Flupyradifurone

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  • Identifiers

    CAS number
    951659-40-8

    Molecular formula
    C12H11ClF2N2O2

    SMILES
    C1C(=CC(=O)O1)N(CC2=CN=C(C=C2)Cl)CC(F)F

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 63.76%
    Savory 30.99%
    Meaty 28.99%
    Roasted 27.09%
    Cooked 22.48%
    Nutty 20.99%
    Popcorn 20.96%
    Cooling 19.26%
    Milky 19.13%
    Fishy 18.39%

     

    Flavor
    Bitter 80.09%
    Odorless 38.07%
    Bland 28.5%
    Sweet-like 20.87%
    Cedarleaf 19.97%
    Nitrile 19.51%
    Mild 18.95%
    Scallion 18.38%
    Taco 18.3%
    Bread crust 18.22%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    4.95 (weak acid)

    Molecular weight
    288.68 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    560°C

    Flash point

    • 194.57 ˚C est.

  • Synonyms

    • Flupyradifurone
    • 951659-40-8
    • 4-(((6-chloropyridin-3-yl)methyl)(2,2-difluoroethyl)amino)furan-2(5H)-one
    • 8H7JT159D0
    • BYI-02960
    • CHEBI:133997
    • DTXSID10872811
    • 4-{[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one
    • 4-[[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one
    • RefChem:141031
    • DTXCID60820387
    • 4-(((6-chloropyridin-3-yl)methyl)(2,2-difluoroethyl)amino)furan-2(5H)-one; flupyradifurone
    • 804-373-8
    • Flupyradifurone [ISO]
    • 3-[(6-chloropyridin-3-yl)methyl-(2,2-difluoroethyl)amino]-2H-furan-5-one
    • Sivanto
    • Flupyradifuron
    • UNII-8H7JT159D0
    • 2(5H)-FURANONE, 4-(((6-CHLORO-3-PYRIDINYL)METHYL)(2,2-DIFLUOROETHYL)AMINO)-
    • 2(5H)-Furanone, 4-[[(6-chloro-3-pyridinyl)methyl](2,2-difluoroethyl)amino]-
    • 2(5H)-Furanone, 4-[[(6-chloro-3-pyridinyl)methyl](2,2-difluoroethyl)amino]-; 3-[[(6-Chloro-3-pyridyl)methyl](2,2-difluoroethyl)amino]-2H-furan-5-one; 4-[[(6-Chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one; BYI 02960; Flupyradifurone
    • BetaYI02960
    • Flupyradifurone (Standard)
    • C12H11ClF2N2O2
    • SCHEMBL123283
    • orb1982981
    • CHEMBL5206787
    • SCHEMBL29394548
    • YQF1879
    • BNB65940
    • MSK20501
    • EBC-08419
    • MFCD22373627
    • 4-[(6-chloro-3-pyridylmethyl)(2,2-difluoroethyl)amino]furan-2(5H)-one
    • AT26716
    • HY-145295R
    • 4-{[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino}-2,5-dihydrofuran-2-one
    • DA-73408
    • MS-24124
    • HY-145295
    • CS-0370911
    • Flupyradifurone 100 microg/mL in Acetonitrile
    • Flupyradifurone, PESTANAL(R), analytical standard
    • Q21050747
    • Z3664682052
    • 3-[(6-chloro-3-pyridyl)methyl-(2,2-difluoroethyl)amino]-2H-furan-5-one
    • 4-[[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)one
    • 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5h)-one
    • 4[[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one
    • 3-[2,2-bis(fluoranyl)ethyl-[(6-chloranylpyridin-3-yl)methyl]amino]-2~{H}-furan-5-one
    • 4-[[(6-chloro-3-pyridinyl)methyl](2,2-difluoroethyl)amino]-2(5H)-furanone
    • 4-[[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan- 2(5H)-one
    • 951659-40-8

  • Applications

    Flupyradifurone (CAS 951659-40-8) is a systemic insecticide used in agriculture to control sap-sucking pests on a range of crops. It is typically applied as a foliar spray or soil treatment and translocates within the plant to protect leaves, stems, and developing fruit. Common use areas include vegetables (greenhouse and field crops), fruit crops (including apples and other pome fruits), grapes, citrus, and ornamental plants in nurseries and greenhouse production. It is usually managed within integrated pest management programs and is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 45.81
    methanol 95.62
    isopropanol 21.9
    water 1.35
    ethyl acetate 36.78
    n-propanol 25.09
    acetone 201.83
    n-butanol 18.36
    acetonitrile 97.79
    DMF 317.81
    toluene 6.23
    isobutanol 16.33
    1,4-dioxane 37.92
    methyl acetate 63.49
    THF 106.23
    2-butanone 93.74
    n-pentanol 14.51
    sec-butanol 19.64
    n-hexane 0.2
    ethylene glycol 30.29
    NMP 212.44
    cyclohexane 0.32
    DMSO 637.17
    n-butyl acetate 17.86
    n-octanol 3.62
    chloroform 52.03
    n-propyl acetate 24.69
    acetic acid 102.84
    dichloromethane 108.19
    cyclohexanone 61.83
    propylene glycol 21.32
    isopropyl acetate 17.86
    DMAc 438.8
    2-ethoxyethanol 81.86
    isopentanol 16.97
    n-heptane 0.45
    ethyl formate 51.54
    1,2-dichloroethane 62.71
    n-hexanol 10.28
    2-methoxyethanol 146.55
    isobutyl acetate 9.87
    tetrachloromethane 3.6
    n-pentyl acetate 10.22
    transcutol 129.02
    n-heptanol 5.74
    ethylbenzene 3.75
    MIBK 21.15
    2-propoxyethanol 49.21
    tert-butanol 22.34
    MTBE 10.22
    2-butoxyethanol 26.77
    propionic acid 32.13
    o-xylene 6.4
    formic acid 138.34
    diethyl ether 12.63
    m-xylene 5.32
    p-xylene 5.37
    chlorobenzene 9.2
    dimethyl carbonate 41.19
    n-octane 0.18
    formamide 231.72
    cyclopentanone 99.59
    2-pentanone 46.04
    anisole 20.5
    cyclopentyl methyl ether 17.96
    gamma-butyrolactone 111.14
    1-methoxy-2-propanol 73.15
    pyridine 51.25
    3-pentanone 35.58
    furfural 135.35
    n-dodecane 0.19
    diethylene glycol 70.22
    diisopropyl ether 2.4
    tert-amyl alcohol 20.22
    acetylacetone 75.38
    n-hexadecane 0.22
    acetophenone 33.66
    methyl propionate 45.37
    isopentyl acetate 14.74
    trichloroethylene 115.37
    n-nonanol 4.07
    cyclohexanol 11.63
    benzyl alcohol 27.23
    2-ethylhexanol 6.72
    isooctanol 5.03
    dipropyl ether 8.88
    1,2-dichlorobenzene 11.48
    ethyl lactate 27.41
    propylene carbonate 50.27
    n-methylformamide 145.72
    2-pentanol 8.47
    n-pentane 0.24
    1-propoxy-2-propanol 30.17
    1-methoxy-2-propyl acetate 34.25
    2-(2-methoxypropoxy) propanol 45.91
    mesitylene 2.99
    ε-caprolactone 51.59
    p-cymene 4.45
    epichlorohydrin 145.19
    1,1,1-trichloroethane 23.08
    2-aminoethanol 39.42
    morpholine-4-carbaldehyde 152.28
    sulfolane 160.37
    2,2,4-trimethylpentane 0.3
    2-methyltetrahydrofuran 35.07
    n-hexyl acetate 10.77
    isooctane 0.17
    2-(2-butoxyethoxy)ethanol 44.08
    sec-butyl acetate 12.44
    tert-butyl acetate 16.56
    decalin 0.33
    glycerin 51.41
    diglyme 97.34
    acrylic acid 44.64
    isopropyl myristate 5.2
    n-butyric acid 31.9
    acetyl acetate 26.93
    di(2-ethylhexyl) phthalate 11.57
    ethyl propionate 23.7
    nitromethane 270.1
    1,2-diethoxyethane 23.88
    benzonitrile 28.0
    trioctyl phosphate 6.58
    1-bromopropane 14.54
    gamma-valerolactone 133.94
    n-decanol 3.36
    triethyl phosphate 14.48
    4-methyl-2-pentanol 5.6
    propionitrile 40.32
    vinylene carbonate 52.27
    1,1,2-trichlorotrifluoroethane 133.96
    DMS 23.25
    cumene 2.9
    2-octanol 3.02
    2-hexanone 28.73
    octyl acetate 7.58
    limonene 5.49
    1,2-dimethoxyethane 114.09
    ethyl orthosilicate 11.59
    tributyl phosphate 9.21
    diacetone alcohol 39.21
    N,N-dimethylaniline 16.98
    acrylonitrile 70.51
    aniline 18.86
    1,3-propanediol 44.81
    bromobenzene 8.01
    dibromomethane 43.14
    1,1,2,2-tetrachloroethane 64.3
    2-methyl-cyclohexyl acetate 15.62
    tetrabutyl urea 17.47
    diisobutyl methanol 4.22
    2-phenylethanol 20.36
    styrene 4.51
    dioctyl adipate 13.44
    dimethyl sulfate 91.88
    ethyl butyrate 19.96
    methyl lactate 48.22
    butyl lactate 17.34
    diethyl carbonate 17.32
    propanediol butyl ether 24.89
    triethyl orthoformate 14.96
    p-tert-butyltoluene 3.68
    methyl 4-tert-butylbenzoate 26.5
    morpholine 59.98
    tert-butylamine 6.98
    n-dodecanol 2.65
    dimethoxymethane 113.91
    ethylene carbonate 38.6
    cyrene 61.52
    2-ethoxyethyl acetate 23.13
    2-ethylhexyl acetate 10.85
    1,2,4-trichlorobenzene 17.7
    4-methylpyridine 43.99
    dibutyl ether 4.76
    2,6-dimethyl-4-heptanol 4.22
    DEF 72.35
    dimethyl isosorbide 67.09
    tetrachloroethylene 34.56
    eugenol 30.84
    triacetin 25.51
    span 80 23.18
    1,4-butanediol 22.48
    1,1-dichloroethane 34.89
    2-methyl-1-pentanol 13.22
    methyl formate 122.21
    2-methyl-1-butanol 16.61
    n-decane 0.28
    butyronitrile 32.82
    3,7-dimethyl-1-octanol 5.2
    1-chlorooctane 1.64
    1-chlorotetradecane 0.82
    n-nonane 0.23
    undecane 0.23
    tert-butylcyclohexane 0.27
    cyclooctane 0.14
    cyclopentanol 18.73
    tetrahydropyran 18.19
    tert-amyl methyl ether 11.42
    2,5,8-trioxanonane 76.84
    1-hexene 1.51
    2-isopropoxyethanol 39.38
    2,2,2-trifluoroethanol 57.55
    methyl butyrate 35.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction