Ethylestrenol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    965-90-2

    Molecular formula
    C20H32O

    SMILES
    CC[C@@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CCCC[C@H]34)C)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Woody 62.54%
    Floral 45.43%
    Sweet 44.35%
    Amber 40.06%
    Balsamic 37.9%
    Musk 37.39%
    Sandalwood 37.13%
    Fruity 35.23%
    Dry 34.45%
    Earthy 32.41%

     

    Flavor
    Earthy 37.31%
    Sweet 34.38%
    Fruity 33.44%
    Herb 31.88%
    Wood 30.02%
    Fruit 29.45%
    Woody 28.94%
    Spicy 28.62%
    Musty 27.3%
    Herbal 26.91%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.1

    pKa est.
    9.05 (weak base)

    Molecular weight
    288.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    418°C

    Melting point expt.

    • about 50
    • 76-78 °C

    Flash point

    • 181.6 ˚C est.

    Solubility expt.

    • FREELY SOL IN ALC; SOL IN CHLOROFORM, ACETONE, METHANOL; PRACTICALLY INSOL IN WATER

  • Synonyms

    • ethylestrenol
    • Orabolin
    • Maxibolin
    • Ethylnandrol
    • Duraboral
    • Durabolin-O
    • Etilestrenol
    • Neodurabolin
    • Maxibalin
    • Orgabolin
    • Orgaboral
    • 965-90-2
    • Ethylestrenolum
    • Ethyloestrenolum
    • Ethyloestrenol
    • Etilestrenolo
    • 19-Nor-17alpha-pregn-4-en-17beta-ol
    • 17alpha-Ethylestr-4-en-17beta-ol
    • HSDB 3327
    • 17alpha-Ethyl-17beta-hydroxy-4-estrene
    • 19-Norpregn-4-en-17-ol, (17alpha)-
    • UNII-ADC79EK5Q8
    • EINECS 213-523-6
    • Etilestrenol [INN-Spanish]
    • ADC79EK5Q8
    • Estr-4-en-17beta-ol, 17-ethyl-
    • NSC 37726
    • Ethylestrenolum [INN-Latin]
    • (17-alpha)-19-Norpregn-4-en-17-ol
    • 17beta-Hydroxy-17alpha-ethyl-19-nor-4-androstene
    • DTXSID6023024
    • CHEBI:31578
    • NSC-37726
    • 19-Nor-17alpha-pregn-4-en-17-ol
    • (17alpha)-19-norpregn-4-en-17-ol
    • 19-Nor-17-alpha-pregn-4-en-17-ol
    • DTXCID503024
    • ORG-483
    • 19-Norpregn-4-en-17-ol, (17-alpha)-
    • Ethylnandrol (JAN)
    • NCGC00167514-01
    • ETHYLNANDROL [JAN]
    • Etilestrenol (INN-Spanish)
    • Ethylestrenolum (INN-Latin)
    • (8R,9S,10R,13S,14S,17S)-17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
    • ETHYLESTRENOL (MART.)
    • ETHYLESTRENOL [MART.]
    • Etilestrenolo [DCIT]
    • (17beta)-17-ethylestr-4-en-17-ol
    • CAS-965-90-2
    • SMR000238204
    • Ethylestrenol (1.0mg/ml in Acetonitrile)
    • Ethylestrenol [USAN:INN:BAN]
    • Orabolin (TN)
    • ETHYLESTRENOL [MI]
    • ETHYLESTRENOL [INN]
    • Ethylestrenol (USAN/INN)
    • ETHYLESTRENOL [HSDB]
    • ETHYLESTRENOL [USAN]
    • ETHYLESTRENOL [VANDF]
    • MLS000759411
    • MLS001424123
    • SCHEMBL147908
    • ETHYLESTRENOL [WHO-DD]
    • GTPL6948
    • CHEMBL1200623
    • A14AB02
    • AOXRBFRFYPMWLR-XGXHKTLJSA-N
    • HMS2051P08
    • ETHYLESTRENOL [ORANGE BOOK]
    • Tox21_112512
    • Tox21_112512_1
    • CCG-101014
    • DB01493
    • NC00264
    • NCGC00167514-02
    • NS00040493
    • 19-NORPREGN-4-EN-17-OL, (17alpha)
    • D01414
    • 17alpha-Ethylestr-4-en-17beta-ol; Ethylnandrol
    • Q764283
    • 19-NORPREGN-4-EN-17-OL, (17.ALPHA.)
    • W-100138
    • 213-523-6

  • Applications

    Ethylestrenol is a synthetic steroid used in the pharmaceutical sector, and may serve as an active pharmaceutical ingredient (API) or as an intermediate in the synthesis of other steroid compounds. In medicinal chemistry research and development, it may be used as a reference compound for steroid synthesis and analytical method development. It may also be explored as a precursor in veterinary pharmaceutical development involving steroid hormones, subject to local regulations. Additionally, it may serve as a chemical intermediate in steroid manufacturing to access related hormones and metabolites.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 224.92
    methanol 138.86
    isopropanol 249.98
    water 0.56
    ethyl acetate 357.02
    n-propanol 265.31
    acetone 412.33
    n-butanol 327.18
    acetonitrile 131.37
    DMF 324.71
    toluene 665.38
    isobutanol 178.12
    1,4-dioxane 772.59
    methyl acetate 171.23
    THF 1031.4
    2-butanone 268.3
    n-pentanol 60.53
    sec-butanol 74.62
    n-hexane 12.16
    ethylene glycol 10.15
    NMP 85.63
    cyclohexane 77.08
    DMSO 88.31
    n-butyl acetate 244.32
    n-octanol 37.75
    chloroform 641.9
    n-propyl acetate 127.2
    acetic acid 66.26
    dichloromethane 467.29
    cyclohexanone 455.35
    propylene glycol 13.55
    isopropyl acetate 394.83
    DMAc 163.04
    2-ethoxyethanol 112.81
    isopentanol 254.07
    n-heptane 17.8
    ethyl formate 106.74
    1,2-dichloroethane 323.65
    n-hexanol 130.31
    2-methoxyethanol 321.17
    isobutyl acetate 134.12
    tetrachloromethane 113.7
    n-pentyl acetate 148.27
    transcutol 852.14
    n-heptanol 66.52
    ethylbenzene 118.48
    MIBK 312.74
    2-propoxyethanol 299.89
    tert-butanol 196.69
    MTBE 316.98
    2-butoxyethanol 164.96
    propionic acid 60.67
    o-xylene 214.53
    formic acid 18.53
    diethyl ether 621.93
    m-xylene 352.51
    p-xylene 131.05
    chlorobenzene 290.6
    dimethyl carbonate 112.07
    n-octane 6.09
    formamide 45.14
    cyclopentanone 398.82
    2-pentanone 409.26
    anisole 223.99
    cyclopentyl methyl ether 373.73
    gamma-butyrolactone 291.07
    1-methoxy-2-propanol 287.44
    pyridine 537.25
    3-pentanone 235.32
    furfural 247.57
    n-dodecane 4.64
    diethylene glycol 129.99
    diisopropyl ether 178.33
    tert-amyl alcohol 65.4
    acetylacetone 421.34
    n-hexadecane 5.85
    acetophenone 148.47
    methyl propionate 204.5
    isopentyl acetate 298.97
    trichloroethylene 491.25
    n-nonanol 43.8
    cyclohexanol 156.65
    benzyl alcohol 109.19
    2-ethylhexanol 76.07
    isooctanol 62.85
    dipropyl ether 186.58
    1,2-dichlorobenzene 229.87
    ethyl lactate 47.81
    propylene carbonate 153.23
    n-methylformamide 108.98
    2-pentanol 136.99
    n-pentane 37.41
    1-propoxy-2-propanol 211.22
    1-methoxy-2-propyl acetate 385.04
    2-(2-methoxypropoxy) propanol 144.99
    mesitylene 202.41
    ε-caprolactone 285.36
    p-cymene 84.45
    epichlorohydrin 427.83
    1,1,1-trichloroethane 298.14
    2-aminoethanol 37.52
    morpholine-4-carbaldehyde 262.59
    sulfolane 153.19
    2,2,4-trimethylpentane 11.63
    2-methyltetrahydrofuran 337.37
    n-hexyl acetate 144.75
    isooctane 19.95
    2-(2-butoxyethoxy)ethanol 227.96
    sec-butyl acetate 134.75
    tert-butyl acetate 392.7
    decalin 21.04
    glycerin 31.47
    diglyme 545.33
    acrylic acid 41.8
    isopropyl myristate 75.18
    n-butyric acid 229.23
    acetyl acetate 224.97
    di(2-ethylhexyl) phthalate 66.85
    ethyl propionate 145.76
    nitromethane 143.28
    1,2-diethoxyethane 359.49
    benzonitrile 181.25
    trioctyl phosphate 44.7
    1-bromopropane 239.96
    gamma-valerolactone 551.83
    n-decanol 31.91
    triethyl phosphate 78.57
    4-methyl-2-pentanol 116.54
    propionitrile 244.87
    vinylene carbonate 178.88
    1,1,2-trichlorotrifluoroethane 136.27
    DMS 148.39
    cumene 73.74
    2-octanol 36.52
    2-hexanone 101.14
    octyl acetate 72.81
    limonene 87.53
    1,2-dimethoxyethane 352.77
    ethyl orthosilicate 90.05
    tributyl phosphate 55.46
    diacetone alcohol 205.48
    N,N-dimethylaniline 122.66
    acrylonitrile 190.22
    aniline 318.57
    1,3-propanediol 156.71
    bromobenzene 360.84
    dibromomethane 321.74
    1,1,2,2-tetrachloroethane 340.85
    2-methyl-cyclohexyl acetate 127.62
    tetrabutyl urea 69.79
    diisobutyl methanol 78.11
    2-phenylethanol 170.3
    styrene 141.87
    dioctyl adipate 95.39
    dimethyl sulfate 94.7
    ethyl butyrate 179.91
    methyl lactate 63.22
    butyl lactate 95.64
    diethyl carbonate 115.65
    propanediol butyl ether 82.26
    triethyl orthoformate 154.12
    p-tert-butyltoluene 87.48
    methyl 4-tert-butylbenzoate 169.36
    morpholine 666.84
    tert-butylamine 161.27
    n-dodecanol 24.52
    dimethoxymethane 597.51
    ethylene carbonate 180.42
    cyrene 88.76
    2-ethoxyethyl acetate 268.8
    2-ethylhexyl acetate 203.92
    1,2,4-trichlorobenzene 224.11
    4-methylpyridine 494.23
    dibutyl ether 98.07
    2,6-dimethyl-4-heptanol 78.11
    DEF 210.71
    dimethyl isosorbide 252.75
    tetrachloroethylene 249.98
    eugenol 147.79
    triacetin 166.47
    span 80 104.47
    1,4-butanediol 21.97
    1,1-dichloroethane 314.33
    2-methyl-1-pentanol 60.76
    methyl formate 70.13
    2-methyl-1-butanol 138.92
    n-decane 8.98
    butyronitrile 282.79
    3,7-dimethyl-1-octanol 64.83
    1-chlorooctane 34.42
    1-chlorotetradecane 15.47
    n-nonane 7.35
    undecane 6.15
    tert-butylcyclohexane 17.89
    cyclooctane 27.96
    cyclopentanol 104.95
    tetrahydropyran 813.94
    tert-amyl methyl ether 117.66
    2,5,8-trioxanonane 280.4
    1-hexene 42.38
    2-isopropoxyethanol 85.5
    2,2,2-trifluoroethanol 31.11
    methyl butyrate 149.96

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction