Fenofibrate

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  • Identifiers

    CAS number
    49562-28-9

    Molecular formula
    C20H21ClO4

    SMILES
    CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Floral 58.98%
    Fruity 42.66%
    Sweet 39.97%
    Grape 36.41%
    Powdery 35.25%
    Neroli 34.35%
    Animal 29.75%
    Honey 29.41%
    Vanilla 28.47%
    Balsamic 28.27%

     

    Flavor
    Bitter 65.79%
    Fruity 48.5%
    Sweet 30.89%
    Grape 27.54%
    Floral 27.19%
    Powdery 24.61%
    Wintergreen 23.82%
    Herbal 22.27%
    Orange blossom 21.47%
    Mild 21.34%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.2

    pKa est.
    7.85 (neutral)

    Molecular weight
    360.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    392°C

    Melting point expt.

    • 79-82
    • 80-81 °C
    • 80.5 °C

    Flash point

    • 178.66 ˚C est.

    Solubility expt.

    • Practically insoluble in water; slightly soluble in methanol, ethanol; soluble in acetone, ether, benzene, chloroform
    • 7.07e-04 g/L

  • Synonyms

    • fenofibrate
    • 49562-28-9
    • Procetofen
    • Lipantil
    • Tricor
    • Lipidil
    • Antara
    • Fenobrate
    • Triglide
    • Secalip
    • Fenoglide
    • Finofibrate
    • Lipanthyl
    • Proctofene
    • Fenogal
    • Lipirex
    • Lipoclar
    • Lipofen
    • Lipofene
    • Sedufen
    • Elasterin
    • Fenotard
    • Protolipan
    • Ankebin
    • Lipifen
    • Liposit
    • Lipsin
    • Nolipax
    • Elasterate
    • Procetofene
    • Lipidex
    • Luxacor
    • Fenofibrato
    • Fenofibratum
    • Supralip
    • Fenofibratum [INN-Latin]
    • Fenofibrato [INN-Spanish]
    • Lipantil (TN)
    • Antara (micronized)
    • Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
    • Tricor (TN)
    • propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
    • TRICOR (MICRONIZED)
    • LF-178
    • FENOFIBRATE (MICRONIZED)
    • Fenofibrate micronized
    • Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
    • Procetoken
    • CCRIS 7282
    • NSC 281319
    • 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
    • Fenofibrate delayed release
    • Isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate
    • EINECS 256-376-3
    • FNF
    • MFCD00133314
    • UNII-U202363UOS
    • BRN 2062462
    • Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, 1-methylethyl ester
    • CHEBI:5001
    • DTXSID2029874
    • HSDB 7736
    • Fenofibrate (Standard)
    • U202363UOS
    • isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
    • CHEMBL672
    • Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-, 1-methylethyl ester
    • MLS000028515
    • DTXCID209874
    • Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate
    • Phenofibrate
    • Lofibra
    • EC 256-376-3
    • Fenofibrate [USAN:USP:INN:BAN]
    • propan-2-yl 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoate
    • NSC-281319
    • NCGC00015437-10
    • Isopropyl 2-[p-(p-chlorobenzoyl)phenoxy]-2-methylpropionate
    • SMR000058299
    • CAS-49562-28-9
    • C20H21ClO4
    • Fenofibratum (INN-Latin)
    • Fenofibrato (INN-Spanish)
    • Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, 1-methylethylester
    • FENOFIBRATE (MART.)
    • FENOFIBRATE [MART.]
    • FENOFIBRATE (EP MONOGRAPH)
    • FENOFIBRATE (USP IMPURITY)
    • FENOFIBRATE [EP MONOGRAPH]
    • FENOFIBRATE [USP IMPURITY]
    • Fenomax
    • Pharmavit
    • Fulcro
    • FENOFIBRATE (USP MONOGRAPH)
    • FENOFIBRATE [USP MONOGRAPH]
    • Fenofibrate (USAN:USP:INN:BAN)
    • CIP-Fenofibrate
    • 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid 1-methylethyl ester
    • LCP-FenoChol
    • LCP-Feno
    • Triglide (TN)
    • Fenofibrate IDD-P
    • Lipofen (TN)
    • Antara (TN)
    • SR-01000000091
    • LF 178
    • Lipidax
    • Isopropyl 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionate
    • propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
    • GRS-027
    • Prestwick_217
    • Fenofibrate (GMP)
    • Fenofibratefilm coated
    • Fenofibrate[USP-RS]
    • Spectrum_001250
    • Opera_ID_328
    • FENOFIBRATE [MI]
    • Prestwick0_000275
    • Prestwick1_000275
    • Prestwick2_000275
    • Prestwick3_000275
    • Spectrum2_001390
    • Spectrum3_001431
    • Spectrum4_000413
    • Spectrum5_001479
    • FENOFIBRATE [INN]
    • FENOFIBRATE [JAN]
    • Lopac-F-6020

  • Applications

    Fenofibrate is primarily used in the pharmaceutical industry as an active pharmaceutical ingredient (API) in dosage forms such as capsules or tablets. It is also encountered in pharmaceutical development and quality control, where it serves as a compound for analytical method development and validation (e.g., HPLC) and as a reference standard in pharmacokinetic and regulatory studies. In research settings, it may be used as a tool compound in preclinical pharmacology and toxicology studies. In formulation development and analytical work, fenofibrate may be used as a model fibrate ester in synthesis or as a reference material for analytical laboratories.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 59.73
    methanol 54.93
    isopropanol 61.74
    water 0.1
    ethyl acetate 592.0
    n-propanol 72.94
    acetone 809.22
    n-butanol 80.04
    acetonitrile 323.12
    DMF 704.62
    toluene 215.98
    isobutanol 66.45
    1,4-dioxane 519.8
    methyl acetate 456.22
    THF 1037.03
    2-butanone 483.08
    n-pentanol 88.51
    sec-butanol 88.18
    n-hexane 16.16
    ethylene glycol 11.87
    NMP 483.39
    cyclohexane 25.07
    DMSO 464.78
    n-butyl acetate 216.94
    n-octanol 52.63
    chloroform 1358.13
    n-propyl acetate 260.78
    acetic acid 222.36
    dichloromethane 1270.8
    cyclohexanone 701.03
    propylene glycol 19.24
    isopropyl acetate 329.58
    DMAc 771.64
    2-ethoxyethanol 201.59
    isopentanol 83.38
    n-heptane 10.0
    ethyl formate 244.25
    1,2-dichloroethane 742.08
    n-hexanol 77.44
    2-methoxyethanol 233.44
    isobutyl acetate 153.34
    tetrachloromethane 108.68
    n-pentyl acetate 167.76
    transcutol 372.28
    n-heptanol 51.25
    ethylbenzene 111.46
    MIBK 217.25
    2-propoxyethanol 202.03
    tert-butanol 99.0
    MTBE 216.29
    2-butoxyethanol 120.15
    propionic acid 130.67
    o-xylene 121.17
    formic acid 54.9
    diethyl ether 327.77
    m-xylene 119.52
    p-xylene 136.0
    chlorobenzene 317.22
    dimethyl carbonate 271.59
    n-octane 7.73
    formamide 126.18
    cyclopentanone 827.39
    2-pentanone 442.31
    anisole 259.88
    cyclopentyl methyl ether 372.74
    gamma-butyrolactone 774.53
    1-methoxy-2-propanol 189.75
    pyridine 425.64
    3-pentanone 399.97
    furfural 535.22
    n-dodecane 6.76
    diethylene glycol 124.53
    diisopropyl ether 82.78
    tert-amyl alcohol 116.42
    acetylacetone 670.56
    n-hexadecane 8.1
    acetophenone 270.12
    methyl propionate 424.12
    isopentyl acetate 178.69
    trichloroethylene 1411.14
    n-nonanol 53.1
    cyclohexanol 153.03
    benzyl alcohol 161.37
    2-ethylhexanol 60.85
    isooctanol 47.17
    dipropyl ether 127.2
    1,2-dichlorobenzene 302.48
    ethyl lactate 111.99
    propylene carbonate 386.78
    n-methylformamide 225.85
    2-pentanol 76.51
    n-pentane 11.98
    1-propoxy-2-propanol 130.85
    1-methoxy-2-propyl acetate 261.39
    2-(2-methoxypropoxy) propanol 135.44
    mesitylene 66.22
    ε-caprolactone 480.22
    p-cymene 51.71
    epichlorohydrin 946.27
    1,1,1-trichloroethane 615.4
    2-aminoethanol 28.12
    morpholine-4-carbaldehyde 561.63
    sulfolane 631.11
    2,2,4-trimethylpentane 11.87
    2-methyltetrahydrofuran 513.53
    n-hexyl acetate 186.17
    isooctane 6.02
    2-(2-butoxyethoxy)ethanol 155.65
    sec-butyl acetate 185.8
    tert-butyl acetate 273.69
    decalin 18.61
    glycerin 43.26
    diglyme 384.94
    acrylic acid 126.85
    isopropyl myristate 76.36
    n-butyric acid 222.48
    acetyl acetate 387.78
    di(2-ethylhexyl) phthalate 74.45
    ethyl propionate 286.07
    nitromethane 746.65
    1,2-diethoxyethane 238.5
    benzonitrile 238.05
    trioctyl phosphate 53.42
    1-bromopropane 319.19
    gamma-valerolactone 837.88
    n-decanol 40.01
    triethyl phosphate 106.17
    4-methyl-2-pentanol 51.21
    propionitrile 215.96
    vinylene carbonate 391.31
    1,1,2-trichlorotrifluoroethane 381.57
    DMS 250.04
    cumene 65.81
    2-octanol 45.14
    2-hexanone 246.71
    octyl acetate 95.93
    limonene 74.64
    1,2-dimethoxyethane 456.95
    ethyl orthosilicate 94.3
    tributyl phosphate 70.49
    diacetone alcohol 212.46
    N,N-dimethylaniline 155.24
    acrylonitrile 295.08
    aniline 178.77
    1,3-propanediol 62.31
    bromobenzene 355.07
    dibromomethane 750.56
    1,1,2,2-tetrachloroethane 1021.16
    2-methyl-cyclohexyl acetate 131.9
    tetrabutyl urea 96.83
    diisobutyl methanol 41.72
    2-phenylethanol 135.67
    styrene 140.45
    dioctyl adipate 117.6
    dimethyl sulfate 379.07
    ethyl butyrate 196.29
    methyl lactate 145.42
    butyl lactate 106.93
    diethyl carbonate 142.86
    propanediol butyl ether 92.85
    triethyl orthoformate 126.95
    p-tert-butyltoluene 48.55
    methyl 4-tert-butylbenzoate 189.79
    morpholine 495.67
    tert-butylamine 56.63
    n-dodecanol 31.62
    dimethoxymethane 542.2
    ethylene carbonate 337.35
    cyrene 184.02
    2-ethoxyethyl acetate 262.44
    2-ethylhexyl acetate 147.55
    1,2,4-trichlorobenzene 316.94
    4-methylpyridine 494.32
    dibutyl ether 104.57
    2,6-dimethyl-4-heptanol 41.72
    DEF 472.65
    dimethyl isosorbide 261.07
    tetrachloroethylene 597.0
    eugenol 147.11
    triacetin 242.8
    span 80 100.64
    1,4-butanediol 40.45
    1,1-dichloroethane 656.34
    2-methyl-1-pentanol 96.69
    methyl formate 270.3
    2-methyl-1-butanol 88.64
    n-decane 12.07
    butyronitrile 209.83
    3,7-dimethyl-1-octanol 57.26
    1-chlorooctane 58.79
    1-chlorotetradecane 23.49
    n-nonane 11.03
    undecane 8.68
    tert-butylcyclohexane 15.74
    cyclooctane 8.29
    cyclopentanol 148.43
    tetrahydropyran 485.61
    tert-amyl methyl ether 196.53
    2,5,8-trioxanonane 241.83
    1-hexene 79.13
    2-isopropoxyethanol 160.59
    2,2,2-trifluoroethanol 121.44
    methyl butyrate 327.08

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction