Ethylacetamide

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  • Identifiers

    CAS number
    625-50-3

    Molecular formula
    C4H9NO

    SMILES
    CCNC(=O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Meaty 46.26%
    Cheesy 42.36%
    Fishy 40.99%
    Savory 30.67%
    Roasted 29.66%
    Sulfurous 26.29%
    Pungent 25.55%
    Ripe 24.22%
    Odorless 24.1%
    Nutty 23.79%

     

    Flavor
    Cheese 34.34%
    Pungent 30.37%
    Acidic 29.12%
    Sour 28.29%
    Odorless 26.51%
    Fruity 24.85%
    Sweat 24.47%
    Fishy 24.24%
    Butter 23.88%
    Rancid 23.67%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.1

    pKa est.
    7.78 (neutral)

    Molecular weight
    87.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point

    • 205.00 °C. @ 760.00 mm Hg

    Flash point

    • 67.06 ˚C est.

  • Synonyms

    • N-ETHYLACETAMIDE
    • 625-50-3
    • Acetamide, N-ethyl-
    • Acetamidoethane
    • Ethylacetamide
    • Acetoethylamide
    • M9Y95ZE6J9
    • NSC-406307
    • DTXSID5060803
    • CHEBI:87370
    • RefChem:163333
    • DTXCID7043370
    • 210-896-7
    • N-Acetylethylamine
    • N-Aethylacetamid
    • MFCD00009029
    • N-Ethyl-acetamide
    • N-Aethylacetamid [German]
    • EINECS 210-896-7
    • NSC 406307
    • BRN 0969292
    • ethyl acetamide
    • AI3-02181
    • N-ethylethanamide
    • N-Ethylacetamide, 99%
    • ETHYLACETAMIDE, N-
    • UNII-M9Y95ZE6J9
    • SCHEMBL31852
    • SCHEMBL45384
    • SCHEMBL97684
    • 4-04-00-00347 (Beilstein Handbook Reference)
    • WLN: 2MV1
    • SCHEMBL209465
    • SCHEMBL209839
    • SCHEMBL7072383
    • SCHEMBL9204030
    • AC2513
    • NSC406307
    • AKOS003857793
    • CS-W011352
    • SY016499
    • DB-054195
    • E0324
    • NS00035066
    • C21404
    • F798396
    • Q27159564
    • InChI=1/C4H9NO/c1-3-5-4(2)6/h3H2,1-2H3,(H,5,6
    • 625-50-3

  • Applications

    Ethylacetamide (CAS 625-50-3) is used as a polar solvent and reaction medium in organic synthesis and general industrial manufacturing; as a pharmaceutical intermediate for the synthesis of acylated compounds; as a solvent and processing aid in polymer and plastics processing; as a solvent for coatings and printing inks; and as a component in cleaning formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 824.68
    methanol 1449.83
    isopropanol 477.81
    water 390.44
    ethyl acetate 143.0
    n-propanol 483.64
    acetone 341.55
    n-butanol 368.16
    acetonitrile 318.28
    DMF 577.27
    toluene 44.02
    isobutanol 302.72
    1,4-dioxane 273.73
    methyl acetate 185.76
    THF 405.42
    2-butanone 214.6
    n-pentanol 207.87
    sec-butanol 353.95
    n-hexane 25.56
    ethylene glycol 412.8
    NMP 599.89
    cyclohexane 18.98
    DMSO 446.28
    n-butyl acetate 67.49
    n-octanol 79.6
    chloroform 278.49
    n-propyl acetate 56.57
    acetic acid 1157.03
    dichloromethane 265.28
    cyclohexanone 241.53
    propylene glycol 390.53
    isopropyl acetate 70.19
    DMAc 486.25
    2-ethoxyethanol 268.6
    isopentanol 216.52
    n-heptane 11.51
    ethyl formate 165.86
    1,2-dichloroethane 123.22
    n-hexanol 151.26
    2-methoxyethanol 619.75
    isobutyl acetate 36.34
    tetrachloromethane 50.06
    n-pentyl acetate 62.07
    transcutol 468.92
    n-heptanol 63.29
    ethylbenzene 18.91
    MIBK 63.66
    2-propoxyethanol 251.38
    tert-butanol 352.08
    MTBE 144.1
    2-butoxyethanol 120.84
    propionic acid 443.9
    o-xylene 35.23
    formic acid 918.47
    diethyl ether 145.18
    m-xylene 31.74
    p-xylene 29.45
    chlorobenzene 71.41
    dimethyl carbonate 37.32
    n-octane 5.08
    formamide 548.04
    cyclopentanone 301.31
    2-pentanone 139.21
    anisole 56.57
    cyclopentyl methyl ether 145.4
    gamma-butyrolactone 371.03
    1-methoxy-2-propanol 328.2
    pyridine 178.33
    3-pentanone 97.86
    furfural 324.27
    n-dodecane 4.88
    diethylene glycol 279.01
    diisopropyl ether 26.93
    tert-amyl alcohol 291.75
    acetylacetone 120.8
    n-hexadecane 5.05
    acetophenone 57.93
    methyl propionate 118.73
    isopentyl acetate 57.04
    trichloroethylene 209.44
    n-nonanol 63.23
    cyclohexanol 215.38
    benzyl alcohol 92.85
    2-ethylhexanol 61.42
    isooctanol 44.99
    dipropyl ether 43.33
    1,2-dichlorobenzene 58.61
    ethyl lactate 49.45
    propylene carbonate 154.12
    n-methylformamide 393.63
    2-pentanol 180.22
    n-pentane 28.15
    1-propoxy-2-propanol 136.16
    1-methoxy-2-propyl acetate 73.05
    2-(2-methoxypropoxy) propanol 113.45
    mesitylene 17.57
    ε-caprolactone 229.92
    p-cymene 17.44
    epichlorohydrin 260.87
    1,1,1-trichloroethane 107.17
    2-aminoethanol 551.22
    morpholine-4-carbaldehyde 415.29
    sulfolane 379.94
    2,2,4-trimethylpentane 13.92
    2-methyltetrahydrofuran 294.79
    n-hexyl acetate 101.97
    isooctane 6.41
    2-(2-butoxyethoxy)ethanol 163.8
    sec-butyl acetate 38.33
    tert-butyl acetate 63.3
    decalin 9.17
    glycerin 469.52
    diglyme 210.67
    acrylic acid 405.64
    isopropyl myristate 31.96
    n-butyric acid 376.64
    acetyl acetate 92.39
    di(2-ethylhexyl) phthalate 49.89
    ethyl propionate 52.82
    nitromethane 676.11
    1,2-diethoxyethane 93.67
    benzonitrile 105.16
    trioctyl phosphate 33.05
    1-bromopropane 88.08
    gamma-valerolactone 398.9
    n-decanol 43.61
    triethyl phosphate 27.32
    4-methyl-2-pentanol 70.59
    propionitrile 185.32
    vinylene carbonate 142.75
    1,1,2-trichlorotrifluoroethane 253.02
    DMS 65.96
    cumene 16.96
    2-octanol 45.78
    2-hexanone 71.91
    octyl acetate 46.75
    limonene 30.82
    1,2-dimethoxyethane 232.84
    ethyl orthosilicate 27.61
    tributyl phosphate 41.42
    diacetone alcohol 113.87
    N,N-dimethylaniline 47.81
    acrylonitrile 217.62
    aniline 123.57
    1,3-propanediol 508.8
    bromobenzene 51.05
    dibromomethane 159.07
    1,1,2,2-tetrachloroethane 167.39
    2-methyl-cyclohexyl acetate 43.54
    tetrabutyl urea 55.54
    diisobutyl methanol 27.88
    2-phenylethanol 75.24
    styrene 25.65
    dioctyl adipate 51.64
    dimethyl sulfate 76.52
    ethyl butyrate 43.42
    methyl lactate 103.42
    butyl lactate 66.12
    diethyl carbonate 29.82
    propanediol butyl ether 152.38
    triethyl orthoformate 34.42
    p-tert-butyltoluene 16.95
    methyl 4-tert-butylbenzoate 69.7
    morpholine 352.11
    tert-butylamine 185.45
    n-dodecanol 31.85
    dimethoxymethane 171.4
    ethylene carbonate 112.33
    cyrene 103.39
    2-ethoxyethyl acetate 85.84
    2-ethylhexyl acetate 44.08
    1,2,4-trichlorobenzene 76.46
    4-methylpyridine 189.79
    dibutyl ether 49.57
    2,6-dimethyl-4-heptanol 27.88
    DEF 190.38
    dimethyl isosorbide 141.31
    tetrachloroethylene 132.09
    eugenol 82.16
    triacetin 85.54
    span 80 112.5
    1,4-butanediol 201.96
    1,1-dichloroethane 144.86
    2-methyl-1-pentanol 155.18
    methyl formate 227.09
    2-methyl-1-butanol 252.2
    n-decane 7.85
    butyronitrile 195.13
    3,7-dimethyl-1-octanol 63.22
    1-chlorooctane 29.43
    1-chlorotetradecane 12.11
    n-nonane 7.94
    undecane 5.88
    tert-butylcyclohexane 10.67
    cyclooctane 5.99
    cyclopentanol 296.4
    tetrahydropyran 213.79
    tert-amyl methyl ether 110.29
    2,5,8-trioxanonane 161.89
    1-hexene 64.42
    2-isopropoxyethanol 141.58
    2,2,2-trifluoroethanol 317.41
    methyl butyrate 78.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction