Fortunellin

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  • Identifiers

    CAS number
    20633-93-6

    Molecular formula
    C28H32O14

    SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)OC)O)CO)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 70.31%
    Vanilla 36.44%
    Sweet 34.85%
    Milky 23.53%
    Phenolic 22.92%
    Creamy 21.26%
    Savory 19.95%
    Bitter 19.79%
    Smoky 17.59%
    Spicy 17.56%

     

    Flavor
    Bitter 74.9%
    Bland 31.58%
    Odorless 30.83%
    Sweet-like 27.38%
    Cedarleaf 20.63%
    Parsley 19.68%
    Eugenol 19.46%
    Very slight 19.4%
    Lovage 19.34%
    Naphthalic 19.33%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    6.65 (neutral)

    Molecular weight
    592.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    5093°C

    Flash point

    • 270.34 ˚C est.

  • Synonyms

    • Fortunellin
    • 20633-93-6
    • DTXSID00861996
    • 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-methoxyphenyl)chromen-4-one
    • 7-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxy-5-hydroxy-2-(4-methoxyphenyl)chromen-4-one
    • RefChem:141361
    • DTXCID201776151
    • 7-((2S,4R,5S)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,4S,5R)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxy-5-hydroxy-2-(4-methoxyphenyl)chromen-4-one;hydrate
    • MFCD00063944
    • acacetin7 neo hesperside
    • Acacetin-7-neohesperidoside
    • orb1682554
    • SCHEMBL4649125
    • SCHEMBL30620890
    • MLWDGPFGTFOLRJ-CUVHLRMHSA-N
    • MSK158720
    • AKOS040761748
    • EBC-618363
    • FS-6820
    • OA71574
    • 7-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
    • HY-119678
    • CS-0077805
    • Q63409698
    • 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-
    • 5-Hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
    • 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-5-hydroxy-2-(4-methoxyphenyl)chromen-4-one
    • 7-[[2-O-(6-7-[[2-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4- one
    • 20633-93-6

  • Applications

    Fortunellin (CAS 20633-93-6) is primarily encountered as a natural product or synthetic intermediate, serving as a building block for flavonoid derivatives in chemical synthesis and medicinal chemistry research. It is studied for antioxidant activity, with potential applications in cosmetics and personal care as a research ingredient within regulatory limits. In pharmaceutical and biomedical research, Fortunellin is often evaluated as a tool compound to explore flavonoid biosynthesis and bioactivity. It is also used as an analytical reference standard in the analysis of plant extracts containing citrus-type flavonoids and may appear in method development for quality control. These roles are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.13
    methanol 1.6
    isopropanol 0.06
    water 0.03
    ethyl acetate 0.02
    n-propanol 0.2
    acetone 0.07
    n-butanol 0.11
    acetonitrile 0.02
    DMF 4.26
    toluene 0.01
    isobutanol 0.06
    1,4-dioxane 0.65
    methyl acetate 0.06
    THF 0.72
    2-butanone 0.11
    n-pentanol 0.06
    sec-butanol 0.09
    n-hexane 0.0
    ethylene glycol 1.82
    NMP 5.94
    cyclohexane 0.0
    DMSO 5.51
    n-butyl acetate 0.01
    n-octanol 0.06
    chloroform 0.02
    n-propyl acetate 0.02
    acetic acid 1.09
    dichloromethane 0.04
    cyclohexanone 0.19
    propylene glycol 2.38
    isopropyl acetate 0.01
    DMAc 4.16
    2-ethoxyethanol 1.3
    isopentanol 0.05
    n-heptane 0.0
    ethyl formate 0.07
    1,2-dichloroethane 0.03
    n-hexanol 0.02
    2-methoxyethanol 4.96
    isobutyl acetate 0.01
    tetrachloromethane 0.0
    n-pentyl acetate 0.05
    transcutol 3.29
    n-heptanol 0.07
    ethylbenzene 0.0
    MIBK 0.02
    2-propoxyethanol 0.7
    tert-butanol 0.03
    MTBE 0.02
    2-butoxyethanol 0.87
    propionic acid 0.31
    o-xylene 0.01
    formic acid 5.17
    diethyl ether 0.02
    m-xylene 0.01
    p-xylene 0.0
    chlorobenzene 0.0
    dimethyl carbonate 0.14
    n-octane 0.0
    formamide 3.07
    cyclopentanone 0.41
    2-pentanone 0.05
    anisole 0.02
    cyclopentyl methyl ether 0.07
    gamma-butyrolactone 0.59
    1-methoxy-2-propanol 1.77
    pyridine 0.19
    3-pentanone 0.04
    furfural 0.93
    n-dodecane 0.0
    diethylene glycol 1.84
    diisopropyl ether 0.0
    tert-amyl alcohol 0.05
    acetylacetone 0.09
    n-hexadecane 0.0
    acetophenone 0.03
    methyl propionate 0.07
    isopentyl acetate 0.01
    trichloroethylene 0.06
    n-nonanol 0.07
    cyclohexanol 0.07
    benzyl alcohol 0.07
    2-ethylhexanol 0.01
    isooctanol 0.04
    dipropyl ether 0.03
    1,2-dichlorobenzene 0.01
    ethyl lactate 0.12
    propylene carbonate 0.11
    n-methylformamide 1.61
    2-pentanol 0.03
    n-pentane 0.0
    1-propoxy-2-propanol 0.34
    1-methoxy-2-propyl acetate 0.09
    2-(2-methoxypropoxy) propanol 0.8
    mesitylene 0.0
    ε-caprolactone 0.23
    p-cymene 0.0
    epichlorohydrin 0.47
    1,1,1-trichloroethane 0.0
    2-aminoethanol 1.82
    morpholine-4-carbaldehyde 6.06
    sulfolane 3.15
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.13
    n-hexyl acetate 0.06
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 1.26
    sec-butyl acetate 0.01
    tert-butyl acetate 0.01
    decalin 0.0
    glycerin 10.21
    diglyme 2.29
    acrylic acid 0.78
    isopropyl myristate 0.01
    n-butyric acid 0.15
    acetyl acetate 0.02
    di(2-ethylhexyl) phthalate 0.06
    ethyl propionate 0.02
    nitromethane 1.09
    1,2-diethoxyethane 0.11
    benzonitrile 0.02
    trioctyl phosphate 0.04
    1-bromopropane 0.01
    gamma-valerolactone 2.79
    n-decanol 0.04
    triethyl phosphate 0.02
    4-methyl-2-pentanol 0.01
    propionitrile 0.03
    vinylene carbonate 0.14
    1,1,2-trichlorotrifluoroethane 2.68
    DMS 0.06
    cumene 0.0
    2-octanol 0.03
    2-hexanone 0.03
    octyl acetate 0.04
    limonene 0.01
    1,2-dimethoxyethane 0.87
    ethyl orthosilicate 0.02
    tributyl phosphate 0.03
    diacetone alcohol 0.16
    N,N-dimethylaniline 0.02
    acrylonitrile 0.08
    aniline 0.05
    1,3-propanediol 1.36
    bromobenzene 0.0
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.06
    2-methyl-cyclohexyl acetate 0.02
    tetrabutyl urea 0.08
    diisobutyl methanol 0.01
    2-phenylethanol 0.03
    styrene 0.0
    dioctyl adipate 0.06
    dimethyl sulfate 0.58
    ethyl butyrate 0.02
    methyl lactate 0.74
    butyl lactate 0.21
    diethyl carbonate 0.01
    propanediol butyl ether 1.42
    triethyl orthoformate 0.04
    p-tert-butyltoluene 0.0
    methyl 4-tert-butylbenzoate 0.17
    morpholine 1.23
    tert-butylamine 0.01
    n-dodecanol 0.02
    dimethoxymethane 0.96
    ethylene carbonate 0.08
    cyrene 1.27
    2-ethoxyethyl acetate 0.16
    2-ethylhexyl acetate 0.01
    1,2,4-trichlorobenzene 0.01
    4-methylpyridine 0.06
    dibutyl ether 0.02
    2,6-dimethyl-4-heptanol 0.01
    DEF 0.21
    dimethyl isosorbide 0.73
    tetrachloroethylene 0.04
    eugenol 0.26
    triacetin 0.22
    span 80 0.72
    1,4-butanediol 0.39
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.03
    methyl formate 0.9
    2-methyl-1-butanol 0.07
    n-decane 0.0
    butyronitrile 0.02
    3,7-dimethyl-1-octanol 0.02
    1-chlorooctane 0.01
    1-chlorotetradecane 0.0
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.14
    tetrahydropyran 0.1
    tert-amyl methyl ether 0.02
    2,5,8-trioxanonane 1.61
    1-hexene 0.0
    2-isopropoxyethanol 0.32
    2,2,2-trifluoroethanol 0.51
    methyl butyrate 0.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction