Ficin

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  • Identifiers

    CAS number
    9001-33-6

    Molecular formula
    CH2FI2N

    SMILES
    C(=IF)I=N

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Pungent 74.58%
    Radish 58.7%
    Garlic 40.43%
    Sulfurous 39.89%
    Alliaceous 34.47%
    Onion 33.69%
    Cabbage 28.93%
    Odorless 27.94%
    Cooked 24.36%
    Green 24.34%

     

    Flavor
    Bitter 56.77%
    Mustard 52.85%
    Pungent 43.75%
    Sulfur 41.74%
    Horseradish 38.04%
    Garlic 33.33%
    Nutty 23.79%
    Strong 23.08%
    Formyl 22.91%
    Odorless 22.71%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    1.51 (strong acid)

    Molecular weight
    300.841 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    266°C

    Flash point

    • 68.26 ˚C est.

  • Synonyms

    • Ficin
    • 9001-33-6
    • Debricin
    • Ficus protease
    • Ficus proteinase
    • Higueroxyl delabarre
    • RefChem:599189
    • DTXSID3093787
    • EINECS 232-599-1
    • TL 367
    • 232-599-1
    • FICIN FROM FIG TREE HYGROSCOPIC
    • CHEBI:196308
    • POTUGHMKJGOKRI-UHFFFAOYSA-N
    • NS00080349
    • luoro-[(imino-lambda3-iodanyl)methylidene]-lambda3-iodane
    • 9001-33-6

  • Applications

    Ficin (CAS 9001-33-6) is a plant-derived protease enzyme from Ficus carica. In industrial practice, ficin is used primarily as a proteolytic enzyme in several applications: meat tenderization in food processing; hydrolysis of proteins to peptides and protein hydrolysates to create functional ingredients or improve texture and flavor precursors; leather processing with dehairing and bating; inclusion in detergent and cosmetic formulations to aid the breakdown of protein soils or to enhance cleansing activity; also employed as a biotechnological tool in research and development for proteolysis and peptide generation; may be evaluated for the production of protein hydrolysates and flavor precursor materials in food processing contexts.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 301.17
    methanol 426.16
    isopropanol 247.84
    water 125.51
    ethyl acetate 131.28
    n-propanol 226.03
    acetone 473.97
    n-butanol 189.44
    acetonitrile 259.36
    DMF 1329.48
    toluene 32.1
    isobutanol 165.33
    1,4-dioxane 281.08
    methyl acetate 188.81
    THF 558.3
    2-butanone 292.38
    n-pentanol 166.55
    sec-butanol 182.32
    n-hexane 22.19
    ethylene glycol 318.27
    NMP 1054.25
    cyclohexane 20.99
    DMSO 1277.93
    n-butyl acetate 112.35
    n-octanol 119.72
    chloroform 124.26
    n-propyl acetate 144.06
    acetic acid 272.15
    dichloromethane 135.26
    cyclohexanone 259.21
    propylene glycol 304.08
    isopropyl acetate 107.5
    DMAc 989.47
    2-ethoxyethanol 410.34
    isopentanol 144.91
    n-heptane 28.85
    ethyl formate 165.48
    1,2-dichloroethane 129.44
    n-hexanol 133.58
    2-methoxyethanol 582.34
    isobutyl acetate 91.97
    tetrachloromethane 40.16
    n-pentyl acetate 109.6
    transcutol 701.64
    n-heptanol 99.16
    ethylbenzene 32.35
    MIBK 158.06
    2-propoxyethanol 355.65
    tert-butanol 231.59
    MTBE 120.44
    2-butoxyethanol 231.32
    propionic acid 193.16
    o-xylene 44.78
    formic acid 300.45
    diethyl ether 140.19
    m-xylene 38.07
    p-xylene 42.25
    chlorobenzene 41.0
    dimethyl carbonate 161.06
    n-octane 13.12
    formamide 477.8
    cyclopentanone 401.89
    2-pentanone 235.91
    anisole 121.17
    cyclopentyl methyl ether 208.33
    gamma-butyrolactone 359.63
    1-methoxy-2-propanol 466.82
    pyridine 168.78
    3-pentanone 205.94
    furfural 394.38
    n-dodecane 13.77
    diethylene glycol 434.36
    diisopropyl ether 55.62
    tert-amyl alcohol 175.81
    acetylacetone 273.26
    n-hexadecane 14.58
    acetophenone 160.37
    methyl propionate 193.2
    isopentyl acetate 92.18
    trichloroethylene 176.47
    n-nonanol 113.82
    cyclohexanol 149.58
    benzyl alcohol 136.95
    2-ethylhexanol 86.0
    isooctanol 80.13
    dipropyl ether 120.94
    1,2-dichlorobenzene 52.93
    ethyl lactate 173.41
    propylene carbonate 176.6
    n-methylformamide 535.62
    2-pentanol 139.64
    n-pentane 25.44
    1-propoxy-2-propanol 261.38
    1-methoxy-2-propyl acetate 170.86
    2-(2-methoxypropoxy) propanol 283.08
    mesitylene 34.87
    ε-caprolactone 214.01
    p-cymene 40.0
    epichlorohydrin 308.27
    1,1,1-trichloroethane 91.47
    2-aminoethanol 356.04
    morpholine-4-carbaldehyde 743.14
    sulfolane 632.17
    2,2,4-trimethylpentane 14.44
    2-methyltetrahydrofuran 252.1
    n-hexyl acetate 138.44
    isooctane 11.93
    2-(2-butoxyethoxy)ethanol 338.18
    sec-butyl acetate 92.27
    tert-butyl acetate 131.71
    decalin 16.68
    glycerin 453.16
    diglyme 489.21
    acrylic acid 229.8
    isopropyl myristate 78.3
    n-butyric acid 172.31
    acetyl acetate 99.48
    di(2-ethylhexyl) phthalate 95.4
    ethyl propionate 134.56
    nitromethane 516.2
    1,2-diethoxyethane 185.74
    benzonitrile 106.37
    trioctyl phosphate 78.88
    1-bromopropane 65.57
    gamma-valerolactone 498.28
    n-decanol 94.65
    triethyl phosphate 84.14
    4-methyl-2-pentanol 94.08
    propionitrile 169.41
    vinylene carbonate 155.83
    1,1,2-trichlorotrifluoroethane 420.53
    DMS 121.66
    cumene 37.3
    2-octanol 75.21
    2-hexanone 196.01
    octyl acetate 103.72
    limonene 59.77
    1,2-dimethoxyethane 519.47
    ethyl orthosilicate 78.59
    tributyl phosphate 88.32
    diacetone alcohol 254.74
    N,N-dimethylaniline 158.28
    acrylonitrile 225.99
    aniline 100.65
    1,3-propanediol 319.36
    bromobenzene 28.89
    dibromomethane 83.64
    1,1,2,2-tetrachloroethane 181.78
    2-methyl-cyclohexyl acetate 109.18
    tetrabutyl urea 168.01
    diisobutyl methanol 62.94
    2-phenylethanol 120.93
    styrene 37.06
    dioctyl adipate 129.38
    dimethyl sulfate 291.94
    ethyl butyrate 117.16
    methyl lactate 254.21
    butyl lactate 155.42
    diethyl carbonate 81.57
    propanediol butyl ether 303.82
    triethyl orthoformate 105.31
    p-tert-butyltoluene 42.15
    methyl 4-tert-butylbenzoate 188.56
    morpholine 401.21
    tert-butylamine 149.73
    n-dodecanol 79.49
    dimethoxymethane 510.26
    ethylene carbonate 131.78
    cyrene 353.52
    2-ethoxyethyl acetate 148.41
    2-ethylhexyl acetate 76.72
    1,2,4-trichlorobenzene 75.76
    4-methylpyridine 148.68
    dibutyl ether 94.81
    2,6-dimethyl-4-heptanol 62.94
    DEF 364.57
    dimethyl isosorbide 424.43
    tetrachloroethylene 130.56
    eugenol 233.12
    triacetin 171.28
    span 80 247.3
    1,4-butanediol 218.77
    1,1-dichloroethane 91.6
    2-methyl-1-pentanol 123.03
    methyl formate 366.07
    2-methyl-1-butanol 142.23
    n-decane 18.06
    butyronitrile 156.37
    3,7-dimethyl-1-octanol 97.08
    1-chlorooctane 47.33
    1-chlorotetradecane 29.36
    n-nonane 16.56
    undecane 15.36
    tert-butylcyclohexane 15.88
    cyclooctane 11.52
    cyclopentanol 217.4
    tetrahydropyran 178.99
    tert-amyl methyl ether 122.17
    2,5,8-trioxanonane 430.09
    1-hexene 52.34
    2-isopropoxyethanol 267.1
    2,2,2-trifluoroethanol 233.38
    methyl butyrate 178.38

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction