Etidronate Disodium

Overview IFRA Request a quote

  • Identifiers

    CAS number
    7414-83-7

    Molecular formula
    C2H6Na2O7P2

    SMILES
    CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 79.42%
    Sweet 23.26%
    Clean 16.92%
    Savory 16.78%
    Sour 15.05%
    Bitter 13.99%
    Sharp 13.78%
    Milky 13.25%
    Caramellic 13.02%
    Burnt 12.81%

     

    Flavor
    Odorless 70.4%
    Bland 28.41%
    Sour 27.28%
    Very mild 26.76%
    Mild 24.92%
    Yeast 20.43%
    Sweet-like 20.4%
    Mousy 18.83%
    Caramellic 18.82%
    Soy 18.77%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.19 (weak acid)

    Molecular weight
    249.99 g/mol

    Flash point

    • 260.38 ˚C est.

  • Synonyms

    • Etidronate disodium
    • 7414-83-7
    • Disodium etidronate
    • Sodium etidronate
    • Disodium ethydronate
    • Sodium ethidronate
    • Sodium ethydronate
    • Etidronic Acid Disodium Salt
    • Turpinal 2NZ
    • Disodium ethanol-1,1-diphosphonate
    • Disodium 1-hydroxyethylidene phosphonate
    • Disodium (1-hydroxyethylidene)diphosphonate
    • Disodium dihydrogen (1-hydroxyethylidene)diphosphonate
    • Disodium ethane-1-hydroxy-1,1-diphosphonate
    • (1-Hydroxyethane-1,1-diyl)diphosphonic acid disodium salt
    • M16PXG993G
    • DTXSID1029671
    • (1-Hydroxyethylidene)diphosphonic acid, disodium salt
    • 1-Hydroxyethylidene-1,1-diphosphonic acid disodium salt
    • Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt
    • NSC-759157
    • CHEBI:4906
    • DTXCID609671
    • Didronel IV
    • Didronel PMO
    • Calcimux
    • RefChem:55166
    • Disodium 1 Hydroxyethylene Diphosphonate
    • Disodium 1-Hydroxyethylene Diphosphonate
    • Disodium Dihydrogen (1-hydroxyethylidene)bis(phosphonate)
    • Disodium dihydrogen 1-hydroxyethane-1,1-diyldiphosphonate
    • Didronel
    • Disodium Etidronate Hydrate
    • Etidronic acid disodium
    • 1-Hydroxyethane-1,1-diphosphonic Acid Disodium Salt
    • HEDPA;HEDP
    • Etidronic acid, disodium salt
    • Didronel R
    • CAS-7414-83-7
    • disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
    • disodium (1-hydroxyethane-1,1-diyl)bis[hydrogen (phosphonate)]
    • Etidronsaeure dinatriumsalz
    • MFCD00152567
    • NCGC00159352-02
    • EINECS 231-025-7
    • Etidronate disodium hydrate
    • SM-5600
    • UNII-M16PXG993G
    • Disodium 1-hydroxyethane-1,1-diphosphonate hydrate
    • Etidronate disodium; Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate
    • Etidronatedisodium
    • Phosphonic acid, (1-hydroxyethylidene)bis-, sodium salt
    • Didronel (TN)
    • Ethane-1-hydroxy-1,1-diphosphonate, disodium salt
    • Etidronate disodium [USAN:USP:JAN]
    • Prestwick_1061
    • Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate
    • Ethane-1-hydroxy-1,1-diphosphonic acid, disodium salt
    • Phosphonic acid, (1-hydroxyethylidene)di-, disodium salt
    • Etidronate disodium CRS
    • (1-Hydroxyethylidene)bis-phosphonic acid disodium salt
    • orb1309394
    • SCHEMBL1649923
    • CHEMBL1201042
    • ETIDRONATE DISODIUM [JAN]
    • Etidronate disodium (JP18/USP)
    • ETIDRONATE DISODIUM [USAN]
    • HMS1570N07
    • HMS2093P03
    • HMS2097N07
    • ETIDRONATE DISODIUM [VANDF]
    • ETIDRONATE DISODIUM [MART.]
    • Tox21_111596
    • EBC-03471
    • ETIDRONATE DISODIUM [USP-RS]
    • ETIDRONATE DISODIUM [WHO-DD]
    • AKOS015961949
    • Tox21_111596_1
    • AC-2078
    • CCG-213569
    • FE35145
    • KS-1297
    • NSC 759157
    • ETIDRONATE DISODIUM [ORANGE BOOK]
    • NCGC00017072-01
    • NCGC00179380-04
    • BE164429
    • ETIDRONATE DISODIUM [EP MONOGRAPH]
    • ETIDRONIC ACID DISODIUM SALT [MI]
    • ETIDRONATE DISODIUM [USP MONOGRAPH]
    • Disodium 1-Hydroxyethane-1,1-diphosphonate
    • D4159
    • Etidronate disodium salt - Bio-X trade mark
    • NS00075674
    • D00314
    • H11387
    • EN300-8162703
    • Etidronate disodium;HEDPA disodium;HEDP disodium
    • Etidronate disodium hydrate, >=97% (NMR), solid
    • Q27106537
    • disodium hydrogen (1-hydrogen phosphono-1-hydroxyethyl)phosphonate
    • Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:2)
    • 7414-83-7

  • Applications

    Etidronate Disodium (CAS 7414-83-7) is widely used as a chelating agent and a scale/corrosion inhibitor in water treatment and cooling tower or boiler systems; in detergents and cleaners it acts as a builder to soften hard water and improve cleaning performance; in cosmetics and personal care it serves as a chelating agent to improve formulation stability and prevent metal-catalyzed degradation; in coatings and inks it helps prevent metal ion–induced pigment discoloration and enhances long-term formulation stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 71.3
    methanol 248.53
    isopropanol 44.23
    water 1305.64
    ethyl acetate 4.44
    n-propanol 32.03
    acetone 48.63
    n-butanol 25.15
    acetonitrile 6.32
    DMF 323.88
    toluene 2.29
    isobutanol 17.27
    1,4-dioxane 21.72
    methyl acetate 3.99
    THF 67.17
    2-butanone 10.62
    n-pentanol 12.26
    sec-butanol 19.69
    n-hexane 1.84
    ethylene glycol 210.78
    NMP 103.69
    cyclohexane 3.63
    DMSO 396.94
    n-butyl acetate 2.38
    n-octanol 8.79
    chloroform 1.52
    n-propyl acetate 2.95
    acetic acid 21.03
    dichloromethane 2.76
    cyclohexanone 12.19
    propylene glycol 90.61
    isopropyl acetate 6.11
    DMAc 96.72
    2-ethoxyethanol 87.39
    isopentanol 17.05
    n-heptane 3.5
    ethyl formate 7.61
    1,2-dichloroethane 3.84
    n-hexanol 11.13
    2-methoxyethanol 247.19
    isobutyl acetate 1.24
    tetrachloromethane 1.68
    n-pentyl acetate 3.31
    transcutol 45.8
    n-heptanol 11.96
    ethylbenzene 1.14
    MIBK 16.41
    2-propoxyethanol 55.33
    tert-butanol 50.94
    MTBE 9.87
    2-butoxyethanol 34.34
    propionic acid 7.83
    o-xylene 3.15
    formic acid 185.48
    diethyl ether 15.28
    m-xylene 3.25
    p-xylene 1.33
    chlorobenzene 0.58
    dimethyl carbonate 12.84
    n-octane 1.8
    formamide 270.02
    cyclopentanone 31.18
    2-pentanone 19.88
    anisole 3.68
    cyclopentyl methyl ether 22.8
    gamma-butyrolactone 21.21
    1-methoxy-2-propanol 169.92
    pyridine 5.56
    3-pentanone 10.13
    furfural 19.51
    n-dodecane 0.78
    diethylene glycol 112.29
    diisopropyl ether 7.29
    tert-amyl alcohol 22.61
    acetylacetone 22.82
    n-hexadecane 0.81
    acetophenone 4.54
    methyl propionate 9.07
    isopentyl acetate 1.98
    trichloroethylene 2.45
    n-nonanol 8.05
    cyclohexanol 13.52
    benzyl alcohol 5.68
    2-ethylhexanol 4.6
    isooctanol 7.5
    dipropyl ether 9.64
    1,2-dichlorobenzene 0.64
    ethyl lactate 9.3
    propylene carbonate 5.81
    n-methylformamide 108.5
    2-pentanol 19.67
    n-pentane 4.15
    1-propoxy-2-propanol 32.15
    1-methoxy-2-propyl acetate 8.84
    2-(2-methoxypropoxy) propanol 20.0
    mesitylene 3.83
    ε-caprolactone 6.85
    p-cymene 1.92
    epichlorohydrin 15.36
    1,1,1-trichloroethane 1.26
    2-aminoethanol 151.48
    morpholine-4-carbaldehyde 77.73
    sulfolane 68.68
    2,2,4-trimethylpentane 1.14
    2-methyltetrahydrofuran 15.69
    n-hexyl acetate 3.82
    isooctane 1.4
    2-(2-butoxyethoxy)ethanol 31.42
    sec-butyl acetate 2.07
    tert-butyl acetate 10.4
    decalin 0.75
    glycerin 232.69
    diglyme 54.61
    acrylic acid 10.02
    isopropyl myristate 2.28
    n-butyric acid 9.85
    acetyl acetate 2.74
    di(2-ethylhexyl) phthalate 2.31
    ethyl propionate 3.68
    nitromethane 32.99
    1,2-diethoxyethane 8.21
    benzonitrile 1.38
    trioctyl phosphate 2.85
    1-bromopropane 2.28
    gamma-valerolactone 39.84
    n-decanol 6.0
    triethyl phosphate 2.49
    4-methyl-2-pentanol 12.45
    propionitrile 3.71
    vinylene carbonate 3.61
    1,1,2-trichlorotrifluoroethane 23.92
    DMS 2.59
    cumene 1.25
    2-octanol 7.48
    2-hexanone 6.04
    octyl acetate 2.92
    limonene 3.23
    1,2-dimethoxyethane 67.51
    ethyl orthosilicate 2.86
    tributyl phosphate 1.89
    diacetone alcohol 41.2
    N,N-dimethylaniline 6.97
    acrylonitrile 5.18
    aniline 5.05
    1,3-propanediol 108.46
    bromobenzene 0.44
    dibromomethane 2.21
    1,1,2,2-tetrachloroethane 3.57
    2-methyl-cyclohexyl acetate 2.44
    tetrabutyl urea 5.9
    diisobutyl methanol 6.02
    2-phenylethanol 5.31
    styrene 1.0
    dioctyl adipate 2.53
    dimethyl sulfate 31.38
    ethyl butyrate 3.27
    methyl lactate 34.55
    butyl lactate 7.21
    diethyl carbonate 1.54
    propanediol butyl ether 31.15
    triethyl orthoformate 3.57
    p-tert-butyltoluene 2.57
    methyl 4-tert-butylbenzoate 11.35
    morpholine 34.52
    tert-butylamine 24.05
    n-dodecanol 4.33
    dimethoxymethane 168.76
    ethylene carbonate 3.39
    cyrene 30.82
    2-ethoxyethyl acetate 4.54
    2-ethylhexyl acetate 1.39
    1,2,4-trichlorobenzene 0.76
    4-methylpyridine 4.53
    dibutyl ether 3.92
    2,6-dimethyl-4-heptanol 6.02
    DEF 29.33
    dimethyl isosorbide 27.18
    tetrachloroethylene 4.07
    eugenol 15.61
    triacetin 4.67
    span 80 14.96
    1,4-butanediol 44.36
    1,1-dichloroethane 1.78
    2-methyl-1-pentanol 6.97
    methyl formate 60.95
    2-methyl-1-butanol 13.11
    n-decane 1.47
    butyronitrile 4.74
    3,7-dimethyl-1-octanol 5.17
    1-chlorooctane 2.13
    1-chlorotetradecane 0.97
    n-nonane 1.59
    undecane 1.04
    tert-butylcyclohexane 0.68
    cyclooctane 2.49
    cyclopentanol 24.45
    tetrahydropyran 10.14
    tert-amyl methyl ether 10.53
    2,5,8-trioxanonane 41.51
    1-hexene 2.3
    2-isopropoxyethanol 36.3
    2,2,2-trifluoroethanol 23.85
    methyl butyrate 5.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction