Gamma-Tocotrienol

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  • Identifiers

    CAS number
    14101-61-2

    Molecular formula
    C28H42O2

    SMILES
    CC1=C(C=C2CC[C@@](OC2=C1C)(C)CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)O

    Safety labels

  • Odor profile

    Fragrance
    Floral 59.36%
    Fruity 49.77%
    Woody 44.5%
    Balsamic 39.74%
    Sweet 38.65%
    Spicy 35.83%
    Powdery 31.09%
    Waxy 28.96%
    Fresh 24.73%
    Rose 24.28%

     

    Flavor
    Woody 44.3%
    Wood 36.52%
    Balsam 30.38%
    Spice 29.62%
    Floral 28.21%
    Spicy 27.36%
    Flower 25.15%
    Herbal 24.93%
    Fresh 23.82%
    Balsamic 23.52%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.9

    pKa est.
    9.02 (weak base)

    Molecular weight
    410.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    604°C

    Flash point

    • 177.1 ˚C est.

  • Synonyms

    • gamma-Tocotrienol
    • 14101-61-2
    • 185QAE24TR
    • J13.903C
    • (2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
    • CHEBI:33277
    • DTXSID101019984
    • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (R-(E,E))-
    • 2H-1-BENZOPYRAN-6-OL, 3,4-DIHYDRO-2,7,8-TRIMETHYL-2-((3E,7E)-4,8,12-TRIMETHYL-3,7,11-TRIDECATRIEN-1-YL)-, (2R)-
    • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, [R-(E,E)]-
    • 2R,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-chromen-6-ol
    • tocotrienol, gamma
    • (2R)-2,7,8-trimethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol
    • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-, (2R)-
    • 2R,7,8-trimethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)-3,4-dihydro-2H-chromen-6-ol
    • RefChem:639608
    • DTXCID901477841
    • plastochromanol 8, plastochromanol 3
    • 604-216-1
    • D-gamma-Tocotrienol
    • Gama-Tocotrienol
    • 7,8-Dimethyltocotrienol
    • Plastochromanol 3
    • .gamma.-Tocotrienol
    • D-.gamma.-Tocotrienol
    • (R)-.gamma.-Tocotrienol
    • (R)-2,7,8-Trimethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chroman-6-ol
    • (2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-1-benzopyran-6-ol
    • (R-(E,E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
    • MFCD00901547
    • (2R)-3,4-Dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-2H-1-benzopyran-6-ol
    • 2H-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2R)-
    • UNII-185QAE24TR
    • Plastochromanol
    • _-Tocotrienol
    • gamma -Tocotrienol
    • 2H-1-BENZOPYRAN-6-OL, 3,4-DIHYDRO-2,7,8-TRIMETHYL-2-((3E,7E)-4,8,12-TRIMETHYL-3,7,11-TRIDECATRIENYL)-, (2R)-
    • 2R-gamma-tocotrienol
    • (R)-gamma-Tocotrienol
    • BIDD:PXR0016
    • CHEMBL120697
    • SCHEMBL3272929
    • SCHEMBL29354672
    • HMS3650C14
    • GAMMA TOCOTRIENOL [WHO-DD]
    • 3,4-Dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol
    • LMPR02020057
    • gamma-Tocotrienol, analytical standard
    • AKOS040744431
    • EBC-618348
    • HY-108694R
    • DA-73639
    • FT138332
    • SY115909
    • HY-108694
    • CS-0029988
    • G13332
    • SR-01000946268
    • SR-01000946268-1
    • Q15633932
    • (2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]chroman-6-ol
    • 6-Chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-
    • 6-Chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)- (7CI,8CI)
    • (2R)-2,7,8-trimethyl-2-(4',8',12'-trimethyl-trideca-3',7',11'-trienyl)-6-hydroxychroman
    • (2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-chromen-6-ol
    • (r)-2,7,8-trimethyl-2-((3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl) chroman-6-ol
    • 2,7,8-TRIMETHYL-2-[(3E,7E,11E,15E,19E,23E,27E)-4,8,12,16,20,24,28,32-O CTAMETHYL-3,7,11,15,19,23,27,31-TRITRIACONTAOCTAENYL]-6-CHROMANOL
    • 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2R)- (9CI)
    • D-|A-Tocotrienol; |A-Tocotrienol; (R-(all-E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12,16,20,24,28,32-octamethyl-3,7,11,15,19,23,27,31-tritriacontaoctaenyl)-2H-1-benzopyran-6-ol
    • 14101-61-2

  • Applications

    Gamma-Tocotrienol is primarily used as an antioxidant ingredient in cosmetics and personal care formulations to protect lipids and pigments from oxidative degradation, helping to extend shelf life and preserve product quality. In nutraceuticals and functional foods, it is commonly evaluated or used as a vitamin E component (tocotrienol fraction) in dietary supplements, contributing nutritional value and stabilizing fats and oils. In food processing and related systems, it serves to inhibit lipid oxidation in oils and fat-containing products, supporting product stability during processing and storage. In industrial manufacturing, gamma-tocotrienol acts as an antioxidant stabilizer for oil-based formulations, polymers, coatings, and inks, helping to inhibit oxidation during processing and storage. In animal nutrition, tocotrienols are employed as feed additives to supplement vitamin E requirements for livestock and poultry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.76
    methanol 5.14
    isopropanol 8.07
    water 0.01
    ethyl acetate 57.93
    n-propanol 15.54
    acetone 16.87
    n-butanol 22.78
    acetonitrile 5.54
    DMF 14.49
    toluene 68.45
    isobutanol 13.71
    1,4-dioxane 94.27
    methyl acetate 27.81
    THF 176.75
    2-butanone 48.82
    n-pentanol 31.99
    sec-butanol 19.42
    n-hexane 12.33
    ethylene glycol 0.18
    NMP 34.22
    cyclohexane 14.55
    DMSO 14.06
    n-butyl acetate 101.16
    n-octanol 27.47
    chloroform 239.15
    n-propyl acetate 69.3
    acetic acid 9.23
    dichloromethane 176.88
    cyclohexanone 88.03
    propylene glycol 0.84
    isopropyl acetate 52.49
    DMAc 72.02
    2-ethoxyethanol 38.58
    isopentanol 28.82
    n-heptane 12.47
    ethyl formate 14.85
    1,2-dichloroethane 74.9
    n-hexanol 40.56
    2-methoxyethanol 17.7
    isobutyl acetate 67.97
    tetrachloromethane 26.57
    n-pentyl acetate 100.89
    transcutol 256.42
    n-heptanol 33.4
    ethylbenzene 60.37
    MIBK 47.12
    2-propoxyethanol 68.44
    tert-butanol 14.69
    MTBE 74.27
    2-butoxyethanol 66.65
    propionic acid 9.75
    o-xylene 42.43
    formic acid 1.43
    diethyl ether 73.73
    m-xylene 45.61
    p-xylene 65.77
    chlorobenzene 67.19
    dimethyl carbonate 9.52
    n-octane 4.84
    formamide 2.68
    cyclopentanone 58.8
    2-pentanone 47.96
    anisole 105.63
    cyclopentyl methyl ether 77.77
    gamma-butyrolactone 47.96
    1-methoxy-2-propanol 21.09
    pyridine 75.36
    3-pentanone 48.18
    furfural 46.34
    n-dodecane 3.38
    diethylene glycol 11.42
    diisopropyl ether 26.42
    tert-amyl alcohol 30.99
    acetylacetone 44.97
    n-hexadecane 4.12
    acetophenone 76.32
    methyl propionate 30.67
    isopentyl acetate 116.94
    trichloroethylene 163.25
    n-nonanol 35.32
    cyclohexanol 27.1
    benzyl alcohol 38.09
    2-ethylhexanol 49.61
    isooctanol 36.74
    dipropyl ether 85.0
    1,2-dichlorobenzene 71.05
    ethyl lactate 18.22
    propylene carbonate 35.67
    n-methylformamide 4.95
    2-pentanol 18.07
    n-pentane 5.71
    1-propoxy-2-propanol 62.56
    1-methoxy-2-propyl acetate 97.69
    2-(2-methoxypropoxy) propanol 93.69
    mesitylene 28.84
    ε-caprolactone 103.45
    p-cymene 39.94
    epichlorohydrin 102.66
    1,1,1-trichloroethane 88.33
    2-aminoethanol 1.5
    morpholine-4-carbaldehyde 61.35
    sulfolane 50.43
    2,2,4-trimethylpentane 8.02
    2-methyltetrahydrofuran 131.0
    n-hexyl acetate 114.6
    isooctane 4.94
    2-(2-butoxyethoxy)ethanol 105.34
    sec-butyl acetate 76.45
    tert-butyl acetate 72.07
    decalin 15.07
    glycerin 1.53
    diglyme 215.8
    acrylic acid 5.58
    isopropyl myristate 53.4
    n-butyric acid 30.13
    acetyl acetate 31.03
    di(2-ethylhexyl) phthalate 49.51
    ethyl propionate 60.76
    nitromethane 15.6
    1,2-diethoxyethane 163.27
    benzonitrile 31.69
    trioctyl phosphate 27.32
    1-bromopropane 80.46
    gamma-valerolactone 103.58
    n-decanol 23.84
    triethyl phosphate 51.55
    4-methyl-2-pentanol 18.72
    propionitrile 12.28
    vinylene carbonate 33.09
    1,1,2-trichlorotrifluoroethane 41.53
    DMS 42.07
    cumene 43.96
    2-octanol 24.21
    2-hexanone 78.48
    octyl acetate 59.2
    limonene 51.28
    1,2-dimethoxyethane 116.75
    ethyl orthosilicate 69.76
    tributyl phosphate 33.93
    diacetone alcohol 40.45
    N,N-dimethylaniline 73.9
    acrylonitrile 8.9
    aniline 32.32
    1,3-propanediol 5.54
    bromobenzene 92.43
    dibromomethane 114.22
    1,1,2,2-tetrachloroethane 138.03
    2-methyl-cyclohexyl acetate 111.0
    tetrabutyl urea 47.37
    diisobutyl methanol 29.8
    2-phenylethanol 62.14
    styrene 59.18
    dioctyl adipate 77.79
    dimethyl sulfate 14.19
    ethyl butyrate 96.31
    methyl lactate 7.26
    butyl lactate 44.52
    diethyl carbonate 52.66
    propanediol butyl ether 31.7
    triethyl orthoformate 99.28
    p-tert-butyltoluene 36.93
    methyl 4-tert-butylbenzoate 93.0
    morpholine 93.21
    tert-butylamine 11.52
    n-dodecanol 16.95
    dimethoxymethane 31.38
    ethylene carbonate 30.65
    cyrene 62.85
    2-ethoxyethyl acetate 123.46
    2-ethylhexyl acetate 120.49
    1,2,4-trichlorobenzene 83.52
    4-methylpyridine 82.69
    dibutyl ether 81.92
    2,6-dimethyl-4-heptanol 29.8
    DEF 49.5
    dimethyl isosorbide 177.8
    tetrachloroethylene 73.55
    eugenol 77.02
    triacetin 90.04
    span 80 70.37
    1,4-butanediol 3.3
    1,1-dichloroethane 58.68
    2-methyl-1-pentanol 51.86
    methyl formate 4.12
    2-methyl-1-butanol 30.77
    n-decane 8.03
    butyronitrile 20.32
    3,7-dimethyl-1-octanol 39.65
    1-chlorooctane 35.45
    1-chlorotetradecane 12.85
    n-nonane 6.41
    undecane 4.88
    tert-butylcyclohexane 14.48
    cyclooctane 6.71
    cyclopentanol 14.55
    tetrahydropyran 145.17
    tert-amyl methyl ether 72.25
    2,5,8-trioxanonane 148.06
    1-hexene 43.48
    2-isopropoxyethanol 45.25
    2,2,2-trifluoroethanol 3.24
    methyl butyrate 68.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction