Ethyl syringate

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  • Identifiers

    CAS number
    3943-80-4

    Molecular formula
    C11H14O5

    SMILES
    CCOC(=O)C1=CC(=C(C(=C1)OC)O)OC

    Safety labels

  • Odor profile

    Fragrance
    Floral 73.83%
    Vanilla 63.26%
    Sweet 60.3%
    Spicy 52.03%
    Balsamic 50.69%
    Powdery 46.29%
    Phenolic 40.46%
    Fruity 37.96%
    Woody 37.22%
    Clove 34.43%

     

    Flavor
    Bitter 49.53%
    Woody 35.99%
    Sweet 31.36%
    Vanilla 29.22%
    Powdery 27.19%
    Spice 26.74%
    Smoky 26.38%
    Mild 24.43%
    Creamy 24.0%
    Eugenol 23.89%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    7.21 (neutral)

    Molecular weight
    226.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    367°C

    Flash point

    • 143.36 ˚C est.

  • Synonyms

    • 3943-80-4
    • Ethyl syringate
    • BENZOIC ACID, 3,5-DIMETHOXY-4-HYDROXY-, ETHYL ESTER
    • DTXSID40192599
    • RefChem:1085104
    • DTXCID30115090
    • ethyl 4-hydroxy-3,5-dimethoxybenzoate
    • ethyl 4-hydroxy-3,5-dimethoxy-benzoate
    • 3,5-Dimethoxy-4-hydroxybenzoic acid ethyl ester
    • Ethyl4-hydroxy-3,5-dimethoxybenzoate
    • BRN 2113673
    • Ester etylowy kwasu syringowego [Polish]
    • Ester etylowy kwasu syringowego
    • Ethyl syringoate
    • MFCD01661203
    • Benzoic acid, 4-hydroxy-3,5-dimethoxy-, ethyl ester
    • ethyl 3,5-dimethoxy-4-hydroxybenzoate
    • syringic acid ethyl ester
    • SCHEMBL582920
    • DAA94380
    • AKOS016003287
    • DB-069813
    • E79234
    • 3943-80-4

  • Applications

    Ethyl syringate (CAS 3943-80-4) is primarily used as an aromatic ester in fragrance technology and related consumer products. In perfumery and flavor applications, it serves as an odorant or fragrance precursor, and in cosmetics and personal care it can appear as a fragrance ingredient in permitted formulations. It is also used as a chemical intermediate in organic synthesis, including routes to syringyl- and lignin-derived aromatic compounds. In research and industrial settings, it may be evaluated for use in coatings or inks as an aroma additive, subject to regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 67.99
    methanol 94.32
    isopropanol 47.46
    water 0.62
    ethyl acetate 218.52
    n-propanol 49.46
    acetone 336.0
    n-butanol 42.88
    acetonitrile 207.02
    DMF 690.74
    toluene 38.8
    isobutanol 32.85
    1,4-dioxane 215.17
    methyl acetate 263.61
    THF 443.96
    2-butanone 200.64
    n-pentanol 33.62
    sec-butanol 47.9
    n-hexane 2.17
    ethylene glycol 52.17
    NMP 651.7
    cyclohexane 5.62
    DMSO 1050.3
    n-butyl acetate 124.27
    n-octanol 21.4
    chloroform 260.6
    n-propyl acetate 126.01
    acetic acid 302.98
    dichloromethane 438.52
    cyclohexanone 259.59
    propylene glycol 30.05
    isopropyl acetate 114.33
    DMAc 539.34
    2-ethoxyethanol 161.84
    isopentanol 46.36
    n-heptane 3.0
    ethyl formate 142.96
    1,2-dichloroethane 346.15
    n-hexanol 37.03
    2-methoxyethanol 282.96
    isobutyl acetate 61.74
    tetrachloromethane 36.67
    n-pentyl acetate 59.26
    transcutol 275.03
    n-heptanol 22.1
    ethylbenzene 33.4
    MIBK 78.66
    2-propoxyethanol 122.17
    tert-butanol 113.33
    MTBE 104.58
    2-butoxyethanol 70.21
    propionic acid 125.78
    o-xylene 42.03
    formic acid 183.48
    diethyl ether 87.64
    m-xylene 33.93
    p-xylene 43.01
    chlorobenzene 85.96
    dimethyl carbonate 179.83
    n-octane 1.67
    formamide 523.15
    cyclopentanone 475.12
    2-pentanone 143.49
    anisole 111.7
    cyclopentyl methyl ether 138.17
    gamma-butyrolactone 699.31
    1-methoxy-2-propanol 154.54
    pyridine 233.1
    3-pentanone 120.68
    furfural 513.71
    n-dodecane 1.82
    diethylene glycol 136.68
    diisopropyl ether 26.48
    tert-amyl alcohol 97.24
    acetylacetone 299.71
    n-hexadecane 2.16
    acetophenone 150.56
    methyl propionate 208.21
    isopentyl acetate 103.41
    trichloroethylene 597.27
    n-nonanol 21.13
    cyclohexanol 60.84
    benzyl alcohol 92.68
    2-ethylhexanol 31.32
    isooctanol 20.62
    dipropyl ether 40.15
    1,2-dichlorobenzene 109.79
    ethyl lactate 72.37
    propylene carbonate 275.19
    n-methylformamide 320.78
    2-pentanol 33.71
    n-pentane 2.27
    1-propoxy-2-propanol 79.83
    1-methoxy-2-propyl acetate 134.57
    2-(2-methoxypropoxy) propanol 90.09
    mesitylene 22.96
    ε-caprolactone 252.22
    p-cymene 26.46
    epichlorohydrin 593.17
    1,1,1-trichloroethane 189.35
    2-aminoethanol 62.99
    morpholine-4-carbaldehyde 480.43
    sulfolane 872.33
    2,2,4-trimethylpentane 3.75
    2-methyltetrahydrofuran 238.15
    n-hexyl acetate 72.42
    isooctane 1.83
    2-(2-butoxyethoxy)ethanol 93.32
    sec-butyl acetate 76.35
    tert-butyl acetate 143.72
    decalin 6.26
    glycerin 88.92
    diglyme 250.27
    acrylic acid 169.48
    isopropyl myristate 30.64
    n-butyric acid 134.3
    acetyl acetate 185.56
    di(2-ethylhexyl) phthalate 35.74
    ethyl propionate 113.56
    nitromethane 940.62
    1,2-diethoxyethane 91.02
    benzonitrile 107.49
    trioctyl phosphate 25.52
    1-bromopropane 76.92
    gamma-valerolactone 510.04
    n-decanol 16.21
    triethyl phosphate 67.61
    4-methyl-2-pentanol 24.08
    propionitrile 106.4
    vinylene carbonate 251.77
    1,1,2-trichlorotrifluoroethane 402.93
    DMS 136.17
    cumene 25.0
    2-octanol 15.81
    2-hexanone 88.65
    octyl acetate 39.2
    limonene 35.37
    1,2-dimethoxyethane 256.5
    ethyl orthosilicate 56.94
    tributyl phosphate 36.65
    diacetone alcohol 149.53
    N,N-dimethylaniline 83.09
    acrylonitrile 198.03
    aniline 88.99
    1,3-propanediol 90.06
    bromobenzene 85.68
    dibromomethane 212.95
    1,1,2,2-tetrachloroethane 364.9
    2-methyl-cyclohexyl acetate 83.18
    tetrabutyl urea 49.35
    diisobutyl methanol 22.49
    2-phenylethanol 82.35
    styrene 43.05
    dioctyl adipate 57.84
    dimethyl sulfate 371.57
    ethyl butyrate 94.68
    methyl lactate 113.32
    butyl lactate 49.24
    diethyl carbonate 83.74
    propanediol butyl ether 53.57
    triethyl orthoformate 67.29
    p-tert-butyltoluene 24.92
    methyl 4-tert-butylbenzoate 98.44
    morpholine 263.52
    tert-butylamine 48.2
    n-dodecanol 12.7
    dimethoxymethane 331.01
    ethylene carbonate 190.18
    cyrene 137.17
    2-ethoxyethyl acetate 108.75
    2-ethylhexyl acetate 80.21
    1,2,4-trichlorobenzene 146.11
    4-methylpyridine 185.84
    dibutyl ether 31.68
    2,6-dimethyl-4-heptanol 22.49
    DEF 231.11
    dimethyl isosorbide 198.95
    tetrachloroethylene 255.46
    eugenol 90.1
    triacetin 117.19
    span 80 55.87
    1,4-butanediol 34.39
    1,1-dichloroethane 170.07
    2-methyl-1-pentanol 40.9
    methyl formate 312.0
    2-methyl-1-butanol 41.07
    n-decane 2.78
    butyronitrile 74.02
    3,7-dimethyl-1-octanol 25.29
    1-chlorooctane 16.61
    1-chlorotetradecane 7.85
    n-nonane 2.36
    undecane 2.19
    tert-butylcyclohexane 4.82
    cyclooctane 2.18
    cyclopentanol 88.33
    tetrahydropyran 135.01
    tert-amyl methyl ether 85.88
    2,5,8-trioxanonane 163.85
    1-hexene 11.92
    2-isopropoxyethanol 95.33
    2,2,2-trifluoroethanol 174.39
    methyl butyrate 146.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction