Famoxadone

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  • Identifiers

    CAS number
    131807-57-3

    Molecular formula
    C22H18N2O4

    SMILES
    CC1(C(=O)N(C(=O)O1)NC2=CC=CC=C2)C3=CC=C(C=C3)OC4=CC=CC=C4

    Safety labels

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fruity 43.42%
    Floral 37.11%
    Sweet 35.89%
    Odorless 34.84%
    Grape 32.86%
    Honey 28.02%
    Neroli 26.91%
    Green 26.54%
    Balsamic 25.28%
    Bitter 25.11%

     

    Flavor
    Bitter 85.79%
    Odorless 20.85%
    Cedarleaf 20.14%
    Lovage 19.64%
    Nitrile 19.5%
    Sweet-like 19.28%
    Orange blossom 19.09%
    Ethyl benzoate 18.93%
    Broom 18.89%
    Indole 18.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    6.57 (neutral)

    Molecular weight
    374.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    731°C

    Melting point expt.

    • 140.3-141.8 °C

    Flash point

    • 211.94 ˚C est.

    Solubility expt.

    • In water, 143 ug/L at pH 2; 191 ug/L at pH 3; 243 ug/L at pH 5; 111 ug/L at pH 7; 38 ug/L at pH 9
    • Solubility in acetone 274 g/L, acetonitrile 125 g/L, dichloromethane 239 g/L, ethyl acetate 125 g/L, hexane 0.0476 g/L, methanol 10.0 g/L, 1-octanol 1.87 g/L, toluene 13.3 g/L
    • In water, 0.052 mg/L (unbuffered water pH 7.8-8.9 at 20 °C)

  • Synonyms

    • Famoxadone
    • 131807-57-3
    • Famoxate
    • Famoxadon
    • 3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione
    • DPX-JE 874
    • 2,4-Oxazolidinedione, 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-
    • V1C07OR6II
    • DPX-JE874
    • DTXSID8034588
    • DTXCID6014588
    • 5-METHYL-5-(4-PHENOXYPHENYL)-3-(PHENYLAMINO)-2,4-OXAZOLIDINEDIONE
    • RefChem:597150
    • CHEBI:59340
    • 603-520-1
    • DPX-JE 874;Famoxate
    • MFCD03427409
    • 2,4-oxazolidinedione, 5-methyl-5-(4-phenoxyphenyl)-3- (phenylamino)-
    • 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione
    • Famoxadone [ISO:BSI]
    • HSDB 7266
    • UNII-V1C07OR6II
    • DPX JE874
    • Famoxate solution
    • 3-Anilino-5-methyl-5-(4-phenoxyphenyl)oxazolidine-2,4-dione
    • Famoxadone (Standard)
    • Famoxadone 10 microg/mL in Cyclohexane
    • FAMOXADONE [MI]
    • FAMOXATE [HSDB]
    • FAMOXADONE [ISO]
    • 2,4-Oxazolidinedione,5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-
    • SCHEMBL63351
    • orb1693963
    • CHEMBL1812200
    • CHEBI:83250
    • HY-B2008R
    • HFA58412
    • HNA06145
    • HY-B2008
    • MSK21094
    • Tox21_301144
    • AKOS015917628
    • FF74632
    • NCGC00168306-01
    • NCGC00168306-02
    • NCGC00168306-03
    • NCGC00255042-01
    • AS-35178
    • DB-042062
    • CAS-131807-57-3
    • CS-0014109
    • F1206
    • NS00000488
    • 807F573
    • Q412776
    • 5-Methyl-5-(4-phenoxyphenyl)-3-phenylamino-2,4-oxazolidinedione
    • 131807-57-3

  • Applications

    Famoxadone is a systemic fungicide used in crop protection to control a range of fungal and oomycete diseases on vegetables and fruit crops, notably potatoes and tomatoes. It is commonly formulated in commercial products and is often tank-mixed with cymoxanil to broaden spectrum. It is applied as foliar sprays in field and greenhouse crops and is typically integrated into integrated pest management programs. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.8
    methanol 9.0
    isopropanol 4.08
    water 0.03
    ethyl acetate 17.5
    n-propanol 5.94
    acetone 43.69
    n-butanol 5.96
    acetonitrile 16.39
    DMF 48.95
    toluene 12.95
    isobutanol 3.93
    1,4-dioxane 34.4
    methyl acetate 22.61
    THF 143.04
    2-butanone 39.39
    n-pentanol 7.61
    sec-butanol 5.52
    n-hexane 0.23
    ethylene glycol 1.97
    NMP 39.07
    cyclohexane 0.54
    DMSO 61.44
    n-butyl acetate 9.79
    n-octanol 4.38
    chloroform 81.08
    n-propyl acetate 10.65
    acetic acid 20.23
    dichloromethane 91.9
    cyclohexanone 57.8
    propylene glycol 2.78
    isopropyl acetate 12.0
    DMAc 121.81
    2-ethoxyethanol 17.68
    isopentanol 6.33
    n-heptane 0.41
    ethyl formate 12.75
    1,2-dichloroethane 48.73
    n-hexanol 6.09
    2-methoxyethanol 24.23
    isobutyl acetate 7.77
    tetrachloromethane 2.61
    n-pentyl acetate 9.89
    transcutol 42.55
    n-heptanol 5.57
    ethylbenzene 6.5
    MIBK 15.08
    2-propoxyethanol 20.29
    tert-butanol 5.65
    MTBE 6.86
    2-butoxyethanol 15.75
    propionic acid 11.08
    o-xylene 6.41
    formic acid 9.33
    diethyl ether 9.56
    m-xylene 5.33
    p-xylene 8.52
    chlorobenzene 21.6
    dimethyl carbonate 23.28
    n-octane 0.35
    formamide 21.12
    cyclopentanone 78.59
    2-pentanone 23.95
    anisole 15.68
    cyclopentyl methyl ether 16.53
    gamma-butyrolactone 69.32
    1-methoxy-2-propanol 17.82
    pyridine 50.48
    3-pentanone 24.84
    furfural 51.27
    n-dodecane 0.54
    diethylene glycol 14.55
    diisopropyl ether 2.34
    tert-amyl alcohol 6.28
    acetylacetone 39.92
    n-hexadecane 0.64
    acetophenone 21.0
    methyl propionate 20.7
    isopentyl acetate 11.0
    trichloroethylene 105.7
    n-nonanol 5.55
    cyclohexanol 8.39
    benzyl alcohol 16.57
    2-ethylhexanol 4.76
    isooctanol 5.27
    dipropyl ether 7.33
    1,2-dichlorobenzene 18.22
    ethyl lactate 10.43
    propylene carbonate 27.23
    n-methylformamide 18.23
    2-pentanol 4.05
    n-pentane 0.19
    1-propoxy-2-propanol 13.27
    1-methoxy-2-propyl acetate 19.16
    2-(2-methoxypropoxy) propanol 20.18
    mesitylene 2.75
    ε-caprolactone 32.74
    p-cymene 3.95
    epichlorohydrin 95.0
    1,1,1-trichloroethane 22.84
    2-aminoethanol 3.88
    morpholine-4-carbaldehyde 43.79
    sulfolane 76.65
    2,2,4-trimethylpentane 0.28
    2-methyltetrahydrofuran 28.99
    n-hexyl acetate 11.35
    isooctane 0.16
    2-(2-butoxyethoxy)ethanol 22.53
    sec-butyl acetate 8.95
    tert-butyl acetate 13.66
    decalin 0.57
    glycerin 6.98
    diglyme 42.77
    acrylic acid 13.72
    isopropyl myristate 7.27
    n-butyric acid 14.41
    acetyl acetate 17.26
    di(2-ethylhexyl) phthalate 9.32
    ethyl propionate 12.2
    nitromethane 52.18
    1,2-diethoxyethane 17.15
    benzonitrile 20.59
    trioctyl phosphate 5.94
    1-bromopropane 12.87
    gamma-valerolactone 77.01
    n-decanol 4.65
    triethyl phosphate 8.79
    4-methyl-2-pentanol 3.48
    propionitrile 16.97
    vinylene carbonate 29.29
    1,1,2-trichlorotrifluoroethane 41.68
    DMS 17.51
    cumene 3.85
    2-octanol 3.71
    2-hexanone 17.62
    octyl acetate 8.68
    limonene 4.54
    1,2-dimethoxyethane 33.68
    ethyl orthosilicate 8.26
    tributyl phosphate 7.46
    diacetone alcohol 18.88
    N,N-dimethylaniline 10.45
    acrylonitrile 25.48
    aniline 15.17
    1,3-propanediol 7.86
    bromobenzene 21.63
    dibromomethane 41.78
    1,1,2,2-tetrachloroethane 66.85
    2-methyl-cyclohexyl acetate 12.02
    tetrabutyl urea 13.03
    diisobutyl methanol 3.73
    2-phenylethanol 14.55
    styrene 8.39
    dioctyl adipate 13.05
    dimethyl sulfate 34.93
    ethyl butyrate 10.84
    methyl lactate 14.66
    butyl lactate 10.41
    diethyl carbonate 9.06
    propanediol butyl ether 9.62
    triethyl orthoformate 10.25
    p-tert-butyltoluene 3.36
    methyl 4-tert-butylbenzoate 19.55
    morpholine 30.32
    tert-butylamine 2.59
    n-dodecanol 3.88
    dimethoxymethane 43.21
    ethylene carbonate 21.77
    cyrene 24.58
    2-ethoxyethyl acetate 17.0
    2-ethylhexyl acetate 8.58
    1,2,4-trichlorobenzene 23.21
    4-methylpyridine 32.85
    dibutyl ether 7.54
    2,6-dimethyl-4-heptanol 3.73
    DEF 25.58
    dimethyl isosorbide 34.9
    tetrachloroethylene 36.13
    eugenol 20.88
    triacetin 19.06
    span 80 13.93
    1,4-butanediol 4.13
    1,1-dichloroethane 28.03
    2-methyl-1-pentanol 8.23
    methyl formate 19.81
    2-methyl-1-butanol 5.93
    n-decane 0.81
    butyronitrile 13.61
    3,7-dimethyl-1-octanol 5.28
    1-chlorooctane 3.65
    1-chlorotetradecane 2.13
    n-nonane 0.58
    undecane 0.65
    tert-butylcyclohexane 0.4
    cyclooctane 0.19
    cyclopentanol 9.73
    tetrahydropyran 25.93
    tert-amyl methyl ether 7.23
    2,5,8-trioxanonane 35.64
    1-hexene 2.17
    2-isopropoxyethanol 13.5
    2,2,2-trifluoroethanol 9.83
    methyl butyrate 15.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction