Fipronil

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  • Identifiers

    CAS number
    120068-37-3

    Molecular formula
    C12H4Cl2F6N4OS

    SMILES
    C1=C(C=C(C(=C1Cl)N2C(=C(C(=N2)C#N)S(=O)C(F)(F)F)N)Cl)C(F)(F)F

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 66.72%
    Savory 22.62%
    Cooling 19.94%
    Bitter 18.9%
    Meaty 18.23%
    Cooked 17.77%
    Animal 17.45%
    Dry 16.24%
    Milky 16.1%
    Fatty 15.6%

     

    Flavor
    Bitter 71.18%
    Odorless 41.49%
    Bland 25.22%
    Mild 20.09%
    Sweet-like 19.07%
    Nitrile 18.76%
    Scallion 17.87%
    Very strong 17.67%
    Bread crust 17.58%
    Taco 17.52%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    4.5

    pKa est.
    -7.41 (strong acid)

    Molecular weight
    437.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    510°C

    Melting point expt.

    • 200-201 °C
    • 201 °C

    Flash point

    • 252.17 ˚C est.

    Solubility expt.

    • In water, 1.9 mg/L (pH 5), 2.4 mg/L (pH 9), 1.9 mg/L (distilled), all at 20 °C
    • In water, 2 mg/L
    • In organic solvents (g/L at 20 °C): acetone 545.9, dichloromethane 22.3, hexane 0.028, toluene 3.0
    • In acetone, >50%; corn oil >10,000 mg/L
    • Solubility in water: very poor

  • Synonyms

    • fipronil
    • 120068-37-3
    • Termidor
    • RM 1601
    • MB 46030
    • DTXSID4034609
    • 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile
    • 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1h-pyrazole-3-carbonitrile
    • 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile
    • NSC-758960
    • FRONTLINE
    • Fipronil (ema epar: veterinary)
    • QGH063955F
    • RM-1601
    • MB-46030
    • DTXCID2014609
    • CHEBI:83394
    • BROADLINE COMPONENT FIPRONIL
    • (RS)-5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile
    • 1H-Pyrazole-3-carbonitrile, 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-
    • 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-trifluoromethanesulfinyl-1H-pyrazole-3-carbonitrile
    • 1H-Pyrazole-3-carbonitrile, 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-
    • 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile
    • 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-trifluoromethanesulfinyl-1H-pyrazole-3-carbonitrile
    • RefChem:55202
    • 5-amino-1-(2,6-dichloro-alpha,alpha,alpha-trifluoro-p-tolyl)-4-trifluoromethylsulfinylpyrazole-3-carbonitile
    • CHEBI:5063
    • 424-610-5
    • 5-AMINO-1-(2,6-DICHLORO-alpha,alpha,alpha-TRIFLUORO-P-TOLYL)-4-((TRIFLUOROMETHYL)SULFINYL)PYRAZOLE-3-CARBONITRILE
    • fipronil (ISO); (+-)-5-amino-1-(2,6-dichloro-alpha,alpha,alpha-trifluoro-para-tolyl)-4-trifluoromethylsulfinyl-pyrazole-3-carbonitrile
    • C12H4Cl2F6N4OS
    • Fipronil [ISO]
    • (+/-)-Fipronil
    • MFCD00867812
    • CHEMBL101326
    • Fipronil (JAN)
    • NCGC00094574-06
    • FIPRONIL [JAN]
    • 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole
    • 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethane)sulfinyl-1H-pyrazole-3-carbonitrile
    • 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(S)-trifluoromethylsulfinyl]pyrazole-3-carbonitrile
    • 1-(2,6-Dichloro-4-trifluoromethylphenyl)-3-cyano-5-amino-4-(trifluoromethylsulfinyl)pyrazole
    • CAS-120068-37-3
    • HSDB 7051
    • UNII-QGH063955F
    • Fipronil CRS
    • M & B 46030
    • Fipronil (Standard)
    • Fipronil 1000 microg/mL in Acetone
    • Fipronil 10 microg/mL in Acetonitrile
    • Fipronil 100 microg/mL in Acetonitrile
    • Fipronil [INN:BAN]
    • FIPRONIL [HSDB]
    • FIPRONIL [MI]
    • FIPRONIL [MART.]
    • UPCMLD-DP011
    • EC 424-610-5
    • Fluocyanobenpyrazole;Termidor
    • CBiol_001754
    • SCHEMBL15088
    • BSPBio_001315
    • BSPBio_002266
    • KBioGR_000035
    • KBioSS_000035
    • MLS004712079
    • SPECTRUM1505354
    • orb1306142
    • UPCMLD-DP011:001
    • UPCMLD-DP011:002
    • BCBcMAP01_000152
    • HY-B0822R
    • KBio2_000035
    • KBio2_002603
    • KBio2_005171
    • KBio3_000069
    • KBio3_000070
    • Bio1_000040
    • Bio1_000529
    • Bio1_001018
    • Bio2_000035
    • Bio2_000515
    • HMS1361B17
    • HMS1791B17
    • HMS1922F08
    • HMS1989B17
    • HMS2093D09
    • HMS3402B17
    • HMS5084G14
    • Pharmakon1600-01505354
    • Fipronil for system suitability CRS
    • HY-B0822
    • MSK20305
    • Tox21_111300
    • Tox21_301114
    • AC-427
    • BDBM50106148
    • CM-102
    • EBC-44121
    • NSC758960
    • s5366
    • AKOS015960931
    • Fluocyanobenpyrazole, Taurus, Termidor
    • Tox21_111300_1
    • CCG-213975
    • FA23290
    • KS-5066
    • NSC 758960
    • IDI1_033785
    • NCGC00094574-01
    • NCGC00094574-02
    • NCGC00094574-03
    • NCGC00094574-05
    • NCGC00094574-07
    • NCGC00094574-08
    • NCGC00094574-09
    • NCGC00094574-10
    • NCGC00094574-11
    • NCGC00094574-12
    • NCGC00094574-13
    • NCGC00094574-15
    • NCGC00255014-01
    • SMR000777967
    • SY066868
    • SBI-0206839.P001
    • DB-041522
    • CS-0012838
    • F0822
    • 120068-37-3

  • Applications

    Fipronil (CAS 120068-37-3) is a broad-spectrum insecticide used in agriculture to control pests on crops, applied as seed treatments, soil treatments, or foliar sprays to manage insects such as aphids and beetles. It is also used in veterinary products for companion animals, in topical formulations to control fleas and ticks. In urban and structural pest control, fipronil serves as a termiticide and is used in termite bait systems and wood-protection treatments. It appears in consumer household pest control products (sprays or baits) for controlling ants, cockroaches, and other insects. Additionally, it is used in wood preservation and coatings to protect timber from termite and other wood-destroying insects, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 37.52
    methanol 67.08
    isopropanol 18.1
    water 0.35
    ethyl acetate 114.78
    n-propanol 23.73
    acetone 180.67
    n-butanol 14.92
    acetonitrile 99.11
    DMF 439.9
    toluene 16.38
    isobutanol 13.16
    1,4-dioxane 114.12
    methyl acetate 144.67
    THF 294.43
    2-butanone 119.0
    n-pentanol 13.68
    sec-butanol 16.85
    n-hexane 0.57
    ethylene glycol 28.29
    NMP 342.79
    cyclohexane 1.19
    DMSO 508.46
    n-butyl acetate 65.81
    n-octanol 15.17
    chloroform 47.03
    n-propyl acetate 83.77
    acetic acid 97.72
    dichloromethane 61.96
    cyclohexanone 91.45
    propylene glycol 19.97
    isopropyl acetate 69.44
    DMAc 374.07
    2-ethoxyethanol 94.34
    isopentanol 10.85
    n-heptane 1.72
    ethyl formate 79.58
    1,2-dichloroethane 45.92
    n-hexanol 17.72
    2-methoxyethanol 157.55
    isobutyl acetate 30.85
    tetrachloromethane 4.63
    n-pentyl acetate 58.23
    transcutol 135.03
    n-heptanol 16.95
    ethylbenzene 8.87
    MIBK 39.28
    2-propoxyethanol 104.0
    tert-butanol 17.79
    MTBE 28.45
    2-butoxyethanol 63.36
    propionic acid 49.64
    o-xylene 13.34
    formic acid 89.09
    diethyl ether 43.41
    m-xylene 10.02
    p-xylene 10.46
    chlorobenzene 16.05
    dimethyl carbonate 140.5
    n-octane 1.05
    formamide 167.5
    cyclopentanone 201.81
    2-pentanone 80.8
    anisole 56.51
    cyclopentyl methyl ether 63.17
    gamma-butyrolactone 277.49
    1-methoxy-2-propanol 93.31
    pyridine 98.47
    3-pentanone 74.07
    furfural 231.86
    n-dodecane 1.22
    diethylene glycol 94.04
    diisopropyl ether 11.36
    tert-amyl alcohol 18.11
    acetylacetone 197.85
    n-hexadecane 1.44
    acetophenone 71.05
    methyl propionate 128.35
    isopentyl acetate 41.35
    trichloroethylene 94.77
    n-nonanol 15.59
    cyclohexanol 13.44
    benzyl alcohol 32.58
    2-ethylhexanol 12.5
    isooctanol 11.67
    dipropyl ether 31.85
    1,2-dichlorobenzene 17.57
    ethyl lactate 52.59
    propylene carbonate 116.37
    n-methylformamide 186.55
    2-pentanol 10.51
    n-pentane 0.91
    1-propoxy-2-propanol 64.71
    1-methoxy-2-propyl acetate 107.01
    2-(2-methoxypropoxy) propanol 70.55
    mesitylene 5.72
    ε-caprolactone 101.31
    p-cymene 10.07
    epichlorohydrin 199.78
    1,1,1-trichloroethane 28.71
    2-aminoethanol 31.53
    morpholine-4-carbaldehyde 312.88
    sulfolane 329.07
    2,2,4-trimethylpentane 0.57
    2-methyltetrahydrofuran 96.9
    n-hexyl acetate 54.83
    isooctane 0.31
    2-(2-butoxyethoxy)ethanol 81.6
    sec-butyl acetate 43.72
    tert-butyl acetate 67.55
    decalin 0.75
    glycerin 42.41
    diglyme 176.37
    acrylic acid 67.72
    isopropyl myristate 26.45
    n-butyric acid 44.21
    acetyl acetate 113.75
    di(2-ethylhexyl) phthalate 27.27
    ethyl propionate 78.98
    nitromethane 466.77
    1,2-diethoxyethane 69.73
    benzonitrile 41.52
    trioctyl phosphate 21.85
    1-bromopropane 19.1
    gamma-valerolactone 277.06
    n-decanol 12.43
    triethyl phosphate 32.7
    4-methyl-2-pentanol 6.58
    propionitrile 52.01
    vinylene carbonate 110.37
    1,1,2-trichlorotrifluoroethane 139.25
    DMS 92.37
    cumene 5.52
    2-octanol 12.75
    2-hexanone 63.89
    octyl acetate 37.71
    limonene 13.6
    1,2-dimethoxyethane 186.6
    ethyl orthosilicate 25.74
    tributyl phosphate 23.53
    diacetone alcohol 66.36
    N,N-dimethylaniline 36.56
    acrylonitrile 92.2
    aniline 27.3
    1,3-propanediol 35.14
    bromobenzene 14.97
    dibromomethane 32.36
    1,1,2,2-tetrachloroethane 61.59
    2-methyl-cyclohexyl acetate 42.8
    tetrabutyl urea 44.51
    diisobutyl methanol 8.46
    2-phenylethanol 41.19
    styrene 12.42
    dioctyl adipate 44.94
    dimethyl sulfate 234.58
    ethyl butyrate 57.39
    methyl lactate 95.18
    butyl lactate 46.72
    diethyl carbonate 44.33
    propanediol butyl ether 43.06
    triethyl orthoformate 41.08
    p-tert-butyltoluene 9.93
    methyl 4-tert-butylbenzoate 67.62
    morpholine 122.34
    tert-butylamine 7.74
    n-dodecanol 9.81
    dimethoxymethane 266.86
    ethylene carbonate 82.4
    cyrene 94.31
    2-ethoxyethyl acetate 114.44
    2-ethylhexyl acetate 34.41
    1,2,4-trichlorobenzene 27.27
    4-methylpyridine 74.6
    dibutyl ether 21.08
    2,6-dimethyl-4-heptanol 8.46
    DEF 122.04
    dimethyl isosorbide 147.23
    tetrachloroethylene 38.82
    eugenol 71.54
    triacetin 94.25
    span 80 49.95
    1,4-butanediol 17.4
    1,1-dichloroethane 29.87
    2-methyl-1-pentanol 10.25
    methyl formate 201.28
    2-methyl-1-butanol 11.8
    n-decane 1.84
    butyronitrile 33.76
    3,7-dimethyl-1-octanol 12.18
    1-chlorooctane 8.36
    1-chlorotetradecane 4.28
    n-nonane 1.48
    undecane 1.46
    tert-butylcyclohexane 0.59
    cyclooctane 0.57
    cyclopentanol 26.05
    tetrahydropyran 53.75
    tert-amyl methyl ether 28.28
    2,5,8-trioxanonane 139.33
    1-hexene 3.92
    2-isopropoxyethanol 53.34
    2,2,2-trifluoroethanol 60.34
    methyl butyrate 86.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction