Folic Acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    59-30-3

    Molecular formula
    C19H19N7O6

    SMILES
    C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 76.97%
    Savory 35.34%
    Meaty 28.16%
    Cooked 27.66%
    Roasted 19.71%
    Milky 19.62%
    Bitter 18.88%
    Grape 17.73%
    Burnt 17.19%
    Cooling 15.27%

     

    Flavor
    Bitter 72.39%
    Odorless 64.45%
    Bland 32.03%
    Mild 30.5%
    Very mild 26.6%
    Sweet-like 22.04%
    Yeast 21.06%
    Nitrile 19.67%
    Bread crust 18.85%
    Taco 18.64%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -1.1

    pKa est.
    6.5 (neutral)

    Molecular weight
    441.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    288°C

    Melting point expt.

    • 482 °F (decomposes) (NTP, 1992)
    • 250 °C

    Flash point

    • 412.96 ˚C est.

    Solubility expt.

    • Almost insoluble (NTP, 1992)
    • Slightly sol in methanol, less in ethanol and butanol; insol in acetone, chloroform, ether, benzene; relatively sol in acetic acid, phenol, pyridine, and in soln of alkali hydroxides and carbonates. Soluble in hot dil HCl and H2SO4.
    • In water, 1.6 mg/L at 25 °C; soluble up to about 1% in boiling water
    • 0.0016 mg/mL

  • Synonyms

    • folic acid
    • 59-30-3
    • Pteroylglutamic acid
    • Vitamin M
    • Folacin
    • Vitamin Bc
    • PteGlu
    • Folacid
    • Vitamin B9
    • Foliamin
    • Folicet
    • Folvite
    • Incafolic
    • Folettes
    • Folipac
    • Folsan
    • Millafol
    • Acifolic
    • Cytofol
    • Pteroyl-L-glutamic acid
    • Folsaure
    • Folbal
    • Folsav
    • Vitamin Be
    • Foldine
    • Pteroyl-L-monoglutamic acid
    • Facid
    • Pteroylmonoglutamic acid
    • Antianemia factor
    • Factor U
    • Folico (Italy)
    • Folina (Italy)
    • Acfol (Spain)
    • Folcidin
    • Folasic (Australia)
    • Usaf cb-13
    • Foldine [France]
    • Acidum folicum
    • Acido folico
    • Folaemin [Netherlands]
    • Nifolin [Denmark]
    • Folaemin
    • Acide folique
    • Kyselina listova
    • Novofolacid [Canada]
    • Liver Lactobacillus casei factor
    • Dosfolat B activ
    • Vitamin B11
    • N-pteroyl-L-glutamic acid
    • Folsaeure
    • Megafol
    • NSC 3073
    • Preconceive
    • Folicare
    • Lexpec
    • Bio Science
    • Natur Flow
    • NSC-3073
    • N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
    • Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
    • DTXSID0022519
    • CHEBI:27470
    • B03BB01
    • 935E97BOY8
    • 4-Pteridinol, 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-
    • Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, l-
    • L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
    • DTXCID102519
    • Foldine (France)
    • Nifolin (Denmark)
    • N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
    • Novofolacid (Canada)
    • Folaemin (Netherlands)
    • (2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
    • Folicacid
    • N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
    • folite
    • Falessa
    • Multitam
    • Ventrixyl
    • Vitramyn
    • Vitranol
    • Vitrexyl
    • Venexa
    • Acfol
    • Solid powder
    • N-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid
    • (2S)-2-((4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)amino)phenyl)formamido)pentanedioic acid
    • N-((4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)amino)phenyl)carbonyl)-L-glutamic acid
    • B9, Vitamin
    • Folic D3
    • Folic Acid 400 mcg
    • RefChem:6436
    • T-dol JIANG SUAN BAO
    • PureVita Folic Acid 400 mcg
    • V04CX02
    • CHEBI:176842
    • N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic Acid
    • N-(4-((2-Amino-4-hydroxypteridin-6-ylmethyl)amino)benzoyl)-L-glutamic acid
    • 2-(4-((2-amino-4-oxo-1H-pteridin-6-yl)methylamino)benzoyl)aminopentanedioic acid
    • Folic Acid, Magnesium Citrate, Calcium Citrate, Vitamin D3, N-Acetyl-L-Cysteine
    • L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo-yl)-
    • 200-419-0
    • ALPHA-TOCOPHEROL ACETATE, DL-; ASCORBIC ACID; CALCIUM CARBONATE; CHOLECALCIFEROL; CHROMIUM NICOTINATE; CYANOCOBALAMIN; FOLIC ACID; MAGNESIUM OXIDE; MANGANESE SULFATE; MOLYBDENUM; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN; SELENIUM; THIAMINE MONONITRATE; VITAMIN A ACETATE; ZINC OXIDE
    • Fefol
    • NSC3073
    • Mittafol
    • Folan
    • Pteroylmonoglutamate
    • Folcidin (VAN)
    • Kyselina listova [Czech]
    • Mission prenatal
    • Acide folique [INN-French]
    • Acido folico [INN-Spanish]
    • Acidum folicum [INN-Latin]
    • PGA (VAN)
    • Folic
    • Glutamic acid, pteroyl-, l-
    • MFCD00079305
    • Pteroyl-L-glutamate
    • N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
    • AI3-26387
    • C19H19N7O6
    • PGA
    • L-Glutamic acid, N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
    • N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
    • 112339-08-9
    • 59-30-3

  • Applications

    Folic Acid (CAS 59-30-3) is widely used as a nutritional vitamin in pharmaceuticals and dietary supplements, typically formulated in tablets or capsules; in the food industry, folic acid is used for fortification of grain-based foods in certain markets; in animal nutrition, it is added to feed to support growth and metabolism in livestock and poultry; in research and development, folic acid is used as a vitamin component in cell culture media and biochemical assays.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.03
    methanol 0.07
    isopropanol 0.02
    water 0.04
    ethyl acetate 0.0
    n-propanol 0.04
    acetone 0.0
    n-butanol 0.02
    acetonitrile 0.0
    DMF 0.54
    toluene 0.0
    isobutanol 0.02
    1,4-dioxane 0.02
    methyl acetate 0.0
    THF 0.05
    2-butanone 0.01
    n-pentanol 0.01
    sec-butanol 0.03
    n-hexane 0.0
    ethylene glycol 0.32
    NMP 1.34
    cyclohexane 0.0
    DMSO 1.23
    n-butyl acetate 0.0
    n-octanol 0.0
    chloroform 0.0
    n-propyl acetate 0.0
    acetic acid 0.05
    dichloromethane 0.0
    cyclohexanone 0.02
    propylene glycol 0.38
    isopropyl acetate 0.0
    DMAc 1.22
    2-ethoxyethanol 0.19
    isopentanol 0.01
    n-heptane 0.0
    ethyl formate 0.01
    1,2-dichloroethane 0.0
    n-hexanol 0.01
    2-methoxyethanol 0.78
    isobutyl acetate 0.0
    tetrachloromethane 0.0
    n-pentyl acetate 0.0
    transcutol 0.15
    n-heptanol 0.01
    ethylbenzene 0.0
    MIBK 0.0
    2-propoxyethanol 0.11
    tert-butanol 0.01
    MTBE 0.0
    2-butoxyethanol 0.11
    propionic acid 0.05
    o-xylene 0.0
    formic acid 0.55
    diethyl ether 0.0
    m-xylene 0.0
    p-xylene 0.0
    chlorobenzene 0.0
    dimethyl carbonate 0.01
    n-octane 0.0
    formamide 0.48
    cyclopentanone 0.04
    2-pentanone 0.01
    anisole 0.0
    cyclopentyl methyl ether 0.01
    gamma-butyrolactone 0.04
    1-methoxy-2-propanol 0.27
    pyridine 0.02
    3-pentanone 0.01
    furfural 0.09
    n-dodecane 0.0
    diethylene glycol 0.28
    diisopropyl ether 0.0
    tert-amyl alcohol 0.02
    acetylacetone 0.0
    n-hexadecane 0.0
    acetophenone 0.0
    methyl propionate 0.01
    isopentyl acetate 0.0
    trichloroethylene 0.0
    n-nonanol 0.0
    cyclohexanol 0.01
    benzyl alcohol 0.01
    2-ethylhexanol 0.0
    isooctanol 0.0
    dipropyl ether 0.01
    1,2-dichlorobenzene 0.0
    ethyl lactate 0.02
    propylene carbonate 0.01
    n-methylformamide 0.18
    2-pentanol 0.01
    n-pentane 0.0
    1-propoxy-2-propanol 0.07
    1-methoxy-2-propyl acetate 0.01
    2-(2-methoxypropoxy) propanol 0.09
    mesitylene 0.0
    ε-caprolactone 0.02
    p-cymene 0.0
    epichlorohydrin 0.02
    1,1,1-trichloroethane 0.0
    2-aminoethanol 0.37
    morpholine-4-carbaldehyde 0.5
    sulfolane 0.36
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.01
    n-hexyl acetate 0.0
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.12
    sec-butyl acetate 0.0
    tert-butyl acetate 0.0
    decalin 0.0
    glycerin 2.31
    diglyme 0.22
    acrylic acid 0.09
    isopropyl myristate 0.0
    n-butyric acid 0.02
    acetyl acetate 0.0
    di(2-ethylhexyl) phthalate 0.0
    ethyl propionate 0.0
    nitromethane 0.04
    1,2-diethoxyethane 0.01
    benzonitrile 0.0
    trioctyl phosphate 0.0
    1-bromopropane 0.0
    gamma-valerolactone 0.19
    n-decanol 0.0
    triethyl phosphate 0.01
    4-methyl-2-pentanol 0.0
    propionitrile 0.01
    vinylene carbonate 0.01
    1,1,2-trichlorotrifluoroethane 0.17
    DMS 0.0
    cumene 0.0
    2-octanol 0.0
    2-hexanone 0.01
    octyl acetate 0.0
    limonene 0.0
    1,2-dimethoxyethane 0.19
    ethyl orthosilicate 0.01
    tributyl phosphate 0.0
    diacetone alcohol 0.02
    N,N-dimethylaniline 0.0
    acrylonitrile 0.01
    aniline 0.01
    1,3-propanediol 0.31
    bromobenzene 0.0
    dibromomethane 0.0
    1,1,2,2-tetrachloroethane 0.0
    2-methyl-cyclohexyl acetate 0.0
    tetrabutyl urea 0.01
    diisobutyl methanol 0.0
    2-phenylethanol 0.0
    styrene 0.0
    dioctyl adipate 0.0
    dimethyl sulfate 0.04
    ethyl butyrate 0.0
    methyl lactate 0.07
    butyl lactate 0.02
    diethyl carbonate 0.0
    propanediol butyl ether 0.11
    triethyl orthoformate 0.01
    p-tert-butyltoluene 0.0
    methyl 4-tert-butylbenzoate 0.01
    morpholine 0.08
    tert-butylamine 0.0
    n-dodecanol 0.0
    dimethoxymethane 0.06
    ethylene carbonate 0.0
    cyrene 0.14
    2-ethoxyethyl acetate 0.0
    2-ethylhexyl acetate 0.0
    1,2,4-trichlorobenzene 0.0
    4-methylpyridine 0.01
    dibutyl ether 0.0
    2,6-dimethyl-4-heptanol 0.0
    DEF 0.04
    dimethyl isosorbide 0.07
    tetrachloroethylene 0.0
    eugenol 0.03
    triacetin 0.01
    span 80 0.04
    1,4-butanediol 0.07
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 0.01
    methyl formate 0.04
    2-methyl-1-butanol 0.02
    n-decane 0.0
    butyronitrile 0.0
    3,7-dimethyl-1-octanol 0.0
    1-chlorooctane 0.0
    1-chlorotetradecane 0.0
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.03
    tetrahydropyran 0.01
    tert-amyl methyl ether 0.0
    2,5,8-trioxanonane 0.17
    1-hexene 0.0
    2-isopropoxyethanol 0.04
    2,2,2-trifluoroethanol 0.05
    methyl butyrate 0.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction