Everninic Acid

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  • Identifiers

    CAS number
    570-10-5

    Molecular formula
    C9H10O4

    SMILES
    CC1=CC(=CC(=C1C(=O)O)O)OC

  • Odor profile

    Phenolic 57.86%
    Sweet 42.49%
    Odorless 39.54%
    Woody 36.84%
    Dry 30.94%
    Balsamic 30.56%
    Powdery 29.76%
    Spicy 29.4%
    Animal 29.24%
    Vanilla 28.94%

    Scent© AI

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    7.57 (neutral)

    Molecular weight
    182.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    347°C

    Flash point est.
    155.48 ˚C

  • Synonyms

    • Everninic acid
    • 2-hydroxy-4-methoxy-6-methylbenzoic acid
    • 570-10-5
    • 2,6-Cresotic acid, 4-methoxy-
    • Benzoic acid, 2-hydroxy-4-methoxy-6-methyl-
    • 2-Hydroxy-4-methoxy-6-methyl-benzoic acid
    • Everninsaure
    • EVERNINate
    • 5-O-Methylorsellinate
    • Spectrum5_001710
    • 5-O-methylorsellinic acid
    • SCHEMBL609931
    • CHEMBL1077577
    • CHEBI:191109
    • DTXSID401346865
    • 2-Hydroxy-4-methoxy-6-methylbenzoate
    • CCG-214768

  • Applications

    Everninic acid (CAS 570-10-5) is an aromatic phenolic acid used mainly as an intermediate in organic and medicinal synthesis (for ester/amide formation, protecting-group derivatives, and polyketide scaffold construction), as a reference standard for QC/quantification and HPLC/LC-MS method development, and as a model probe in structure–activity studies of dihydroxybenzoic acids (radical-scavenging, metal chelation, and effects on redox enzymes); in natural-products work it serves as a marker/internal standard for identifying and quantifying phenolic constituents in lichens and plants; additionally, the phenolic features of Everninic acid are explored in materials science to design functional fragments for coatings, polymers, and drug-delivery matrices, where it can act as a UV-absorbing/antioxidant motif and a metal-coordinating handle to tune surface properties or catalytic behavior.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 131.06
    methanol 161.77
    isopropanol 83.42
    water 2.4
    ethyl acetate 104.13
    n-propanol 101.55
    acetone 177.37
    n-butanol 88.96
    acetonitrile 58.68
    DMF 503.72
    toluene 14.33
    isobutanol 55.51
    1,4-dioxane 99.76
    methyl acetate 95.09
    THF 543.99
    2-butanone 120.11
    n-pentanol 63.07
    sec-butanol 73.86
    n-hexane 4.2
    ethylene glycol 81.01
    NMP 423.82
    cyclohexane 1.49
    DMSO 1128.57
    n-butyl acetate 57.43
    n-octanol 25.1
    chloroform 38.34
    n-propyl acetate 55.43
    acetic acid 106.58
    dichloromethane 50.75
    cyclohexanone 116.99
    propylene glycol 88.11
    isopropyl acetate 60.45
    DMAc 239.24
    2-ethoxyethanol 152.58
    isopentanol 61.6
    n-heptane 3.31
    ethyl formate 71.71
    1,2-dichloroethane 60.17
    n-hexanol 66.25
    2-methoxyethanol 330.31
    isobutyl acetate 25.08
    tetrachloromethane 10.11
    n-pentyl acetate 31.65
    transcutol 204.19
    n-heptanol 29.12
    ethylbenzene 10.25
    MIBK 78.83
    2-propoxyethanol 181.49
    tert-butanol 104.12
    MTBE 52.51
    2-butoxyethanol 69.84
    propionic acid 89.48
    o-xylene 12.73
    formic acid 121.29
    diethyl ether 78.83
    m-xylene 18.28
    p-xylene 9.27
    chlorobenzene 21.38
    dimethyl carbonate 106.54
    n-octane 1.12
    formamide 207.37
    cyclopentanone 279.2
    2-pentanone 138.88
    anisole 49.24
    cyclopentyl methyl ether 155.78
    gamma-butyrolactone 357.85
    1-methoxy-2-propanol 287.1
    pyridine 52.58
    3-pentanone 82.92
    furfural 201.73
    n-dodecane 0.93
    diethylene glycol 177.45
    diisopropyl ether 23.55
    tert-amyl alcohol 80.09
    acetylacetone 157.64
    n-hexadecane 1.06
    acetophenone 51.62
    methyl propionate 133.6
    isopentyl acetate 44.63
    trichloroethylene 92.43
    n-nonanol 22.27
    cyclohexanol 51.11
    benzyl alcohol 38.79
    2-ethylhexanol 32.27
    isooctanol 21.46
    dipropyl ether 37.75
    1,2-dichlorobenzene 23.19
    ethyl lactate 58.11
    propylene carbonate 132.99
    n-methylformamide 251.3
    2-pentanol 72.59
    n-pentane 4.09
    1-propoxy-2-propanol 113.67
    1-methoxy-2-propyl acetate 102.62
    2-(2-methoxypropoxy) propanol 77.59
    mesitylene 11.4
    ε-caprolactone 115.43
    p-cymene 10.66
    epichlorohydrin 324.72
    1,1,1-trichloroethane 36.9
    2-aminoethanol 111.3
    morpholine-4-carbaldehyde 248.55
    sulfolane 607.34
    2,2,4-trimethylpentane 2.9
    2-methyltetrahydrofuran 186.8
    n-hexyl acetate 48.12
    isooctane 2.76
    2-(2-butoxyethoxy)ethanol 93.37
    sec-butyl acetate 35.01
    tert-butyl acetate 84.18
    decalin 2.5
    glycerin 169.8
    diglyme 156.8
    acrylic acid 94.56
    isopropyl myristate 18.55
    n-butyric acid 96.87
    acetyl acetate 53.66
    di(2-ethylhexyl) phthalate 21.57
    ethyl propionate 69.83
    nitromethane 285.77
    1,2-diethoxyethane 47.61
    benzonitrile 26.85
    trioctyl phosphate 20.08
    1-bromopropane 31.35
    gamma-valerolactone 278.97
    n-decanol 16.21
    triethyl phosphate 30.09
    4-methyl-2-pentanol 38.69
    propionitrile 52.45
    vinylene carbonate 85.82
    1,1,2-trichlorotrifluoroethane 181.96
    DMS 56.5
    cumene 9.09
    2-octanol 18.97
    2-hexanone 71.94
    octyl acetate 26.98
    limonene 16.68
    1,2-dimethoxyethane 187.03
    ethyl orthosilicate 25.94
    tributyl phosphate 23.91
    diacetone alcohol 159.62
    N,N-dimethylaniline 36.49
    acrylonitrile 73.77
    aniline 38.17
    1,3-propanediol 140.21
    bromobenzene 15.89
    dibromomethane 31.05
    1,1,2,2-tetrachloroethane 73.49
    2-methyl-cyclohexyl acetate 37.08
    tetrabutyl urea 32.82
    diisobutyl methanol 19.34
    2-phenylethanol 47.47
    styrene 9.98
    dioctyl adipate 30.76
    dimethyl sulfate 245.13
    ethyl butyrate 46.25
    methyl lactate 131.46
    butyl lactate 41.22
    diethyl carbonate 30.9
    propanediol butyl ether 74.24
    triethyl orthoformate 33.48
    p-tert-butyltoluene 11.62
    methyl 4-tert-butylbenzoate 56.55
    morpholine 169.42
    tert-butylamine 44.5
    n-dodecanol 11.36
    dimethoxymethane 327.84
    ethylene carbonate 67.87
    cyrene 99.33
    2-ethoxyethyl acetate 52.12
    2-ethylhexyl acetate 32.56
    1,2,4-trichlorobenzene 29.83
    4-methylpyridine 60.9
    dibutyl ether 19.37
    2,6-dimethyl-4-heptanol 19.34
    DEF 134.98
    dimethyl isosorbide 146.67
    tetrachloroethylene 43.97
    eugenol 56.86
    triacetin 49.91
    span 80 56.79
    1,4-butanediol 47.89
    1,1-dichloroethane 41.16
    2-methyl-1-pentanol 44.61
    methyl formate 192.23
    2-methyl-1-butanol 59.56
    n-decane 1.72
    butyronitrile 54.34
    3,7-dimethyl-1-octanol 23.72
    1-chlorooctane 11.02
    1-chlorotetradecane 3.68
    n-nonane 1.62
    undecane 1.25
    tert-butylcyclohexane 2.96
    cyclooctane 1.17
    cyclopentanol 96.28
    tetrahydropyran 84.24
    tert-amyl methyl ether 54.82
    2,5,8-trioxanonane 108.52
    1-hexene 16.19
    2-isopropoxyethanol 82.75
    2,2,2-trifluoroethanol 70.33
    methyl butyrate 78.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Oakmoss absolute (Morocco) 9000-50-4 Evernia prunastri (L.) Ach., fam. Usneaceae 0.2%
Oakmoss (Yugoslavia) 1 9000-50-4 Evernia prunastri (L.) Ach., fam. Usneaceae 0.2%
Oakmoss (Yugoslavia) 2 9000-50-4 Evernia prunastri (L.) Ach., fam. Usneaceae 3.7%
Sassafras (Brazil) 1 8006-80-2 Sassafras albidum (Nutt.) Nees, fam. Lauraceae 0.01%
Treemoss concrete 9000-50-4 Evernia ssp., fam. Usneaceae 0.01%