gamma-Hydroxypropyl ethyl sulfide

Overview IFRA Request a quote

  • Identifiers

    CAS number
    18721-61-4

    Molecular formula
    C5H12OS

    SMILES
    CCSCCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sulfurous 81.98%
    Meaty 68.77%
    Onion 55.66%
    Vegetable 55.3%
    Savory 53.08%
    Garlic 49.95%
    Alliaceous 47.35%
    Potato 42.89%
    Roasted 41.87%
    Cooked 40.2%

     

    Flavor
    Sulfurous 68.57%
    Onion 52.99%
    Sweet 52.25%
    Vegetable 51.94%
    Sulfury 38.09%
    Potato 36.43%
    Garlic 34.66%
    Meaty 34.3%
    Fatty 31.68%
    Tomato 31.47%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    6.74 (neutral)

    Molecular weight
    120.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    206°C

    Flash point

    • 82.3 ˚C est.

  • Synonyms

    • 3-(Ethylthio)propanol
    • 18721-61-4
    • 3-(ethylthio)propan-1-ol
    • 1-Propanol, 3-(ethylthio)-
    • 3-ethylsulfanylpropan-1-ol
    • 3-(ethylsulfanyl)propan-1-ol
    • GV26YUE5ZT
    • 3-(ethylthio)-1-propanol
    • Ethyl 3-hydroxypropyl sulfide
    • EINECS 242-534-9
    • NSC-139001
    • gamma-Hydroxypropyl ethyl sulfide
    • DTXSID50171991
    • NSC 139001
    • .GAMMA.-HYDROXYPROPYL ETHYL SULFIDE
    • 3-ethyl thiopropanol
    • NSC139001
    • UNII-GV26YUE5ZT
    • 3-ethylsulfanyl-propan-1-ol
    • SCHEMBL698635
    • DTXCID1094482
    • MFCD00236041
    • STK695314
    • 3-(ETHYLSULFANYL)-1-PROPANOL
    • AKOS005606720
    • AS-58321
    • CS-0299691
    • NS00021788
    • G78110
    • EN300-1827425
    • 242-534-9

  • Applications

    gamma-Hydroxypropyl ethyl sulfide (CAS 18721-61-4) is typically used as an organic-synthesis intermediate and a processing aid in industrial manufacturing. It can serve as a building block for sulfur-containing polymers and specialty chemicals, and may function as a solvent or coupling agent in coatings, inks, and adhesive formulations. It also has potential as a precursor in polyol or resin systems employed in polymer chemistry, where its thioether and hydroxyl functionality enable functionalization steps. Use is subject to formulation needs and applicable regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2765.75
    methanol 2232.91
    isopropanol 2087.05
    water 2.81
    ethyl acetate 736.54
    n-propanol 1989.15
    acetone 1728.61
    n-butanol 1947.05
    acetonitrile 873.39
    DMF 1461.79
    toluene 241.36
    isobutanol 1180.5
    1,4-dioxane 1790.17
    methyl acetate 618.05
    THF 3256.36
    2-butanone 925.53
    n-pentanol 809.57
    sec-butanol 1204.46
    n-hexane 72.71
    ethylene glycol 509.63
    NMP 1056.21
    cyclohexane 224.3
    DMSO 3071.13
    n-butyl acetate 946.98
    n-octanol 359.14
    chloroform 1538.29
    n-propyl acetate 469.62
    acetic acid 1367.58
    dichloromethane 1518.46
    cyclohexanone 1901.55
    propylene glycol 669.69
    isopropyl acetate 397.49
    DMAc 532.4
    2-ethoxyethanol 839.23
    isopentanol 1046.56
    n-heptane 188.48
    ethyl formate 712.56
    1,2-dichloroethane 861.98
    n-hexanol 1156.55
    2-methoxyethanol 1839.78
    isobutyl acetate 273.01
    tetrachloromethane 323.36
    n-pentyl acetate 422.62
    transcutol 1839.21
    n-heptanol 423.5
    ethylbenzene 105.32
    MIBK 409.6
    2-propoxyethanol 1164.99
    tert-butanol 1544.71
    MTBE 602.15
    2-butoxyethanol 611.89
    propionic acid 1064.84
    o-xylene 154.17
    formic acid 354.82
    diethyl ether 759.27
    m-xylene 160.99
    p-xylene 141.99
    chlorobenzene 412.42
    dimethyl carbonate 132.5
    n-octane 49.02
    formamide 472.23
    cyclopentanone 2005.54
    2-pentanone 927.96
    anisole 274.28
    cyclopentyl methyl ether 966.82
    gamma-butyrolactone 1769.34
    1-methoxy-2-propanol 1190.55
    pyridine 1142.35
    3-pentanone 430.77
    furfural 1245.56
    n-dodecane 30.5
    diethylene glycol 809.33
    diisopropyl ether 179.58
    tert-amyl alcohol 842.8
    acetylacetone 724.91
    n-hexadecane 34.2
    acetophenone 267.76
    methyl propionate 464.82
    isopentyl acetate 599.44
    trichloroethylene 1419.36
    n-nonanol 288.44
    cyclohexanol 1242.74
    benzyl alcohol 323.64
    2-ethylhexanol 557.7
    isooctanol 292.11
    dipropyl ether 722.62
    1,2-dichlorobenzene 314.93
    ethyl lactate 200.28
    propylene carbonate 756.88
    n-methylformamide 971.22
    2-pentanol 895.41
    n-pentane 107.27
    1-propoxy-2-propanol 1001.74
    1-methoxy-2-propyl acetate 520.55
    2-(2-methoxypropoxy) propanol 350.47
    mesitylene 108.23
    ε-caprolactone 1238.24
    p-cymene 160.12
    epichlorohydrin 1477.1
    1,1,1-trichloroethane 737.55
    2-aminoethanol 971.54
    morpholine-4-carbaldehyde 1205.08
    sulfolane 1807.84
    2,2,4-trimethylpentane 41.84
    2-methyltetrahydrofuran 1903.39
    n-hexyl acetate 480.96
    isooctane 39.77
    2-(2-butoxyethoxy)ethanol 576.17
    sec-butyl acetate 240.92
    tert-butyl acetate 381.89
    decalin 54.61
    glycerin 683.53
    diglyme 1137.25
    acrylic acid 707.69
    isopropyl myristate 180.26
    n-butyric acid 1663.99
    acetyl acetate 337.38
    di(2-ethylhexyl) phthalate 165.72
    ethyl propionate 296.96
    nitromethane 1462.11
    1,2-diethoxyethane 722.99
    benzonitrile 521.19
    trioctyl phosphate 158.52
    1-bromopropane 597.66
    gamma-valerolactone 2143.12
    n-decanol 202.81
    triethyl phosphate 167.31
    4-methyl-2-pentanol 334.46
    propionitrile 825.18
    vinylene carbonate 668.38
    1,1,2-trichlorotrifluoroethane 888.24
    DMS 220.54
    cumene 80.04
    2-octanol 262.79
    2-hexanone 511.39
    octyl acetate 235.58
    limonene 320.16
    1,2-dimethoxyethane 1154.82
    ethyl orthosilicate 179.69
    tributyl phosphate 181.64
    diacetone alcohol 560.3
    N,N-dimethylaniline 163.8
    acrylonitrile 848.72
    aniline 474.97
    1,3-propanediol 1466.91
    bromobenzene 358.47
    dibromomethane 1033.38
    1,1,2,2-tetrachloroethane 1039.59
    2-methyl-cyclohexyl acetate 325.83
    tetrabutyl urea 251.69
    diisobutyl methanol 292.45
    2-phenylethanol 388.41
    styrene 148.18
    dioctyl adipate 264.19
    dimethyl sulfate 229.09
    ethyl butyrate 580.13
    methyl lactate 272.02
    butyl lactate 340.08
    diethyl carbonate 270.24
    propanediol butyl ether 523.19
    triethyl orthoformate 354.03
    p-tert-butyltoluene 144.59
    methyl 4-tert-butylbenzoate 281.15
    morpholine 2341.39
    tert-butylamine 883.76
    n-dodecanol 155.36
    dimethoxymethane 691.77
    ethylene carbonate 614.84
    cyrene 337.03
    2-ethoxyethyl acetate 438.76
    2-ethylhexyl acetate 447.48
    1,2,4-trichlorobenzene 379.51
    4-methylpyridine 868.71
    dibutyl ether 414.86
    2,6-dimethyl-4-heptanol 292.45
    DEF 780.19
    dimethyl isosorbide 588.26
    tetrachloroethylene 746.51
    eugenol 309.46
    triacetin 325.46
    span 80 459.6
    1,4-butanediol 456.08
    1,1-dichloroethane 891.93
    2-methyl-1-pentanol 486.37
    methyl formate 582.45
    2-methyl-1-butanol 902.77
    n-decane 56.28
    butyronitrile 1263.7
    3,7-dimethyl-1-octanol 311.61
    1-chlorooctane 192.72
    1-chlorotetradecane 74.32
    n-nonane 59.34
    undecane 39.42
    tert-butylcyclohexane 49.88
    cyclooctane 59.59
    cyclopentanol 1615.06
    tetrahydropyran 2280.27
    tert-amyl methyl ether 367.39
    2,5,8-trioxanonane 675.14
    1-hexene 262.49
    2-isopropoxyethanol 501.04
    2,2,2-trifluoroethanol 287.36
    methyl butyrate 517.72

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction