Fluoxymesterone

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  • Identifiers

    CAS number
    76-43-7

    Molecular formula
    C20H29FO3

    SMILES
    C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]2([C@H](C[C@]4([C@H]3CC[C@]4(C)O)C)O)F

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Woody 67.14%
    Spicy 35.91%
    Earthy 35.2%
    Cedar 33.67%
    Balsamic 30.99%
    Camphoreous 30.5%
    Amber 30.48%
    Dry 27.78%
    Herbal 26.23%
    Mint 25.61%

     

    Flavor
    Bitter 67.9%
    Minty 28.49%
    Fruity 26.94%
    Cedarleaf 23.39%
    Ripe apricot 21.63%
    Beet 21.47%
    Patchouli 21.38%
    Soil 21.35%
    Red fruit 21.13%
    Sweet-like 21.04%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    7.28 (neutral)

    Molecular weight
    336.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    345°C

    Melting point expt.

    • 265 undefined
    • About 240 °C with some decomposition
    • 270 °C

    Flash point

    • 204.21 ˚C est.

    Solubility expt.

    • 67.5 mg/L
    • Soluble in pyridine; slightly soluble in acetone, chloroform; sparingly soluble in methanol; practically insoluble in water, ether, benzene, hexanes
    • 4.52e-02 g/L

  • Synonyms

    • fluoxymesterone
    • 76-43-7
    • Fluoximesterone
    • Halotestin
    • Androfluorene
    • Androfluorone
    • Fluoxymestrone
    • Fluotestin
    • Ora-Testryl
    • Androsterolo
    • Fluosterone
    • Flusteron
    • Flutestos
    • Oralsterone
    • Oratestin
    • Testoral
    • Ultandren
    • Ultandrene
    • Fluoximesteronum
    • Android-f
    • Neo-Ormonal
    • Ora Testryl
    • Fluoximesterona
    • Fluoxymesteronum
    • Fluossimesterone [DCIT]
    • Fluossimesterone
    • Fluoxymesteronum [INN-Latin]
    • Fluoximesterona [INN-Spanish]
    • NSC-12165
    • Androxy
    • Halodrin
    • Fluoxymesterone ciii
    • 9alpha-Fluoro-11beta-hydroxy-17-methyltestosterone
    • 9-Fluoro-11beta,17beta-dihydroxy-17-methylandrost-4-en-3-one
    • CCRIS 9036
    • U 6040
    • HSDB 3333
    • UNII-9JU12S4YFY
    • (8S,9R,10S,11S,13S,14S,17S)-9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
    • EINECS 200-961-8
    • 9JU12S4YFY
    • NSC 10704
    • NSC-10704
    • BRN 2008796
    • CHEBI:5120
    • Testosterone, 9-fluoro-11beta-hydroxy-17-methyl-
    • 9-alpha-Fluoro-11-beta-hydroxy-17-methyltestosterone
    • AI3-52940
    • 17-alpha-Methyl-9-alpha-fluoro-11-beta-hydroxytesterone
    • FXM
    • 9-Fluoro-11-beta,17-beta-dihydroxy-17-methylandrost-4-en-3-one
    • 9alpha-Fluoro-17alpha-methyl-11beta,17-dihydroxy-4-androsten-3-one
    • 17alpha-Methyl-9alpha-fluoro-11beta-hydroxytesterone
    • 11beta,17beta-Dihydroxy-9alpha-fluoro-17alpha-methyl-4-androsten-3-one
    • 9-alpha-Fluoro-17-alpha-methyl-11-beta,17-dihydroxy-4-androsten-3-one
    • 9alpha-Fluoro-11beta,17beta-dihydroxy-17alpha-methyl-4-androstene-3-one
    • 11-beta,17-beta-Dihydroxy-9-alpha-fluoro-17-alpha-methyl-4-androster-3-one
    • 9-alpha-Fluoro-11-beta,17-beta-dihydroxy-17-alpha-methyl-4-androstene-3-one
    • Androst-4-en-3-one, 9-fluoro-11,17-dihydroxy-17-methyl-, (11beta,17beta)-
    • Fluoximesteron
    • DTXSID8033512
    • Androst-4-en-3-one, 9-fluoro-11beta,17beta-dihydroxy-17-methyl-
    • Anadroid-F
    • 11beta,17beta-Dihydroxy-9alpha-fluoro-17alpha-methyl-4-androster-3-one
    • 4-08-00-02057 (Beilstein Handbook Reference)
    • NSC12165
    • Fluoro-9-alpha dihydroxy-11-beta,17-beta methyl-17-alpha androstene-4 one-3
    • Fluoxymesterone [USP:INN:BAN:JAN]
    • component of Halodrin
    • 9-fluoro-11beta,17beta-dihydroxy-17alpha-methylandrost-4-en-3-one
    • (11beta,17beta)-9-fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one
    • Fluoxymesteron
    • Fluoxymesteronum (INN-Latin)
    • Fluoximesterona (INN-Spanish)
    • FLUOXYMESTERONE (MART.)
    • FLUOXYMESTERONE [MART.]
    • 9.alpha.-Fluoro-11.beta.-hydroxy-17-methyltestosterone
    • DTXCID6013512
    • 9alpha-Fluoro-11beta,17beta-dihydroxy-17-methylandrost-4-en-3-one
    • Fluoxymesterone (USP:INN:BAN:JAN)
    • FLUOXYMESTERONE CIII (USP-RS)
    • FLUOXYMESTERONE CIII [USP-RS]
    • FLUOXYMESTERONE (USP MONOGRAPH)
    • FLUOXYMESTERONE [USP MONOGRAPH]
    • 9.alpha.-Fluoro-11.beta.,17.beta.-dihydroxy-17.alpha.-methyl-4-androstene-3-one
    • CAS-76-43-7
    • Halotestin (TN)
    • (8S,9R,10S,11S,13S,14S,17S)-9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
    • Fluoxymesterone (1.0 mg/ml in Methanol)
    • Fluoxymesterone (1mg/ml in Acetonitrile)
    • Fluoxymesterone (1mg/ml in 1,2-Dimethoxyethane)
    • Testosterone, 9-fluoro-11.beta.-hydroxy-17-methyl-
    • Androst-4-en-3-one, 9-fluoro-11,17-dihydroxy-17-methyl-, (11.beta.,17.beta.)-
    • NCGC00182970-01
    • Androxy (TN)
    • Fluoro-9-alpha dihydroxy-11-beta,17-beta methyl-17-alpha androstene-4 one-3 [French]
    • SCHEMBL5096
    • CHEMBL1445
    • FLUOXYMESTERONE [MI]
    • FLUOXYMESTERONE [INN]
    • FLUOXYMESTERONE [JAN]
    • MLS001055414
    • FLUOXYMESTERONE [HSDB]
    • FLUOXYMESTERONE [VANDF]
    • GTPL2861
    • 9alpha-Fluoro-11beta-hydroxy-17alpha-methyltestosterone
    • FLUOXYMESTERONE [WHO-DD]
    • BDBM18189
    • Fluoxymesterone (JAN/USP/INN)
    • G03BA01
    • YLRFCQOZQXIBAB-RBZZARIASA-N
    • HMS2272B06
    • BCP10776
    • NSC10704
    • Tox21_113158
    • Tox21_200854
    • FLUOXYMESTERONE [ORANGE BOOK]
    • LMST02020025
    • AKOS015895109
    • Androst-4-en-3-one, 9-fluoro-11beta,17beta-dihydroxy-17-methyl- (VAN)
    • Androst-4-en-3-one, 9-fluoro-11beta,17beta-dihydroxy-17-methyl-(VAN)
    • DB01185
    • Fluoxymesterone, solid (photosensitive)
    • Fluoxymesterone, 1mg/ml in Acetonitrile
    • NCGC00091037-01
    • NCGC00091037-02
    • NCGC00258408-01
    • AC-29744

  • Applications

    Fluoxymesterone is primarily handled as an active pharmaceutical ingredient in certain prescription anabolic-steroid formulations; it is also used as a starting material or intermediate in steroid synthesis and related pharmaceutical research. In analytical laboratories, it serves as a reference standard for method development and calibration in steroid analysis. In chemical development and process chemistry, it is considered as part of synthetic routes to related androgenic compounds. Formulation development and quality-control testing may involve Fluoxymesterone to monitor purity and potency, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 116.71
    methanol 300.58
    isopropanol 74.47
    water 1.44
    ethyl acetate 42.07
    n-propanol 83.6
    acetone 124.77
    n-butanol 55.28
    acetonitrile 56.92
    DMF 623.79
    toluene 28.87
    isobutanol 35.13
    1,4-dioxane 166.54
    methyl acetate 36.46
    THF 326.32
    2-butanone 48.78
    n-pentanol 17.48
    sec-butanol 16.71
    n-hexane 0.53
    ethylene glycol 48.12
    NMP 72.08
    cyclohexane 1.58
    DMSO 287.96
    n-butyl acetate 23.24
    n-octanol 10.06
    chloroform 116.62
    n-propyl acetate 21.19
    acetic acid 108.67
    dichloromethane 76.07
    cyclohexanone 74.43
    propylene glycol 33.31
    isopropyl acetate 37.17
    DMAc 126.82
    2-ethoxyethanol 92.09
    isopentanol 32.42
    n-heptane 0.54
    ethyl formate 39.86
    1,2-dichloroethane 41.43
    n-hexanol 26.48
    2-methoxyethanol 305.28
    isobutyl acetate 15.12
    tetrachloromethane 14.07
    n-pentyl acetate 22.83
    transcutol 143.27
    n-heptanol 19.03
    ethylbenzene 9.81
    MIBK 37.96
    2-propoxyethanol 141.56
    tert-butanol 47.06
    MTBE 13.09
    2-butoxyethanol 66.43
    propionic acid 37.75
    o-xylene 13.57
    formic acid 120.97
    diethyl ether 32.06
    m-xylene 20.46
    p-xylene 11.83
    chlorobenzene 25.6
    dimethyl carbonate 59.26
    n-octane 0.36
    formamide 197.72
    cyclopentanone 125.6
    2-pentanone 50.82
    anisole 36.38
    cyclopentyl methyl ether 44.95
    gamma-butyrolactone 117.9
    1-methoxy-2-propanol 204.71
    pyridine 99.33
    3-pentanone 30.93
    furfural 131.57
    n-dodecane 0.25
    diethylene glycol 156.47
    diisopropyl ether 7.34
    tert-amyl alcohol 12.9
    acetylacetone 103.85
    n-hexadecane 0.31
    acetophenone 36.55
    methyl propionate 45.18
    isopentyl acetate 23.9
    trichloroethylene 97.33
    n-nonanol 11.49
    cyclohexanol 21.07
    benzyl alcohol 38.95
    2-ethylhexanol 9.7
    isooctanol 14.21
    dipropyl ether 12.58
    1,2-dichlorobenzene 24.21
    ethyl lactate 24.82
    propylene carbonate 50.23
    n-methylformamide 240.98
    2-pentanol 17.14
    n-pentane 0.88
    1-propoxy-2-propanol 65.44
    1-methoxy-2-propyl acetate 59.26
    2-(2-methoxypropoxy) propanol 44.62
    mesitylene 11.24
    ε-caprolactone 52.43
    p-cymene 6.37
    epichlorohydrin 145.05
    1,1,1-trichloroethane 30.39
    2-aminoethanol 90.21
    morpholine-4-carbaldehyde 187.75
    sulfolane 123.98
    2,2,4-trimethylpentane 0.4
    2-methyltetrahydrofuran 42.09
    n-hexyl acetate 25.12
    isooctane 0.58
    2-(2-butoxyethoxy)ethanol 64.97
    sec-butyl acetate 14.83
    tert-butyl acetate 39.85
    decalin 0.83
    glycerin 95.18
    diglyme 142.22
    acrylic acid 50.27
    isopropyl myristate 9.68
    n-butyric acid 60.04
    acetyl acetate 49.02
    di(2-ethylhexyl) phthalate 16.11
    ethyl propionate 23.91
    nitromethane 218.42
    1,2-diethoxyethane 33.61
    benzonitrile 37.41
    trioctyl phosphate 11.02
    1-bromopropane 12.64
    gamma-valerolactone 237.73
    n-decanol 7.13
    triethyl phosphate 12.88
    4-methyl-2-pentanol 14.08
    propionitrile 41.8
    vinylene carbonate 63.75
    1,1,2-trichlorotrifluoroethane 117.63
    DMS 35.41
    cumene 6.18
    2-octanol 8.45
    2-hexanone 19.84
    octyl acetate 12.3
    limonene 6.46
    1,2-dimethoxyethane 147.79
    ethyl orthosilicate 12.03
    tributyl phosphate 10.74
    diacetone alcohol 59.41
    N,N-dimethylaniline 21.78
    acrylonitrile 74.52
    aniline 44.47
    1,3-propanediol 132.99
    bromobenzene 21.84
    dibromomethane 36.18
    1,1,2,2-tetrachloroethane 66.07
    2-methyl-cyclohexyl acetate 18.43
    tetrabutyl urea 17.3
    diisobutyl methanol 7.76
    2-phenylethanol 43.71
    styrene 11.46
    dioctyl adipate 17.09
    dimethyl sulfate 83.84
    ethyl butyrate 18.87
    methyl lactate 60.5
    butyl lactate 27.91
    diethyl carbonate 15.22
    propanediol butyl ether 46.88
    triethyl orthoformate 17.6
    p-tert-butyltoluene 6.46
    methyl 4-tert-butylbenzoate 39.98
    morpholine 173.89
    tert-butylamine 16.42
    n-dodecanol 4.37
    dimethoxymethane 358.32
    ethylene carbonate 50.68
    cyrene 51.48
    2-ethoxyethyl acetate 46.37
    2-ethylhexyl acetate 15.49
    1,2,4-trichlorobenzene 28.08
    4-methylpyridine 69.84
    dibutyl ether 7.2
    2,6-dimethyl-4-heptanol 7.76
    DEF 49.05
    dimethyl isosorbide 73.27
    tetrachloroethylene 51.94
    eugenol 48.96
    triacetin 37.89
    span 80 33.96
    1,4-butanediol 28.58
    1,1-dichloroethane 31.84
    2-methyl-1-pentanol 11.14
    methyl formate 157.52
    2-methyl-1-butanol 18.94
    n-decane 0.56
    butyronitrile 35.31
    3,7-dimethyl-1-octanol 9.58
    1-chlorooctane 3.34
    1-chlorotetradecane 1.1
    n-nonane 0.44
    undecane 0.36
    tert-butylcyclohexane 0.7
    cyclooctane 0.6
    cyclopentanol 32.14
    tetrahydropyran 65.94
    tert-amyl methyl ether 8.61
    2,5,8-trioxanonane 83.34
    1-hexene 2.73
    2-isopropoxyethanol 44.67
    2,2,2-trifluoroethanol 60.26
    methyl butyrate 27.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction