Flavone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    525-82-6

    Molecular formula
    C15H10O2

    SMILES
    C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 61.84%
    Coumarinic 44.5%
    Phenolic 41.16%
    Floral 40.42%
    Balsamic 38.82%
    Powdery 38.77%
    Bitter 32.93%
    Coconut 30.94%
    Fruity 30.19%
    Almond 30.09%

     

    Flavor
    Bitter 88.17%
    Balsam 29.61%
    Sweet 28.82%
    Tonka 28.61%
    Green 26.6%
    New mown hay 22.73%
    Moth ball 22.22%
    Naphthelene 21.95%
    Very strong 21.35%
    Tar 21.07%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.6

    pKa est.
    6.9 (neutral)

    Molecular weight
    222.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    400°C

    Melting point expt.

    • 100 °C

    Flash point

    • 156.15 ˚C est.

  • Synonyms

    • FLAVONE
    • 525-82-6
    • 2-Phenyl-4H-chromen-4-one
    • 2-Phenylchromone
    • 2-Phenyl-4-chromone
    • Asmacoril
    • Chromocor
    • Cromaril
    • 2-Phenyl-4H-1-benzopyran-4-one
    • 2-phenylchromen-4-one
    • Phenylchromone
    • 2-Phenyl-4-benzopyron
    • Cromarile
    • 2-Phenyl-gamma-benzopyrone
    • Flavon
    • 2-Phenylbenzopyran-4-one
    • 2-Phenyl-4H-benzopyran-4-one
    • NSC-19028
    • DTXSID2022048
    • 2-phenyl-1,4-benzopyrone
    • S2V45N7G3B
    • DTXCID602048
    • CHEBI:42491
    • RefChem:140659
    • CHEBI:24043
    • 208-383-8
    • 4H-1-Benzopyran-4-one, 2-phenyl-
    • MFCD00006825
    • 2-Phenyl-.gamma.-benzopyrone
    • NSC 19028
    • NSC19028
    • MLS002638647
    • CHEMBL275638
    • NCGC00090962-05
    • 2-Phenyl-4H-chromen-4-on
    • CAS-525-82-6
    • FLN
    • SMR000112315
    • Flavone (VAN)
    • CCRIS 4288
    • EINECS 208-383-8
    • BRN 0157598
    • UNII-S2V45N7G3B
    • Flavone, Flavone
    • 4hki
    • 2-phenyl-4H-chromone
    • FLAVONE [MI]
    • Maybridge3_005286
    • bmse000945
    • CBiol_000263
    • SCHEMBL18879
    • GTPL409
    • 5-17-10-00552 (Beilstein Handbook Reference)
    • MLS002177804
    • MLS002473400
    • 2-Phenylbenzo[b]pyran-4-one
    • BIDD:ER0515
    • 2-phenyl-1-benzopyran-4-one
    • MEGxp0_001685
    • orb1304901
    • SCHEMBL5711741
    • SCHEMBL9698458
    • SCHEMBL13738984
    • SCHEMBL15263674
    • SCHEMBL15668191
    • SCHEMBL31316377
    • 2-Phenyl-4H-chromen-4-one #
    • ACon1_000055
    • HMS1446A06
    • HMS2269O06
    • HMS3604K19
    • HMS5082P07
    • HY-N2424
    • Tox21_202987
    • Tox21_400059
    • BDBM50028962
    • EBC-26233
    • ICCB2_000263
    • LMPK12110097
    • MSK158898
    • s3967
    • SBB072435
    • STK164205
    • AKOS000603572
    • CCG-214679
    • DB07776
    • FF52488
    • IDI1_016673
    • NCGC00090962-01
    • NCGC00090962-02
    • NCGC00090962-03
    • NCGC00090962-04
    • NCGC00090962-06
    • NCGC00168837-01
    • NCGC00260532-01
    • AC-35144
    • AS-58464
    • SY012830
    • DB-052142
    • CS-0022637
    • F0015
    • NS00007856
    • ST45028199
    • C10043
    • 525F826
    • AH-357/03404044
    • EN300-18246169
    • F814377
    • L001213
    • CU-00000000060-1
    • Q2742033
    • BRD-K86741145-001-01-5
    • 6CC153EB-39A6-42FC-BE96-C8BF1D585E27
    • 11091-19-3
    • InChI=1/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10
    • Flavone

  • Applications

    Flavone (CAS 525-82-6) is primarily used as an intermediate in chemical synthesis, enabling the preparation of flavonoid derivatives and core structures for pharmaceuticals, dyes, and related products. It is also employed as a research reagent or standard in organic synthesis and analytical studies. In cosmetics and personal care, flavone is evaluated as a natural polyphenol with potential as a colorant precursor and antioxidant in formulations. In coatings and inks, its derivatives are explored as pigments or UV-absorbing components for color, protection, and polymer systems. More generally, flavone serves as a building block in materials science and product development, with practical use governed by local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.65
    methanol 4.14
    isopropanol 2.97
    water 0.01
    ethyl acetate 17.24
    n-propanol 4.66
    acetone 28.81
    n-butanol 4.77
    acetonitrile 13.41
    DMF 105.1
    toluene 17.6
    isobutanol 4.16
    1,4-dioxane 64.41
    methyl acetate 29.23
    THF 118.8
    2-butanone 32.02
    n-pentanol 5.77
    sec-butanol 3.53
    n-hexane 0.33
    ethylene glycol 2.12
    NMP 69.07
    cyclohexane 0.64
    DMSO 59.19
    n-butyl acetate 24.21
    n-octanol 4.2
    chloroform 50.47
    n-propyl acetate 23.9
    acetic acid 17.32
    dichloromethane 87.84
    cyclohexanone 58.77
    propylene glycol 2.11
    isopropyl acetate 15.3
    DMAc 108.91
    2-ethoxyethanol 15.6
    isopentanol 6.77
    n-heptane 0.74
    ethyl formate 16.91
    1,2-dichloroethane 97.5
    n-hexanol 7.21
    2-methoxyethanol 24.34
    isobutyl acetate 19.26
    tetrachloromethane 1.65
    n-pentyl acetate 15.66
    transcutol 168.35
    n-heptanol 5.08
    ethylbenzene 13.36
    MIBK 18.97
    2-propoxyethanol 21.96
    tert-butanol 5.21
    MTBE 8.61
    2-butoxyethanol 16.06
    propionic acid 11.27
    o-xylene 10.26
    formic acid 5.01
    diethyl ether 10.3
    m-xylene 9.57
    p-xylene 16.07
    chlorobenzene 28.84
    dimethyl carbonate 19.51
    n-octane 0.45
    formamide 16.97
    cyclopentanone 86.98
    2-pentanone 20.25
    anisole 36.85
    cyclopentyl methyl ether 25.24
    gamma-butyrolactone 95.28
    1-methoxy-2-propanol 16.14
    pyridine 104.24
    3-pentanone 17.94
    furfural 106.37
    n-dodecane 0.67
    diethylene glycol 19.67
    diisopropyl ether 4.09
    tert-amyl alcohol 5.42
    acetylacetone 43.29
    n-hexadecane 0.84
    acetophenone 38.52
    methyl propionate 18.53
    isopentyl acetate 26.58
    trichloroethylene 184.31
    n-nonanol 5.19
    cyclohexanol 7.32
    benzyl alcohol 22.39
    2-ethylhexanol 8.23
    isooctanol 5.64
    dipropyl ether 12.83
    1,2-dichlorobenzene 31.22
    ethyl lactate 11.28
    propylene carbonate 40.47
    n-methylformamide 23.52
    2-pentanol 3.14
    n-pentane 0.2
    1-propoxy-2-propanol 15.87
    1-methoxy-2-propyl acetate 32.93
    2-(2-methoxypropoxy) propanol 29.77
    mesitylene 5.77
    ε-caprolactone 51.03
    p-cymene 8.78
    epichlorohydrin 164.2
    1,1,1-trichloroethane 21.94
    2-aminoethanol 3.93
    morpholine-4-carbaldehyde 86.86
    sulfolane 92.33
    2,2,4-trimethylpentane 0.52
    2-methyltetrahydrofuran 41.53
    n-hexyl acetate 19.47
    isooctane 0.38
    2-(2-butoxyethoxy)ethanol 35.38
    sec-butyl acetate 18.52
    tert-butyl acetate 20.36
    decalin 1.45
    glycerin 6.12
    diglyme 102.51
    acrylic acid 15.89
    isopropyl myristate 10.47
    n-butyric acid 14.8
    acetyl acetate 19.69
    di(2-ethylhexyl) phthalate 12.4
    ethyl propionate 20.24
    nitromethane 56.85
    1,2-diethoxyethane 39.83
    benzonitrile 32.41
    trioctyl phosphate 6.66
    1-bromopropane 17.8
    gamma-valerolactone 116.96
    n-decanol 4.33
    triethyl phosphate 15.66
    4-methyl-2-pentanol 4.33
    propionitrile 13.56
    vinylene carbonate 47.06
    1,1,2-trichlorotrifluoroethane 53.4
    DMS 35.31
    cumene 9.28
    2-octanol 3.39
    2-hexanone 24.9
    octyl acetate 11.31
    limonene 9.32
    1,2-dimethoxyethane 66.25
    ethyl orthosilicate 14.16
    tributyl phosphate 10.02
    diacetone alcohol 23.89
    N,N-dimethylaniline 22.06
    acrylonitrile 29.52
    aniline 20.95
    1,3-propanediol 7.33
    bromobenzene 28.24
    dibromomethane 37.61
    1,1,2,2-tetrachloroethane 97.77
    2-methyl-cyclohexyl acetate 23.35
    tetrabutyl urea 14.58
    diisobutyl methanol 7.16
    2-phenylethanol 21.38
    styrene 17.59
    dioctyl adipate 19.63
    dimethyl sulfate 34.18
    ethyl butyrate 22.36
    methyl lactate 11.97
    butyl lactate 13.68
    diethyl carbonate 18.25
    propanediol butyl ether 12.08
    triethyl orthoformate 18.64
    p-tert-butyltoluene 7.64
    methyl 4-tert-butylbenzoate 28.05
    morpholine 55.38
    tert-butylamine 3.17
    n-dodecanol 3.72
    dimethoxymethane 46.42
    ethylene carbonate 31.84
    cyrene 27.8
    2-ethoxyethyl acetate 31.97
    2-ethylhexyl acetate 21.54
    1,2,4-trichlorobenzene 41.42
    4-methylpyridine 61.42
    dibutyl ether 13.87
    2,6-dimethyl-4-heptanol 7.16
    DEF 33.2
    dimethyl isosorbide 63.85
    tetrachloroethylene 50.26
    eugenol 29.36
    triacetin 31.63
    span 80 18.54
    1,4-butanediol 3.12
    1,1-dichloroethane 25.76
    2-methyl-1-pentanol 8.97
    methyl formate 24.6
    2-methyl-1-butanol 5.8
    n-decane 0.95
    butyronitrile 11.81
    3,7-dimethyl-1-octanol 7.01
    1-chlorooctane 5.1
    1-chlorotetradecane 2.76
    n-nonane 0.73
    undecane 0.78
    tert-butylcyclohexane 1.38
    cyclooctane 0.26
    cyclopentanol 9.36
    tetrahydropyran 35.3
    tert-amyl methyl ether 8.88
    2,5,8-trioxanonane 65.78
    1-hexene 3.51
    2-isopropoxyethanol 13.64
    2,2,2-trifluoroethanol 7.98
    methyl butyrate 29.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction