Ethylene glycol diethyl ether

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  • Identifiers

    CAS number
    629-14-1

    Molecular formula
    C6H14O2

    SMILES
    CCOCCOCC

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Ethereal 84.24%
    Sweet 65.2%
    Alcoholic 59.17%
    Fruity 52.02%
    Solvent 47.34%
    Fermented 43.01%
    Rummy 36.11%
    Pungent 31.06%
    Winey 30.48%
    Cognac 30.39%

     

    Flavor
    Sweet 73.2%
    Green 50.43%
    Fruit 44.25%
    Earthy 43.99%
    Vegetable 42.39%
    Ether 41.78%
    Alcoholic 40.73%
    Alcohol 39.76%
    Fusel 33.46%
    Ethereal 33.13%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    6.32 (neutral)

    Molecular weight
    118.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -101 °F (NTP, 1992)
    • -74 °C

    Boiling point

    • 250.5 °F at 760 mmHg (NTP, 1992)
    • 121.4 °C

    Flash point

    • 22.79 ˚C est.
    • 95 °F (NTP, 1992)
    • 95 °F (35 °C) (OPEN CUP)
    • 35 °C o.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
    • SOLUBILITY IN WATER 2%; SOL IN OILS
    • Very soluble in acetone, benzene, ethyl ether, ethanol
    • In water, 8.37X10+4 mg/L at 25 °C
    • Solubility in water: moderate

  • Synonyms

    • 1,2-Diethoxyethane
    • 629-14-1
    • ETHYLENE GLYCOL DIETHYL ETHER
    • Diethyl cellosolve
    • Ethane, 1,2-diethoxy-
    • 3,6-Dioxaoctane
    • Hisolve EME
    • Glyme-1
    • 2-Ethoxyethyl ethyl ether
    • EGDEE
    • Diethyl Glycol
    • HSDB 71
    • 1,2-Ethanediol, diethyl ether
    • Diethylether ethylenglykolu
    • UNII-F99O7F0CYH
    • EINECS 211-076-1
    • UN1153
    • BRN 1732917
    • DTXSID5025285
    • AI3-19760
    • F99O7F0CYH
    • DTXCID305285
    • UN 1153
    • ETHYLENE GLYCOL DIETHYL ETHER [HSDB]
    • 53609-62-4
    • Diethylether ethylenglykolu [Czech]
    • Ethyleneglycol diethyl ether
    • diethylcellosolve
    • Ethyl glyme
    • Glyme1
    • 3,6 dioxaoctane
    • 3.6-dioxaoctane
    • EGdiEE
    • 1,2diethoxyethane
    • 1,2 diethoxyethane
    • MFCD00009253
    • Ethane, 1,2diethoxy
    • 2Ethoxyethyl ethyl ether
    • GLYCOL DIETHYL ETHER
    • SCHEMBL22247
    • 1,2-Ethanol, diethyl ether
    • 1,2Ethanediol, diethyl ether
    • CHEMBL1877517
    • Ethylene glycol diethyl ether, 98%
    • Tox21_200656
    • AKOS015899579
    • NCGC00091756-01
    • NCGC00091756-02
    • NCGC00258210-01
    • CAS-629-14-1
    • FD175611
    • DB-054328
    • D0456
    • NS00004869
    • Q1223259
    • Ethylene glycol diethyl ether, technical, >=90% (GC)
    • Ethylene glycol diethyl ether [UN1153] [Flammable liquid]

  • Applications

    Ethylene glycol diethyl ether (CAS 629-14-1) is a polar ether solvent used as a reaction medium and solvent in industrial-scale organic synthesis. It is commonly employed as a solvent for coatings, resins, inks, and adhesives formulations. In the plastics and polymer sector it serves as a processing solvent and aid for resin formulation and processing. It is also used in cleaning formulations for industrial equipment and degreasing. Additionally, it functions as an intermediate and solvent in chemical manufacturing, with use subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 495.19
    methanol 718.89
    isopropanol 309.8
    water 5.73
    ethyl acetate 207.12
    n-propanol 378.19
    acetone 229.94
    n-butanol 324.44
    acetonitrile 315.93
    DMF 368.26
    toluene 186.44
    isobutanol 231.19
    1,4-dioxane 710.16
    methyl acetate 227.53
    THF 707.8
    2-butanone 192.76
    n-pentanol 177.59
    sec-butanol 280.87
    n-hexane 127.73
    ethylene glycol 202.35
    NMP 428.78
    cyclohexane 469.3
    DMSO 429.21
    n-butyl acetate 159.61
    n-octanol 95.11
    chloroform 1579.26
    n-propyl acetate 115.67
    acetic acid 677.61
    dichloromethane 1202.74
    cyclohexanone 403.82
    propylene glycol 192.42
    isopropyl acetate 96.03
    DMAc 300.87
    2-ethoxyethanol 285.76
    isopentanol 179.73
    n-heptane 141.82
    ethyl formate 179.64
    1,2-dichloroethane 532.45
    n-hexanol 208.98
    2-methoxyethanol 533.95
    isobutyl acetate 70.54
    tetrachloromethane 412.31
    n-pentyl acetate 99.02
    transcutol 488.21
    n-heptanol 88.05
    ethylbenzene 88.4
    MIBK 59.66
    2-propoxyethanol 300.16
    tert-butanol 319.94
    MTBE 177.41
    2-butoxyethanol 149.94
    propionic acid 368.78
    o-xylene 115.28
    formic acid 294.32
    diethyl ether 301.46
    m-xylene 87.7
    p-xylene 117.91
    chlorobenzene 279.83
    dimethyl carbonate 51.73
    n-octane 38.98
    formamide 284.97
    cyclopentanone 361.68
    2-pentanone 121.56
    anisole 141.43
    cyclopentyl methyl ether 294.99
    gamma-butyrolactone 425.25
    1-methoxy-2-propanol 267.58
    pyridine 679.94
    3-pentanone 128.71
    furfural 500.57
    n-dodecane 24.43
    diethylene glycol 273.83
    diisopropyl ether 55.5
    tert-amyl alcohol 257.57
    acetylacetone 124.8
    n-hexadecane 26.73
    acetophenone 121.7
    methyl propionate 145.38
    isopentyl acetate 120.21
    trichloroethylene 880.29
    n-nonanol 89.3
    cyclohexanol 430.36
    benzyl alcohol 165.17
    2-ethylhexanol 138.34
    isooctanol 67.04
    dipropyl ether 197.17
    1,2-dichlorobenzene 247.62
    ethyl lactate 84.1
    propylene carbonate 218.35
    n-methylformamide 272.22
    2-pentanol 164.87
    n-pentane 137.57
    1-propoxy-2-propanol 205.29
    1-methoxy-2-propyl acetate 117.27
    2-(2-methoxypropoxy) propanol 137.08
    mesitylene 52.34
    ε-caprolactone 346.34
    p-cymene 71.46
    epichlorohydrin 449.92
    1,1,1-trichloroethane 531.13
    2-aminoethanol 311.07
    morpholine-4-carbaldehyde 444.77
    sulfolane 426.24
    2,2,4-trimethylpentane 37.62
    2-methyltetrahydrofuran 514.52
    n-hexyl acetate 127.24
    isooctane 18.65
    2-(2-butoxyethoxy)ethanol 179.63
    sec-butyl acetate 73.75
    tert-butyl acetate 81.86
    decalin 73.48
    glycerin 262.08
    diglyme 336.72
    acrylic acid 356.11
    isopropyl myristate 61.42
    n-butyric acid 349.13
    acetyl acetate 154.33
    di(2-ethylhexyl) phthalate 68.73
    ethyl propionate 109.12
    nitromethane 474.25
    1,2-diethoxyethane 204.36
    benzonitrile 221.57
    trioctyl phosphate 44.15
    1-bromopropane 413.3
    gamma-valerolactone 464.9
    n-decanol 65.78
    triethyl phosphate 87.43
    4-methyl-2-pentanol 64.26
    propionitrile 295.41
    vinylene carbonate 239.84
    1,1,2-trichlorotrifluoroethane 531.64
    DMS 109.0
    cumene 57.78
    2-octanol 60.15
    2-hexanone 105.2
    octyl acetate 76.95
    limonene 123.32
    1,2-dimethoxyethane 419.09
    ethyl orthosilicate 91.07
    tributyl phosphate 62.86
    diacetone alcohol 104.76
    N,N-dimethylaniline 98.7
    acrylonitrile 343.62
    aniline 277.02
    1,3-propanediol 322.18
    bromobenzene 288.17
    dibromomethane 890.17
    1,1,2,2-tetrachloroethane 813.85
    2-methyl-cyclohexyl acetate 114.56
    tetrabutyl urea 79.78
    diisobutyl methanol 72.48
    2-phenylethanol 150.79
    styrene 130.02
    dioctyl adipate 104.02
    dimethyl sulfate 86.15
    ethyl butyrate 130.7
    methyl lactate 99.28
    butyl lactate 88.72
    diethyl carbonate 101.86
    propanediol butyl ether 120.7
    triethyl orthoformate 123.9
    p-tert-butyltoluene 69.14
    methyl 4-tert-butylbenzoate 105.06
    morpholine 834.35
    tert-butylamine 263.17
    n-dodecanol 53.88
    dimethoxymethane 196.69
    ethylene carbonate 198.73
    cyrene 131.36
    2-ethoxyethyl acetate 118.6
    2-ethylhexyl acetate 111.9
    1,2,4-trichlorobenzene 291.16
    4-methylpyridine 391.88
    dibutyl ether 143.67
    2,6-dimethyl-4-heptanol 72.48
    DEF 218.6
    dimethyl isosorbide 210.73
    tetrachloroethylene 737.24
    eugenol 114.46
    triacetin 146.02
    span 80 163.07
    1,4-butanediol 132.54
    1,1-dichloroethane 521.02
    2-methyl-1-pentanol 122.56
    methyl formate 175.7
    2-methyl-1-butanol 190.54
    n-decane 42.26
    butyronitrile 250.81
    3,7-dimethyl-1-octanol 94.9
    1-chlorooctane 89.71
    1-chlorotetradecane 42.11
    n-nonane 44.8
    undecane 30.05
    tert-butylcyclohexane 52.78
    cyclooctane 97.74
    cyclopentanol 430.95
    tetrahydropyran 736.5
    tert-amyl methyl ether 139.12
    2,5,8-trioxanonane 249.96
    1-hexene 203.17
    2-isopropoxyethanol 155.61
    2,2,2-trifluoroethanol 226.63
    methyl butyrate 141.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction