Forskolin

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  • Identifiers

    CAS number
    66575-29-9

    Molecular formula
    C22H34O7

    SMILES
    CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 46.5%
    Odorless 40.01%
    Sweet 38.23%
    Mint 30.77%
    Spicy 30.06%
    Cooling 26.42%
    Herbal 25.28%
    Fresh 24.26%
    Camphoreous 24.16%
    Dry 23.91%

     

    Flavor
    Bitter 63.51%
    Fruity 32.13%
    Woody 30.53%
    Minty 30.04%
    Sweet 26.91%
    Herbal 24.21%
    Cedarleaf 21.2%
    Camphor 20.93%
    Ripe apricot 20.91%
    Fir 20.75%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    6.86 (neutral)

    Molecular weight
    410.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    328°C

    Flash point

    • 213.04 ˚C est.

  • Synonyms

    • forskolin
    • Colforsin
    • 66575-29-9
    • Coleonol
    • colforsina
    • colforsine
    • colforsinum
    • Boforsin
    • Coleonolk
    • HL 362
    • L 75 1362B
    • HL-362
    • 7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one
    • 1F7A44V6OU
    • DTXSID8040484
    • L-751362B
    • NSC-357088
    • NSC-375489
    • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate
    • [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
    • DTXCID6020484
    • L-75-1362B
    • CHEBI:42471
    • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-5-yl acetate
    • ((3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo(f)chromen-5-yl) acetate
    • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho(2,1-b)pyran-5-yl acetate
    • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo(f)chromen-5-yl acetate
    • RefChem:578508
    • 266-410-9
    • N,N-dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester HCl
    • MFCD00082317
    • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate
    • Forskolin (GMP)
    • (-)-Forskolin
    • CHEMBL52606
    • 66428-89-5
    • NSC375489
    • NCGC00024996-02
    • 64657-11-0
    • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho(2,1-b)pyran-1-one 5-acetate
    • Colforsine [French]
    • Colforsinum [Latin]
    • Colforsina [Spanish]
    • Coleonol;Colforsin
    • ForsLean
    • Colforsin [USAN:INN]
    • [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
    • 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-
    • FOK
    • SMR000471881
    • CAS-66575-29-9
    • EINECS 266-410-9
    • NSC 357088
    • NSC 375489
    • UNII-1F7A44V6OU
    • Forscoline
    • Ocufors
    • Forskolin?
    • Timsaponin-C
    • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho[2,1-b]pyran-1-one 5-acetate
    • Forskolin (Standard)
    • COLFORSIN [INN]
    • COLFORSIN [MI]
    • Colforsin (USAN/INN)
    • COLFORSIN [USAN]
    • FORSKOLIN [VANDF]
    • COLFORSIN [MART.]
    • MolMap_000021
    • 7-beta-Acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one
    • COLFORSIN [WHO-DD]
    • FORSKOLIN [USP-RS]
    • SCHEMBL4928
    • cid_47936
    • MLS001066384
    • MLS001333255
    • MLS001333256
    • MLS002172462
    • MLS002695942
    • Forskolin, analytical standard
    • Forskolin - Bio-X trade mark
    • REGID_for_CID_47936
    • GTPL5190
    • BCBcMAP01_000132
    • OHCQJHSOBUTRHG-KGGHGJDLSA-
    • Bio1_000443
    • Bio1_000932
    • Bio1_001421
    • GLXC-05197
    • HMS2235C17
    • HMS3267I16
    • HMS3412G19
    • HMS3676G19
    • EX-A5963
    • Tox21_110940
    • Tox21_302399
    • BDBM50010261
    • HB1348
    • HY-15371G
    • HY-15371R
    • s2449
    • AKOS024456384
    • Tox21_110940_1
    • CCG-268774
    • CS-1454
    • DB02587
    • EBC-157221
    • FF23593
    • LMPR0104030004
    • SMP1_000128
    • NCGC00024996-03
    • NCGC00024996-04
    • NCGC00024996-05
    • NCGC00024996-06
    • NCGC00024996-07
    • NCGC00024996-10
    • NCGC00024996-34
    • NCGC00177971-03
    • NCGC00255526-01
    • [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate
    • 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-
    • 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-
    • 1H-Naphtho(2,1-b)pyran-1-one, dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pentamethyl-6,10,10b-trihydroxy-, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-
    • 5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho(2,1-b)pyran-1-one
    • AC-33150
    • AS-17443
    • BF164487
    • FF170900
    • 66575-29-9

  • Applications

    Forskolin (CAS 66575-29-9) is a natural diterpene isolated from Coleus forskohlii; in pharmaceutical research and molecular biology, it is used as a biochemical tool to stimulate adenylyl cyclase and raise cAMP levels in cellular assays. In addition, forskolin-containing extracts are used as dietary supplements (Coleus forskohlii extract) in nutraceutical products. Forskolin also serves as an analytical reference standard for quantifying it in botanical extracts by HPLC. In cosmetics and personal care, it may be included as an active ingredient in certain formulations; industrially, forskolin can be used as a natural starting material or intermediate for synthesis of related diterpenoids.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 217.34
    methanol 393.22
    isopropanol 133.85
    water 2.67
    ethyl acetate 93.56
    n-propanol 171.14
    acetone 194.72
    n-butanol 119.28
    acetonitrile 76.56
    DMF 628.98
    toluene 44.0
    isobutanol 97.67
    1,4-dioxane 297.67
    methyl acetate 117.61
    THF 811.84
    2-butanone 139.51
    n-pentanol 83.32
    sec-butanol 85.07
    n-hexane 3.04
    ethylene glycol 112.47
    NMP 680.16
    cyclohexane 6.09
    DMSO 726.12
    n-butyl acetate 65.55
    n-octanol 19.72
    chloroform 168.21
    n-propyl acetate 66.45
    acetic acid 480.5
    dichloromethane 154.36
    cyclohexanone 229.45
    propylene glycol 117.36
    isopropyl acetate 61.82
    DMAc 443.32
    2-ethoxyethanol 206.92
    isopentanol 72.12
    n-heptane 2.12
    ethyl formate 121.74
    1,2-dichloroethane 127.33
    n-hexanol 75.93
    2-methoxyethanol 435.37
    isobutyl acetate 42.99
    tetrachloromethane 31.05
    n-pentyl acetate 48.54
    transcutol 129.3
    n-heptanol 33.5
    ethylbenzene 19.41
    MIBK 62.22
    2-propoxyethanol 250.85
    tert-butanol 95.51
    MTBE 37.66
    2-butoxyethanol 112.43
    propionic acid 157.42
    o-xylene 27.76
    formic acid 401.34
    diethyl ether 63.5
    m-xylene 28.92
    p-xylene 24.25
    chlorobenzene 56.13
    dimethyl carbonate 122.99
    n-octane 0.96
    formamide 346.19
    cyclopentanone 400.58
    2-pentanone 108.71
    anisole 50.17
    cyclopentyl methyl ether 148.09
    gamma-butyrolactone 525.49
    1-methoxy-2-propanol 268.66
    pyridine 209.7
    3-pentanone 79.07
    furfural 337.99
    n-dodecane 0.65
    diethylene glycol 230.65
    diisopropyl ether 12.55
    tert-amyl alcohol 63.9
    acetylacetone 138.95
    n-hexadecane 0.78
    acetophenone 70.38
    methyl propionate 120.27
    isopentyl acetate 55.82
    trichloroethylene 224.63
    n-nonanol 20.39
    cyclohexanol 93.07
    benzyl alcohol 85.01
    2-ethylhexanol 26.77
    isooctanol 24.25
    dipropyl ether 28.92
    1,2-dichlorobenzene 51.99
    ethyl lactate 59.57
    propylene carbonate 208.98
    n-methylformamide 391.17
    2-pentanol 53.72
    n-pentane 3.91
    1-propoxy-2-propanol 116.66
    1-methoxy-2-propyl acetate 99.3
    2-(2-methoxypropoxy) propanol 66.99
    mesitylene 15.78
    ε-caprolactone 223.47
    p-cymene 12.67
    epichlorohydrin 471.2
    1,1,1-trichloroethane 76.47
    2-aminoethanol 181.5
    morpholine-4-carbaldehyde 522.3
    sulfolane 596.39
    2,2,4-trimethylpentane 1.81
    2-methyltetrahydrofuran 237.15
    n-hexyl acetate 50.73
    isooctane 1.32
    2-(2-butoxyethoxy)ethanol 90.37
    sec-butyl acetate 38.81
    tert-butyl acetate 54.84
    decalin 3.64
    glycerin 218.05
    diglyme 156.63
    acrylic acid 182.87
    isopropyl myristate 16.25
    n-butyric acid 166.06
    acetyl acetate 82.23
    di(2-ethylhexyl) phthalate 32.99
    ethyl propionate 56.94
    nitromethane 434.65
    1,2-diethoxyethane 46.1
    benzonitrile 69.61
    trioctyl phosphate 25.4
    1-bromopropane 54.48
    gamma-valerolactone 565.65
    n-decanol 13.3
    triethyl phosphate 29.03
    4-methyl-2-pentanol 29.07
    propionitrile 73.09
    vinylene carbonate 199.19
    1,1,2-trichlorotrifluoroethane 299.89
    DMS 69.77
    cumene 13.7
    2-octanol 16.25
    2-hexanone 70.21
    octyl acetate 26.07
    limonene 17.69
    1,2-dimethoxyethane 227.65
    ethyl orthosilicate 25.89
    tributyl phosphate 24.24
    diacetone alcohol 99.02
    N,N-dimethylaniline 42.0
    acrylonitrile 116.37
    aniline 83.09
    1,3-propanediol 216.27
    bromobenzene 45.62
    dibromomethane 97.76
    1,1,2,2-tetrachloroethane 181.39
    2-methyl-cyclohexyl acetate 49.94
    tetrabutyl urea 38.14
    diisobutyl methanol 13.59
    2-phenylethanol 80.88
    styrene 20.83
    dioctyl adipate 32.94
    dimethyl sulfate 219.52
    ethyl butyrate 42.56
    methyl lactate 131.27
    butyl lactate 53.15
    diethyl carbonate 31.74
    propanediol butyl ether 79.2
    triethyl orthoformate 33.17
    p-tert-butyltoluene 12.56
    methyl 4-tert-butylbenzoate 61.87
    morpholine 399.33
    tert-butylamine 33.34
    n-dodecanol 8.69
    dimethoxymethane 350.67
    ethylene carbonate 173.35
    cyrene 136.77
    2-ethoxyethyl acetate 77.07
    2-ethylhexyl acetate 42.87
    1,2,4-trichlorobenzene 73.56
    4-methylpyridine 163.01
    dibutyl ether 11.89
    2,6-dimethyl-4-heptanol 13.59
    DEF 150.59
    dimethyl isosorbide 139.09
    tetrachloroethylene 126.68
    eugenol 69.11
    triacetin 59.11
    span 80 61.8
    1,4-butanediol 94.83
    1,1-dichloroethane 84.73
    2-methyl-1-pentanol 55.67
    methyl formate 312.18
    2-methyl-1-butanol 73.5
    n-decane 1.26
    butyronitrile 65.23
    3,7-dimethyl-1-octanol 17.06
    1-chlorooctane 7.61
    1-chlorotetradecane 2.81
    n-nonane 1.06
    undecane 0.87
    tert-butylcyclohexane 2.57
    cyclooctane 2.11
    cyclopentanol 172.67
    tetrahydropyran 190.58
    tert-amyl methyl ether 35.98
    2,5,8-trioxanonane 99.31
    1-hexene 13.45
    2-isopropoxyethanol 103.9
    2,2,2-trifluoroethanol 185.08
    methyl butyrate 81.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction