Galangin 3-methyl ether

Overview IFRA Request a quote

  • Identifiers

    CAS number
    6665-74-3

    Molecular formula
    C16H12O5

    SMILES
    COC1=C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 53.3%
    Odorless 40.28%
    Burnt 33.59%
    Fruity 31.47%
    Spicy 27.6%
    Smoky 25.08%
    Vanilla 24.33%
    Medicinal 24.28%
    Sweet 23.86%
    Balsamic 23.67%

     

    Flavor
    Bitter 91.36%
    Cedarleaf 20.64%
    Parsley 20.62%
    Lovage 20.54%
    Odorless 20.08%
    Very strong 20.0%
    Eugenol 19.94%
    Indole 19.9%
    Sweet-like 19.82%
    Nitrile 19.64%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    9.25 (weak base)

    Molecular weight
    284.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    698°C

    Melting point expt.

    • 299 °C

    Flash point

    • 197.03 ˚C est.

  • Synonyms

    • Galangin 3-methyl ether
    • 6665-74-3
    • 3-O-Methylgalangin
    • 3-Methylgalangin
    • 5,7-Dihydroxy-3-methoxyflavone
    • 5,7-Dihydroxy-3-methoxy-2-phenyl-4H-1-benzopyran-4-one
    • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-methoxy-2-phenyl-
    • 02887TX99X
    • CHEBI:1602
    • DTXSID20216823
    • RefChem:922007
    • DTXCID50139314
    • GALANGIN-3-METHYLETHER
    • 5,7-dihydroxy-3-methoxy-2-phenylchromen-4-one
    • 5,7-dihydroxy-3-methoxy-2-phenyl-4H-chromen-4-one
    • Galangin 3-O-methyl ether
    • CHEMBL1822221
    • MFCD03864942
    • Galangin 3-methyl ether;3-Methylgalangin
    • UNII-02887TX99X
    • Galangin3-O-methylether
    • galangin-3-methyl ether
    • orb1301565
    • SCHEMBL4631662
    • HY-N4167
    • BDBM50423814
    • LMPK12111654
    • s3307
    • AKOS015906503
    • CCG-214442
    • EBC-521525
    • AC-34262
    • DA-63668
    • MS-24038
    • FLAVONE, 5,7-DIHYDROXY-3-METHOXY-
    • CS-0032292
    • G13252
    • 5,7-dihydroxy-3-methoxy-2-phenyl-chromen-4-one
    • AN-829/41530199
    • Q27105478
    • 6665-74-3

  • Applications

    Galangin 3-methyl ether (CAS 6665-74-3) can be used as an intermediate in organic synthesis and pharmaceutical research. Its polyphenolic structure suggests antioxidant and stabilizing potential, making it of interest for cosmetic and personal care formulations as an antioxidant and stabilizer for oils, creams, and other skin-care formulations. It may be employed as an additive in polymers and plastics to improve material stability and longevity, and as an antioxidant in coatings and inks. As a flavonoid derivative, it can serve as a precursor for the synthesis of related flavonoid compounds in chemical manufacturing and formulation development. These applications are typically subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.84
    methanol 2.24
    isopropanol 2.28
    water 0.0
    ethyl acetate 3.13
    n-propanol 3.11
    acetone 8.82
    n-butanol 2.98
    acetonitrile 2.96
    DMF 54.04
    toluene 0.85
    isobutanol 2.54
    1,4-dioxane 8.16
    methyl acetate 4.66
    THF 59.55
    2-butanone 9.32
    n-pentanol 3.29
    sec-butanol 2.5
    n-hexane 0.02
    ethylene glycol 3.26
    NMP 61.25
    cyclohexane 0.04
    DMSO 208.77
    n-butyl acetate 4.59
    n-octanol 2.48
    chloroform 1.08
    n-propyl acetate 4.56
    acetic acid 9.62
    dichloromethane 2.29
    cyclohexanone 19.54
    propylene glycol 4.38
    isopropyl acetate 2.75
    DMAc 49.96
    2-ethoxyethanol 13.7
    isopentanol 3.66
    n-heptane 0.05
    ethyl formate 4.37
    1,2-dichloroethane 3.72
    n-hexanol 3.1
    2-methoxyethanol 36.13
    isobutyl acetate 3.2
    tetrachloromethane 0.11
    n-pentyl acetate 4.14
    transcutol 51.34
    n-heptanol 2.6
    ethylbenzene 0.6
    MIBK 4.76
    2-propoxyethanol 18.04
    tert-butanol 3.72
    MTBE 1.33
    2-butoxyethanol 11.23
    propionic acid 5.19
    o-xylene 0.76
    formic acid 4.65
    diethyl ether 0.92
    m-xylene 0.72
    p-xylene 0.9
    chlorobenzene 1.38
    dimethyl carbonate 5.06
    n-octane 0.03
    formamide 11.75
    cyclopentanone 39.53
    2-pentanone 6.35
    anisole 2.68
    cyclopentyl methyl ether 7.56
    gamma-butyrolactone 40.78
    1-methoxy-2-propanol 24.12
    pyridine 11.5
    3-pentanone 3.46
    furfural 33.83
    n-dodecane 0.08
    diethylene glycol 24.4
    diisopropyl ether 0.32
    tert-amyl alcohol 3.02
    acetylacetone 12.04
    n-hexadecane 0.1
    acetophenone 6.38
    methyl propionate 5.63
    isopentyl acetate 5.04
    trichloroethylene 8.89
    n-nonanol 2.73
    cyclohexanol 4.41
    benzyl alcohol 5.89
    2-ethylhexanol 2.45
    isooctanol 2.58
    dipropyl ether 1.66
    1,2-dichlorobenzene 1.63
    ethyl lactate 6.57
    propylene carbonate 13.28
    n-methylformamide 14.14
    2-pentanol 1.78
    n-pentane 0.02
    1-propoxy-2-propanol 12.43
    1-methoxy-2-propyl acetate 10.6
    2-(2-methoxypropoxy) propanol 14.79
    mesitylene 0.43
    ε-caprolactone 16.75
    p-cymene 1.03
    epichlorohydrin 47.93
    1,1,1-trichloroethane 1.1
    2-aminoethanol 5.33
    morpholine-4-carbaldehyde 42.65
    sulfolane 98.87
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 12.65
    n-hexyl acetate 5.63
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 19.71
    sec-butyl acetate 2.65
    tert-butyl acetate 4.33
    decalin 0.09
    glycerin 17.32
    diglyme 34.6
    acrylic acid 7.9
    isopropyl myristate 2.34
    n-butyric acid 6.55
    acetyl acetate 2.63
    di(2-ethylhexyl) phthalate 4.5
    ethyl propionate 3.57
    nitromethane 24.01
    1,2-diethoxyethane 6.53
    benzonitrile 5.39
    trioctyl phosphate 3.15
    1-bromopropane 0.98
    gamma-valerolactone 56.95
    n-decanol 2.1
    triethyl phosphate 3.65
    4-methyl-2-pentanol 1.7
    propionitrile 3.13
    vinylene carbonate 10.3
    1,1,2-trichlorotrifluoroethane 42.85
    DMS 6.88
    cumene 0.56
    2-octanol 1.67
    2-hexanone 6.54
    octyl acetate 3.32
    limonene 1.38
    1,2-dimethoxyethane 22.39
    ethyl orthosilicate 3.1
    tributyl phosphate 3.83
    diacetone alcohol 16.01
    N,N-dimethylaniline 2.64
    acrylonitrile 7.35
    aniline 3.57
    1,3-propanediol 10.48
    bromobenzene 0.89
    dibromomethane 1.02
    1,1,2,2-tetrachloroethane 6.77
    2-methyl-cyclohexyl acetate 4.83
    tetrabutyl urea 6.27
    diisobutyl methanol 1.72
    2-phenylethanol 6.36
    styrene 0.63
    dioctyl adipate 5.13
    dimethyl sulfate 17.28
    ethyl butyrate 3.89
    methyl lactate 12.08
    butyl lactate 7.5
    diethyl carbonate 2.86
    propanediol butyl ether 12.58
    triethyl orthoformate 3.8
    p-tert-butyltoluene 0.94
    methyl 4-tert-butylbenzoate 8.47
    morpholine 18.37
    tert-butylamine 1.08
    n-dodecanol 1.56
    dimethoxymethane 19.57
    ethylene carbonate 7.17
    cyrene 19.89
    2-ethoxyethyl acetate 8.0
    2-ethylhexyl acetate 3.67
    1,2,4-trichlorobenzene 3.17
    4-methylpyridine 8.04
    dibutyl ether 2.14
    2,6-dimethyl-4-heptanol 1.72
    DEF 10.38
    dimethyl isosorbide 26.16
    tetrachloroethylene 3.07
    eugenol 10.11
    triacetin 8.23
    span 80 11.16
    1,4-butanediol 3.47
    1,1-dichloroethane 1.17
    2-methyl-1-pentanol 3.77
    methyl formate 11.29
    2-methyl-1-butanol 3.13
    n-decane 0.11
    butyronitrile 3.35
    3,7-dimethyl-1-octanol 2.7
    1-chlorooctane 0.79
    1-chlorotetradecane 0.41
    n-nonane 0.07
    undecane 0.09
    tert-butylcyclohexane 0.08
    cyclooctane 0.02
    cyclopentanol 7.37
    tetrahydropyran 5.48
    tert-amyl methyl ether 1.69
    2,5,8-trioxanonane 24.75
    1-hexene 0.23
    2-isopropoxyethanol 8.61
    2,2,2-trifluoroethanol 3.67
    methyl butyrate 6.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction