo-based pharmaceuticals, nutraceuticals, and cosmetic formulations. In research and development, it is used as a synthetic intermediate for bioactive derivatives and for structure-activity relationship studies. It has been investigated for antimicrobial and antifungal activity, informing potential pharmaceutical or agricultural exploration. Due to allergen concerns, it may be present in crude ginkgo-derived oils used in cosmetics or personal-care products, but its use is typically regulated, restricted, or removed in finished formulations. In academic and industrial settings it is used as a reference compound in safety evaluations of natural products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2339.89
    methanol 1648.56
    isopropanol 1820.83
    water 0.14
    ethyl acetate 853.17
    n-propanol 2140.92
    acetone 2863.32
    n-butanol 1369.11
    acetonitrile 429.48
    DMF 2988.68
    toluene 370.11
    isobutanol 1329.15
    1,4-dioxane 1307.38
    methyl acetate 701.41
    THF 4934.96
    2-butanone 1684.18
    n-pentanol 675.32
    sec-butanol 1308.96
    n-hexane 57.91
    ethylene glycol 95.96
    NMP 2335.26
    cyclohexane 160.16
    DMSO 4643.22
    n-butyl acetate 481.07
    n-octanol 143.53
    chloroform 1076.68
    n-propyl acetate 488.42
    acetic acid 570.44
    dichloromethane 1322.85
    cyclohexanone 2233.22
    propylene glycol 360.16
    isopropyl acetate 581.82
    DMAc 2077.58
    2-ethoxyethanol 809.46
    isopentanol 911.71
    n-heptane 22.48
    ethyl formate 382.24
    1,2-dichloroethane 1676.29
    n-hexanol 423.93
    2-methoxyethanol 1845.64
    isobutyl acetate 332.58
    tetrachloromethane 218.82
    n-pentyl acetate 393.13
    transcutol 1520.74
    n-heptanol 192.47
    ethylbenzene 134.42
    MIBK 703.23
    2-propoxyethanol 771.49
    tert-butanol 1431.59
    MTBE 1183.88
    2-butoxyethanol 459.13
    propionic acid 642.14
    o-xylene 203.4
    formic acid 140.74
    diethyl ether 1161.94
    m-xylene 214.48
    p-xylene 173.58
    chlorobenzene 443.88
    dimethyl carbonate 287.5
    n-octane 12.62
    formamide 370.63
    cyclopentanone 3070.96
    2-pentanone 1491.9
    anisole 315.84
    cyclopentyl methyl ether 1556.66
    gamma-butyrolactone 2047.36
    1-methoxy-2-propanol 1491.32
    pyridine 1153.77
    3-pentanone 859.22
    furfural 821.85
    n-dodecane 9.88
    diethylene glycol 332.78
    diisopropyl ether 229.06
    tert-amyl alcohol 1026.46
    acetylacetone 1094.95
    n-hexadecane 11.84
    acetophenone 316.52
    methyl propionate 852.33
    isopentyl acetate 465.07
    trichloroethylene 1777.76
    n-nonanol 138.31
    cyclohexanol 1098.6
    benzyl alcohol 321.2
    2-ethylhexanol 198.08
    isooctanol 176.91
    dipropyl ether 331.26
    1,2-dichlorobenzene 326.72
    ethyl lactate 203.44
    propylene carbonate 701.18
    n-methylformamide 1095.27
    2-pentanol 746.4
    n-pentane 74.33
    1-propoxy-2-propanol 547.25
    1-methoxy-2-propyl acetate 519.47
    2-(2-methoxypropoxy) propanol 298.52
    mesitylene 127.22
    ε-caprolactone 1291.75
    p-cymene 76.07
    epichlorohydrin 2602.23
    1,1,1-trichloroethane 1010.61
    2-aminoethanol 541.61
    morpholine-4-carbaldehyde 1333.61
    sulfolane 2983.0
    2,2,4-trimethylpentane 40.51
    2-methyltetrahydrofuran 2587.8
    n-hexyl acetate 414.79
    isooctane 29.87
    2-(2-butoxyethoxy)ethanol 491.99
    sec-butyl acetate 327.69
    tert-butyl acetate 691.1
    decalin 46.36
    glycerin 315.9
    diglyme 912.78
    acrylic acid 353.74
    isopropyl myristate 135.54
    n-butyric acid 1077.2
    acetyl acetate 323.07
    di(2-ethylhexyl) phthalate 118.86
    ethyl propionate 389.18
    nitromethane 1092.98
    1,2-diethoxyethane 582.36
    benzonitrile 308.72
    trioctyl phosphate 100.44
    1-bromopropane 972.87
    gamma-valerolactone 2502.47
    n-decanol 95.77
    triethyl phosphate 123.64
    4-methyl-2-pentanol 313.94
    propionitrile 513.36
    vinylene carbonate 447.41
    1,1,2-trichlorotrifluoroethane 972.54
    DMS 295.84
    cumene 89.15
    2-octanol 134.33
    2-hexanone 653.07
    octyl acetate 180.87
    limonene 148.5
    1,2-dimethoxyethane 1128.76
    ethyl orthosilicate 131.81
    tributyl phosphate 121.34
    diacetone alcohol 871.74
    N,N-dimethylaniline 218.76
    acrylonitrile 475.44
    aniline 565.73
    1,3-propanediol 871.96
    bromobenzene 406.16
    dibromomethane 954.98
    1,1,2,2-tetrachloroethane 1604.49
    2-methyl-cyclohexyl acetate 259.13
    tetrabutyl urea 188.66
    diisobutyl methanol 118.98
    2-phenylethanol 260.23
    styrene 180.22
    dioctyl adipate 207.61
    dimethyl sulfate 575.56
    ethyl butyrate 298.76
    methyl lactate 368.64
    butyl lactate 292.19
    diethyl carbonate 156.04
    propanediol butyl ether 360.41
    triethyl orthoformate 203.71
    p-tert-butyltoluene 78.07
    methyl 4-tert-butylbenzoate 298.01
    morpholine 2683.7
    tert-butylamine 809.82
    n-dodecanol 69.36
    dimethoxymethane 1768.94
    ethylene carbonate 485.98
    cyrene 335.64
    2-ethoxyethyl acetate 512.6
    2-ethylhexyl acetate 323.25
    1,2,4-trichlorobenzene 414.9
    4-methylpyridine 1002.29
    dibutyl ether 236.29
    2,6-dimethyl-4-heptanol 118.98
    DEF 1236.21
    dimethyl isosorbide 579.83
    tetrachloroethylene 920.48
    eugenol 250.92
    triacetin 315.51
    span 80 266.26
    1,4-butanediol 231.12
    1,1-dichloroethane 1356.02
    2-methyl-1-pentanol 482.3
    methyl formate 493.73
    2-methyl-1-butanol 927.81
    n-decane 17.85
    butyronitrile 644.66
    3,7-dimethyl-1-octanol 168.8
    1-chlorooctane 108.95
    1-chlorotetradecane 38.2
    n-nonane 16.07
    undecane 12.72
    tert-butylcyclohexane 37.65
    cyclooctane 32.22
    cyclopentanol 1528.4
    tetrahydropyran 2727.54
    tert-amyl methyl ether 702.73
    2,5,8-trioxanonane 499.07
    1-hexene 251.25
    2-isopropoxyethanol 514.54
    2,2,2-trifluoroethanol 162.41
    methyl butyrate 564.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction