Flunitrazepam

Overview IFRA Request a quote

  • Identifiers

    CAS number
    1622-62-4

    Molecular formula
    C16H12FN3O3

    SMILES
    CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3F

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 50.02%
    Sweet 30.71%
    Grape 28.27%
    Neroli 25.95%
    Bitter 25.84%
    Powdery 22.89%
    Burnt 21.44%
    Floral 21.4%
    Fatty 21.02%
    Roasted 20.35%

     

    Flavor
    Bitter 89.53%
    Odorless 36.25%
    Nitrile 20.26%
    Very strong 19.67%
    Sweet-like 19.39%
    Bread crust 19.34%
    Indole 19.34%
    Bland 19.1%
    Cedarleaf 18.81%
    Taco 18.76%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    8.58 (weak base)

    Molecular weight
    313.28 g/mol

    Melting point expt.

    • 166-167 °C
    • Also reported as crystals from acetonitrile and methanol; melting point: 170-72 °C.
    • 166 - 167 °C

    Flash point

    • 264.82 ˚C est.

    Solubility expt.

    • 8.58e-03 g/L

  • Synonyms

    • flunitrazepam
    • Rohypnol
    • 1622-62-4
    • Narcozep
    • Roipnol
    • Fluninoc
    • Primun
    • flunipam
    • Flunitrazepamum
    • Fluridrazepam
    • Flunitrazepamum [INN-Latin]
    • Silece
    • Ro 5-4200
    • flunidazepam
    • RO-5-4200
    • [3H]flunitrazepam
    • Rohypnol (TN)
    • Flunitrazepam [USAN:INN:BAN:JAN]
    • 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-
    • 5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
    • Hipnosedon
    • CCRIS 5287
    • Flunita
    • Fluscand
    • Hypnodorm
    • Valsera
    • 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one
    • Hypnor
    • Primum
    • RO54200
    • HSDB 6960
    • EINECS 216-597-8
    • Ro-54200
    • 1-Methyl-7-nitro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one
    • 1,3-Dihydro-5-(o-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
    • BRN 0702691
    • DEA No. 2763
    • UNII-620X0222FQ
    • N05CD03
    • FLUNITRAZEPAM [MI]
    • 620X0222FQ
    • FLUNITRAZEPAM [INN]
    • FLUNITRAZEPAM [JAN]
    • FLUNITRAZEPAM [HSDB]
    • FLUNITRAZEPAM [USAN]
    • CHEMBL13280
    • FLUNITRAZEPAM [MART.]
    • 2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-5-(2-FLUOROPHENYL)-1-METHYL-7-NITRO-
    • FLUNITRAZEPAM [WHO-DD]
    • DTXSID7023065
    • CHEBI:31622
    • 5-24-04-00350 (Beilstein Handbook Reference)
    • FLUNITRAZEPAM [EP MONOGRAPH]
    • 5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
    • 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one
    • Flunitrazepamum (INN-Latin)
    • FLUNITRAZEPAM (MART.)
    • FLUNITRAZEPAM (EP MONOGRAPH)
    • 5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydrobenzo[e][1,4]diazepin-2-one
    • Flunitrazepam (1.0 mg/mL in Methanol)
    • Flunitrazepam (1.0mg/ml in Acetonitrile)
    • Roofies
    • 5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydrobenzo(e)(1,4)diazepin-2-one
    • [3H]Rohypnol
    • Flunitrazepamum (Latin)
    • 5-(2-Fluorophenyl)-1-methyl-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one
    • SCHEMBL44169
    • MLS003899224
    • DivK1c_000981
    • DTXCID103065
    • GTPL4193
    • GTPL4360
    • BDBM25878
    • HMS503E03
    • KBio1_000981
    • NINDS_000981
    • Flunitrazepam (JP17/USAN/INN)
    • Flunitrazepam, 1mg/ml in Methanol
    • LBC44808
    • UIA53364
    • NSC708829
    • Flunitrazepam 0.1 mg/ml in Methanol
    • Flunitrazepam 1.0 mg/ml in Methanol
    • AKOS005066009
    • DB01544
    • NSC-708829
    • IDI1_000981
    • SMR000058981
    • DB-043520
    • NS00007996
    • D01230
    • Q62947
    • A810363
    • Flunitrazepam, European Pharmacopoeia (EP) Reference Standard
    • Flunitrazepam-13C6, 100 mug/mL in methanol, certified reference material
    • 1,3-dihydro-5-(2-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
    • 5-(2-Fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
    • 216-597-8
    • Circles, Forget Me Pill, La Rocha, Lunch Money Drug, Mexican Valium, Pingus, R2, Roach 2, Ruffies, Rophies, Wolfies

  • Applications

    Flunitrazepam, CAS 1622-62-4, is primarily an active pharmaceutical ingredient in controlled sedative-hypnotic formulations within the pharmaceutical industry. In analytical laboratories, it is commonly used as a reference standard for method development and quantification of benzodiazepines. It is also evaluated in pharmacology and pharmacokinetics research to understand its action and metabolism in controlled laboratory studies. In formulation development, it supports drug product stabilization and dosage form optimization under regulatory oversight. Finally, its status as a controlled substance drives regulatory/compliance activities across manufacturing, handling, and supply chains to meet local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.34
    methanol 6.51
    isopropanol 2.82
    water 0.01
    ethyl acetate 34.84
    n-propanol 3.64
    acetone 72.82
    n-butanol 2.88
    acetonitrile 40.09
    DMF 127.97
    toluene 18.48
    isobutanol 2.93
    1,4-dioxane 56.39
    methyl acetate 55.92
    THF 94.93
    2-butanone 56.87
    n-pentanol 3.88
    sec-butanol 3.64
    n-hexane 0.11
    ethylene glycol 4.06
    NMP 122.92
    cyclohexane 0.15
    DMSO 156.43
    n-butyl acetate 21.38
    n-octanol 1.11
    chloroform 60.28
    n-propyl acetate 26.19
    acetic acid 38.62
    dichloromethane 102.6
    cyclohexanone 59.97
    propylene glycol 3.17
    isopropyl acetate 18.27
    DMAc 160.47
    2-ethoxyethanol 28.73
    isopentanol 3.86
    n-heptane 0.14
    ethyl formate 27.82
    1,2-dichloroethane 60.33
    n-hexanol 3.77
    2-methoxyethanol 36.26
    isobutyl acetate 10.86
    tetrachloromethane 2.99
    n-pentyl acetate 10.72
    transcutol 94.13
    n-heptanol 2.38
    ethylbenzene 7.32
    MIBK 14.26
    2-propoxyethanol 29.25
    tert-butanol 5.22
    MTBE 7.08
    2-butoxyethanol 15.36
    propionic acid 18.15
    o-xylene 9.35
    formic acid 26.82
    diethyl ether 8.02
    m-xylene 7.68
    p-xylene 10.01
    chlorobenzene 27.34
    dimethyl carbonate 46.91
    n-octane 0.06
    formamide 62.65
    cyclopentanone 105.18
    2-pentanone 26.32
    anisole 35.43
    cyclopentyl methyl ether 15.53
    gamma-butyrolactone 134.4
    1-methoxy-2-propanol 21.14
    pyridine 86.77
    3-pentanone 26.98
    furfural 154.51
    n-dodecane 0.08
    diethylene glycol 31.86
    diisopropyl ether 2.0
    tert-amyl alcohol 5.92
    acetylacetone 75.69
    n-hexadecane 0.1
    acetophenone 45.94
    methyl propionate 37.91
    isopentyl acetate 17.64
    trichloroethylene 169.98
    n-nonanol 1.55
    cyclohexanol 4.43
    benzyl alcohol 27.96
    2-ethylhexanol 3.73
    isooctanol 2.46
    dipropyl ether 6.58
    1,2-dichlorobenzene 28.76
    ethyl lactate 20.9
    propylene carbonate 59.39
    n-methylformamide 49.01
    2-pentanol 2.05
    n-pentane 0.07
    1-propoxy-2-propanol 18.81
    1-methoxy-2-propyl acetate 39.42
    2-(2-methoxypropoxy) propanol 30.6
    mesitylene 3.39
    ε-caprolactone 51.7
    p-cymene 4.8
    epichlorohydrin 159.78
    1,1,1-trichloroethane 28.11
    2-aminoethanol 5.36
    morpholine-4-carbaldehyde 141.35
    sulfolane 151.64
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 31.57
    n-hexyl acetate 9.55
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 29.94
    sec-butyl acetate 15.26
    tert-butyl acetate 19.61
    decalin 0.31
    glycerin 12.41
    diglyme 82.81
    acrylic acid 31.3
    isopropyl myristate 5.31
    n-butyric acid 16.37
    acetyl acetate 36.31
    di(2-ethylhexyl) phthalate 11.92
    ethyl propionate 26.06
    nitromethane 189.06
    1,2-diethoxyethane 23.65
    benzonitrile 37.28
    trioctyl phosphate 5.47
    1-bromopropane 9.58
    gamma-valerolactone 152.33
    n-decanol 1.36
    triethyl phosphate 16.39
    4-methyl-2-pentanol 2.06
    propionitrile 20.02
    vinylene carbonate 66.7
    1,1,2-trichlorotrifluoroethane 99.62
    DMS 36.47
    cumene 4.08
    2-octanol 1.2
    2-hexanone 23.73
    octyl acetate 7.01
    limonene 5.22
    1,2-dimethoxyethane 68.17
    ethyl orthosilicate 12.68
    tributyl phosphate 8.39
    diacetone alcohol 27.16
    N,N-dimethylaniline 17.9
    acrylonitrile 46.13
    aniline 25.53
    1,3-propanediol 7.59
    bromobenzene 27.65
    dibromomethane 34.86
    1,1,2,2-tetrachloroethane 79.71
    2-methyl-cyclohexyl acetate 18.43
    tetrabutyl urea 12.56
    diisobutyl methanol 2.73
    2-phenylethanol 23.2
    styrene 11.86
    dioctyl adipate 14.9
    dimethyl sulfate 92.96
    ethyl butyrate 21.44
    methyl lactate 30.67
    butyl lactate 14.21
    diethyl carbonate 20.33
    propanediol butyl ether 10.6
    triethyl orthoformate 16.59
    p-tert-butyltoluene 4.04
    methyl 4-tert-butylbenzoate 28.14
    morpholine 47.33
    tert-butylamine 1.99
    n-dodecanol 1.16
    dimethoxymethane 57.49
    ethylene carbonate 44.17
    cyrene 46.08
    2-ethoxyethyl acetate 31.13
    2-ethylhexyl acetate 14.04
    1,2,4-trichlorobenzene 43.46
    4-methylpyridine 65.87
    dibutyl ether 3.38
    2,6-dimethyl-4-heptanol 2.73
    DEF 41.27
    dimethyl isosorbide 62.44
    tetrachloroethylene 42.65
    eugenol 31.04
    triacetin 32.31
    span 80 17.88
    1,4-butanediol 4.94
    1,1-dichloroethane 28.81
    2-methyl-1-pentanol 5.19
    methyl formate 62.74
    2-methyl-1-butanol 3.79
    n-decane 0.1
    butyronitrile 12.14
    3,7-dimethyl-1-octanol 2.32
    1-chlorooctane 0.89
    1-chlorotetradecane 0.56
    n-nonane 0.07
    undecane 0.09
    tert-butylcyclohexane 0.25
    cyclooctane 0.06
    cyclopentanol 6.33
    tetrahydropyran 18.83
    tert-amyl methyl ether 7.38
    2,5,8-trioxanonane 59.54
    1-hexene 1.12
    2-isopropoxyethanol 19.83
    2,2,2-trifluoroethanol 27.6
    methyl butyrate 32.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction