Evernic Acid

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    537-09-7

    Molecular formula
    C17H16O7

    SMILES
    CC1=CC(=CC(=C1C(=O)OC2=CC(=C(C(=C2)C)C(=O)O)O)O)OC

  • Odor profile

    Phenolic 47.72%
    Odorless 45.34%
    Woody 34.33%
    Sweet 32.89%
    Balsamic 31.65%
    Dry 29.46%
    Floral 28.1%
    Fruity 27.78%
    Powdery 26.91%
    Animal 26.31%

    Scent© AI

  • Properties

    XLogP3-AA
    4.0

    pKa est.
    7.41 (neutral)

    Molecular weight
    332.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    568°C

    Flash point est.
    241.44 ˚C

  • Synonyms

    • Evernic acid
    • 537-09-7
    • NSC 81164
    • EINECS 208-658-2
    • 2-hydroxy-4-(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy-6-methylbenzoic acid
    • UNII-2EQ5W5403J
    • BRN 2227186
    • 2EQ5W5403J
    • NSC-81164
    • Benzoic acid, 2-hydroxy-4-((2-hydroxy-4-methoxy-6-methylbenzoyl)oxy)-6-methyl-
    • 4-((4-Methoxy-6-methylsalicyloyl)oxy)-6-methylsalicylic acid
    • DTXSID20201956
    • 3-10-00-01488 (Beilstein Handbook Reference)
    • 2,6-CRESOTIC ACID, 4-METHOXY-, 4-ESTER with 6-METHYL-beta-RESORCYLATE
    • 2,6-Cresotic acid, 4-methoxy-, 4-ester with 6-methyl-beta-resorcylic acid
    • 4-[(4-methoxy-6-methylsalicyloyl)oxy]-6-methylsalicylic acid
    • 2,6-Cresotic acid, 4-methoxy-, 4-ester with 6-methyl-.beta.-resorcylate
    • 2,6-CRESOTIC ACID, 4-METHOXY-, 4-ESTER WITH 6-METHYL-.BETA.-RESORCYLIC ACID
    • Evernic acid, pruiss
    • Evernsaure
    • Evernate
    • Benzoic acid, 2-hydroxy-4-[(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy]-6-methyl-
    • MFCD00045824
    • SpecPlus_000646
    • 2-Hydroxy-4-[2-hydroxy-4-methoxy-6-methylbenzoyloxy]-6-methylbenzoic acid
    • Oprea1_749224
    • MLS001049100
    • DivK1c_006742
    • REGID_for_CID_10829
    • SCHEMBL2552354
    • CHEMBL1484978
    • KBio1_001686
    • DTXCID50124447
    • CHEBI:111284
    • GODLCSLPZIBRMG-UHFFFAOYSA-N
    • HMS2267A10
    • NSC81164
    • BDBM50491952
    • AKOS015969692
    • CCG-231001
    • FE65686
    • NCGC00246189-01
    • SMR000386932
    • WLN: QR CQ E1 DVOVR BQ F1 DO1
    • HY-121362
    • CS-0081796
    • NS00018299
    • AB00053221-08
    • Q27190901
    • 2, 4-methoxy-, 4-ester with 6-methyl-.beta.-resorcylate
    • 2,6-Cresotic acid, 4-methoxy-, 4-ester with 6-methyl-beta-resorcylic acid (8CI)
    • 2-hydroxy-4-(2-hydroxy-4-methoxy-6-methyl-benzoyl)oxy-6-methyl-benzoic acid
    • Benzoic acid, 2-hydroxy-4-((2-hydroxy-4-methoxy-6-methylbenzoyl)oxy)-6-methyl-(9CI)

  • Applications

    Evernic acid (CAS 537-09-7) is a lichen-derived depside used primarily as an analytical reference standard (HPLC/LC–MS/GC–MS) for qualitative/quantitative profiling and quality control of lichen and oakmoss extracts in the fragrance industry, as well as for monitoring compliance with IFRA guidance and EU regulations on fragrance allergens; it is used in dermatology research as a reference contact allergen for patch testing when assessing contact dermatitis related to Evernia prunastri extracts; it is widely explored in pharmacology and microbiology for reported antibacterial, antifungal, antioxidant and antibiofilm activities and selective cytotoxicity, supporting structure–activity optimization and derivative development; and it serves as a model molecule to study depside chemistry/biology (photostability, protein interactions, UV absorption), with exploratory evaluations as a natural preservative/antimicrobial or photoprotective agent in experimental formulations.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.78
    methanol 22.89
    isopropanol 13.96
    water 0.01
    ethyl acetate 30.72
    n-propanol 18.27
    acetone 65.88
    n-butanol 14.82
    acetonitrile 18.56
    DMF 394.73
    toluene 1.64
    isobutanol 11.3
    1,4-dioxane 35.85
    methyl acetate 29.84
    THF 298.69
    2-butanone 43.12
    n-pentanol 13.47
    sec-butanol 12.4
    n-hexane 0.23
    ethylene glycol 21.35
    NMP 267.48
    cyclohexane 0.08
    DMSO 1045.51
    n-butyl acetate 19.08
    n-octanol 5.12
    chloroform 7.17
    n-propyl acetate 23.91
    acetic acid 48.69
    dichloromethane 8.96
    cyclohexanone 42.29
    propylene glycol 48.48
    isopropyl acetate 21.03
    DMAc 226.23
    2-ethoxyethanol 92.67
    isopentanol 12.66
    n-heptane 0.26
    ethyl formate 20.69
    1,2-dichloroethane 10.34
    n-hexanol 8.22
    2-methoxyethanol 228.57
    isobutyl acetate 11.53
    tetrachloromethane 0.61
    n-pentyl acetate 11.8
    transcutol 156.9
    n-heptanol 5.55
    ethylbenzene 1.11
    MIBK 26.02
    2-propoxyethanol 118.62
    tert-butanol 23.18
    MTBE 8.68
    2-butoxyethanol 32.97
    propionic acid 33.18
    o-xylene 1.24
    formic acid 37.36
    diethyl ether 9.78
    m-xylene 1.87
    p-xylene 1.41
    chlorobenzene 2.57
    dimethyl carbonate 47.18
    n-octane 0.13
    formamide 85.51
    cyclopentanone 154.95
    2-pentanone 43.69
    anisole 9.47
    cyclopentyl methyl ether 33.81
    gamma-butyrolactone 230.65
    1-methoxy-2-propanol 213.32
    pyridine 15.69
    3-pentanone 22.07
    furfural 98.65
    n-dodecane 0.16
    diethylene glycol 121.84
    diisopropyl ether 2.51
    tert-amyl alcohol 16.3
    acetylacetone 85.84
    n-hexadecane 0.19
    acetophenone 15.91
    methyl propionate 54.19
    isopentyl acetate 15.63
    trichloroethylene 22.27
    n-nonanol 5.53
    cyclohexanol 8.99
    benzyl alcohol 12.3
    2-ethylhexanol 5.19
    isooctanol 4.88
    dipropyl ether 10.56
    1,2-dichlorobenzene 3.33
    ethyl lactate 36.39
    propylene carbonate 61.49
    n-methylformamide 125.81
    2-pentanol 9.95
    n-pentane 0.17
    1-propoxy-2-propanol 78.89
    1-methoxy-2-propyl acetate 63.27
    2-(2-methoxypropoxy) propanol 51.8
    mesitylene 1.19
    ε-caprolactone 47.41
    p-cymene 1.4
    epichlorohydrin 178.09
    1,1,1-trichloroethane 5.49
    2-aminoethanol 39.2
    morpholine-4-carbaldehyde 196.81
    sulfolane 492.85
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 46.96
    n-hexyl acetate 15.83
    isooctane 0.16
    2-(2-butoxyethoxy)ethanol 63.65
    sec-butyl acetate 12.55
    tert-butyl acetate 30.71
    decalin 0.16
    glycerin 126.06
    diglyme 101.53
    acrylic acid 39.19
    isopropyl myristate 7.39
    n-butyric acid 35.41
    acetyl acetate 18.47
    di(2-ethylhexyl) phthalate 9.64
    ethyl propionate 26.24
    nitromethane 199.42
    1,2-diethoxyethane 26.37
    benzonitrile 7.66
    trioctyl phosphate 8.02
    1-bromopropane 3.66
    gamma-valerolactone 227.1
    n-decanol 4.25
    triethyl phosphate 12.88
    4-methyl-2-pentanol 6.95
    propionitrile 14.75
    vinylene carbonate 41.16
    1,1,2-trichlorotrifluoroethane 111.49
    DMS 24.47
    cumene 0.95
    2-octanol 4.06
    2-hexanone 25.55
    octyl acetate 9.83
    limonene 2.15
    1,2-dimethoxyethane 117.95
    ethyl orthosilicate 10.8
    tributyl phosphate 10.96
    diacetone alcohol 86.87
    N,N-dimethylaniline 7.37
    acrylonitrile 27.57
    aniline 6.24
    1,3-propanediol 57.57
    bromobenzene 1.96
    dibromomethane 4.53
    1,1,2,2-tetrachloroethane 19.81
    2-methyl-cyclohexyl acetate 13.65
    tetrabutyl urea 17.63
    diisobutyl methanol 4.89
    2-phenylethanol 12.24
    styrene 1.18
    dioctyl adipate 15.15
    dimethyl sulfate 144.14
    ethyl butyrate 19.02
    methyl lactate 94.13
    butyl lactate 22.97
    diethyl carbonate 12.05
    propanediol butyl ether 39.78
    triethyl orthoformate 16.2
    p-tert-butyltoluene 1.74
    methyl 4-tert-butylbenzoate 25.77
    morpholine 73.62
    tert-butylamine 5.33
    n-dodecanol 3.12
    dimethoxymethane 209.16
    ethylene carbonate 30.19
    cyrene 75.91
    2-ethoxyethyl acetate 27.56
    2-ethylhexyl acetate 10.25
    1,2,4-trichlorobenzene 5.19
    4-methylpyridine 15.68
    dibutyl ether 6.58
    2,6-dimethyl-4-heptanol 4.89
    DEF 61.17
    dimethyl isosorbide 127.91
    tetrachloroethylene 6.81
    eugenol 28.06
    triacetin 30.9
    span 80 34.61
    1,4-butanediol 19.43
    1,1-dichloroethane 6.22
    2-methyl-1-pentanol 10.38
    methyl formate 84.31
    2-methyl-1-butanol 11.49
    n-decane 0.27
    butyronitrile 12.03
    3,7-dimethyl-1-octanol 5.91
    1-chlorooctane 1.81
    1-chlorotetradecane 0.79
    n-nonane 0.22
    undecane 0.2
    tert-butylcyclohexane 0.21
    cyclooctane 0.06
    cyclopentanol 22.17
    tetrahydropyran 15.78
    tert-amyl methyl ether 10.61
    2,5,8-trioxanonane 79.73
    1-hexene 1.3
    2-isopropoxyethanol 48.11
    2,2,2-trifluoroethanol 25.45
    methyl butyrate 33.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Oakmoss absolute (Morocco) 9000-50-4 Evernia prunastri (L.) Ach., fam. Usneaceae 0.01%
Oakmoss (Yugoslavia) 1 9000-50-4 Evernia prunastri (L.) Ach., fam. Usneaceae 0.7%
Oakmoss (Yugoslavia) 2 9000-50-4 Evernia prunastri (L.) Ach., fam. Usneaceae 0.1%
Thymus quinquecostatus 2 Thymus quinquecostatus var. prazewalskii, fam. Lamiaceae (Labiatae) 0.05%