Fluridil

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  • Identifiers

    CAS number
    260980-89-0

    Molecular formula
    C13H11F6N3O5

    SMILES
    CC(CNC(=O)C(F)(F)F)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 66.17%
    Sweet 32.8%
    Savory 28.07%
    Cooling 26.22%
    Milky 21.41%
    Bitter 19.38%
    Dry 15.97%
    Clean 15.96%
    Musk 15.74%
    Animal 15.19%

     

    Flavor
    Bitter 61.01%
    Odorless 56.29%
    Bland 30.66%
    Mild 24.69%
    Sweet-like 21.99%
    Very mild 20.06%
    Yeast 18.99%
    Nitrile 18.68%
    Bread crust 18.22%
    Taco 17.79%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    6.31 (neutral)

    Molecular weight
    403.23 g/mol

    Flash point

    • 175.65 ˚C est.

  • Synonyms

    • Topilutamide
    • 260980-89-0
    • Fluridil
    • TOPILUTAMIDA
    • A8EU2FXY13
    • BP-766
    • DTXSID30870298
    • 2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-3-(2,2,2-trifluoroacetylamino)propanamide
    • topilutamidum
    • RefChem:190413
    • DTXCID30818054
    • 444-070-4
    • Topilutamide [INN]
    • UNII-A8EU2FXY13
    • 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)amino]propanamide
    • 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-3-(2,2,2-trifluoroacetamido)propanamide
    • 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(2,2,2-trifluoroacetamido)propanamide
    • PropanaMide,2-hydroxy-2-Methyl-N-[4-nitro-3-(trifluoroMethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)aMino
    • (2RS)-2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-3-((trifluoroacetyl)amino)propanamide
    • Topilutamide (BP766)
    • TOPILUTAMIDE [WHO-DD]
    • orb1308998
    • SCHEMBL2950382
    • CHEMBL2107790
    • C13H11F6N3O5
    • BP766
    • GLXC-04467
    • EX-A9486
    • MFCD30532579
    • AKOS040740438
    • CS-6603
    • DA-78535
    • HY-19470
    • MS-26882
    • NS00134147
    • G15918
    • PROPANAMIDE, 2-HYDROXY-2-METHYL-N-(4-NITRO-3-(TRIFLUOROMETHYL)PHENYL)-3-((2,2,2-TRIFLUOROACETYL)AMINO)-
    • 260980-89-0

  • Applications

    Fluridil (CAS 260980-89-0) is a specialty chemical with several industrial applications: it can serve as an intermediate in organic synthesis; it may function as a specialty solvent or reagent in manufacturing processes; it provides a fluorinated building block for polymers and plastics; it is used as a processing additive for coatings, inks, and adhesives to improve flow, dispersion, and surface properties; it can act as a surface modifier or coupling agent in electronics and other advanced materials; and it may be evaluated for use in consumer chemical formulations or cleaning products, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 185.55
    methanol 322.13
    isopropanol 99.78
    water 1.71
    ethyl acetate 52.55
    n-propanol 92.83
    acetone 396.6
    n-butanol 57.28
    acetonitrile 77.11
    DMF 468.33
    toluene 8.51
    isobutanol 43.61
    1,4-dioxane 130.46
    methyl acetate 93.4
    THF 473.62
    2-butanone 147.61
    n-pentanol 43.38
    sec-butanol 65.84
    n-hexane 0.39
    ethylene glycol 49.72
    NMP 207.68
    cyclohexane 0.79
    DMSO 1206.68
    n-butyl acetate 25.57
    n-octanol 22.87
    chloroform 9.22
    n-propyl acetate 37.97
    acetic acid 117.9
    dichloromethane 17.58
    cyclohexanone 83.21
    propylene glycol 48.18
    isopropyl acetate 30.82
    DMAc 371.73
    2-ethoxyethanol 218.26
    isopentanol 38.42
    n-heptane 0.89
    ethyl formate 49.49
    1,2-dichloroethane 24.45
    n-hexanol 27.18
    2-methoxyethanol 354.1
    isobutyl acetate 10.19
    tetrachloromethane 0.99
    n-pentyl acetate 26.88
    transcutol 164.18
    n-heptanol 24.4
    ethylbenzene 3.63
    MIBK 37.34
    2-propoxyethanol 130.98
    tert-butanol 98.76
    MTBE 42.59
    2-butoxyethanol 79.99
    propionic acid 48.78
    o-xylene 6.16
    formic acid 115.05
    diethyl ether 57.94
    m-xylene 4.3
    p-xylene 3.74
    chlorobenzene 2.73
    dimethyl carbonate 43.48
    n-octane 0.75
    formamide 243.65
    cyclopentanone 188.48
    2-pentanone 97.17
    anisole 22.65
    cyclopentyl methyl ether 47.83
    gamma-butyrolactone 162.04
    1-methoxy-2-propanol 194.47
    pyridine 59.63
    3-pentanone 51.55
    furfural 80.95
    n-dodecane 0.72
    diethylene glycol 110.24
    diisopropyl ether 6.96
    tert-amyl alcohol 70.49
    acetylacetone 109.75
    n-hexadecane 0.77
    acetophenone 28.31
    methyl propionate 64.43
    isopentyl acetate 15.33
    trichloroethylene 23.38
    n-nonanol 22.04
    cyclohexanol 23.62
    benzyl alcohol 27.45
    2-ethylhexanol 9.66
    isooctanol 14.22
    dipropyl ether 21.92
    1,2-dichlorobenzene 2.1
    ethyl lactate 27.33
    propylene carbonate 32.92
    n-methylformamide 207.77
    2-pentanol 33.11
    n-pentane 0.96
    1-propoxy-2-propanol 67.35
    1-methoxy-2-propyl acetate 40.51
    2-(2-methoxypropoxy) propanol 55.77
    mesitylene 2.23
    ε-caprolactone 61.18
    p-cymene 3.35
    epichlorohydrin 163.18
    1,1,1-trichloroethane 6.22
    2-aminoethanol 80.22
    morpholine-4-carbaldehyde 191.2
    sulfolane 220.27
    2,2,4-trimethylpentane 0.38
    2-methyltetrahydrofuran 115.47
    n-hexyl acetate 28.9
    isooctane 0.22
    2-(2-butoxyethoxy)ethanol 93.52
    sec-butyl acetate 15.13
    tert-butyl acetate 33.44
    decalin 0.26
    glycerin 69.39
    diglyme 157.52
    acrylic acid 45.06
    isopropyl myristate 10.42
    n-butyric acid 43.19
    acetyl acetate 20.66
    di(2-ethylhexyl) phthalate 10.99
    ethyl propionate 28.23
    nitromethane 309.81
    1,2-diethoxyethane 56.04
    benzonitrile 13.23
    trioctyl phosphate 9.79
    1-bromopropane 11.22
    gamma-valerolactone 209.68
    n-decanol 16.09
    triethyl phosphate 7.99
    4-methyl-2-pentanol 13.92
    propionitrile 37.71
    vinylene carbonate 24.16
    1,1,2-trichlorotrifluoroethane 56.99
    DMS 20.84
    cumene 2.22
    2-octanol 16.14
    2-hexanone 54.88
    octyl acetate 18.64
    limonene 4.72
    1,2-dimethoxyethane 251.58
    ethyl orthosilicate 7.52
    tributyl phosphate 8.13
    diacetone alcohol 82.73
    N,N-dimethylaniline 16.39
    acrylonitrile 52.27
    aniline 19.34
    1,3-propanediol 108.5
    bromobenzene 1.82
    dibromomethane 10.83
    1,1,2,2-tetrachloroethane 20.1
    2-methyl-cyclohexyl acetate 12.12
    tetrabutyl urea 24.21
    diisobutyl methanol 5.53
    2-phenylethanol 22.44
    styrene 4.05
    dioctyl adipate 16.51
    dimethyl sulfate 66.04
    ethyl butyrate 19.58
    methyl lactate 56.87
    butyl lactate 24.43
    diethyl carbonate 9.75
    propanediol butyl ether 55.41
    triethyl orthoformate 12.8
    p-tert-butyltoluene 3.39
    methyl 4-tert-butylbenzoate 30.13
    morpholine 179.79
    tert-butylamine 27.07
    n-dodecanol 10.69
    dimethoxymethane 301.88
    ethylene carbonate 20.83
    cyrene 63.44
    2-ethoxyethyl acetate 47.51
    2-ethylhexyl acetate 9.75
    1,2,4-trichlorobenzene 3.75
    4-methylpyridine 44.07
    dibutyl ether 15.47
    2,6-dimethyl-4-heptanol 5.53
    DEF 99.56
    dimethyl isosorbide 69.37
    tetrachloroethylene 11.5
    eugenol 32.68
    triacetin 27.71
    span 80 37.13
    1,4-butanediol 49.34
    1,1-dichloroethane 12.58
    2-methyl-1-pentanol 24.72
    methyl formate 159.97
    2-methyl-1-butanol 36.48
    n-decane 1.21
    butyronitrile 30.22
    3,7-dimethyl-1-octanol 11.43
    1-chlorooctane 5.09
    1-chlorotetradecane 2.06
    n-nonane 1.05
    undecane 0.93
    tert-butylcyclohexane 0.23
    cyclooctane 0.31
    cyclopentanol 46.34
    tetrahydropyran 69.64
    tert-amyl methyl ether 32.97
    2,5,8-trioxanonane 114.07
    1-hexene 2.87
    2-isopropoxyethanol 99.95
    2,2,2-trifluoroethanol 35.59
    methyl butyrate 40.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction