Galangin

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  • Identifiers

    CAS number
    548-83-4

    Molecular formula
    C15H10O5

    SMILES
    C1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 54.71%
    Phenolic 52.93%
    Burnt 36.08%
    Medicinal 23.16%
    Fruity 22.03%
    Smoky 22.01%
    Spicy 21.25%
    Bitter 20.97%
    Balsamic 19.69%
    Savory 19.25%

     

    Flavor
    Bitter 94.3%
    Odorless 21.59%
    Very strong 20.86%
    Cedarleaf 20.64%
    Indole 20.57%
    Sweet-like 20.49%
    Nitrile 20.39%
    Lovage 20.22%
    Parsley 19.63%
    Eugenol 19.62%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    9.73 (weak base)

    Molecular weight
    270.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    839°C

    Melting point expt.

    • 217 - 218 °C

    Flash point

    • 206.75 ˚C est.

  • Synonyms

    • Galangin
    • 548-83-4
    • Norizalpinin
    • 3,5,7-Trihydroxyflavone
    • 3,5,7-triOH-Flavone
    • 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl-
    • 3,5,7-Trihydroxy-2-phenyl-4-benzopyrone
    • 3,5,7-trihydroxy-2-phenylchromen-4-one
    • FLAVONE, 3,5,7-TRIHYDROXY-
    • 4H-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl-
    • 142FWE6ECS
    • NSC-407229
    • 3,5,7-trihydroxy-2-phenyl-4H-benzopyran-4-one
    • DTXSID70203288
    • CHEBI:5262
    • RefChem:142148
    • DTXCID70125779
    • 208-960-4
    • 3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one
    • MFCD00006833
    • 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
    • NSC407229
    • 3,5,7-trihydroxy-2-phenyl-chromen-4-one
    • CHEMBL309490
    • TNP00099
    • Norizalpinin;3,5,7-Trihydroxyflavone
    • EINECS 208-960-4
    • UNII-142FWE6ECS
    • NSC 407229
    • BRN 0272179
    • teptochrysin
    • CCRIS 8471
    • Galangin (Standard)
    • 3,7-Trihydroxyflavone
    • 5,7-Dihydroxyflavonol
    • GALANGIN [MI]
    • 3,5,7-Trihydroxy-Flavone
    • GTPL410
    • 5-18-04-00567 (Beilstein Handbook Reference)
    • MLS002473087
    • SCHEMBL117225
    • MEGxp0_000533
    • orb1303934
    • SCHEMBL29393121
    • ACon1_000977
    • cid_5281616
    • HY-N0382R
    • MSK7408
    • HMS2268D24
    • EX-A4261
    • HY-N0382
    • BDBM50049391
    • LMPK12111653
    • s5529
    • SBB063756
    • Galangin, autophagy inducing flavonoid
    • AKOS003672546
    • AC-6383
    • CCG-208629
    • CS-5619
    • EBC-157191
    • FG40127
    • NCGC00017220-01
    • NCGC00017220-02
    • NCGC00017220-03
    • NCGC00142457-01
    • NCGC00169794-01
    • AS-14766
    • SMR000112582
    • ST056288
    • G0370
    • NS00018339
    • 3,5,7-tris(oxidanyl)-2-phenyl-chromen-4-one
    • 3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one #
    • 4H-1-Benzopyran-4-one,5,7-trihydroxy-2-phenyl-
    • 548G834
    • SR-05000002165
    • Q2456591
    • SR-05000002165-2
    • BRD-K16503581-001-01-5
    • BRD-K16503581-001-04-9
    • Z1980554245
    • 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one, 9CI
    • 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl- (9CI)
    • 548-83-4

  • Applications

    Galangin (CAS 548-83-4) is a flavonol used across several industrial sectors as a natural antioxidant and a building block for chemical synthesis. In cosmetics and personal care, it is employed as an antioxidant additive and stabilizer in formulations to help protect active ingredients from oxidation. In polymers and coatings, it is explored as a natural antioxidant/stabilizer and a functional additive to improve aging resistance. In food processing and packaging, it is evaluated as a natural antioxidant and potential functional additive for extending shelf life. In pharmaceuticals and medicinal chemistry research, it serves as a useful scaffold for synthesis and a platform for flavonoid derivatives, supporting structure-activity studies. In agriculture, it is studied for antimicrobial activity against plant pathogens and as a potential lead compound for crop protection research.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.11
    methanol 6.3
    isopropanol 7.26
    water 0.0
    ethyl acetate 6.83
    n-propanol 8.36
    acetone 9.76
    n-butanol 9.1
    acetonitrile 2.83
    DMF 67.86
    toluene 0.74
    isobutanol 5.22
    1,4-dioxane 9.63
    methyl acetate 7.17
    THF 124.26
    2-butanone 18.29
    n-pentanol 5.5
    sec-butanol 8.57
    n-hexane 0.01
    ethylene glycol 5.22
    NMP 57.39
    cyclohexane 0.01
    DMSO 434.79
    n-butyl acetate 7.13
    n-octanol 4.34
    chloroform 0.04
    n-propyl acetate 5.87
    acetic acid 7.32
    dichloromethane 0.08
    cyclohexanone 21.08
    propylene glycol 7.58
    isopropyl acetate 6.39
    DMAc 77.63
    2-ethoxyethanol 22.93
    isopentanol 8.69
    n-heptane 0.04
    ethyl formate 4.55
    1,2-dichloroethane 0.62
    n-hexanol 5.75
    2-methoxyethanol 77.64
    isobutyl acetate 2.39
    tetrachloromethane 0.02
    n-pentyl acetate 5.51
    transcutol 71.27
    n-heptanol 4.03
    ethylbenzene 0.47
    MIBK 8.92
    2-propoxyethanol 33.24
    tert-butanol 9.38
    MTBE 3.65
    2-butoxyethanol 15.74
    propionic acid 5.82
    o-xylene 0.71
    formic acid 4.47
    diethyl ether 2.49
    m-xylene 0.62
    p-xylene 0.49
    chlorobenzene 0.35
    dimethyl carbonate 5.34
    n-octane 0.02
    formamide 13.03
    cyclopentanone 50.72
    2-pentanone 14.13
    anisole 2.66
    cyclopentyl methyl ether 14.02
    gamma-butyrolactone 39.31
    1-methoxy-2-propanol 60.03
    pyridine 9.88
    3-pentanone 5.96
    furfural 22.49
    n-dodecane 0.07
    diethylene glycol 31.08
    diisopropyl ether 0.68
    tert-amyl alcohol 9.62
    acetylacetone 18.63
    n-hexadecane 0.09
    acetophenone 5.08
    methyl propionate 9.55
    isopentyl acetate 6.52
    trichloroethylene 1.11
    n-nonanol 4.56
    cyclohexanol 7.44
    benzyl alcohol 5.3
    2-ethylhexanol 3.76
    isooctanol 3.35
    dipropyl ether 3.05
    1,2-dichlorobenzene 0.42
    ethyl lactate 7.69
    propylene carbonate 9.76
    n-methylformamide 18.12
    2-pentanol 6.28
    n-pentane 0.02
    1-propoxy-2-propanol 24.86
    1-methoxy-2-propyl acetate 17.19
    2-(2-methoxypropoxy) propanol 19.16
    mesitylene 0.33
    ε-caprolactone 19.07
    p-cymene 0.92
    epichlorohydrin 41.88
    1,1,1-trichloroethane 0.21
    2-aminoethanol 9.91
    morpholine-4-carbaldehyde 43.31
    sulfolane 104.32
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 25.82
    n-hexyl acetate 7.96
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 27.32
    sec-butyl acetate 4.06
    tert-butyl acetate 8.66
    decalin 0.05
    glycerin 25.31
    diglyme 43.38
    acrylic acid 6.3
    isopropyl myristate 3.3
    n-butyric acid 9.73
    acetyl acetate 2.97
    di(2-ethylhexyl) phthalate 3.56
    ethyl propionate 5.49
    nitromethane 22.29
    1,2-diethoxyethane 9.99
    benzonitrile 3.67
    trioctyl phosphate 3.14
    1-bromopropane 0.37
    gamma-valerolactone 62.29
    n-decanol 3.31
    triethyl phosphate 3.41
    4-methyl-2-pentanol 4.04
    propionitrile 4.31
    vinylene carbonate 5.89
    1,1,2-trichlorotrifluoroethane 27.66
    DMS 6.82
    cumene 0.39
    2-octanol 3.13
    2-hexanone 9.38
    octyl acetate 4.31
    limonene 1.41
    1,2-dimethoxyethane 33.44
    ethyl orthosilicate 2.92
    tributyl phosphate 3.62
    diacetone alcohol 32.56
    N,N-dimethylaniline 2.33
    acrylonitrile 7.85
    aniline 3.69
    1,3-propanediol 23.42
    bromobenzene 0.18
    dibromomethane 0.06
    1,1,2,2-tetrachloroethane 1.19
    2-methyl-cyclohexyl acetate 4.3
    tetrabutyl urea 6.1
    diisobutyl methanol 2.77
    2-phenylethanol 6.47
    styrene 0.4
    dioctyl adipate 4.97
    dimethyl sulfate 16.25
    ethyl butyrate 5.31
    methyl lactate 18.51
    butyl lactate 8.95
    diethyl carbonate 2.66
    propanediol butyl ether 17.05
    triethyl orthoformate 4.52
    p-tert-butyltoluene 0.9
    methyl 4-tert-butylbenzoate 8.17
    morpholine 32.22
    tert-butylamine 2.13
    n-dodecanol 2.26
    dimethoxymethane 31.32
    ethylene carbonate 4.7
    cyrene 17.5
    2-ethoxyethyl acetate 9.71
    2-ethylhexyl acetate 4.39
    1,2,4-trichlorobenzene 0.99
    4-methylpyridine 8.79
    dibutyl ether 3.84
    2,6-dimethyl-4-heptanol 2.77
    DEF 21.02
    dimethyl isosorbide 29.17
    tetrachloroethylene 0.5
    eugenol 9.64
    triacetin 8.45
    span 80 12.81
    1,4-butanediol 4.39
    1,1-dichloroethane 0.22
    2-methyl-1-pentanol 6.01
    methyl formate 9.4
    2-methyl-1-butanol 7.58
    n-decane 0.11
    butyronitrile 5.33
    3,7-dimethyl-1-octanol 4.07
    1-chlorooctane 0.91
    1-chlorotetradecane 0.39
    n-nonane 0.06
    undecane 0.09
    tert-butylcyclohexane 0.05
    cyclooctane 0.01
    cyclopentanol 10.79
    tetrahydropyran 9.11
    tert-amyl methyl ether 5.0
    2,5,8-trioxanonane 29.72
    1-hexene 0.17
    2-isopropoxyethanol 12.87
    2,2,2-trifluoroethanol 2.36
    methyl butyrate 8.51

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction