Fisetin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    528-48-3

    Molecular formula
    C15H10O6

    SMILES
    C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 61.26%
    Odorless 56.86%
    Burnt 44.04%
    Smoky 27.94%
    Medicinal 26.18%
    Spicy 22.36%
    Vanilla 21.43%
    Balsamic 21.1%
    Savory 20.92%
    Bitter 19.4%

     

    Flavor
    Bitter 94.64%
    Odorless 22.21%
    Sweet-like 21.19%
    Very strong 20.33%
    Indole 19.9%
    Cedarleaf 19.72%
    Eugenol 19.69%
    Nitrile 19.62%
    Rotten 19.6%
    Curry 19.26%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    10.04 (weak base)

    Molecular weight
    286.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    774°C

    Flash point

    • 242.94 ˚C est.

  • Synonyms

    • Fisetin
    • 528-48-3
    • 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one
    • 5-Desoxyquercetin
    • 3,3',4',7-Tetrahydroxyflavone
    • 3,7,3',4'-Tetrahydroxyflavone
    • Fustel
    • Viset
    • Fisetholz
    • Superfustel
    • Cotinin
    • Fietin
    • Fustet
    • Junger fustik
    • C.I. Natural Brown 1
    • C.I. 75620
    • Fisidenolon 1521
    • 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
    • 7,3',4'-Trihydroxyflavonol
    • 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one
    • NSC-407010
    • NSC-656275
    • OO2ABO9578
    • DTXSID4022317
    • CHEBI:42567
    • 5-Desoxy-quercetin
    • RefChem:599234
    • 7,3',4'-Flavon-3-ol
    • DTXCID902317
    • 3,3',4',7-Tetrahydroxy-flavone
    • 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-1-benzopyrylium
    • 208-434-4
    • Ventin sumach
    • Young fustic
    • Zante fustic
    • Superfustel K
    • Ungarisches gelbholz
    • Young fustic crystals
    • Bois bleu de Honqrie
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-
    • MFCD00006829
    • Fisetin (Standard)
    • NSC 407010
    • NSC 656275
    • NSC407010
    • 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromen-4-one
    • CHEMBL31574
    • FLAVONE, 3,3',4',7-TETRAHYDROXY-
    • TNP00284
    • Fisetin hydrate
    • NSC656275
    • 5-Deoxyquercetin
    • BOIS bleude honqrie
    • FSE
    • CCRIS 9034
    • SR-05000002249
    • EINECS 208-434-4
    • BRN 0292829
    • UNII-OO2ABO9578
    • Fisetine
    • Fisetin (Fustel)
    • Fisetin, 15
    • Spectrum_001196
    • 1xo2
    • SpecPlus_000460
    • FISETIN [MI]
    • Spectrum2_001160
    • Spectrum3_001536
    • Spectrum4_001070
    • Spectrum5_001797
    • FISETIN [WHO-DD]
    • NCIMech_000006
    • SCHEMBL39454
    • 3,3'4'7-tetOH-Flavone
    • 3,4',7-Tetrahydroxyflavone
    • BSPBio_002952
    • KBioGR_001400
    • KBioSS_001676
    • 5-18-05-00291 (Beilstein Handbook Reference)
    • MLS006011782
    • BIDD:ER0141
    • DivK1c_006556
    • SPECTRUM1502247
    • SPBio_001119
    • BDBM7457
    • GTPL5182
    • orb1304898
    • SCHEMBL29349742
    • SCHEMBL29381611
    • SCHEMBL29394036
    • HY-N0182R
    • KBio1_001500
    • KBio2_001676
    • KBio2_004244
    • KBio2_006812
    • KBio3_002452
    • Flavone,3',4',7-tetrahydroxy-
    • HMS3604H03
    • HMS3655L22
    • BB_NC-02603
    • HY-N0182
    • TNP00004
    • BBL027612
    • CCG-35267
    • EBC-11090
    • LMPK12111566
    • s2298
    • SBB066118
    • STL146392
    • AKOS000277885
    • CS-7840
    • DB07795
    • FF29463
    • SDCCGMLS-0066657.P001
    • NCGC00017344-01
    • NCGC00017344-02
    • NCGC00017344-03
    • NCGC00017344-04
    • NCGC00017344-05
    • NCGC00017344-06
    • NCGC00017344-14
    • NCGC00095663-01
    • NCGC00095663-02
    • NCGC00178374-01
    • AC-34567
    • AS-15520
    • NCI60_003865
    • Fisetin

  • Applications

    Fisetin (CAS 528-48-3) is a plant-derived flavonoid with real-world applications across several industries: as an antioxidant ingredient in cosmetics/personal care formulations; as a bioactive polyphenol studied in pharmaceutical/natural product research; evaluated for use as a natural antioxidant in food processing and in packaging materials; investigated as a stabilizing additive in polymer formulations, coatings, and inks to improve oxidative stability of materials; and examined in agriculture and plant science for potential natural plant-protection roles and as a reference standard in plant chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.54
    methanol 1.52
    isopropanol 2.13
    water 0.01
    ethyl acetate 1.0
    n-propanol 3.19
    acetone 0.05
    n-butanol 3.18
    acetonitrile 0.07
    DMF 10.29
    toluene 0.05
    isobutanol 1.39
    1,4-dioxane 2.49
    methyl acetate 0.8
    THF 14.01
    2-butanone 1.56
    n-pentanol 1.22
    sec-butanol 5.47
    n-hexane 0.0
    ethylene glycol 3.07
    NMP 7.59
    cyclohexane 0.0
    DMSO 20.38
    n-butyl acetate 0.97
    n-octanol 2.05
    chloroform 0.0
    n-propyl acetate 0.69
    acetic acid 0.97
    dichloromethane 0.0
    cyclohexanone 1.37
    propylene glycol 3.36
    isopropyl acetate 1.16
    DMAc 25.51
    2-ethoxyethanol 15.08
    isopentanol 2.83
    n-heptane 0.01
    ethyl formate 0.4
    1,2-dichloroethane 0.0
    n-hexanol 1.23
    2-methoxyethanol 40.25
    isobutyl acetate 0.18
    tetrachloromethane 0.0
    n-pentyl acetate 1.74
    transcutol 33.24
    n-heptanol 2.17
    ethylbenzene 0.05
    MIBK 1.0
    2-propoxyethanol 14.85
    tert-butanol 3.74
    MTBE 1.71
    2-butoxyethanol 9.26
    propionic acid 1.48
    o-xylene 0.1
    formic acid 2.18
    diethyl ether 0.53
    m-xylene 0.07
    p-xylene 0.04
    chlorobenzene 0.0
    dimethyl carbonate 1.06
    n-octane 0.01
    formamide 5.78
    cyclopentanone 2.47
    2-pentanone 0.99
    anisole 0.63
    cyclopentyl methyl ether 2.07
    gamma-butyrolactone 3.82
    1-methoxy-2-propanol 33.0
    pyridine 0.81
    3-pentanone 0.6
    furfural 2.82
    n-dodecane 0.02
    diethylene glycol 15.49
    diisopropyl ether 0.18
    tert-amyl alcohol 7.53
    acetylacetone 1.51
    n-hexadecane 0.02
    acetophenone 0.79
    methyl propionate 1.92
    isopentyl acetate 1.23
    trichloroethylene 0.0
    n-nonanol 2.5
    cyclohexanol 1.76
    benzyl alcohol 0.99
    2-ethylhexanol 0.92
    isooctanol 1.68
    dipropyl ether 1.14
    1,2-dichlorobenzene 0.01
    ethyl lactate 2.09
    propylene carbonate 0.78
    n-methylformamide 3.41
    2-pentanol 2.83
    n-pentane 0.0
    1-propoxy-2-propanol 11.59
    1-methoxy-2-propyl acetate 5.05
    2-(2-methoxypropoxy) propanol 10.59
    mesitylene 0.05
    ε-caprolactone 3.17
    p-cymene 0.17
    epichlorohydrin 2.39
    1,1,1-trichloroethane 0.0
    2-aminoethanol 5.7
    morpholine-4-carbaldehyde 14.73
    sulfolane 8.7
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 4.29
    n-hexyl acetate 2.62
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 16.35
    sec-butyl acetate 0.71
    tert-butyl acetate 2.31
    decalin 0.01
    glycerin 14.39
    diglyme 22.8
    acrylic acid 1.35
    isopropyl myristate 1.16
    n-butyric acid 1.99
    acetyl acetate 0.27
    di(2-ethylhexyl) phthalate 1.02
    ethyl propionate 0.99
    nitromethane 1.66
    1,2-diethoxyethane 5.13
    benzonitrile 0.17
    trioctyl phosphate 0.98
    1-bromopropane 0.01
    gamma-valerolactone 11.35
    n-decanol 1.78
    triethyl phosphate 0.85
    4-methyl-2-pentanol 1.34
    propionitrile 0.29
    vinylene carbonate 0.42
    1,1,2-trichlorotrifluoroethane 3.86
    DMS 1.36
    cumene 0.05
    2-octanol 1.74
    2-hexanone 0.74
    octyl acetate 1.65
    limonene 0.23
    1,2-dimethoxyethane 14.71
    ethyl orthosilicate 0.93
    tributyl phosphate 0.92
    diacetone alcohol 10.89
    N,N-dimethylaniline 0.62
    acrylonitrile 0.48
    aniline 0.56
    1,3-propanediol 11.31
    bromobenzene 0.0
    dibromomethane 0.0
    1,1,2,2-tetrachloroethane 0.01
    2-methyl-cyclohexyl acetate 0.87
    tetrabutyl urea 1.92
    diisobutyl methanol 0.91
    2-phenylethanol 1.3
    styrene 0.03
    dioctyl adipate 1.7
    dimethyl sulfate 2.56
    ethyl butyrate 1.09
    methyl lactate 6.06
    butyl lactate 3.32
    diethyl carbonate 0.56
    propanediol butyl ether 8.5
    triethyl orthoformate 1.75
    p-tert-butyltoluene 0.2
    methyl 4-tert-butylbenzoate 3.19
    morpholine 10.65
    tert-butylamine 0.73
    n-dodecanol 1.13
    dimethoxymethane 9.39
    ethylene carbonate 0.37
    cyrene 5.79
    2-ethoxyethyl acetate 3.83
    2-ethylhexyl acetate 0.73
    1,2,4-trichlorobenzene 0.03
    4-methylpyridine 0.53
    dibutyl ether 1.58
    2,6-dimethyl-4-heptanol 0.91
    DEF 5.3
    dimethyl isosorbide 10.92
    tetrachloroethylene 0.01
    eugenol 3.92
    triacetin 2.65
    span 80 6.16
    1,4-butanediol 1.98
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 1.5
    methyl formate 1.08
    2-methyl-1-butanol 3.44
    n-decane 0.04
    butyronitrile 0.27
    3,7-dimethyl-1-octanol 1.69
    1-chlorooctane 0.18
    1-chlorotetradecane 0.08
    n-nonane 0.02
    undecane 0.03
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 1.87
    tetrahydropyran 1.21
    tert-amyl methyl ether 3.33
    2,5,8-trioxanonane 16.8
    1-hexene 0.01
    2-isopropoxyethanol 6.8
    2,2,2-trifluoroethanol 0.46
    methyl butyrate 1.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction