Fluocinolone Acetonide

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  • Identifiers

    CAS number
    67-73-2

    Molecular formula
    C24H30F2O6

    SMILES
    C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@@]53C)F)F)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Odorless 50.75%
    Woody 36.52%
    Spicy 19.05%
    Sweet 17.54%
    Roasted 17.32%
    Dry 16.71%
    Savory 16.1%
    Cooling 16.09%
    Nutty 15.88%
    Burnt 15.81%

    Scent© AI

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    5.42 (weak acid)

    Molecular weight
    452.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    596°C

    Melting point expt.

    • 266-268
    • 266 °C

    Flash point est.
    219.25 ˚C

    Solubility expt.

    • Insoluble
    • SOL IN ALC, ACETONE, & METHANOL; INSOL IN WATER; SLIGHTLY SOL IN CHLOROFORM

  • Synonyms

    • FLUOCINOLONE ACETONIDE
    • 67-73-2
    • Synalar
    • Fluonid
    • Synamol
    • Synandone
    • Coriphate
    • Dermalar
    • Flucinar
    • Fluovitif
    • Flupollon
    • Percutina
    • Radiocin
    • Retisert
    • Synandrone
    • Tefunote
    • Jellin
    • Localyn
    • Sinalar
    • Synemol
    • Synotic
    • Synsac
    • Fluocet
    • Omniderm
    • Derma-smoothe/fs
    • Synalar-HP
    • Fluotrex
    • Localyn Syntex
    • Cortiplastol
    • Prodermin
    • Iluvien
    • Fs Shampoo
    • Flucort
    • Capex
    • Fluocinolonacetonidum
    • Fluocinolone 16,17-acetonide
    • Dermatin (steroid)
    • Acetonide de fluocinolone
    • Fluzon
    • 6alpha-Fluorotriamcinolone acetonide
    • Fluocinoloni acetonidum
    • RS-1401 AT
    • Oto-synalar
    • Acetonida de fluocinolona
    • Fluocinolone (Acetonide)
    • RS 1401AT
    • Flucinolone acetonide
    • Fluocinoloni acetonidum [INN-Latin]
    • NSC-92339
    • Fluocinolide (acetate)
    • CCRIS 3250
    • Dermotic
    • 6alpha,9alpha-Difluoro-16alpha-hydroxyprednisolone 16,17-acetonide
    • acetonido de fluocinolona
    • component of Neo-Synalar
    • HSDB 3083
    • UNII-0CD5FD6S2M
    • EINECS 200-668-5
    • 0CD5FD6S2M
    • NSC 92339
    • Acetonide de fluocinolone [INN-French]
    • YUTIQ
    • Acetonida de fluocinolona [INN-Spanish]
    • DTXSID0040674
    • CHEBI:31623
    • Fluocinolone acetonide (Flucort-N)
    • NSC92339
    • MFCD00010525
    • 6alpha,9-Difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone
    • 6-alpha,9-alpha-Difluoro-16-alpha-hydroxyprednisolone 16,17-acetonide
    • Fluocinolone acetonide intravitreal implant
    • MLS000028545
    • MLS001076276
    • Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
    • Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
    • DTXCID8020674
    • Fluzon (Steroid)
    • Fluzon [Steroid]
    • SMR000058329
    • Fluocinolone acetonide [USAN:USP:INN:JAN]
    • OTOVEL COMPONENT FLUOCINOLONE ACETONIDE
    • Fluocinolone acetonide [DCIT]
    • ILUVIEN COMPONENT FLUOCINOLONE ACETONIDE
    • TRI-LUMA COMPONENT FLUOCINOLONE ACETONIDE
    • (6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
    • NEO-SYNALAR COMPONENT FLUOCINOLONE ACETONIDE
    • Fluortriamcinolone Acetonide
    • Fluocinoloni acetonidum (INN-Latin)
    • FLUOCINOLONE ACETONIDE (MART.)
    • FLUOCINOLONE ACETONIDE [MART.]
    • 6.alpha.-Fluorotriamcinolone acetonide
    • FLUOCINOLONE ACETONIDE (USP-RS)
    • FLUOCINOLONE ACETONIDE [USP-RS]
    • Acetonide de fluocinolone (INN-French)
    • CAS-67-73-2
    • Acetonida de fluocinolona (INN-Spanish)
    • Retisert (TN)
    • (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one
    • Fluocet (TN)
    • Synalar (TN)
    • FLUOCINOLONE ACETONIDE (EP MONOGRAPH)
    • Fluocinolone acetonide (USAN:USP:INN:JAN)
    • FLUOCINOLONE ACETONIDE (USP IMPURITY)
    • FLUOCINOLONE ACETONIDE [EP MONOGRAPH]
    • FLUOCINOLONE ACETONIDE [USP IMPURITY]
    • FLUOCINOLONE ACETONIDE (USP MONOGRAPH)
    • FLUOCINOLONE ACETONIDE [USP MONOGRAPH]
    • Acetonide, Fluocinolone
    • 6.Alpha.,9-Difluoro
    • Acetonide, Fluortriamcinolone
    • Synalar Ts
    • Flucort-N
    • Flac Otic Oil
    • NCGC00021301-04
    • (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho(2',1':4,5)indeno(1,2-d)(1,3)dioxol-2-one
    • (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
    • (6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))pregna-1,4-diene-3,20-dione
    • (6alpha,9alpha,11beta,16beta)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
    • Fluocinolon acetonid
    • Fluocinolone acetonide; 6a,9-Difluoro-11ss,21-dihydroxy-16a,17-(1-methylethylidenedioxy)pregna-1,4-diene-3,20-dione
    • FLAC
    • fluocinolone-acetonide
    • XILAPAK
    • fluocinolone (alcohol)
    • Fluocinolone AcetonideOil
    • Synalar Cream Veterinary
    • 6.alpha.,17-acetonide
    • Opera_ID_1295

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 52.15
    methanol 145.88
    isopropanol 24.84
    water 2.91
    ethyl acetate 32.24
    n-propanol 36.93
    acetone 115.38
    n-butanol 24.59
    acetonitrile 71.31
    DMF 274.38
    toluene 6.88
    isobutanol 17.46
    1,4-dioxane 76.39
    methyl acetate 41.01
    THF 153.87
    2-butanone 49.76
    n-pentanol 15.54
    sec-butanol 13.69
    n-hexane 0.5
    ethylene glycol 40.75
    NMP 130.73
    cyclohexane 0.77
    DMSO 410.9
    n-butyl acetate 16.97
    n-octanol 6.72
    chloroform 57.1
    n-propyl acetate 20.47
    acetic acid 138.36
    dichloromethane 61.89
    cyclohexanone 65.75
    propylene glycol 23.08
    isopropyl acetate 20.19
    DMAc 139.35
    2-ethoxyethanol 64.08
    isopentanol 14.07
    n-heptane 0.45
    ethyl formate 42.15
    1,2-dichloroethane 35.49
    n-hexanol 13.3
    2-methoxyethanol 156.1
    isobutyl acetate 10.88
    tetrachloromethane 7.48
    n-pentyl acetate 14.88
    transcutol 41.87
    n-heptanol 10.26
    ethylbenzene 3.4
    MIBK 19.08
    2-propoxyethanol 68.38
    tert-butanol 15.36
    MTBE 7.0
    2-butoxyethanol 35.71
    propionic acid 36.97
    o-xylene 3.93
    formic acid 147.07
    diethyl ether 19.47
    m-xylene 4.15
    p-xylene 4.22
    chlorobenzene 10.25
    dimethyl carbonate 45.76
    n-octane 0.27
    formamide 183.54
    cyclopentanone 115.85
    2-pentanone 39.0
    anisole 12.38
    cyclopentyl methyl ether 22.4
    gamma-butyrolactone 123.78
    1-methoxy-2-propanol 84.57
    pyridine 48.01
    3-pentanone 27.68
    furfural 103.07
    n-dodecane 0.22
    diethylene glycol 86.01
    diisopropyl ether 3.29
    tert-amyl alcohol 9.44
    acetylacetone 66.46
    n-hexadecane 0.26
    acetophenone 19.81
    methyl propionate 38.35
    isopentyl acetate 13.16
    trichloroethylene 66.69
    n-nonanol 7.2
    cyclohexanol 11.73
    benzyl alcohol 17.81
    2-ethylhexanol 5.68
    isooctanol 7.15
    dipropyl ether 8.55
    1,2-dichlorobenzene 10.55
    ethyl lactate 22.14
    propylene carbonate 44.89
    n-methylformamide 163.91
    2-pentanol 9.26
    n-pentane 0.65
    1-propoxy-2-propanol 30.11
    1-methoxy-2-propyl acetate 32.36
    2-(2-methoxypropoxy) propanol 24.69
    mesitylene 2.24
    ε-caprolactone 48.79
    p-cymene 2.54
    epichlorohydrin 120.76
    1,1,1-trichloroethane 18.83
    2-aminoethanol 51.99
    morpholine-4-carbaldehyde 157.99
    sulfolane 150.88
    2,2,4-trimethylpentane 0.23
    2-methyltetrahydrofuran 33.85
    n-hexyl acetate 15.62
    isooctane 0.21
    2-(2-butoxyethoxy)ethanol 29.02
    sec-butyl acetate 10.75
    tert-butyl acetate 17.01
    decalin 0.42
    glycerin 60.58
    diglyme 64.1
    acrylic acid 51.18
    isopropyl myristate 5.65
    n-butyric acid 41.22
    acetyl acetate 35.66
    di(2-ethylhexyl) phthalate 10.42
    ethyl propionate 20.26
    nitromethane 282.66
    1,2-diethoxyethane 15.56
    benzonitrile 20.35
    trioctyl phosphate 7.87
    1-bromopropane 11.36
    gamma-valerolactone 189.01
    n-decanol 4.72
    triethyl phosphate 10.22
    4-methyl-2-pentanol 5.73
    propionitrile 38.33
    vinylene carbonate 57.4
    1,1,2-trichlorotrifluoroethane 89.75
    DMS 20.66
    cumene 2.33
    2-octanol 4.93
    2-hexanone 22.96
    octyl acetate 8.82
    limonene 3.29
    1,2-dimethoxyethane 87.0
    ethyl orthosilicate 8.31
    tributyl phosphate 7.53
    diacetone alcohol 29.85
    N,N-dimethylaniline 9.0
    acrylonitrile 63.47
    aniline 13.19
    1,3-propanediol 59.8
    bromobenzene 8.87
    dibromomethane 31.12
    1,1,2,2-tetrachloroethane 41.55
    2-methyl-cyclohexyl acetate 12.97
    tetrabutyl urea 13.51
    diisobutyl methanol 3.38
    2-phenylethanol 17.5
    styrene 4.02
    dioctyl adipate 11.64
    dimethyl sulfate 80.86
    ethyl butyrate 14.79
    methyl lactate 48.56
    butyl lactate 16.81
    diethyl carbonate 11.97
    propanediol butyl ether 23.77
    triethyl orthoformate 11.63
    p-tert-butyltoluene 2.14
    methyl 4-tert-butylbenzoate 19.64
    morpholine 75.16
    tert-butylamine 5.24
    n-dodecanol 3.03
    dimethoxymethane 167.16
    ethylene carbonate 45.64
    cyrene 43.09
    2-ethoxyethyl acetate 25.39
    2-ethylhexyl acetate 9.98
    1,2,4-trichlorobenzene 13.16
    4-methylpyridine 30.8
    dibutyl ether 4.65
    2,6-dimethyl-4-heptanol 3.38
    DEF 49.74
    dimethyl isosorbide 41.45
    tetrachloroethylene 30.84
    eugenol 25.12
    triacetin 23.43
    span 80 19.7
    1,4-butanediol 25.47
    1,1-dichloroethane 21.44
    2-methyl-1-pentanol 9.61
    methyl formate 132.32
    2-methyl-1-butanol 12.47
    n-decane 0.45
    butyronitrile 28.85
    3,7-dimethyl-1-octanol 4.71
    1-chlorooctane 2.54
    1-chlorotetradecane 0.9
    n-nonane 0.36
    undecane 0.3
    tert-butylcyclohexane 0.32
    cyclooctane 0.3
    cyclopentanol 21.28
    tetrahydropyran 29.96
    tert-amyl methyl ether 6.4
    2,5,8-trioxanonane 41.84
    1-hexene 2.28
    2-isopropoxyethanol 29.59
    2,2,2-trifluoroethanol 65.36
    methyl butyrate 26.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction