Finasteride

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  • Identifiers

    CAS number
    98319-26-7

    Molecular formula
    C23H36N2O2

    SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC(C)(C)C)CC[C@@H]4[C@@]3(C=CC(=O)N4)C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Woody 47.08%
    Cooling 37.21%
    Mint 36.85%
    Spicy 29.47%
    Herbal 28.63%
    Odorless 25.69%
    Cedar 25.59%
    Fresh 24.97%
    Animal 22.65%
    Amber 22.65%

     

    Flavor
    Bitter 63.23%
    Cedarleaf 22.86%
    Herbal 21.02%
    Heather 20.24%
    Ripe apricot 19.9%
    Broom 19.74%
    Basil 19.74%
    Lovage 19.69%
    Genet 19.53%
    Sandalwood 19.51%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    6.11 (neutral)

    Molecular weight
    372.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    217°C

    Melting point expt.

    • 252-254 °C
    • 252 - 254 °C

    Flash point

    • 243.72 ˚C est.

    Solubility expt.

    • 52.8 [ug/mL] (The mean of the results at pH 7.4)
    • Slightly soluble
    • Freely sol in chloroform, DMSO, ethanol, methanol, n-propanol; sparingly sol in propylene glycol, polyethylene glycol 400; very slightly sol in 0.1N hydrogen chloride, 0.1N sodium hydroxide, water.
    • 1.98e-03 g/L

  • Synonyms

    • finasteride
    • 98319-26-7
    • Proscar
    • Propecia
    • Finastid
    • Prostide
    • Chibro-Proscar
    • MK-906
    • Finasterida
    • Finpecia
    • Finasteridum
    • Finasteridum [INN-Latin]
    • MK 906
    • Finasterida [INN-Spanish]
    • CCRIS 7438
    • MK 0906
    • MK-0906
    • HSDB 6793
    • N-tert-Butyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
    • UNII-57GNO57U7G
    • (5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
    • NSC-741485
    • BRN 4269024
    • 57GNO57U7G
    • CHEBI:5062
    • DTXSID3020625
    • L-652,931
    • CHEMBL710
    • NSC-759318
    • 17beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androst-1-en-3-one
    • N-tert-Butyl-3-oxo-4-aza-5alpha-androst-1-en-17beta-carboxamide
    • DTXCID50625
    • N-(2-Methyl-2-propyl)-3-oxo-4-aza-5-alpha-androst-1-ene-17-beta-carboxamide
    • 4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5alpha,17beta)-
    • (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
    • ENTADFI COMPONENT FINASTERIDE
    • Finasteride [USAN:USP:INN:BAN]
    • MFCD00869737
    • NSC 741485
    • NSC 759318
    • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
    • Propeshia
    • Finasteridum (INN-Latin)
    • Finasterida (INN-Spanish)
    • FINASTERIDE (MART.)
    • FINASTERIDE [MART.]
    • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(1,1-dimethylethyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
    • FINASTERIDE (EP IMPURITY)
    • FINASTERIDE [EP IMPURITY]
    • Andozac
    • FINASTERIDE (EP MONOGRAPH)
    • FINASTERIDE (USP IMPURITY)
    • FINASTERIDE [EP MONOGRAPH]
    • FINASTERIDE [USP IMPURITY]
    • FINASTERIDE (USP MONOGRAPH)
    • FINASTERIDE [USP MONOGRAPH]
    • Finasteride (USAN:USP:INN:BAN)
    • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(tert-butyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
    • Propecia (TN)
    • SMR000466304
    • Proscar (TN)
    • MK906
    • SR-01000759414
    • Urprosan
    • Pro-Cure
    • NCGC00016965-01
    • CAS-98319-26-7
    • YM-152
    • KS-1058
    • Finasteride (Proscar)
    • Finasteride (Standard)
    • FINASTERIDE [MI]
    • Prestwick0_000717
    • Prestwick1_000717
    • Prestwick2_000717
    • Prestwick3_000717
    • FINASTERIDE [INN]
    • FINASTERIDE [JAN]
    • FINASTERIDE [USAN]
    • FINASTERIDE [VANDF]
    • N-(2-methyl-2-propyl)-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
    • SCHEMBL5509
    • BSPBio_000933
    • FINASTERIDE [WHO-DD]
    • MLS000759404
    • MLS001165768
    • MLS001424046
    • Finasteride (JAN/USP/INN)
    • SPBio_002854
    • BPBio1_001027
    • GTPL6818
    • Finasteride - Bio-X trade mark
    • D11AX10
    • FINASTERIDE [ORANGE BOOK]
    • G04CB01
    • 4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5.alpha.,17.beta.)-
    • BCPP000229
    • HMS1570O15
    • HMS2051F09
    • HMS2090G22
    • HMS2097O15
    • HMS2235L23
    • HMS3714O15
    • 4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid tert-butylamide
    • EX-A1951
    • Tox21_110717
    • Tox21_201506
    • Tox21_302744
    • BDBM50334788
    • HY-13635R
    • NSC741485
    • NSC757443
    • s1197
    • (5?,17?)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
    • AKOS015894916
    • Tox21_110717_1
    • BCP9000685
    • CCG-100937
    • CS-1767
    • DB01216
    • FF23286
    • FINASTERIDE COMPONENT OF ENTADFI
    • Finasteride, >=98% (HPLC), powder
    • NC00187
    • NSC-757443
    • NCGC00093560-05
    • NCGC00256334-01
    • NCGC00259057-01

  • Applications

    Finasteride (CAS 98319-26-7) is mainly used as an active pharmaceutical ingredient in prescription medications for benign prostatic hyperplasia and male pattern hair loss; beyond its pharmaceutical use, it is evaluated in research and development as a tool to study 5α-reductase–driven androgen pathways; in drug manufacturing contexts it serves as an API in production pipelines; and it is assessed in pharmacology and formulation studies for properties such as pharmacokinetics, stability, and formulation compatibility, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 21.24
    methanol 20.37
    isopropanol 16.75
    water 0.22
    ethyl acetate 19.96
    n-propanol 27.37
    acetone 28.04
    n-butanol 23.49
    acetonitrile 11.2
    DMF 60.98
    toluene 29.08
    isobutanol 21.12
    1,4-dioxane 53.24
    methyl acetate 18.87
    THF 115.99
    2-butanone 36.87
    n-pentanol 24.7
    sec-butanol 13.26
    n-hexane 0.62
    ethylene glycol 3.84
    NMP 77.63
    cyclohexane 1.39
    DMSO 29.16
    n-butyl acetate 24.73
    n-octanol 12.9
    chloroform 90.71
    n-propyl acetate 20.43
    acetic acid 28.72
    dichloromethane 44.49
    cyclohexanone 64.41
    propylene glycol 10.54
    isopropyl acetate 18.16
    DMAc 77.84
    2-ethoxyethanol 34.74
    isopentanol 19.55
    n-heptane 0.53
    ethyl formate 15.76
    1,2-dichloroethane 21.7
    n-hexanol 26.9
    2-methoxyethanol 45.17
    isobutyl acetate 21.54
    tetrachloromethane 9.05
    n-pentyl acetate 27.24
    transcutol 74.08
    n-heptanol 19.79
    ethylbenzene 9.71
    MIBK 21.32
    2-propoxyethanol 69.57
    tert-butanol 10.97
    MTBE 6.64
    2-butoxyethanol 47.45
    propionic acid 22.19
    o-xylene 12.88
    formic acid 13.01
    diethyl ether 11.03
    m-xylene 18.25
    p-xylene 15.05
    chlorobenzene 28.73
    dimethyl carbonate 14.05
    n-octane 0.29
    formamide 16.36
    cyclopentanone 76.94
    2-pentanone 28.09
    anisole 19.62
    cyclopentyl methyl ether 31.41
    gamma-butyrolactone 67.85
    1-methoxy-2-propanol 45.14
    pyridine 64.64
    3-pentanone 24.02
    furfural 61.83
    n-dodecane 0.28
    diethylene glycol 41.04
    diisopropyl ether 3.58
    tert-amyl alcohol 9.37
    acetylacetone 31.39
    n-hexadecane 0.34
    acetophenone 29.26
    methyl propionate 23.13
    isopentyl acetate 24.98
    trichloroethylene 65.09
    n-nonanol 14.1
    cyclohexanol 22.39
    benzyl alcohol 33.03
    2-ethylhexanol 14.05
    isooctanol 15.47
    dipropyl ether 8.03
    1,2-dichlorobenzene 23.13
    ethyl lactate 18.49
    propylene carbonate 36.87
    n-methylformamide 25.73
    2-pentanol 11.44
    n-pentane 0.65
    1-propoxy-2-propanol 44.91
    1-methoxy-2-propyl acetate 36.77
    2-(2-methoxypropoxy) propanol 35.14
    mesitylene 8.38
    ε-caprolactone 55.41
    p-cymene 7.2
    epichlorohydrin 66.37
    1,1,1-trichloroethane 22.09
    2-aminoethanol 15.65
    morpholine-4-carbaldehyde 77.7
    sulfolane 68.15
    2,2,4-trimethylpentane 0.52
    2-methyltetrahydrofuran 45.88
    n-hexyl acetate 29.39
    isooctane 0.44
    2-(2-butoxyethoxy)ethanol 49.97
    sec-butyl acetate 15.83
    tert-butyl acetate 16.25
    decalin 1.13
    glycerin 16.6
    diglyme 63.58
    acrylic acid 21.34
    isopropyl myristate 10.23
    n-butyric acid 32.04
    acetyl acetate 17.61
    di(2-ethylhexyl) phthalate 21.18
    ethyl propionate 16.21
    nitromethane 31.84
    1,2-diethoxyethane 21.46
    benzonitrile 31.86
    trioctyl phosphate 13.86
    1-bromopropane 13.47
    gamma-valerolactone 105.94
    n-decanol 9.19
    triethyl phosphate 11.52
    4-methyl-2-pentanol 10.08
    propionitrile 16.2
    vinylene carbonate 37.49
    1,1,2-trichlorotrifluoroethane 54.61
    DMS 21.06
    cumene 7.01
    2-octanol 10.64
    2-hexanone 26.39
    octyl acetate 15.66
    limonene 7.69
    1,2-dimethoxyethane 38.72
    ethyl orthosilicate 11.53
    tributyl phosphate 12.86
    diacetone alcohol 26.05
    N,N-dimethylaniline 14.55
    acrylonitrile 19.52
    aniline 34.21
    1,3-propanediol 23.55
    bromobenzene 26.51
    dibromomethane 29.24
    1,1,2,2-tetrachloroethane 51.99
    2-methyl-cyclohexyl acetate 23.51
    tetrabutyl urea 18.64
    diisobutyl methanol 6.2
    2-phenylethanol 38.68
    styrene 10.68
    dioctyl adipate 18.61
    dimethyl sulfate 20.45
    ethyl butyrate 16.9
    methyl lactate 21.48
    butyl lactate 29.38
    diethyl carbonate 11.87
    propanediol butyl ether 41.56
    triethyl orthoformate 15.54
    p-tert-butyltoluene 6.26
    methyl 4-tert-butylbenzoate 29.53
    morpholine 66.21
    tert-butylamine 5.09
    n-dodecanol 5.73
    dimethoxymethane 42.27
    ethylene carbonate 31.46
    cyrene 49.27
    2-ethoxyethyl acetate 38.36
    2-ethylhexyl acetate 21.84
    1,2,4-trichlorobenzene 33.61
    4-methylpyridine 56.74
    dibutyl ether 6.61
    2,6-dimethyl-4-heptanol 6.2
    DEF 27.12
    dimethyl isosorbide 55.87
    tetrachloroethylene 33.29
    eugenol 38.07
    triacetin 30.49
    span 80 34.88
    1,4-butanediol 14.83
    1,1-dichloroethane 24.38
    2-methyl-1-pentanol 19.01
    methyl formate 17.53
    2-methyl-1-butanol 17.95
    n-decane 0.56
    butyronitrile 19.17
    3,7-dimethyl-1-octanol 11.09
    1-chlorooctane 4.22
    1-chlorotetradecane 1.37
    n-nonane 0.43
    undecane 0.37
    tert-butylcyclohexane 0.84
    cyclooctane 0.54
    cyclopentanol 27.99
    tetrahydropyran 44.51
    tert-amyl methyl ether 7.0
    2,5,8-trioxanonane 43.17
    1-hexene 3.8
    2-isopropoxyethanol 30.41
    2,2,2-trifluoroethanol 13.92
    methyl butyrate 20.73

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction