Ethyl Thioglycolate

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  • Identifiers

    CAS number
    623-51-8

    Molecular formula
    C4H8O2S

    SMILES
    CCOC(=O)CS

    Safety labels

    Flammable
    Flammable

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 90.88%
    Sulfurous 74.55%
    Green 71.67%
    Tropical 67.16%
    Meaty 43.33%
    Onion 41.49%
    Alliaceous 39.26%
    Vegetable 37.64%
    Sweet 36.2%
    Pineapple 35.21%

     

    Flavor
    Fruity 73.0%
    Fatty 42.14%
    Sweet 35.28%
    Floral 33.83%
    Pineapple 32.99%
    Tropical 32.01%
    Green 30.75%
    Nutty 30.66%
    Fruit 30.43%
    Vegetable 29.62%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    8.65 (weak base)

    Molecular weight
    120.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    173°C

    Flash point

    • 47.04 ˚C est.

  • Synonyms

    • Ethyl thioglycolate
    • 623-51-8
    • Ethyl 2-mercaptoacetate
    • Ethyl mercaptoacetate
    • ethyl 2-sulfanylacetate
    • ethylthioglycolate
    • Acetic acid, mercapto-, ethyl ester
    • Mercaptoacetic acid ethyl ester
    • Ethyl thioglycollate
    • Thioglycolic acid ethyl ester
    • USAF EK-2070
    • Ethyl mercaptoacetic acid
    • Thioglykolsaeure-aethylester
    • Ethyl sulfanylacetate
    • NSC 8834
    • Ethyl .alpha.-mercaptoacetate
    • Acetic acid, 2-mercapto-, ethyl ester
    • UNII-Z5SD8DD6CP
    • Z5SD8DD6CP
    • EINECS 210-800-3
    • Thioglykolsaeure-aethylester [German]
    • MFCD00004874
    • BRN 0605581
    • AI3-23030
    • 2-mercaptoacetic acid ethyl ester
    • NSC-8834
    • Ethyl alpha-mercaptoacetate
    • ETHOXYCARBONYLMETHANETHIOL
    • Acetic acid,mercapto-,ethylester
    • DTXSID8049337
    • mercapto-acetic acid ethyl ester
    • Mercaptoacetic acid, ethyl ester
    • 4-03-00-00616 (Beilstein Handbook Reference)
    • ACETIC ACID,MERCAPTO,ETHYL ESTER
    • 2-ethyl thioglycolate
    • ethyl mercapto-acetate
    • 2-ethyl mercaptoacetate
    • ethyl-2 mercaptoacetate
    • ethyl-2-mercaptoacetate
    • Ethyl sulfanylacetate #
    • ethyl 2-mercapto-acetate
    • ethyl 2-sulfanylethanoate
    • Ethyl-2-mercapto-acetate
    • Thioglykolsaeureaethylester
    • Ethyl thioglycolate, 97%
    • WLN: SH1VO2
    • SCHEMBL98169
    • CHEMBL3181965
    • DTXCID2029294
    • NSC8834
    • ETHYL THIOGLYCOLATE [INCI]
    • Acetic acid, mercapto, ethyl ester
    • Tox21_202860
    • Acetic acid, 2mercapto, ethyl ester
    • BBL011508
    • STL146623
    • AKOS000120357
    • MERCAPTO ACETIC ACID ETHYLESTER
    • CS-W001139
    • FE34642
    • NCGC00260406-01
    • CAS-623-51-8
    • VS-02965
    • NS00013667
    • T0211
    • EN300-20380
    • F21271
    • A833729
    • Q27295042
    • F0001-1673

  • Applications

    Ethyl Thioglycolate (CAS 623-51-8) is primarily used as an organic synthesis intermediate and a sulfur-containing building block. It serves as a precursor to thiol-containing monomers and thioesters, enabling transformations such as thiol-ene and thiol-epoxy chemistries in coatings, adhesives, and specialty polymers. In polymer processing, it can act as a chain-transfer agent to regulate molecular weight in radical polymerizations. It also finds use as a reactive thiol component in resin formulations and as a source for sulfur-containing derivatives in industrial manufacturing. Its exact applications depend on formulation and are subject to local regulations and limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 337.16
    methanol 658.94
    isopropanol 224.73
    water 28.07
    ethyl acetate 303.99
    n-propanol 218.19
    acetone 744.22
    n-butanol 181.68
    acetonitrile 630.91
    DMF 1231.48
    toluene 98.19
    isobutanol 153.19
    1,4-dioxane 478.75
    methyl acetate 383.71
    THF 486.34
    2-butanone 387.78
    n-pentanol 164.83
    sec-butanol 179.25
    n-hexane 38.51
    ethylene glycol 201.82
    NMP 980.3
    cyclohexane 33.83
    DMSO 1367.09
    n-butyl acetate 162.31
    n-octanol 115.61
    chloroform 475.12
    n-propyl acetate 199.97
    acetic acid 709.79
    dichloromethane 587.68
    cyclohexanone 440.88
    propylene glycol 143.03
    isopropyl acetate 176.62
    DMAc 965.93
    2-ethoxyethanol 371.99
    isopentanol 144.08
    n-heptane 21.8
    ethyl formate 279.96
    1,2-dichloroethane 409.31
    n-hexanol 113.11
    2-methoxyethanol 616.51
    isobutyl acetate 117.25
    tetrachloromethane 89.0
    n-pentyl acetate 148.85
    transcutol 768.67
    n-heptanol 71.94
    ethylbenzene 77.23
    MIBK 169.84
    2-propoxyethanol 275.19
    tert-butanol 243.9
    MTBE 187.53
    2-butoxyethanol 174.51
    propionic acid 297.54
    o-xylene 99.9
    formic acid 382.4
    diethyl ether 220.96
    m-xylene 89.79
    p-xylene 114.93
    chlorobenzene 209.11
    dimethyl carbonate 158.46
    n-octane 14.44
    formamide 457.8
    cyclopentanone 590.16
    2-pentanone 292.65
    anisole 209.68
    cyclopentyl methyl ether 220.07
    gamma-butyrolactone 675.53
    1-methoxy-2-propanol 380.88
    pyridine 374.04
    3-pentanone 259.76
    furfural 734.72
    n-dodecane 16.46
    diethylene glycol 329.77
    diisopropyl ether 71.17
    tert-amyl alcohol 187.82
    acetylacetone 487.68
    n-hexadecane 18.1
    acetophenone 245.55
    methyl propionate 269.51
    isopentyl acetate 128.7
    trichloroethylene 668.95
    n-nonanol 95.81
    cyclohexanol 162.57
    benzyl alcohol 192.79
    2-ethylhexanol 75.9
    isooctanol 62.28
    dipropyl ether 100.71
    1,2-dichlorobenzene 230.36
    ethyl lactate 131.26
    propylene carbonate 318.11
    n-methylformamide 552.63
    2-pentanol 123.62
    n-pentane 33.05
    1-propoxy-2-propanol 164.44
    1-methoxy-2-propyl acetate 179.94
    2-(2-methoxypropoxy) propanol 219.9
    mesitylene 65.28
    ε-caprolactone 383.54
    p-cymene 56.13
    epichlorohydrin 564.01
    1,1,1-trichloroethane 284.77
    2-aminoethanol 229.02
    morpholine-4-carbaldehyde 819.79
    sulfolane 908.27
    2,2,4-trimethylpentane 21.81
    2-methyltetrahydrofuran 327.43
    n-hexyl acetate 231.75
    isooctane 14.93
    2-(2-butoxyethoxy)ethanol 278.87
    sec-butyl acetate 123.62
    tert-butyl acetate 183.04
    decalin 28.84
    glycerin 255.7
    diglyme 498.0
    acrylic acid 348.04
    isopropyl myristate 89.84
    n-butyric acid 284.4
    acetyl acetate 249.35
    di(2-ethylhexyl) phthalate 99.76
    ethyl propionate 189.17
    nitromethane 1297.05
    1,2-diethoxyethane 230.78
    benzonitrile 302.63
    trioctyl phosphate 72.04
    1-bromopropane 181.45
    gamma-valerolactone 768.93
    n-decanol 73.39
    triethyl phosphate 88.75
    4-methyl-2-pentanol 76.76
    propionitrile 306.78
    vinylene carbonate 340.39
    1,1,2-trichlorotrifluoroethane 464.82
    DMS 209.68
    cumene 66.67
    2-octanol 66.7
    2-hexanone 211.96
    octyl acetate 116.44
    limonene 76.62
    1,2-dimethoxyethane 615.34
    ethyl orthosilicate 82.06
    tributyl phosphate 95.39
    diacetone alcohol 226.65
    N,N-dimethylaniline 176.57
    acrylonitrile 460.47
    aniline 159.71
    1,3-propanediol 268.57
    bromobenzene 198.41
    dibromomethane 344.95
    1,1,2,2-tetrachloroethane 489.26
    2-methyl-cyclohexyl acetate 114.7
    tetrabutyl urea 142.57
    diisobutyl methanol 56.34
    2-phenylethanol 135.6
    styrene 107.86
    dioctyl adipate 142.97
    dimethyl sulfate 352.2
    ethyl butyrate 139.64
    methyl lactate 192.86
    butyl lactate 124.64
    diethyl carbonate 104.32
    propanediol butyl ether 209.2
    triethyl orthoformate 96.9
    p-tert-butyltoluene 53.4
    methyl 4-tert-butylbenzoate 192.19
    morpholine 473.07
    tert-butylamine 146.97
    n-dodecanol 59.2
    dimethoxymethane 453.74
    ethylene carbonate 253.93
    cyrene 226.19
    2-ethoxyethyl acetate 224.39
    2-ethylhexyl acetate 102.89
    1,2,4-trichlorobenzene 262.47
    4-methylpyridine 389.46
    dibutyl ether 122.03
    2,6-dimethyl-4-heptanol 56.34
    DEF 429.97
    dimethyl isosorbide 303.14
    tetrachloroethylene 330.3
    eugenol 208.64
    triacetin 245.48
    span 80 177.32
    1,4-butanediol 153.08
    1,1-dichloroethane 329.58
    2-methyl-1-pentanol 140.15
    methyl formate 457.2
    2-methyl-1-butanol 144.54
    n-decane 23.35
    butyronitrile 270.67
    3,7-dimethyl-1-octanol 96.71
    1-chlorooctane 75.74
    1-chlorotetradecane 38.27
    n-nonane 23.02
    undecane 19.05
    tert-butylcyclohexane 28.99
    cyclooctane 15.07
    cyclopentanol 212.97
    tetrahydropyran 276.01
    tert-amyl methyl ether 155.84
    2,5,8-trioxanonane 379.13
    1-hexene 100.07
    2-isopropoxyethanol 225.81
    2,2,2-trifluoroethanol 274.92
    methyl butyrate 254.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction