Genkwanin

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  • Identifiers

    CAS number
    437-64-9

    Molecular formula
    C16H12O5

    SMILES
    COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 64.69%
    Sweet 40.4%
    Medicinal 33.47%
    Odorless 32.3%
    Vanilla 32.25%
    Burnt 32.09%
    Nutty 28.26%
    Spicy 28.25%
    Smoky 27.98%
    Balsamic 27.3%

     

    Flavor
    Bitter 92.93%
    Very strong 20.4%
    Odorless 20.38%
    Cedarleaf 20.34%
    Parsley 20.32%
    Lovage 20.3%
    Indole 20.29%
    Sweet-like 19.92%
    Nitrile 19.83%
    Ripe apricot 19.57%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    9.0 (weak base)

    Molecular weight
    284.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    573°C

    Flash point

    • 208.15 ˚C est.

  • Synonyms

    • Genkwanin
    • 437-64-9
    • Gengkwanin
    • 7-O-Methylapigenin
    • 7-Methylapigenin
    • 7-Methoxyapigenin
    • Apigenin 7-methyl ether
    • 5,4'-Dihydroxy-7-methoxyflavone
    • 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one
    • 5K3I5D6B2B
    • DTXSID80195908
    • CHEBI:75718
    • 5,4'-dihydroxy-7-methoxy-flavone
    • RefChem:142883
    • DTXCID80118399
    • 4',5-Dihydroxy-7-methoxyflavone
    • Puddumetin
    • 5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one
    • 4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
    • MFCD00017452
    • CHEMBL210635
    • 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-chromen-4-one
    • UNII-5K3I5D6B2B
    • Gonkwanin
    • Henquanin
    • 4'',5-dihydroxy-7-methoxyflavone
    • 7'O-methyl-apigenin
    • Genkwanin (Standard)
    • apigenin 7-methylether
    • Spectrum_000330
    • SpecPlus_000835
    • Spectrum2_001355
    • Spectrum3_001401
    • Spectrum4_001667
    • Spectrum5_000573
    • BSPBio_003042
    • KBioGR_002193
    • KBioSS_000810
    • DivK1c_006931
    • Genkwanin, analytical standard
    • SCHEMBL866123
    • SPBio_001569
    • orb1300267
    • 4,5-Dihydroxy-7-methoxyflavone
    • Genkwanin, >=98% (HPLC)
    • SCHEMBL29445006
    • HY-N0731R
    • KBio1_001875
    • KBio2_000810
    • KBio2_003378
    • KBio2_005946
    • KBio3_002262
    • 5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
    • HY-N0731
    • 4'',5-dihydroxy-7-methoxy flavone
    • BDBM50187658
    • CCG-38838
    • LMPK12111018
    • MSK158067
    • s9287
    • AKOS015896775
    • Flavone, 4',5-dihydroxy-7-methoxy-
    • EBC-457056
    • FG23656
    • NCGC00178332-01
    • NCGC00178332-02
    • AC-34953
    • AS-60761
    • ST057642
    • DB-051163
    • CS-0009744
    • NS00083543
    • 4',5-Dihydroxy-7-methoxyflavone, AldrichCPR
    • C10046
    • Q3050376
    • BRD-K29160894-001-02-9
    • 5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one #
    • Genkwanin

  • Applications

    Genkwanin, CAS 437-64-9, is a natural flavone used primarily as a synthetic intermediate for flavonoid derivatives in pharmaceutical research; it is also evaluated as a bioactive compound with potential applications in cosmetics and personal care as an antioxidant; in coatings and inks, it can be employed as a natural additive to improve stability and performance; in polymers and plastics, it is studied as an antioxidant/stabilizer; in agriculture, it is explored as a bioactive constituent for potential agrochemical or plant-protection applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.9
    methanol 0.87
    isopropanol 1.28
    water 0.0
    ethyl acetate 1.93
    n-propanol 1.36
    acetone 5.03
    n-butanol 1.25
    acetonitrile 2.45
    DMF 47.33
    toluene 0.14
    isobutanol 1.13
    1,4-dioxane 9.19
    methyl acetate 4.84
    THF 58.85
    2-butanone 7.41
    n-pentanol 0.92
    sec-butanol 1.51
    n-hexane 0.0
    ethylene glycol 5.84
    NMP 43.17
    cyclohexane 0.01
    DMSO 782.44
    n-butyl acetate 2.5
    n-octanol 0.46
    chloroform 0.24
    n-propyl acetate 2.85
    acetic acid 7.07
    dichloromethane 0.31
    cyclohexanone 8.15
    propylene glycol 9.31
    isopropyl acetate 1.88
    DMAc 81.74
    2-ethoxyethanol 16.74
    isopentanol 1.61
    n-heptane 0.01
    ethyl formate 1.97
    1,2-dichloroethane 0.72
    n-hexanol 0.49
    2-methoxyethanol 43.57
    isobutyl acetate 1.92
    tetrachloromethane 0.03
    n-pentyl acetate 1.39
    transcutol 137.3
    n-heptanol 0.56
    ethylbenzene 0.12
    MIBK 2.49
    2-propoxyethanol 17.57
    tert-butanol 2.59
    MTBE 1.14
    2-butoxyethanol 6.61
    propionic acid 4.52
    o-xylene 0.17
    formic acid 4.36
    diethyl ether 0.45
    m-xylene 0.14
    p-xylene 0.21
    chlorobenzene 0.28
    dimethyl carbonate 4.67
    n-octane 0.0
    formamide 12.06
    cyclopentanone 24.0
    2-pentanone 2.96
    anisole 1.89
    cyclopentyl methyl ether 3.19
    gamma-butyrolactone 31.98
    1-methoxy-2-propanol 29.24
    pyridine 4.18
    3-pentanone 2.01
    furfural 23.86
    n-dodecane 0.01
    diethylene glycol 30.43
    diisopropyl ether 0.19
    tert-amyl alcohol 2.12
    acetylacetone 11.14
    n-hexadecane 0.02
    acetophenone 3.56
    methyl propionate 4.04
    isopentyl acetate 3.37
    trichloroethylene 2.0
    n-nonanol 0.58
    cyclohexanol 1.4
    benzyl alcohol 2.69
    2-ethylhexanol 0.61
    isooctanol 0.67
    dipropyl ether 0.99
    1,2-dichlorobenzene 0.47
    ethyl lactate 5.83
    propylene carbonate 7.37
    n-methylformamide 11.14
    2-pentanol 0.7
    n-pentane 0.0
    1-propoxy-2-propanol 12.48
    1-methoxy-2-propyl acetate 11.45
    2-(2-methoxypropoxy) propanol 18.09
    mesitylene 0.1
    ε-caprolactone 9.08
    p-cymene 0.26
    epichlorohydrin 41.38
    1,1,1-trichloroethane 0.41
    2-aminoethanol 6.03
    morpholine-4-carbaldehyde 51.98
    sulfolane 102.61
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 8.49
    n-hexyl acetate 2.08
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 21.87
    sec-butyl acetate 1.89
    tert-butyl acetate 3.71
    decalin 0.02
    glycerin 36.48
    diglyme 52.27
    acrylic acid 6.78
    isopropyl myristate 1.21
    n-butyric acid 3.51
    acetyl acetate 2.29
    di(2-ethylhexyl) phthalate 2.21
    ethyl propionate 2.51
    nitromethane 33.11
    1,2-diethoxyethane 8.45
    benzonitrile 1.83
    trioctyl phosphate 1.24
    1-bromopropane 0.16
    gamma-valerolactone 53.05
    n-decanol 0.48
    triethyl phosphate 3.16
    4-methyl-2-pentanol 0.69
    propionitrile 1.84
    vinylene carbonate 5.53
    1,1,2-trichlorotrifluoroethane 36.05
    DMS 5.99
    cumene 0.13
    2-octanol 0.31
    2-hexanone 3.35
    octyl acetate 1.44
    limonene 0.33
    1,2-dimethoxyethane 28.07
    ethyl orthosilicate 2.49
    tributyl phosphate 2.03
    diacetone alcohol 13.73
    N,N-dimethylaniline 1.46
    acrylonitrile 4.38
    aniline 1.35
    1,3-propanediol 10.12
    bromobenzene 0.19
    dibromomethane 0.13
    1,1,2,2-tetrachloroethane 2.32
    2-methyl-cyclohexyl acetate 3.32
    tetrabutyl urea 3.4
    diisobutyl methanol 0.73
    2-phenylethanol 2.2
    styrene 0.14
    dioctyl adipate 3.62
    dimethyl sulfate 20.28
    ethyl butyrate 2.78
    methyl lactate 13.6
    butyl lactate 4.09
    diethyl carbonate 2.48
    propanediol butyl ether 8.23
    triethyl orthoformate 3.73
    p-tert-butyltoluene 0.26
    methyl 4-tert-butylbenzoate 5.76
    morpholine 19.08
    tert-butylamine 0.5
    n-dodecanol 0.4
    dimethoxymethane 17.76
    ethylene carbonate 3.86
    cyrene 17.49
    2-ethoxyethyl acetate 5.92
    2-ethylhexyl acetate 2.19
    1,2,4-trichlorobenzene 1.09
    4-methylpyridine 2.8
    dibutyl ether 1.08
    2,6-dimethyl-4-heptanol 0.73
    DEF 6.43
    dimethyl isosorbide 33.34
    tetrachloroethylene 0.65
    eugenol 6.79
    triacetin 7.83
    span 80 7.59
    1,4-butanediol 2.8
    1,1-dichloroethane 0.29
    2-methyl-1-pentanol 1.3
    methyl formate 7.84
    2-methyl-1-butanol 1.39
    n-decane 0.02
    butyronitrile 1.36
    3,7-dimethyl-1-octanol 0.87
    1-chlorooctane 0.13
    1-chlorotetradecane 0.09
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.02
    cyclooctane 0.0
    cyclopentanol 2.88
    tetrahydropyran 2.68
    tert-amyl methyl ether 1.3
    2,5,8-trioxanonane 38.02
    1-hexene 0.03
    2-isopropoxyethanol 8.97
    2,2,2-trifluoroethanol 3.24
    methyl butyrate 3.86

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction