(+)-Fucose

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  • Identifiers

    CAS number
    3615-37-0

    Molecular formula
    C6H12O5

    SMILES
    C[C@H]([C@@H]([C@@H]([C@H](C=O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 68.48%
    Sweet 36.78%
    Caramellic 29.56%
    Buttery 28.01%
    Milky 20.63%
    Savory 18.96%
    Bitter 17.13%
    Sharp 16.38%
    Creamy 15.81%
    Fruity 14.97%

     

    Flavor
    Odorless 62.42%
    Sweet 30.9%
    Sweet-like 28.48%
    Very mild 25.68%
    Very slight 21.15%
    Mild 20.78%
    Yeast 19.61%
    Bland 19.59%
    Fruity 19.35%
    Acetoin 19.25%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.4

    pKa est.
    5.11 (weak acid)

    Molecular weight
    164.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    474°C

    Flash point

    • 175.84 ˚C est.

  • Synonyms

    • 3615-37-0
    • (2R,3S,4S,5R)-2,3,4,5-tetrahydroxyhexanal
    • (+)-fucose
    • D-Galactose, 6-deoxy-
    • Rhodeose
    • 603I57Y449
    • DTXSID80883994
    • RefChem:583625
    • GlyTouCan:G02671KD
    • CHEBI:28847
    • DTXCID801023469
    • G02671KD
    • 222-792-9
    • (2S,3R,4S,5R,6R)-6-methyloxane-2,3,4,5-tetrol
    • D-Fucose
    • D-(+)-Fucose
    • D(+)-Fucose
    • aldehydo-D-fucose
    • MFCD00135603
    • Fucose, D-
    • 6-Deoxy-D-Galactose , D-(+)-Rhodeose
    • UNII-603I57Y449
    • EINECS 222-792-9
    • D-FUCOSE [MI]
    • D-(+)-Fucose (Standard)
    • SCHEMBL21210
    • GTPL4722
    • orb1304739
    • CHEMBL3343362
    • CHEBI:48203
    • HY-N5102R
    • D-(+)-Fucose, >=98%
    • HY-N5102
    • GEO-01439
    • MSK012285
    • AKOS015924852
    • MF00381
    • AS-35297
    • DA-52275
    • SY112105
    • CS-0032367
    • NS00083126
    • 615D370
    • Rel-(2R,3S,4S,5R)-2,3,4,5-tetrahydroxyhexanal
    • Q27077034
    • 3615-37-0

  • Applications

    (+)-Fucose (CAS 3615-37-0) is primarily used as a chiral building block and glycosyl donor in carbohydrate chemistry and drug research. It serves as an intermediate for the synthesis of fucosylated oligosaccharides and glycosides, enabling the production of glycoconjugates and glycoforms relevant to medicinal chemistry. It also functions as a reference material or analytical standard for monosaccharide analysis in laboratories (e.g., HPLC/LC-MS). In research contexts, it is used to study fucosylation enzymes and glycoengineering approaches, and it may be employed as a precursor in polymer or biomaterial synthesis when glycosylation motifs are required. Applications are typically exploratory and subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.39
    methanol 26.16
    isopropanol 2.11
    water 972.18
    ethyl acetate 1.55
    n-propanol 3.56
    acetone 1.65
    n-butanol 2.44
    acetonitrile 1.58
    DMF 122.04
    toluene 0.26
    isobutanol 2.14
    1,4-dioxane 6.72
    methyl acetate 1.28
    THF 6.59
    2-butanone 1.71
    n-pentanol 1.15
    sec-butanol 3.32
    n-hexane 0.11
    ethylene glycol 206.51
    NMP 134.24
    cyclohexane 0.7
    DMSO 388.9
    n-butyl acetate 0.92
    n-octanol 1.57
    chloroform 0.28
    n-propyl acetate 0.75
    acetic acid 32.08
    dichloromethane 0.52
    cyclohexanone 5.64
    propylene glycol 68.08
    isopropyl acetate 1.25
    DMAc 81.76
    2-ethoxyethanol 21.72
    isopentanol 2.29
    n-heptane 0.63
    ethyl formate 2.2
    1,2-dichloroethane 0.74
    n-hexanol 2.49
    2-methoxyethanol 71.19
    isobutyl acetate 0.45
    tetrachloromethane 0.35
    n-pentyl acetate 0.85
    transcutol 23.25
    n-heptanol 2.16
    ethylbenzene 0.3
    MIBK 1.84
    2-propoxyethanol 14.69
    tert-butanol 5.04
    MTBE 1.21
    2-butoxyethanol 8.05
    propionic acid 11.36
    o-xylene 0.83
    formic acid 484.76
    diethyl ether 0.77
    m-xylene 0.63
    p-xylene 0.36
    chlorobenzene 0.2
    dimethyl carbonate 4.28
    n-octane 0.26
    formamide 254.04
    cyclopentanone 7.35
    2-pentanone 1.72
    anisole 1.01
    cyclopentyl methyl ether 3.48
    gamma-butyrolactone 12.94
    1-methoxy-2-propanol 29.52
    pyridine 1.52
    3-pentanone 1.81
    furfural 18.09
    n-dodecane 0.16
    diethylene glycol 60.89
    diisopropyl ether 0.56
    tert-amyl alcohol 6.07
    acetylacetone 5.04
    n-hexadecane 0.17
    acetophenone 2.23
    methyl propionate 3.27
    isopentyl acetate 1.02
    trichloroethylene 0.9
    n-nonanol 1.47
    cyclohexanol 5.49
    benzyl alcohol 2.49
    2-ethylhexanol 1.71
    isooctanol 1.91
    dipropyl ether 1.43
    1,2-dichlorobenzene 0.48
    ethyl lactate 5.37
    propylene carbonate 5.7
    n-methylformamide 48.13
    2-pentanol 1.78
    n-pentane 0.18
    1-propoxy-2-propanol 8.29
    1-methoxy-2-propyl acetate 3.96
    2-(2-methoxypropoxy) propanol 10.78
    mesitylene 0.78
    ε-caprolactone 7.43
    p-cymene 0.84
    epichlorohydrin 4.61
    1,1,1-trichloroethane 0.28
    2-aminoethanol 91.18
    morpholine-4-carbaldehyde 81.33
    sulfolane 83.14
    2,2,4-trimethylpentane 0.25
    2-methyltetrahydrofuran 3.28
    n-hexyl acetate 1.34
    isooctane 0.15
    2-(2-butoxyethoxy)ethanol 12.89
    sec-butyl acetate 0.63
    tert-butyl acetate 2.12
    decalin 0.27
    glycerin 235.58
    diglyme 21.47
    acrylic acid 21.79
    isopropyl myristate 0.74
    n-butyric acid 6.66
    acetyl acetate 1.76
    di(2-ethylhexyl) phthalate 1.89
    ethyl propionate 1.19
    nitromethane 24.48
    1,2-diethoxyethane 1.63
    benzonitrile 0.93
    trioctyl phosphate 1.71
    1-bromopropane 0.22
    gamma-valerolactone 24.62
    n-decanol 1.16
    triethyl phosphate 2.1
    4-methyl-2-pentanol 1.62
    propionitrile 0.96
    vinylene carbonate 4.8
    1,1,2-trichlorotrifluoroethane 31.99
    DMS 2.03
    cumene 0.42
    2-octanol 1.19
    2-hexanone 0.78
    octyl acetate 1.06
    limonene 1.44
    1,2-dimethoxyethane 10.85
    ethyl orthosilicate 1.81
    tributyl phosphate 1.41
    diacetone alcohol 11.21
    N,N-dimethylaniline 2.06
    acrylonitrile 2.27
    aniline 1.16
    1,3-propanediol 49.89
    bromobenzene 0.15
    dibromomethane 0.32
    1,1,2,2-tetrachloroethane 1.27
    2-methyl-cyclohexyl acetate 1.84
    tetrabutyl urea 2.9
    diisobutyl methanol 1.73
    2-phenylethanol 2.51
    styrene 0.23
    dioctyl adipate 1.65
    dimethyl sulfate 20.2
    ethyl butyrate 1.39
    methyl lactate 19.59
    butyl lactate 3.03
    diethyl carbonate 0.95
    propanediol butyl ether 11.38
    triethyl orthoformate 1.68
    p-tert-butyltoluene 0.96
    methyl 4-tert-butylbenzoate 5.41
    morpholine 11.44
    tert-butylamine 1.7
    n-dodecanol 0.96
    dimethoxymethane 14.81
    ethylene carbonate 3.49
    cyrene 27.67
    2-ethoxyethyl acetate 1.7
    2-ethylhexyl acetate 0.78
    1,2,4-trichlorobenzene 0.69
    4-methylpyridine 1.16
    dibutyl ether 0.66
    2,6-dimethyl-4-heptanol 1.73
    DEF 11.88
    dimethyl isosorbide 17.32
    tetrachloroethylene 1.56
    eugenol 6.92
    triacetin 3.54
    span 80 9.53
    1,4-butanediol 17.84
    1,1-dichloroethane 0.19
    2-methyl-1-pentanol 1.4
    methyl formate 19.92
    2-methyl-1-butanol 2.66
    n-decane 0.24
    butyronitrile 0.78
    3,7-dimethyl-1-octanol 1.57
    1-chlorooctane 0.45
    1-chlorotetradecane 0.26
    n-nonane 0.25
    undecane 0.19
    tert-butylcyclohexane 0.19
    cyclooctane 0.49
    cyclopentanol 7.29
    tetrahydropyran 2.0
    tert-amyl methyl ether 2.07
    2,5,8-trioxanonane 21.36
    1-hexene 0.16
    2-isopropoxyethanol 8.28
    2,2,2-trifluoroethanol 41.47
    methyl butyrate 1.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction