Molecular formula
C3H6O3-2

SMILES
CCOC([O-])[O-]

Fragrance
Odorless	48.39%
Fruity	47.28%
Alcoholic	34.78%
Sweet	30.38%
Ethereal	30.01%
Fresh	23.05%
Green	22.39%
Winey	21.37%
Pungent	20.52%
Bitter	19.22%

 

Flavor
Odorless	42.89%
Sweet	30.23%
Sulfurous	27.59%
Fruity	26.78%
Onion	25.18%
Alcoholic	23.46%
Very slight	23.03%
Sweet-like	22.65%
Sulfury	21.5%
Soup	21.48%

 

Odor impact est.
High

XLogP3-AA
1.6

pKa est.
4.56 (weak acid)

Molecular weight
90.08 g/mol

Flash point

• 34.67 ˚C est.

• ethylorthoformate
• ethyl-orthoformate
• ethyl ortho formate
• ethyl ortho-formate
• WJYLLOQXAYKDEW-UHFFFAOYSA-N

Ethylorthoformate is primarily used as a formylating reagent in organic synthesis, providing a source of formyl groups to convert amines into formamides and to enable formation of formylated intermediates for subsequent transformations such as imine formation and heterocycle synthesis. It is widely used in pharmaceutical and agrochemical manufacturing as a building block for formylated intermediates and for heterocycle precursors. It also serves as an important precursor in the synthesis of dyes, pigments, and other specialty chemicals. In process development and research settings, it is employed for formylation steps and as a flexible reagent in multi-step syntheses, with handling and use governed by local regulations.

gpt-5-nano

Solvent	Solubility (g/L)
ethanol	180.96
methanol	382.04
isopropanol	108.55
water	81.18
ethyl acetate	112.98
n-propanol	112.18
acetone	271.56
n-butanol	90.0
acetonitrile	274.92
DMF	855.64
toluene	23.77
isobutanol	65.38
1,4-dioxane	231.9
methyl acetate	173.42
THF	197.39
2-butanone	131.94
n-pentanol	58.65
sec-butanol	77.6
n-hexane	7.01
ethylene glycol	231.77
NMP	722.42
cyclohexane	12.46
DMSO	894.62
n-butyl acetate	57.35
n-octanol	51.1
chloroform	133.87
n-propyl acetate	56.09
acetic acid	1011.02
dichloromethane	208.96
cyclohexanone	191.81
propylene glycol	130.67
isopropyl acetate	52.13
DMAc	483.42
2-ethoxyethanol	173.99
isopentanol	56.97
n-heptane	6.02
ethyl formate	147.63
1,2-dichloroethane	158.97
n-hexanol	46.5
2-methoxyethanol	362.63
isobutyl acetate	23.25
tetrachloromethane	18.66
n-pentyl acetate	54.17
transcutol	400.79
n-heptanol	32.29
ethylbenzene	19.58
MIBK	49.04
2-propoxyethanol	121.5
tert-butanol	122.8
MTBE	50.76
2-butoxyethanol	74.98
propionic acid	299.74
o-xylene	31.26
formic acid	763.72
diethyl ether	65.38
m-xylene	21.81
p-xylene	27.72
chlorobenzene	79.57
dimethyl carbonate	84.98
n-octane	4.22
formamide	835.25
cyclopentanone	229.42
2-pentanone	93.77
anisole	64.49
cyclopentyl methyl ether	72.52
gamma-butyrolactone	394.66
1-methoxy-2-propanol	201.11
pyridine	196.8
3-pentanone	79.11
furfural	480.15
n-dodecane	4.75
diethylene glycol	177.02
diisopropyl ether	15.48
tert-amyl alcohol	91.49
acetylacetone	156.32
n-hexadecane	5.12
acetophenone	92.67
methyl propionate	133.11
isopentyl acetate	42.1
trichloroethylene	276.35
n-nonanol	43.65
cyclohexanol	88.34
benzyl alcohol	81.79
2-ethylhexanol	28.91
isooctanol	25.31
dipropyl ether	29.65
1,2-dichlorobenzene	96.83
ethyl lactate	56.94
propylene carbonate	178.9
n-methylformamide	473.17
2-pentanol	50.42
n-pentane	7.34
1-propoxy-2-propanol	73.87
1-methoxy-2-propyl acetate	66.05
2-(2-methoxypropoxy) propanol	109.6
mesitylene	17.96
ε-caprolactone	202.73
p-cymene	17.77
epichlorohydrin	260.9
1,1,1-trichloroethane	65.3
2-aminoethanol	213.05
morpholine-4-carbaldehyde	520.32
sulfolane	567.6
2,2,4-trimethylpentane	4.9
2-methyltetrahydrofuran	125.11
n-hexyl acetate	91.18
isooctane	3.09
2-(2-butoxyethoxy)ethanol	147.53
sec-butyl acetate	29.66
tert-butyl acetate	57.9
decalin	7.44
glycerin	266.0
diglyme	226.49
acrylic acid	449.51
isopropyl myristate	31.9
n-butyric acid	201.66
acetyl acetate	107.0
di(2-ethylhexyl) phthalate	46.01
ethyl propionate	58.88
nitromethane	1054.85
1,2-diethoxyethane	78.36
benzonitrile	121.75
trioctyl phosphate	30.88
1-bromopropane	48.49
gamma-valerolactone	387.4
n-decanol	33.79
triethyl phosphate	33.98
4-methyl-2-pentanol	27.27
propionitrile	120.86
vinylene carbonate	214.61
1,1,2-trichlorotrifluoroethane	313.04
DMS	101.68
cumene	17.77
2-octanol	27.03
2-hexanone	53.36
octyl acetate	49.53
limonene	25.66
1,2-dimethoxyethane	221.23
ethyl orthosilicate	27.53
tributyl phosphate	38.42
diacetone alcohol	108.42
N,N-dimethylaniline	58.6
acrylonitrile	265.93
aniline	77.99
1,3-propanediol	212.26
bromobenzene	59.19
dibromomethane	105.26
1,1,2,2-tetrachloroethane	197.06
2-methyl-cyclohexyl acetate	40.71
tetrabutyl urea	62.05
diisobutyl methanol	19.73
2-phenylethanol	58.65
styrene	29.02
dioctyl adipate	60.01
dimethyl sulfate	192.83
ethyl butyrate	45.96
methyl lactate	126.73
butyl lactate	61.53
diethyl carbonate	39.03
propanediol butyl ether	116.12
triethyl orthoformate	32.65
p-tert-butyltoluene	16.42
methyl 4-tert-butylbenzoate	89.05
morpholine	248.5
tert-butylamine	56.91
n-dodecanol	26.61
dimethoxymethane	198.04
ethylene carbonate	146.86
cyrene	114.78
2-ethoxyethyl acetate	86.15
2-ethylhexyl acetate	32.72
1,2,4-trichlorobenzene	117.34
4-methylpyridine	162.87
dibutyl ether	37.26
2,6-dimethyl-4-heptanol	19.73
DEF	199.28
dimethyl isosorbide	144.21
tetrachloroethylene	149.67
eugenol	102.17
triacetin	114.16
span 80	105.3
1,4-butanediol	88.56
1,1-dichloroethane	85.49
2-methyl-1-pentanol	44.78
methyl formate	347.38
2-methyl-1-butanol	56.87
n-decane	6.69
butyronitrile	90.74
3,7-dimethyl-1-octanol	38.9
1-chlorooctane	24.91
1-chlorotetradecane	12.47
n-nonane	6.3
undecane	5.47
tert-butylcyclohexane	6.12
cyclooctane	4.8
cyclopentanol	112.27
tetrahydropyran	109.04
tert-amyl methyl ether	47.45
2,5,8-trioxanonane	197.28
1-hexene	20.04
2-isopropoxyethanol	86.5
2,2,2-trifluoroethanol	354.45
methyl butyrate	85.99

Scent© AI